SCtUIBB'S M ATE RI A ME D I C A FOR THE PHYSICIAN AND THE SURGEON DESK COPY TO RESEARCH WORKERS To Foster. Scientific Medicine Was one of the reasons for founding The Squibb Laboratories, and today it is a prime motive of then activities. Conse- quently, roe shall be glad to participate in the study of biological, biochemical, chemi- cal- or pharmaceutical problems, either by ourselves uridertaking suggested researches, or by assisting in the prosecution of such, or by the placing of our laboratories at the per- sonal service of investigators. Pursuant to this, we invite correspondence relative to the elaboration or the commercial adaptation of new processes; also in regard to the physiological examination of products ; as well as concerning the preparation of special material for clinical or for laboratory experimentation; and in the interest of a cooperation in the solving of problems con- nected with the public health. For work such as outlined above, our laboratories, by virtue 6f their, staff and equipment, are eminently adapted. All communications relating to such special Work should be addressed : THIS BOOK IS THE GIFT OF Henry Pelouze de Forest Class of 1884 SQUIBB'S MATERIA MEDICA 1919 EDITION Cornell University Library arV18966 Squibb's materia medica 3 1924 031 294 311 olin.anx Cornell University Library The original of tliis book is in the Cornell University Library. There are no known copyright restrictions in the United States on the use of the text. http://www.archive.org/details/cu31924031294311 SQUIBB'S MATERIA MEDIGA 1919 Edition A Complete Alphabetical List OF the Squibb Products, indud- x ing all the articles of the United States Pharmacopceia (IXth Revision) and of the National Formulary (IVth, 1916, edition), to- gether with the Non-official Chemicals, Phar- maceuticals and Newer Remedies in general use; setting forth their Origin, Latin and English Tides, Ssmohyms, Physical and Chem- ical Characteristics,^ Incompatibilities, Antidotes, Therapeutic Indications;- Doses, etc. Also a Comprehensive Descrip- tive List of Tablets for internal and for Hypodermic Use; of BlOLOGlCAL Products, and of Reagents, indudihg Test Solutions, Volumetric Solutions and Indicators. PUBUSHED FOR THE PHYSICIAN AND THE SURGEON BY THE MEDICAL DEPARTMENT ER: Squibb & Sons. New ^ftjRK MANUFACTirRING CHEMISTS TO THE MEDICAL PKOFESSION SINCE 1SS8. a o O ~< p. o a a X •o s a 3 a- a> JS H ^i^^'TuHu M..cn.u^. (9^^u^M. Dr. E. R. Squibb "The late Dr. Edward R. Squibb was a true gentleman of the older school, whose thoughts, words and adtions were guided by those^terling qualities of principle, honor and integrity. One need but look at his photograph to discern that he was a good and noble man. His charadter is in his face. I honor and revere the name of this distinguished gentleman whose life work was devoted to the highest ideals in the pradice of medicine and pharmacy. The house of E. R. Squibb Si Sons stands today as a living monument to the honor, integrity, zeal and devotion of its founder. The medical and pharmaceutical professions alike owe a debt of gratitude to Dr. Edward R. Squibb which they can never pay. Although Dr. Squibb passed on some few years ago, yet he still lives. In the business which he estab- lished half a century ago he lives. His rare skill, his honor, his integrity and his pride are there. The influence of his noble life and charadter will never die; it will live on forever." WILLIAM MILLER BARTLETT The E. R. Squibb & Sons General Offices Squibb Building, New York City M 3 u n 2 o u o a ■OJ) "o S c a as 3 a" 0) H The One Hundredth Anniversary of the Birth of Doctor Squibb On July The Fourth, 1819. the forty-third anniversary of Our Nation's birth, was born of Quaker parents, in Wilmington, Delaware, Edward Robinson Squibb, who, as a man, was destined to stamp upon pharmacy and medicine an ethical imprint which time cannot efface. Re- ceiving good early education in the public schools of his native towli, he served five years as appren- tice in pharmacy in the drug, stores of Warder Morris and J. M. Sprague of Philadelphia, where he" earned sufficient money to pay for a medical education. He graduated from Jefferson Medical College in 1845. During the two years he practiced medicine in Philadelphia he continued scientific investigation serving his alma mater as Clerk of Clinics, As- sistant Demonstrator of Anatomy and Curator of The Museunr. In 1 847 he joined the U. S. Navy. On March 29, 1847, Dr. Squibb reported at the Philadelphia Navy Yard for duty on board the U. S. Brig Perry, and on April 26, 1847, he received his appointment as Assistant Surgeon, his papers being signed by President Polk. Three weeks later he sailed on an expedition, the purr poses of which were in coiinection with the Mexi- can War and the breaking up of the Sotith Ameri- can slave trade as far as it was carried on in vessels owned in the United State?. During July, 1 849, TTie Perry returned to Hampton Roads, dis- charged at Norfolk and was put out of commission. iv SQUIBB'S MATERIA MEDICA On August 1 1 , 1849, Dr. Squibb reported at the Brooklyn Navy Yard for duty on board the Store Ship Erie and on September 5 sailed for The Mediterranean. While on this cruise he was ordered to The Frigate Cumberland on which he returned to The Charlestown Navy Yard in July, 1 85 1 and left Boston, having been ordered to the Brooklyn Naval Hospital. Here he was assigned to temporary duty on the S. S. Mississippi, the Str. Allegheny and to Naval Rendezvous and finally was attached permanently to the Naval Hospital. During Dr. Squibb's active service at sea he had studied how the national medical service could be improved. Particularly, he had noted the poor quality of ammunition and of medicines furnished the Navy and it was largely through his influence that ammunition and medical supplies were exempted from competitive bids, quality be- ing given preference to price. But Dr. Squibb did more than this. Not only did he exert him- self to have good supplies obtained from outside sources but also he himself endeavored to produce trustworthy pharmaceuticals. Consequently he established a laboratory in an outbuilding belong- ing to the Naval Hospital, equipping it largely with apparatus of his own manufacture or of his own invention. In 1 853, at this Naval Laboratory Dr. Squibb perfected the still which he had devised for the making of the Squibb Ether, which was soon rec- ognized to be and still is The Standard Anaes- thetic Ether. Here also he made the Squibb stills for the manufacture and purification of Chloro- form and his original process produces after all SQUIBB'S- MATERIA MEDICA v these years the best anaesthetic chloroform, one safer and otherwise better than that of the U. S. P. Here he idevised also methods and apparatus for subliming benzoic acid and for making cal- cium chloride; also, he invented and built mills for pdwdering drugs of all sorts. He discovered and established suitable methods for producing phosphoric acid and for crystallizing ammonium phosphate. As today, so sixty years ago, Dr. Squibb's mercurials were unequalled ; and the pro- cesses worked out and perfected by Dr. Squibb for the making of extracts and fluidextracts have not been improved upon since his day. To men- tion the perfection of aconite and ergot prepara- tions, and of other pharmaceutical products and processes, all from Dr. Squibb's own brain and hands, while of great interest, would occupy a treatise by itself. From the start, then. Dr. Squibb was success- ful in producing pharmaceuticals and chemicals of the finest quality. The Historian in the U. S. Naval Medical Bulletin Vol. IX, No. 3, writes, "At first only a few standard mediums were pre- pared for the use of the Naval Hospital at Brook- lyn, but gradually, other hospitals were supplied until the value (of the Squibb Laboratory) be- ing recognized Congress authorized the Navy De- partment to establish a larger pharmaceutical lab- oratory for the manufacture of important articles on the supply table." In this new laboratory Dr. Squibb, the instigator and founder became the chief factor and here he worked until he entered civil life to establish his own laboratory. In 1857 Dr. Squibb resigned his naval posi- tion. Soon after its establishment Congress closed vl SQUIBB'S MATERIA MEDICA the laboratory which had been established at the Naval Hospital. The War Department, how- ever, impressed with the utility of the laboratory as established by Dr. Squibb and with the un- equalled quality of the drugs produced by him, sought to re-establish it but failed on account of political opposition. It was then that Dr. R. S. Satterlee. Chief Medical Purveyor of the Army, persuaded Dr. Squibb to establish a labo- ratory of his own. Dr. Satterlee assured Dr. Squibb that if he would make drugs of as good a quality as he made in the Naval Laboratory, the U. S. Government would buy of him such prod- ucts as it might need. Consequently in 1 858 The Squibb Chemical and Pharmaceutical Labora- tories were established and The House of Squibb was founded. For nearly fifty years Dr. Squibb personally worked in his own establishment. Soon after be- ginning his work a fire which started in the ether house destroyed the laboratories, and severely in- jured Dr. Squibb. However, he rebuilt his laboratories and although crippled and rendered a constant sufferer he continued to labor and toiled faithfully in the interest of scientific phar- macy and medicine until his death, which oc- curred on October 25, 1900. Although Dr. Squibb is no more he lives in the laboratories which he established, and those upon whom his mantle has fallen carry on the work as conscientiously as he did, being actuated, by the same motives, governed by the same policy and making the same earnest effort to spread the influence which originated with Dr. E. R. Squibb. The Sixtieth Anniversary of the Founding of the House of Squibb It is now sixty years since the House of E. R. Squibb and Sons was founded. Instituted not merely for business, the object of which is profit, it began its career with unique intentions. Its in- ception was in a sense of duty. The circumstances in which Dr. Squibb found himself when at the Brooklyn Naval Hospital made him realize that as a citizen and as a naval officer he owed to his country an effort to better certain conditions, and this obligation he immediately set about to fulfil. The integrity of the products made and offered by Drl Squibb gained for the Squibb Labora- tories the confidence, not only of the United States Government, but of physicians and surgeons in civil practice as well. Quality, which to Dr. Squibb had always been first in importance, was appreciated by others. He had realized that in the treatment of the sick the physician was handi- capped unless he had at hetnd remedies which were true tp their formulae and of known potency. And when the physician himself, by using the Squibb drugs, saw their effect, he, too, understood the necessity of trustworthy products. Thus the Squibb ideal proved a success. ' Because of this, it always has been a principle of the Squibb Laboratories to select, with the most scrupulous care, all crude materials usfed in manufacture and also to devise correct methods of manufacturing. In order further to assure perfect results. Dr. Squibb established a Control Laboratory, in which Vll viii SQUIBB'S MATERIA MEDICA experienced chemists are employed to. examine and test every lot of each product as soon as it is made and before it is put into stock. This was an additional check on the quality of the finished drug; therefore, each article which bears the Squibb label represented then, as to-day, a prod- uct in strict conformity with highest standards. The rapid and wide-spread demand for drugs of Squibb Quality soon made expansion impera- tive, so that to-day not only are the original labo- ratories enlarged, but new ones have sprung up in various parts of the Union. For instance, The Squibb Chemical and Pharmaceutical Labora- tories, located in Brooklyn, occupy an entire block with overflows in other parts of the city. The Squibb Chemical, Biological and Research Laboratories, located in New Brunswick, New Jersey, occupy over fifty-six acres. In these New Brunswick Laboratories are piade the Squibb Biological and Bacteriological Products, including the Squibb Antitoxins, Serums, Vac- cines, Leucocyte Extract, etc., etc. Also the Squibb Mercurials including Mercury Bi- chloride, Calomel, etc. Also the Dakin Chlorinated Antiseptics and Disinfectants, in- cluding Chloramine-T, Dichloramine-T, Chlor- cosane, Halazone, etc. Further, in New Bruns- wick, N. J., is located the Squibb Ether Plant, whence comes the Squibb Ether, of one quality only,- the best that can be made for anaesthesia. At Berlin, N. H., are the Laboratories for the manufacture of the Squibb Chloroform, located there because in Berlin, N. H., there is available the purest chlorine at the lowest cost. At Richmond, Cal., are situated the Labora- SQUIBB'S MATERIA MEDICA ix tories for the purifying, testing, bottling and ship- ping of The Squibb Mineral Oil, known as Liquid Petrolatum Squibb, Heavy ( Calif ornian). These laboratories are located there because only in California is found the naphthene oil, a hydro- carbon superior not only to all other American mineral oils, but also to the Russian oils. From this Californian highest quality crude is specially refined under Squibb Control, for internal use, the unequalled Squibb Mineral Oil, which main- tains a high and correct viscosity in the intestine, where it does its work. That the Squibb policy of maintaining Uniform Puriij; and Efficacy and, therefore. Full Relia- bility directs all the activities of the Squibb Laboratories is apparent from what has been said above; it is evident also from thcvfact that when the Pure Food and Drugs Act was passed in 1906, The House of, Squibb did not have to change any of its standards, and it is a matter of record that the products supplied under the Squibb.Label always have been and still are of a quality better than that which is demanded by the United States Pharmacopoeia and by other recognized authorities. It must, therefore, be obvious that the Squibb Laboratories are devoted exclusively to the pro- duction of medicinal agents of the highest qual- ity, true to their name and their forniulae, products the best that can be made for the purposes in- tended: and that in this way the Squibb Labora- tories are endeavoring to serve efficiently the medi- cal profession in whatever manner such service can be rendered most acceptably. E. R. SQUIBB & SONS. Foreword Squibb's Materia Medica is, in part, a conspectus of the products of the Squibb Labo- ratories. In addition, however, to descriptions of these Squibb products, which consist of prepara- tions of the U. S. P. and of the N. F. and also of many other approved medicinal chemicals, galen- icals, etc., there are given facts relating to a large number of nonro£[icial and newer remedies which are approved by the Council of Pharmacy and Chemistry of the American Medicar Association, but which are not offered under the Squibb label. While the scope of SqUIBB's MATERIA Medica is very broad, it gives full yet concise information concerning each product. Of this it sets forth source; physical, chemical and phar- maceutical characteristics ; therapeutic uses ; doses ; incompatibilities; antidotes; etc. It is, therefore, a trustworthy compendium of the approved ma- teria medica of to-day and if_ kept at hand for ready reference, will prove to be a valuable aid to the physician in prescribing and of practical use to the pharmacist in compounding. This 1919 edition of SqUIBB's MATERIA Medica, in the character and the arrangement of its contents, is similar to its predecessors. How- ever, a large number of additions have been made to it, and the names of such products as have become- obsolete, since the preceding edition was issued, have been omitted. All descriptive notes XI xii SQUIBB'S MATERIA MEDICA have been revised carefully and those which con- cern official products now accord with the U. S.P. IXth Revision, which became official Septem- ber 1, 1916. The list of these is complete. As regards the preparations of the National Formulary, all are listed and described, but only those which are considered satisfactory from pharmaceutical and therapeutical standpoints, or which are in more or less common use by the medical profession, are made and sold by us. On the following pages the names of all prod- ucts which are made by us and furnished under the Squibb Label are printed in bold type, fol- lowed by the word Squibb thus : Bismuth Subcarbonate Squibb while the names of products not offered by us but which are included in the list in order that it tnay be complete, are printed in lighter face type, thus: Benzin, Petroleum, Purified. The description of an article of the U. S. Pharmacopoeia begins with its Latin title simply; the description of an article of the National For- mulary begins with its Latin title followed by N. F. ; while in the case of a product which is neither U. S. P. nor N. F. the Latin title is omitted. The chemical formula of the product described is given whenever possible. By "Average Dose" is meant the dose given in the U. S. P. IXth Rev. or in the N. F. IVth Ed. The word "Dose" alone indicates that no dose is given by the U. S. P. or the N. F. and SQUIBB'S MATERIA MEDICA xiii that the dose suggested is that approved by those considered to be authority. It should be borne in mind while using Squibb's Materia Medica that each Squibb product is made from first quality crude material, selected in accordance with the Squibb standards for crude drugs, and is worked by experts who exercise the most scrupulous care in each step necessary to produce a therapeutically active product. Medicinal Tablets have become an essential part of. the physician's armamentarium. The list of the Squibb Tablets comprises not only those composed of a single drug but also some approved combinations which are recommended and em- ployed by internists. In the manufacture of these Squibb tablets, only drugs of the Squibb quality are used and only expert skill is employed in their production. Since experience has proved that in the majority of cases carefully controlled compression pro- duces the best tablet, we make use now of this method except in a very few instances in which the "moulded form" offers some advantage. The coating of the Squibb tablets, listed as "coated," completely masks the taste of the drugs contained in the tablet; prevents loss of volatile ingredients; and hinders chemical reaction be- tween ingredients which should be kept separate Until in the stomach, e.g., Blaud's Tablets. Tab- lets Blaud Squibb are efficacious without excep- tion and, therefore, are preferred by all internists. The reason for this is, the iron and alkali car- bonate are so mingled and the tablet so coated XIV SQUIBB'S MATERIA MEDICA that no combination of the two takes place until, after swallowing, the two chemicals are released and nascent ferrous carbonate is formed in the gastro-intestinal tract. Because of the method of manufacture and the permanent solubility of the coating all Squibb Tablets, coated or uncoated, may be depended upon to disintegrate quickly and completely in the stomach, thus insuring speedy therapeutic action. This is true even of those tablets which contain insoluble medicaments such as acetanilid, bismuth salts, acetphenetidin, salol, and the like. The Titles of the Squibb Tablets deserve at- tention and study. In accordance with the ethi- cal principles formulated by the American Medical Association, we have adopted pharma- ceutical titles in all instances and have discarded from the labels titles derived from diseases for which the tablet may be used or which other- wise might be therapeutically suggestive. Biological Products, while comparatively new as remedial agents, are now recognized to be very valuable for the treatment of certain diseases.^ The Squibb Hst of Biologicals includes all that to-day are recognized to be of value and they are classed as Antitoxins; Serums; Bacterial Vac- cines (Bacterins) ; Haemostatics, as Thrombo- plastin; also Leucocyte Extract; Smallpox Vac- cine, and Pasteur's Anti-Rabic Treatment. Trustworthy Reagents are of prime impor- tance in any laboratory work. Therefore we have added to our list certain Analyzed Reagents. As the quantity of impurity in chemicals used for reagents is small, the amount taken for analy- SQUIBB'S MATERIA MEDICA xv sis may not be sufBciently large to make the im- purity apparent. It is noteworthy then, that of the Squibb Analyzed Reagents, enough is analyzed to insure, either the absence of any im- purity or an accurate determination of the amount present. On our labels either the absence or the exact amount of impurity- — ^together with the quantity analyzed- — is stated. No labels are kept in stock. New labels are printed for each lot of reagents analyzed. E. R. SQUIBB & SONS. January. 1919. PART I Drugs and Chemicals Comprising E^nigs, Chemicals and Pharma- ceuticals of the United States Pharmacopoeia IXth Revision and the National Formulary IVth Edition, Together With Some Non- Official and New Remedies in General Use The Doses are those for adult's by the mouth, unless otherwise stated. Of the official products the average doses as published in the U. S. Pharmacopoeia IXth Revision and the National Formulary IVth Ed. are given. To determine the fraction of the adult dose suitable for children of different ages, divide the age (in years) by 1 2 plus the age. Thus : for a child 2 years old the proportionate dose is 2 divided by (I2-|-2), or 1/7 • that for adults. In the case of powerful narcotic drugs about one-half this proportion holds; whereas of cathartics two or three tinjes this proportion is usual; and children also bear belladonna preparations, pilocarpine, arsenic and mer- , cury well. , The dose for hypodermic injection is ordinarily one- half to two-thirds, the rectal dose one and a half to double, that by mouth. _ , "Av. Dose," or "Aver. Dose," stands for average dose; "Cc." for cubic centimeter; "Gm." for gramme or grammes; "gr." for grain or grains; "mil" (the new U. S. P. succedaneum for "Cc") for milliliter; "min." for minim or minims; "g. s." for. glass-stopper. The solubility statements apply at 25 °C. , An * indicates the form supplied on unspecified orders. Those products whose titles are preceded by an © are included in "Useful Drugs," prepared under the direction and supervision of the Council op Pharmacy and Chemistry of the American Medical Association. A t means that the item is covered by the Harrison Law, and therefore must be ordered on the dfBcial nar- cotic order blank. xvi SQUIBB'S MATERIA MEDICA f Absinthium.- - Absinthium, N. F. ; Wormwood; Madderwort; Vermuth. Dried leaves and flowering tops of Artemisia, Absinthium (Fam. Composita). Aromatic odor; very bitter taste. Ace. to Council on P. & C. of A. M. A., absinthium is an "obsolete aromatic bitter, without advantage over gentian." Average Dose: 30 grains (2 Gm.). Acacia, Squibb * Granulated or Powdered carton, lb. ; % lb. Acacia; Gum Arabic; Gum Acacia. Dried gummy exuda- tion from Acacia Senegal and other African species of Aca- cia. Great care is exercised in selecting a good market grade. Dirt and pieces of bark and twigs, invariably present in the whole tears, are completely removed by a special process be- fore granulating or powdering the gum; hence the article here offered is exceedingly acceptable for pharmaceutical use. Solu- ble slowly and almost completely in' 2t, parts water ; insoluble in alcohol, ether, oils. Demulcent; Vehicle for water-insoluble substances;. EmulsiRer; Adhesive. Incompatible with mineral, acids, alcohol, ether, ammonia, tartar emetic, strongly alcoholic or ethereal tinctures, fluidextracts. AcETAMIDOSALOL. See Salophen. Acetanilid, Squibb * Crystals or Powdered carton, lb. ; !4 lb. AcetaniliJum ; Phenylacetamide ; Antifebrin. CgHgNO. Mon- acetyl derivative of aniline. I Gm. dissolves in 190 mils (Cc.) water, 3.4 alcohol, 3.7 chloroform, 5 glycerin, 17 ether. Antipyretic, Analgesic, Wound Antiseptic. Average Dose: 0.2 Gm. (3 grs.) When mixed with nitrous ether, acetanilid yields a solution turning yellow then red on ^landing. Antidotes : stimulants; atropine or strychnme subculaneously ; oxygen. (See also Powder; Tablets [Part II].) Acetone, Squibb tin, lb. ; ]4 lb. Acelonum;- Dimethylketone. Not less than 99 percent. CgHeO- Perfectly free froin empyreumatic substances, and containing no weighable impurities. Sp. gr. about 0.790. Miscible with water, alcohol, ether, chloroform, most volatile oils. Inflam- mable. Keep protected from fire. Pharmaceutical Solvent, Reagent. \ Acetone-Chloroform. See Chlirbutanol (Chlorefone) . This house supplies only one qu.a!jty of each product: that best suited to, the purposes ir\tpnded. The specification Squibb's' is not open to various interpretations; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 2 SQUIBB'S MATERIA MEDICA ACETOZONE. Acelyl-benozyl Peroxide. Soluble in 1000 parts water, 20 oil, slightly in alcohol, moderately in ether or chloroform, but slowly decomposing in these solvents and on contact with alkalies and organic matter. Marketed only as 50 percient. mixture with inert absorbent powder. Antiseptic, Disinfectant. Dose: 3 to 5 grains (0.2 to 0.3 Gm.), usually in dilute solution. © Acetphenetidin, Squibb carton, oz. AcetpheneiiJinum ; Acetparaphenetidin ; Para- Acetphenetidin ; Phenacetin. C10H13NO2. Monacetyl derivative of para- amidophenetol. White, shining, odorless, tasteless, crystalline powder. I Gm. dissolves in 1310 mils (Cc.) water, 15 alco- hol, 14 chloroform, 90 ether. Antipyretic, Analgesic. Average Dose: 5 grains (0.3 Gm.). Antidotes: same as of Acetanilid. (See also Tablets [Part II] .) ACET-THEOCIN-SODIUM. Soluble Theocin. White powder; 60 percent, theocin. Soluble in about 20 parts water; insoluble in alcohol, ether. Acids precipitate theocin. Diuretic. Dose: 3 to 5 gr. (0.2 to 0.3 Gm.). AcET-THEOPHYLLlN-soDlUM. Same as Acet-theocin-sodium. © Acid Acetic, Squibb bottle, 5 lbs., per lb. ; lb. ; !4 lb- Acidum Acetlcum. 36 to 37 percent. C2H4O2. Caustic, Rubefacient; in diluted form (vinegar), antidote to alkalies. Average Dose: 5 minims (0.3 mil [Cc.]), diluted. Acid Acetic Anhydride, Reagent. See Reagents (Part IV). Acid Acetic Diluted. Acidum Acetlcum Dlluium. Assays 5.7 to 6.3 percent. C2H4O2. Miscible with water or alcohol. Refrigerant, Astringent. Average Dose: 30 minims (2 mils [Cc.]). Acid Acetic Glacial, Squibb g. s. bottle, lb. ; !4 lb. ; oz. Acidum" Acelicum Claciale. The strongest acid obtainable by redistillation is subjected to careful recrystallization, v/hich raises its strength to 99.5 percent, (as against 99 percent, in U. S. P.) and shuts out impurities. Caustic, pure. Antidotes : magnesia, chalk, soap and water, or lime water; emetics; oil and demul- cents. (See also Reagents [Part IV].) Q Acid Acetylsalicylic, Squibb bottle, lb. ; % lb. ; oz. Acetylsalicylic Acid, C9H8O4, is commonly known by the trade name " Aspirin." The article here offered is of high- est purity; free from uncombined salicylic acid. White, odorless needles; acidulous taste. Soluble in about, 300 parts water, 3 alcohol, 20 ether; readily in chloroform. Deconjposed by heat, moisture, diluted acids, alkalies and their carbonates and bicarbonates. Antirheumatic, Analgesic, Antipyretic, like salicylic acid, but better borne it is claimed. Dose: 5 to 15 grains (0.3 to 1 Gm.). Should not be dispensed with quinine or its salts, lest poisonous quinotoxin be formed. (See also Tablete [Part II].) SQUIBB'S MATERIA MEDICA 3 Acid Arsenous. See Arsenic Trioxide. ■ © Acid Benzoic, Squibb tin, lb. ; !4 lb. ; oz. Synthetic (from toluol). Solubility, dose, etc.: same as of following. Acid Benzoic from Benzoin, Squibb tin, lb. ; J4 lb. ; oz. Acidum Benzoicum; Flowers of Benzoin. C7H6O2. True or natural Benzoic Acid, obtained from gum benzoin by sublimation. White or yellowish, lustrous scales; pungent, acid taste. 1 Gm. dissolves in 275 mils (Cc.) water, 2.3 alcohol, 4.5 chloroform, 3 ether, 23 oil turpentine; soluble in oils. Borax or sodium phosphate increases aqueous solubility.. Anti- septic, Diuretic. Average Dose: 8 grains (0.5 Gm.). Keep well stoppered, in cool place. Readily volatihzes in warm room; darkens on exposure to light. Acid Boracic. See Acid Boric. © Acid Boric, Squibb Granulated or * Impalpable Powder tin, lb. ; !4 lb. Impalpable Powder 3-oz. sifter top tins, per doz. Acidum Boricum; Boracic Acid. H3BO3. Very high grade, carefully recrystallized and free from borax,' chlorides, sul- phates, heavy metals, etc. Notwithstanding the well-known difficulty of pulverizing boric acid, due to the peculiarly slip- pery character of the crystals, the powdered acid here offered has been reduced to an impalpable powder in chaser mills, being what is termed an "air-floated" powder, the finest it is possible to produce.- This form is very desirable for use as a dusting powder, for insufflation, for antiseptic dressings, in eye surgery and in prescription work generally. 1 Gm. dissolves in IS mils (Cc.) water, 18 alcohol, 4 glycerin. Mild Anti- septic and Astringent. Used in conjunctivitis, cystitis, wounds, etc. Average Dose: 8 grains (0.5 Gm.). (See also Reagents [Part IV]; Tablets [Part II].) Acid Bromauric. Acidum Bromauricum, N; F. HAuBr4.5H20. Dark red- brown, odorless crystals or granular masses; metallic, acid taste; 32 percent, gold. Melts at about 27° C. Very soluble in water, alcohol. Asserted Alterative, but employed principally for preparing Solution Gold and Arsenic Bromide. Average Dose: VlO grain (0.006 Gm.). The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. They includecontainers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 4 SQUIBB'S MATERIA MEDICA Acid Carbolic Crude, Solution. See Solution Acid Car- bolic. Acid Carbolic Crystals. See Phenol. Acid Carbolic Iodized. See Phenol Iodized. Acid Chromic. See Chromium Trioxide. Acid Chromic Reagertt. See Reagents (Part IV). Acid Chrysophanic, so-called. See Chrysarobin. ©Acid Citric (Cryst.), Squibb bottle, lb. ;141'5- Acidam Cilricum. C6Hg07.H20. Tribasic organic acid usu- ally obtained from juice of limes or lemons. Recrystallized. (99.5 percent.). 1 Gm. dissolves in 0.5 mil (Cc.) water, J. 8 mils alcohol, 30 ether; freely soluble in glycerin. Antiscorbutic; substitute for lemon juice, and for diluted hydrochloric acid in hypoacidity. Average Dose: 8 grains (0.5 Cm.). Used externally pure, or in 5 to 10 percent, solutions. (See also Reagents [Part JV].) Acid Cresylic. See Cresol. Acid Diethylbarbituric. See Barbital. Acid Formic Acidum Formicam, N. F. 24 to 26 percent. HCOOH. Clear, colorless, strongly acid liquid; pungent odor; sp. gr. about 1 .058. Miscible with water, alcohol, glycerin. Caustic irri- tant; Diuretic. Average Dose: 5 minims (03 mil). Acid Gallic, Squibb carton, lb. ; 14 "<>• ; o^- Acidum Calllcum; Trihydroxybenzoic Acid. CyHeOg.HaO. Prepared from tannic acid, of high purity, and free from tan- nin. 1 Gm. dissolves in 87 mils (Cc.) water, 4.6 alcohol, 10 glycerin, 100 ether; almost insoluble in chloroform. 'Astrin- gent. Average Dose: 15 grains (1 Gm.). Applied topically pure or in strong solution. Incompatible with ferric and silver salts, potassium chlorate or permanganate,' lead acetate or opium in solution. (See also Reagents [Part IV] .) Acid Gallotannic. See Acid Tannic. Acid Hydriodic Diluted, Squibb g. s. bottle, lb. 3 1 .25 mil ampuls, 2 in bdx, per box Acidum H^driodicum Dllulum. Contains 9.5 to 10.5 percent. HI. Made by process superior to official one, and insuring a much cleaner and more stable product. Colorless or pale-yellow, odorless liquid; sp. gr. about 1.100. Miscible with water and alcohol. Alterative, acting like potassium iodide. Average Dose: 8 minims (0.5 mil [Cc.]), well diluted, after meals.' (See also Syrup.) SQUIBB'S MATERIA MEDICA 5 Acid Hydrobromic, Squibb g. s. bottle, lb. ; J/4 ^^- '• oz. Highly pure, made by special process, and adjusted to 34 per- cent. HBr, equivalent to just half the bromine strength of potassium bromide, in place of which it is quite generally used. It also serves for making official diluted hydrobromic acid by mixing 5 parts of it with 12 parts distilled water. Dose: 5 to 10 minims (G.3 to 0.6 mil [Cc.]), well diluted. Antidotes: magnesia or alkaline carbonates. (See also Reagents' [Part IV].) Acid Hydrobromic Diluted, Squibb paraffin s. bottle, lb, ; V4 lb, ; oz, AciJum H^drohromicum DiluUim. Contains 9.5 to 10.5 per- cent. HBr. Colorless liquid,, sp. gr. about 1.076. Nervine, Average Dose: 15 minims (1 mil [Cc.]). This acid will be sent on or^lers for hydrobromic acid when no strength is speci- fied. © Acid Hydrochloric, Squibb g. s. bottle. 6 lbs., per lb. ; lb. ; % lb. So-called "C. P." Acidum Hsdrochloricum ; Concentrated Mu- riatic Acid. Contains 31 to 33 percent. HCl. An exceptionally pure quality. Sp. gi-.^about 1.155. Used pharmaceutically - and techniGally. Antidotes: chalk, magnesia; emetics; albumin and demulcents. (See also Reagents [Part IV] .) © Acid Hydrochloric Diluted. Acidum Hsdrochloricum Dilulum, Contains 9.5 to 10.5 per- cent. HCl. Sp. gr. about 1.049. Digestive Acid, Antiseptic. Average Dose: 15 minims (1 mil [Cc.]). © Acid Hydrocyanic Diluted, Squibb ; oz. Acidum H'sdroc^anicum Dilutmtt; Dilute Prussic (Cyanhydric) Acid, Contains 1.9 to 2.1 percent. HCN. The improved method of manufacture gives an acid which is not very prone to decomposition. But however made, the acid' is liable to eventually become discolored, and is then unfit for use. Anti- spasmodic, Cough Sedative; Antipruritic (only on unbroken skin), in 1 :8 to 16 lotions or ointments. Average Dose: 11/2 minims (O.I. mil [Cc.]). Antidotes: hydrogen dioxide freely by mouth and subcutaneously, or arsenic antidote with some iron sulphate, then emetics; ammonia or atropine; brandy later. Acid Hydrofluoric Reagent. See Reagents (Part IV). If difficult/ is experienced In procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 6 SQUIBB'S MATERIA MEDICA Acid Hypophosphorous, Squibb g. s. bottle, lb. ; !4 lb. ; oz. Acidum Hypophosphorosum, 30 to 32 percent. HPH2O2. Colorless, odorless liquid; sp. gr. about 1.130; miscible with water. Serves for preparation of diluted acid. Acid Hypophosphorous Diluted, Squibb g. s. bottle, lb. ; !4 lb. ; oz. Acidum Hypophosphorosum Diluiam. 9.5 to 10.5 percent, abso- lute acid. Used as Nerve Tonic; ingredient of compound hypophosphite preparations. Average Dose: 8 minims (0.5 mil [Cc.]). Incompatible with iodine, arsenical salts, cupric and ferric salts, and sulphuric and sulphurous acids. Acid Lactic, Squibb bottle, lb ; % lb. ; oz. Acidum Lactlcum. High quality. 85 to 90 percent. CsHeOg, as against 75 percent, in previous U. S. P. Colorless or faintly yellow, syrupy, nearly odorless liquid; acid taste. Freely miscible with water, alcohol or ether; insoluble in chloroform. Caustic in 50 to 80 percent, solution ; Astringent internally; also Reagent. Average Dose: 30 minims (2 mils [Cc.]), well diluted. Readily absorbs moisture on exposure, thereby becoming weakened. Acid Methylenecitrylsalicylic. See Novaspirin. Acid Molybdic Reagent. See Reagents (Part IV). Acid Muriatic. See Acid Hydrochloric © Acid Nitric, Squibb g. s. bottle, 7 lbs., per lb. ; lb. ; ' .... 'i^'^- Acidum Nitricum; so-called' "C. P'.'" Concentrated Nitric Acid; Aqua Fortis. 67 to 69 percent. HNO3. An especially pure product. Sp. gr. about 1.403. Caustic. Antidotes: magnesia, chalk, lime water, or soap and water ; emetics ; oil, demulcents. (See also Reagents [Part IV].) Acid Nitrohydrochloric, Squibb g. s. bottle, lb. ; % lb. Acidum Niirohydrochloricum; Aqua Regla. A strong aqueous solution containing hydrochloric acid, nitric acid, nitrosyl chloride and chlorine. Yellow, fuming, very corrosive liquid. Caustic; also used as Hepatic Stimulant. Average Dose: 3 minims (0.2 mil [Cc.]), well diluted. Antidotes: magnesia, chalk, lime water, or soap and water; emetics; oil and de- mulcents. Aao NiTROHYDROCHLOWC DILUTED. Acidum Nilrohydrochloricum Dilutum. Two-ninths strength of preceding article. Used in biliary calculi, dyspepsia, etc. Average Dose: 15 minims (I mil [Cc.]). SQUIBB'S MATERIA MEDICA 7 Acid Oleic, Squibb bottle, lb. - ; '/i lb. ; Y^ lb. Acidum Olelcum; Elaic Acid. Obtained from fats. Q18H34O2. Yellowish or brownish-yellow, oily, liquid, becom- ing darker and absorbing oxygen on exposure. Sp. gr. about 0.895. Soluble in alcohol, chloroform and oils. Because of its freedom from stearin and allied fatly acids, it produces oleates which are more rapidly and completely absorbed than ordinary oleates, and are free from that greasy properly which is so objectionable. Also Reagent. Acid Ortho-Hydroxybenzoic. See Acid Salicylic. Acid Oxalic, Squibb bottle, lb. ; % lb. H2C2O4.2H2O. Of very high purity ; specially recrystallized, free from calcium sulphate and chlorides. Transparent gran- ules; very acid taste. Soluble in water or alcohol. Emmen- agogue, Sedative. Dose: Yz to 1 grain (0.03 to 0.065 Gm.), in sweetened wateV. Antidotes: calcium saccharate, syrup lime, lime water, or magiiesia, then' emetics. (See 'also Reagents [Part IV].) © Acid Phenylcinchoninic. > Acidum Phenylcinchoninicum ; Phenyl-quinoline-carboxylic Acid; Atophan. White or yellowish white, crystalline, bitter powder. Insoluble in water; slightly ~ soluble in alcohol, readily in alkali solutions. Uric-acid Eliminant. Average Dose: 8 grains (0.5 Gm.), with copious draught of water, liberal doses of sodium bicarbonate being taken simultaneously. Acid Phosphoric, Squibb g. s. bottle, lb. ; % lb. Acidum Phosphoricum ; Ortho-phosphoric Acid. Contains 85 to 88 percent. H3PO4. Best syrupy acid. Sp. gr. about 1 .72. Miscible with all proportions of water or alcohol. Antidotes : alkalies and their carbonates and bicarbonates. (See also Reagents [Part IV].) Acid Phosphoric Diluted. ' . Acidum Phosphoricum Dilutum. Contains 9.5 to 10.5 per- cent. H3PO4. Digestive, Refrigerant. Average Dose: 30 minim? (2 mils [Cc.]), diluted. Incompatible with ferric chloride, leaci acetate, solutions soluble iron phosphate and pyrophosphate, and silver nitrate. Acid Phosphoric Glacial, Squibb (Sticks) bottle, lb. ; !4 lb. ; oz. Acid Metaphosphoric. HPO3. Transparent, highly deliques- cent solid. Soluble in water, alcohol. Urine-albumin test; also used pharmaceutically and technically. The. Squibb products are recognized everywhere as the Quality Standard. They are of uniform purity and. strength, lience theraupeuticaily dependabie. When ordering or prescribing medi- cinal products, you will do well always to specify SQUIBB'S. 8 SQUIBB'S MATERIA MEDICA Acid Phosphotungstic Reagent. See Reagents (Part IV). Acid Picric. See Trinilrophenol. Acid Prussic Diluted. See Acid Hydrocyanic Diluted. Acid Pyrogallic. See Pyrogallol. Acid Salicylic, Squibb * Crystals carton, lb. '; 14 lb. ; oz. Powdered carton, lb. ; J4 lb. i oz, Acidum Salicylicum ; Orthohydroxybenzoio Acid. CyHeOs. Recrystallized. A high-grade medicinal acid. 1 Gm. dissolves in 460 mils (Cc.) water, 2.7 alcohol, 42 chloroform, 3 ether. Aqueous solubility increased by borax, potassium citrate, sodium phosphate or sulphite. Antirheumatic; Antiseptic, Germicide, Keratolylic; also Reagent. Average Dose: 12 grains (0.75 Gm.). Incompatible with iron salts, spirit nitrous ether, lead acetate, potassium iodide, and quinine salts, in solution. Acid Salicylic Natural, Squibb carton, lb. ; J4 lb. °z. ' The true, natural acid; from oil betula. Colorless crystals, with characteristic odor. Preferred by niany physicians to the synthetic acid, but, ace. to Council on P. & C. of A. M. A„ not superior to latter. Dose : same as preceding. Acid Stearic, Squibb tin, lb. Acidum Stearicum. CigHseO^. From tallow and other fats. Especially adapted for the manufacture of stearates. Hard, white, nearly odorless, tasteless solid. 1 Cm. dissolves in 21 mils (Cc.) alcohol, 2 chloroform, 3 ether; almost insoluble in water. Uses technical and pharmaceutical; also Reagent. Acid Sulphuric, Squibb g. s. bottle, 9 lbs. lb. ; lb. ; !4 lb. Acidum Sulpharicum; Concentrated, so-called "C. P." Sul- phuric Acid; Oil Vitriol. Contains 93 to 95 percent. H2SO4. Sp. gr. about 1.83. Caustic, oily liquid miscible with water and alcohol with evolution of much heat. Antidotes: chalk, magnesia or albumin. (See also Reagents [Part IV].) Acid Sulphuric Aromatic, Squibb g. s. bottle, lb. ; % lb. Acidum Sulphuricum Aromaiicum; Elixir of Vitriol. Contains 19 to 21 per cent. H2SO4, with tincture ginger, oil cinnamon and alcohol. Intestinal Astringent, Stomachic; good solvent for quinine sulphate. Average Dose: 15 minims (1 mil [Cc.]), well diluted. Acid Sulphuric Diluted. Acidum Sulphuricum Dilutum. Contains 9.5 to 10.5 percent. H2SO4. Sp. gr. about 1.067. Average Dose: 15 minims (1 mil [Cc.]). SQUIBB'S MATERIA MEDICA 9 Acid Sulphurous, Squibb g. s. bottle, lb. ; J4 lb. Acidum Sulphurosum, U. S. P. Vlllth Rev.; dropped from the present pharmacopoeia. Contains about 6.5 percent, S02. Except^nally free from sulphuric acid. Colorless liquid; odor of burning sulphur, and sulphurous taste. Anti- septic and Antizymolic. Average Dose: 30 minims (2 mils [Co.]), well diluted. (See also Reagents [Part IV].) © Acid Tannic, Squibb cajrton, lb. ; }/i,^i>- i oz, Acidum Tannicum; Gallotannia Acid; Tannin. HC14H9O9. A specially repurified, medicinal product; not the regular mar- ket grade. Bulky and light colored. 1 Gm. dissolves in 1 mil (Cc.) glycerin; very soluble in water, alcohol; almost insoluble in ether, chloroform. Prone to darken on exposure. Astrin- gent, Styptic; Antidote for certain alkaloidal and metal- lic salts. Used locally in hemorrhages, pure; in 1 to 10 percent, solutions as mouth wash, injections, lotions, collodion, etc.; internally, in diarrhea, night-sweats, diabetes, etc. Average Dose: 8 grains (0.5 Cm.), Incompatible with salts of antimony, copper, iron, lead, mercury and silver; with alkaloids, albumin, gelatin, iodine, iodoform; with permanganates, chlprates and other oxidizers. (See also Glycerite; Troches [Part II]; Reagents [Part IV],) Acid Tartaric^ Squibb (Powdered) carton, lb, ; J4 lb. Acidum Tartaricum; Dioxysuccinic Acid. Contains not less than 99.5 percent. H2C4H4O6. White powder. I Gm. dis- solves in 0.75 mil (Cc.) water, 3.3 mils alcohol, 4 glycerin; slightly soluble in ether; almost insoluble in chloroform. Re- frigerant and Antiscorbutic, Average Dose: 8 grains (0.5 Gm.). Incompatible with salts of calcium, lead, and mercury. (See also Reagents [Part IV].) Acid Trichloracetic, Squibb g. s. bottle, oz. Acidum Trichloraceiicum. HC2CI3O2, Colorless, deliques- cent crystals; pungent, suffocating odor. 1 Gm. dissolves in 0.1 mil (Cc.) water; very soluble in alcohol or ether. Caustic, Styptic, Astringent; in nasopharyngeal diseases, warts, etc. Applied pure or in concentrated solution, as caustic; in 1 to 3 percent, solution, as astringent. Used also as test for albumin. AciDOL, Betaine Hydrochloride. Colorless crystals; 23.8 percent. HCl. Soluble freely in water. Substitute for diluted hydro- chloric acid as Digestive. Dose: 8 grains (0.5 Gm.), in water. Since we make only one quality of eacti product, that best suited to -the purposes intended, the specification "Squibb's" is not open to various interpretations, but has a plaixi, positive meaning. When ordering or prescribing, specify SQUIBB'S. 10 SQUIBB'S MATERIA MEDICA © Aconite Root, Squibb Ground for Percolation tin, lb. Acomiam; Monkshood; Wolfsbane. Best quality, dried root of Acomtum napellus (Fam. Ranunculacea) . U. S. P. re- quires not less than 0.5 percent, ether-soluble alkaloids. Physi- ologically assayed according to U. S. P. IXth Rev. and found to yield official preparations of not less than standard strength. Circulatory Sedative, Sudorific, Antineuralgic. Average Dose: Yz grain (0.03 Gm.) . Antidotes : emetics ; atropine, digitalis or ammonia; small frequent doses of stimulants; artificial respira- tion. (See also Extract; Fluidextract; Liniment; Tincture.) Aconitine Crystals, Squibb Yb-oz. ; 15-gr. vial Aconilma. C34H47O11N. Crystalline alkaloid from aconite root. Colorless or white, odorless crystals. 1 Gm. dissolves in 28 mils (Cc.) alcohol, about 65 ether; very slightly soluble in water. Antineuralgic, Sudorific, Circulatory Sedative. Average Dose: 1/400 grain (0.00015 Gm.), in pills or tablets. Used externally in 1 :2000 to 500 ointments, or 2 percent, oleate, in neuralgias. Antidotes : stimulants, atropine, digitalis or am- monia. Dangerous to use on ' abraded surfaces, (See also Tablets [Part II].) Adalin. Sromdiethylacetylcarbamide. Nearly" colorless, odorless pow- der. Readily soluble in alcohol, ether, chloroform; sparingly in water. Nerve Sedative, mild Hypnotic. Dose: 5 to 15 grains (0.3 to 1 Gm.). Adeps Lans. See Wool-Fat. Adonis. Adonis, N. F.; Pheasant's Eye. Dried, overground portion of Adonis vernalis (Fam. Ranunculacea) . Cardiac ' Tonic of digi- talis group, but ace. to Council on P. & C. of A. M. A. of unreliable activity. Average Dose: 2 grains (0.13 Gm.). Adrenalin. See under Epinephrine. Agar. Agar; Agar- Agar. Dried mucilaginous substance from marine algae growing along eastern coast of Asia. Odorless, tasteless shreds, or granular powder. Insoluble in cold water; slowly soluble in hot water, forming jelly when cool. Culture medium; mechanical Laxative. Used in chronic constipation; passes through intestines almost unchanged. Average Dose : 1 50 erains (10 Gm.). Agaric. Agaricus, N. F.; White Agaric; Larch Agaric. Dried fruit body of fungus Polsporus officinalis (Fam. Pol^poraceeej. deprived of its outer rind. Used 9s Antihydrotic. Average Dose: 10 grains (0.65 Gm.). SQUIBB'S MATERIA MEDICA 11 ACURIN. Theobromine-Sodiuni Acetate. White, hygroscopic, alkaline powder. <0^ percent, theobromine. Soluble freely in water; decomposed by acids and carbon dioxide. Diuretic. Dose: 8 to IS grains (03 to 1 Gm.}. Aiken's Tonic Pills. See Pills Iron, Quinine, Strychnine and Arsenic, Mild. • AncoL. Airoform; Bismuth Ozyiodogallate. C6H2(OH)3C02- Bi(OH)I. Grayish-green, fine, odorless, insoluble powder; 20 percent, iodine. Vulnerary, Antigonorrheic Incompatible widi wafer and calomel. Albargin. Compound of silver nitrate with gelatose. Coarse^ yellow pow- der, readily soluble in water; contains about 15 percent, silver. Astringent and Bactericide, like silver nitrate. © Alcohol. Alcohol. 923 percent, by weight or 94.9 percent, by volume of C2H5.OH. Sp. gr. not above 0.816 at !5J6° C Stimulant intem2dly; Refrigerant, Rubefacioit, Astringent and Antisq>tic topically. Dose: I to 4 fluidrachms (4 to 16 mils [Cc.]). Incompatible widi acacia, albumin, bromine, chromic acid, ^per- manganates. Alcohol Dehydrated (Absolute), Squibb bottle, gal. (fP/s lbs.), per lb. ; lb. ; % lb. Alcohol DehyJrafum; Anhydnnis Alcohol. CiHs-OH. The U. S. p. permits I percent, water; our product contains only 0.2 percent, and thus runs about 99.8 percent, strength, sp. gr. 0.7945 at 1536** C, contains no empyreumatic impurities, and complies with all official tests. However, when it is kept for any length of time in cork-stoppered bottles, it is apt to show slight traces of discoloration when the sulphuric acid lest is applied, which, however, if within the limits of merely brown- ing die acid, may be regarded as not seriously objectionable. (See also Reagents [Part I\'].) Alcohol Diluted. Alcohol Dilutam. 41 to 42 percent, by weight or 48.4 to 49.5 volume percent C2H5.OH. Alcohol Methyl, Reagent. See Reagents (Part W). The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived aiid labored for them ; and, in the words of William Miller Bartlett, "th^ House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 12 SQUIBB'S MATERIA MEDICA Aletris. Aletris, N. F.; Unicorn Root; Star Grass. Dried rhizome and root of Alelrls farinosa (Fam. Lillacea). Simple Bitter, without advantage over gentian. Largely used in ' female remedies," but, ace. to Council on P. & C„ without good evidence of value. Average Dose; 30 grains (2 Gm.). (See also Fluidextract.) Allspice, Squibb * * Whole tin, lb. Powdered tin, lb. sprinkler-top tins, 4 oz., per doz. 2 ozs., per doz. ; 1 oz., per doz. Pimento, N. F.; Pimento. Dried, nearly ripe fruit of Pimento officinolis (Fam. Myriacece): Derived mostly from Jamaica. Collected just before the berries become ripe and carefully dried in the sun. Its odor resembles a mixture of cin- namon, nutmeg and cloves. Allspice should contain from 3 to 4 percent, of oil, upon which its virtue chiefly rests. Condiment, Aromatic, Stomachic. Average Doge: 15 grains (1 Gm.). Allium. See Garlic. Ally] Sulphocarbamide. See Thiosinamine. Almond, Sweet. / Am})gdola Dulcis, Dried ripe seeds of Pranus amygdalus dulcis (Fam. Rosacea). Demulcent, Nutrient; also used pharmaceutically. @ Aloes. Aloe. Inspissated juice of leaves of Aloe Perryi, A. Vera or A. ferox, respectively Socotrine, Curasao or Cape. AloeS: Moderately active Cathartic, acting mostly on the large intes- tine. Average Dose: 4 grains (0.25 Gm.). Aloes Purified, Squibb Ground for Percolation tin, lb. *Powdered hn. lb. ; 14 lb. Aloes Purlficoio, U. S. P. Vlllth Rev. Dropped from new pharmacopoeia. From best quality Curasao aloes. Dull- brown or reddish-brown powder, almost completely soluble in alcohol also soluble in alkalies. Cathartic; acts mostly on large intestine. Average Dose: 4 grains (0.25 Gm.). © Aloin, Squibb bottle, lb. ; 14 lb. ; oz. Aloinum. Pentoside or mixture of pentosides from aloes. Yel- low to yellowish-brown, very bitter powder; faint odor. Sol- uble in water, alcohol, acetone, ammonia water and alkali solu- tions; slightly soluble in ether. Acts like aloes. Average Dose: % grain (0.015 Gm.). SQUIBB'S MATERIA MEDICA 1 3 Alth«a Leaves, Althtsa Folia, N. F.; Marsh Mallow Leaves. Dried leaves of Allhaa oficinalis (Fam. Malvacea). Emollient, Demulcent; mostly used as cataplasm. Althaea Root Powdered, Squibb tin, lb. , Alihaa; Marsh Mallow Root. Dried root of Althiea offi- cinalis (Fam. Malvacea), deprived of brown, corky layer and small roots. Very rich in mucilaginous prinoiple. Preserve in tightly-closed containers, adding a few drops chloroform from time to lime to prevent insects. Emollient, Demulcent, ©'Alum, Squibb * Granulated carton, lb. Powdered carton, lb. ; % lb. Alumen; Ammonium Alum; Aluminum and Ammonium Sul- phate. A1NH4(S04)2.'12H20. Soluble in water; freely sol- uble in glycerin; insoluble in alcohol. Astringent, Styptic, Emetic; in night-sweats, diarrhea, hemiftrhage, epistaxis, wounds, etc. Average Dose: 8 grains (0.5 Gm.); as emetic, a teaspoonful is usually given. Incompatible with borax, car- bonates, galls, kino, lead acetate, magnesia, mercury salts, phos- phates and tartaric acid. Note: The present U. S. P, recog- nizes both ammomum alum and potassium ajum; the latter is not obtainable at this time. © Alum Exsiccated, Squibb tin, lb. ; 14 lb. Alumen Exsiccatum. Preceding article rendered anhydrous by drying. White, hygroscopic powder; astringent taste. Escharotic, Astringent, Vulnerary. Keep well stoppered, in dry place. (See also Powder Alum Compound.) Alum Powder Compound. See Powder Alum Compound, , Alum, Chrome, Squibb ■ carton, lb. ; % lb. Chromium and Potassium Sulphate. CrK(S04)2.12H20. Dark-violet, large crystals. Soluble in about 5 parts water. Basis for manufacture of pigments (for dyeing, calico-print- ing, etc.). © Aluminum Acetate, Squibb bottle, lb. ; 14 lb; Basic Aluminum Acetate. Fine, white powder; slight as- tringent, acidulous taste. Well-nigh insoluble in water or al- cohol. External and Intestinal Astringent. Dose: 5 to 10 grains (0.3 to 0.65 Gm.). (See also Solution Aluminum Ace- tate.) The Squibb Ideals have taken concrefe form in the Squibb Products; these are universally recognized ..as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 14 SQUIBB'S MATERIA MEDICA Aluminum Chloride. Alummi Chloridam, N. F. A1C13.6H29- White or yellow- ish-while, nearly odorless powder; sweetish, astringent taste. I Gm. dissolves in about 0.5 mil (Cc.) water, 4 alcohol; solu- ble in glycerin. Antiseptic, Astringent; without advantage over alum. Average Dose: 5 grains (0.3 Gm.). Aluminum Hydroxide. Alumini Hydroxidum; Precipitated Aluminum Oxide. Al- (OH)3. White, bulky, odorless, tasteless, amorphous powder. Insoluble in water, alcohol, etc. Astringent, Desiccant Dermic. Aluminum Nitrate Reagent. See Reagents' (Part IV).* Aluminum Sulphate, Squibb '''Granulated or Powdered carton, lb. Alummi Sulphas, N. F. Al2(S04)3.16H20. White granules or powder; sweetish, astringent taste. I Gm. dissolves (not cleai-ly) in about 1 mil (Cc.) water; insoluble in' alcohol. Antiseptic, Astringent; on ulcers, enlarged ' tonsils in en- dometritis, etcf; usually applied in 1 to 5 percent, solutions, oc- casionally in concentrated solution. Also Reagent. Aluminum=Ammonium Sulphate. See Alum. Aluminum-Potassium Sulphate Reagent. See Reagents (Part IV). Alumnol. Aluminum Betanaphthblsulphonate. Al(CioH6[OH]S03)3. White, hygroscopic, bitter powder. Soluble in about 1.5 parts water; easily in glycerin, sparingly in alcohol. Astringent, Antiseptic ; in 0.5 to 3 percent, solutions. Alypin. White, hygroscopic, bitter powder. Soluble very freely in water, easily in alcohol. Local Anesthetic; in 10 percent, solu- tion topically, 1 to 4 percent, hypodermically, Aminoform. Brand of Hexamethylenamine. © Ammonia Water (10%=16° Be.), Squibb g. s. bottle, lb., Aqna Ammonia; Liquor Ammoniac; Spirit of Hartshorn. 10 percent. NH3. Sp. gr. about 0.958. Local Irritant and Anf-_ acid, in liniments ; fugacious indirect Circulatory and Respira- tory Stimulant, internally or hypodermically; antidote in chlorine poisoning, by inhalation; also Reagent. Average Dose: 15 minims (1 mil [Cc.]). Incompatible with chlorine water, iodine,, alkaloidal salts, acids, etc. Liable to deteriorate on keeping. SQUIBB'S MATERIA MEDICA 15 Ammonia Water Stronger (28%-26° Be.)> Squibb g. s. bottle, lb.. Aqua Ammonia Fortior; Concentrated or Stronger Ammonia. 28 percent. NH3. Uses chiefly pharmaceutical, chemical and technical. Antidotes: vinegar; vapor of acetic acid or chlorine water by inhalation. NoTE: Should be handled with extreme caution, lest an accident occur. In warm weather the bottles should preferably be placed on ice for a while, before with- drawing stopper. (See dso Spirit; Reagents [Part IV]). Ammonio=Formaldehyde. See Hezamethylenamlne. Ammonium Benzoate, Squibb botde, lb. ; % lb. ; oz. Ammonii Benzoas. From Synthetic Benzoic Acid. NH4C7- H5O2. White laminse or powder; saline, bitter, acrid taste. I Cm. dissolves in 10 mils (Cc.) water, 35.5 alcohol, 8 gly- cerin. Mild Antiseptic and Diuretic, like sodium benzoate but more irritant; also Reagent. Average Dose: 15 grains (I Gm.). Incompatible with ferric salts. Ammonium Benzoate from Natural (True) Acid, Squibb bottle, lb. ; % lb. ; oz. Ammonium Bromide, Squibb bottle, lb. ; 14 lb. Ammonii Bromidum, NHiBr. White, odorless granules, of pungent, saline taste. 1 Gm. dissolves in 13 mils (Cc.) water, 12 alcohol. Nerve Sedative. Average Dose: 15 grains (I Cm.) . Incompatible with, alkaloidal, mercuric and silver salts. Ammonium Carbonate, Squibb (Cubes) bottle, lb. ; 14 lb. Ammonii Carbonas; Hartshorn; Volatile Salt; Volatile Alkali. Mixture of acid ammonium carbonate, NH4HCO3, and am- monium carbamate, NH-tNH2CO;. The widely known Squibb article which has deservedly won high reputation for its ex- ceptional queility, high strength and reliability. Colorless, translucent, and has but a slight coating of bicarbonate on the surface. It is of full U. S.* P. strength, assaying at time of bottling about 32 percent, ammonia gas. Intended espe- cially for medicinal use, and peculiarly adapted to pre- scription work and for making aromatic spirit of ammonia or solution of ammonium acetate. I Gm. dissolves slowly in 4 mils (Cc.) water, 4 glycerin; partly soluble in alcohol; de- composed by hot water. Cardiac Stimulant and ELxpectorant. Average Dose: 5 grains (03 Gm.). Incompatible with salts of alkaloids, acids and acid salts or syrups, calomel and tartar emetic. Keep well stoppered, in a* cool place; on ex- posure it loses ammonia. A piece of cotton placed into a slit in bottom of cork and kept moist with stronger ammonia water will retard change. (See also Reagents [Part IV].) The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specif SQUIBB'S. 16 SQUIBB'S MATERIA MEDICA Amfflonium Chloride, Squibb (Granulated) carton, lb. ; 14 1I>- Ammonli Chloridum; Ammonium Muriate; Pure Sal Ammo- niac. NH4CI. High quality; prepared from refined sal am- moniac by recrystallizing ; above U. S. P. requirement of 99.5 per cent, purity. I Gm. dissolves in 2.6 mils (Cc.) water, 100- alcohol, 8 glycerin. Liquefying Expectorant, Alterative; in bronchial affections, glandular enlargements, dysmenorrhea, etc. Average Dose: 5 grains (0.3 Gm.). Incompatible with al- kaline hydroxides and carbonates, soluble lead and silver salts. (See also Reagents [Part IV] ; Tablets, Troches, [Part II].) Ammonium Chromate Reagent. See Reagents (Part IV). Ammonium Citrate, Squibb bottle, lb. ; '/4 lb. ; oz. (NH4)3CgH607. Granular, deliquescent; very soluble in water. Diaphoretic, Refrigerant; also Reagent. Dose: 15 grains (1 Gm.). Keep well-stoppered. Ammonium Hypophosphite, Squibb bottle, lb. ; !4 lb. ; oz. - Ammonii Hypophosphis, N. F. NH4PH2O2. White, odor- less, scaly crystals. 1 Gm. dissolves in 1 mil (Cc.) water, 20 mils alcohol. Used as Alterative and Anticatarrhal. Average Dose: 5 grains (0.3 Gm.). Keep from light, and air; darkens Ammonium Iodide, Squibb bottle, lb. ; 14 lb. ; oz. Ammonii lodidum, NH4I. White or nearly white, granular, hygroscopic powder; saline taste. 1 Gm. dissolves in 0.6 mil (Cc.) water, 3.7 mils alcohol, 1 .5 glycerin. Saline Expec- torant, Alterative; more irritant than other iodides. Average Dose: 5 grains (0.3 Gm.). .Keep from light and air; darkens on exposure. A depplji colored salt should not be dispensed. Ammonium Molybdate. See Reagents (Part IV). Ammonium Muriate. See Ammonium Chloride. Ammonium Nitrate Reagent. See. Reagents (Part IV). Ammonium Oxalate Reagent. See Reagents (Part IV). Ammonium Persulphate Reagent. See Reagents (Part Ammonium Phosphate, Squibb bottle, lb. ; J4 lb. Ammonii Phosphas, N. F.; Diammonium Ortho-phosphate. (NH4)oHP04. Colorless, odorless crystals; saline taste. I Gm. dissolves in about 4 mils (Cc.) water; insoluble in alco- hol. Similar in action to sodium phosphate, but used mainly as Antirheumatic and Alterative. Average Doge: 5 grain* (03 Gm.). (See also Reagents [Part IV].) Squibb's materia MEDIGA I 7 Ammonium Salicylate, Squibb < ' bottle, lb. ! % lb. ; oz. Amtnomi Salicylas. NH4C7H5O3. White, odorless, crystal- line powder; faintly saline,- bitter taste. 1 Gm. dissolves in I mil (Cc.) water, 3 mils alcobol. Antirheumatic, Analgesic, ExpectoYant. Average Dose: 8 grains (0.5 Gm.). Ammonium Sulphate Reagent. See Reagents (Part IV). Ammonium Sulphocyanate Reagent. See Reagents (Part IV). Ammonium 5ulphoichthyolate. See Ichthyol. Ammonium Valerate, Squibb g.s. bottle, J4 lb. ; oz. Ammonii Valeras; Ammonium Valerianate. NH4C5H9O2. White plates; valerian odor; sharp, sweetish taste. 1 Gm. dissolves in 0.3 mil (Cc.) water, 0.6 alcohol; soluble in ether. Nerve Sedative in hysteria. Average Dose: 8 grains (0.5 Gm.). SQUIBB'S AMPULS of Sterile; Solutions for Hypodermic or Intramuscular Injection In response" to a request from many physicians we have added to our list a number of sterile solutions for hypodermic or intra- muscular injection, and will add^ others as the demand arises. They are put up in hermetically sealed tubules or ampuls. For use, sterilize the syringe and the needle, break off the stem of the ampul at the file mark on the neck, turn the ampul up- side down, introduce the needle, withdraw the contents and inject. Caffeine Sodio°Salicylate Contains about 50 percent, caffeine, and is soluble in 2 parts water, hence serviceable for hypodermic use (chiefly in acute articular rheumatism complicated with heart disease, and in threatened collapse in pneumonia). 0.1 Giii. OVz g""') *^ 1 Cc. (mil) ampuls, box of 1 dozen. Camphor Is employed subcutaheously as a stimulant in sudden tiepression and collapse as seen in infectious diseases and. other exhausting affections and after operations. The 'ordinary dose is 8 grains per injection; however, in pneumonia larger doses are used — up to 30 grains per day, smaller quantities having proved of no ayail here. Supplies as solutions in expressed oil almond: O.I Gm. (IJ/2 grs.) in I Cc. ampuls, box of I dozen, 0.2 Gm. (3 grs.) in 1 Cc. ampuls, box of 1 dozen. This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's"- is not open to various interpretations; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 18 SQUIBB'S MATERIA MEDICA Squibb's Ampuls (Cont.) Ergot (Sterile). An aqueous solution containing the active constituents of ergot, free from inert extractive. Physiologically tested and stand- ardized; 1 mil (Cc. or 16 min.) equals 2 Gm. best Spanish ergot. Box of 6 x 1 Cc. ampuls. Box of 12 x 1 Cc. ampuls. Iron Arsenite. And combinations. Discontinued in deference to the ruling of the Council on Pharmacy and Chemistry of A. M. A. Iron Citrate Green. Discontinued; see under this title. Iron Cacodylate Is an arsenical compound of iron employed as an alterative and hematinic in chlorosis, leukemia, lymphadenitis, etc. The hypo- dermic dose is 0.03 to 0.1 Gm. (Yz to l'/2 grains) daily. 0.03 Gm. Q/z gr.) in 1 Cc. ampuls, box of a dozen, . - Mercury Iodide Red Is a mercurial commonly employed hypodermically in syphilis. It is supplied in 1 percent, oily solution, in 1 Cc. ampuls, e^ch thus containing O.OI Gm. (]/(, gr.) of the medicament. Per box of I dozen ampuls, . Mercury Salicylate ^ Is offered in sterile suspension in emulsion of wool-fat and almond oil. It is a favorite with many physicians in the sub- cutaneous treatment of syphilis, 0.065 Gm. (1 gr.) in 1 Cc. ampuls, box of 1 dozen. Quinine Dihydrochloride Contains* about 75 percent, of quinine alkaloid, and is the most readily soluble simple salt of quinine. Hence it is well adapted for intramuscular injection as an antiperiodic in obstinate cases of malarial fever. Sizes: 0.25 Gm. ( 3% grs.) in 2 Cc. ampuls, box of 1 dozen, 0.5 Gm. (71/2 grs.) in 2 Cc. ampuls, box of 1 dozen, 1 Gm. (15J/2 grs.) in 2 Cc. ampuls, box of 1 dozen, box of six. Quinine and Urea Hydrochloride Also known as Carbamidated Quinine Dihydrochloride, contains about 70 percent, of alkaloidal quinine and is soluble in an equal part of water. Its 1, percent, solution is employed by injection as a local anesthetic, slower but more prolonged in action than cocaine, and non-toxic ; in 1 to 20 percent.' solution it is applied topically to mucous membranes and wound surfaces. As an antiperiodic it is injected deep into the gluteal or deltoid mus- cles. Offered in sterile aqueous solutions as follows: 0.25 Gm. ( 3J4 grs.) in 2 Cc. ampuls, box of 1 dozen, 0.5 Gm. ( 7!/2 grs.) in 2 Cc. ampuls, box of 1 dozen, 1 Gm. (15]/2 grs.) in 2 Cc. ampuls, box of 1' dozen, 1 % solution, for local anesthesia, in 1 Cc. ampuls, box of 1 doz., I % solution, for local anesthesia, in 5 Cc. ampuls, box of six. SQUIBB'S MATERIA MEDICA 19 Squibb's Ampuls (Cont.) Silver Nitrate 1% Solution box of I dozen, For preventing ophthalmia neonatorum, 1 or 2 -drops being instilled into each eye. Sodium Cacodylate Though it contains 35 percent, of metallic arsenic (equivalent to 47 percent, of arsenic trioxide [so-called arsenous acid]), is regarded as a relatively non-toxic succedaneum for the ordinary arsenical preparations in skin diseases*, chlorosis, malarial cachexia, etc., and It has lately come to the fore in the treatment of syjphilis, .by intramuscular injection. For the latter purpose the ordinary dose is 0.45' Gm. (7 grs.) for men, 0.4 Gm. (6 grs.) for women, and 0.05 Gm. (% gr.) for infants. 0.05 Gm. (J^ gr.) in 1 Cc. ampuls, box of 1 dozen, 0.13 Gm. (2 grs.) in 1 Cc. ampuls, box of 1 dozen, 0.2 Gm. (3 grs.) in I Cc. ampuls, box of 1 dozen, 0.45 Gm. (7 grs.) in 1 Cc. ampuls, box of 1 dozen, Amyl Acetate, Squibb bottle, lb. ~ C5H11.C2H3O2. Colorless liquid; agreeable, pear-like odor. Slightly soluble in water ; miscibla with alcohol, ether. Solvent of resins; constituent of fruit essences and perfumes; Reagent. © Amyl Nitrite, Squibb ampul, oz. ; % oz. covered tubules, 3 minims, box of 10, covered tubules, 5 minims, box of 1 0, Atnylis Niiris. C5H11NO2. Clear, yellowish liquid; ethereal, fruity odor; pungent aromatic taste. Contains when fresh 80 percent. C5H11NO2. Is free from water and aldehyde, and contains much less than permissible limit of free acid. On keeping, it loses in strength and becomes more acid. Miscible with alcohol, ether; ' almost insoluble in water. Offered in tubules covered with tubular braid, which acts as absorbent and inhaler. For use, a tubule is broken between the thumbs and fingers and .the vapor inhaled from the braid covering. Prompt Vaso-dilator; chiefly in spasms of angina pectoris, asthma, general convulsions, "fainting, etc. Average Dose: 3 minims (0.2 mil [Cc.]), by inhalation. Antidotes: atropine; ergot or strychnine hypodermically.' Keep in a cool place, and disturb as little as possible, . Inflammable ! Amylopsin. See Diastase from Pancreas. Angelica Fruit. Angelica Fructus, N. F.; Angelica Seed. Ripe fruit of An- gelica Archangelica and other species of Angelica (Fam. Um- bellifera). Aromatic Stomachic, Carminative. Average Dose: 15 grains (1 Gm.). The prices of the Squibb Products are in all instances as low as the quality and quanti^of ingredients and the expense of man- ufacture allbw. Theyincludecontainers, packing and boxing.. When ordering or prescribing medicinal products, specify SQUIBB'S. 20 SQUIBB'S MATERIA MEDICA Angelica Root. Angelica Radix, N. F. Rhizome and roots of Angelica alro- purpurea (Fam. Umbellifera:) and other species. Stimulating Expectorant. Average Dose: 30 grains (2 Gm.). Anise, Squibb Whole tin, 5 lbs., per lb. ; lb. Anisum; Aniseed. Dried ripe fruit of Pimpinella Anisum (Fam. Umbellifera), obtained from cultivated plants only, of fine aromatic odor and taste. Aromatic Carminative. Average Dose: 8 grains (0.5 Gm.). Anodyne, Hoffmann's. See Spirit Ether Compound. Antidote, Arsenic, Squibb per set. Iron Hydroxide (Ferric) with Magnesium Oxide. In two bot- tles, one containing diluted solution of tersulphate of iron, the other a mixlure of malgnesia and water; all in such proportions that when combined there is produced official Ferri H^Jroxidum cum Magnesii Oxido. Valuable for emergency use. Antifebrin, See Acetanilid. Antilithic, Granular Effervescent. See Sodium Phosphate Compound, Granular Effervescent. Antimony Oxide. Aniimonii Oxidum, N. F. Sb203. White or grayish-while, odorless, tasteless powder. Insoluble in ordinary solvents. Ex- pectorant, Emetic. Average Dose: 1 grain (0.06 Gm.). Antimony Sulphurated. Aniimonium Stdphuraium, N. F.; Kermes Mineral; Red An- timony Sulphide. Chiefly Sb2S3; with small quantities anti- mony trioxide, sodium pyroantimonate and sulphur. Reddish- brown, odorless, tasteless powder. Insoluble in usual solvents. Obsolescent Cathartic, Alterative, Emetic. Ordinary Dose: 2 grains (0.13 Gm.) ; emetic, 10 grains (0.65 Gm.). © Antimony and Potassium Tartrate, Squibb bottle, lb. ; 14 lb. ; oz. Aniimonii ei Potassii Tariras; Tartar Emetic; Tartrated Anti- mony. 2K(Sb0)C4H408.H20. White, odorless, granular powder; sweet, afterwards disagreeable metallic taste. 1 Gm. dissolves in 12 mils (Cc.) water, 15 glycerin. Nauseant Ex- pectorant, Emetic; Pustulant externally. Average Dose: ex- pectorant, l/i2 gr. (0.005 Gm.); emetic, ]/2 gr. (0.03 Gm.). Best to begin with small Joses (l/go gr. [0.001 Gm.]), which may be repeated hourly. Incompatible with antipyrine, mer- curic chloride, alkaline carbonates, tannic acid, and vegetable infusions containing tannin. (See also Wine; Reagents IPart IV].) SQUIBB'S MATERIA MEDIGA 21 © Antipyrine, Squibb bottle, oz. Aniip\)rma; Phenyldimethylpjrrazolone ; Phenazone; Metho- zine. C11H12N2O. White, almost odorless, slightly bitter, crystalline powder. 1 Gm. dissolves in about .1 mil (Cc.) water, 1.3 mils alcohol, 0.7 mil chloroform, 43 mils ether. Antipyretic and Analgesic, internally; Styptic and Antisep- tic, externally. Average Dose: 5 grains (0.3 Gm.). .Applied topically in 1 :8 ointment, or pure, or in 20 percent, solution (in bleeding). Incompatible with alum, amyl nitrite, benzoates, feirric chloride, carbolic acid, calomel, iodides, resorcin, sodium bicarbonate, spirit nitrous ether (when' not very recently made) , tartar emetic and tannic acid, in solution; with chloral hydrat-e and betanaphthol on trituration; astringent infusions. Anti' dotes: stimulants; atropine or strychnine subcutaneoiisly ; oxygen. Antipyrine Salicylate. See Salipyrine. Apiol, Liquid. See Oleoresin Parsley Fruit. u Apocynum. Apocyrium, N. F.;" Black 'Indian or Canadian Hemp. Dried rhizome and roots of Apocynam cannahinum (Fam. Apocy- nacea). Cardiac Tonic, of digitalis group. Average Dose: 12 grains (0.75 Gm.) f© Apomorphine Hydrochloride (Crystals). Apomotphina HsJrochloriJum. C17H17NO2.HCI+J/2H2O. Alkaloidal (derivative of morphine. Grayish-white,, odorless prisms, turning green on exposure to light and air. 1 Gm. dis- solves in 50 mils (Cc.) water, 50 alcohol; slightly soluble in chloroform, ether. Prompt, centrally acting Emetic for hypodermic use; nauseant Expectorant; . Sedative (in delirium tremens) . Average Dose : expectorant and sedative, ^/20 gf • (d.003 Gm.); emetic, hypodermically I/12 gr. (0.005 Gm.), by mouth J/5 gr. (0.01 Gm.). Its solutions decompose rapidly. (See also Tablets [Part II].) Apparatus Stand (Improved), Squibb For filtering, holding burettes, supporting condensers, holding separatory funnels, and supporting crucibles and small beakers. This device has been in use in the Squibb Laboratories for some time and has ptoved very satisfactory. It consists of a nickel-plated, upright rod, about 22 inches in height and ^/4 inch in diameter, secured in an iron cylinder base. Several attachments, adapted for various chemical manipulations, can be readily fitted to the rod. These special attachments consist of spring clamps which slide closely over the rod and lock automatically by binding on the same. A clamp is If difficulty is experienced in procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 22 SQUIBB'S MATERIA MEDICA Apparatus Stand (Improved), Squibb (Cont.) easily shifted up or down or swung sideways by a slight pres- sure. To move an attachment, take hold of the base of the stand with one hand and slide or pull the spring with the other, keeping the direction of the pull parallel to the rod. Oo not attempt to remove an attachment while supporting an object, since its weight locks it to the rod; the greater the downward pressure the more firmly the attachment locks itself. It is advisable to apply a little petrolatum over the rod as lubricant and also to protect the parts from rusting. Should the attach- ments fail to slide easily, remove them and rub the rod lightly with emery powder; if the attachments slide too freely, the springs should be removed and tightened by means of pliers. The advantages of Squibb's Improved Apparatus-Stand over other such stands are in its stability, neat appearance and com- pactness. The stand is simple, portable and can be used for many simultaneous operations. Its uses are: (1) for filtering; (2) for holding burettes, absolutely rigid, and perpendicular, permitting them to be easily moved up or down; (3) for sup- porting light condensers; (4) for holding separatory funnels and pipettes; (5) for supporting* crucibles and «mall beakers. After use, the apparatus can be set aside and occupies no more space than an ordinary reagent bottle. Apple Juice. ^ Succus PomoTum, N. F. Freshly expres^d juice of sound, ripe, sour apples, the fruit of cultivated varieties of P^rus Malus (Fam. Rosacea). Aqua AmmonisE. See Ammonia Water. Aqua Fortis. See Acid Nitric. Aqua Regia. See Acid Nitrohydrochloric. ~ Aralia. Aralia, N. F.; American Spikenard. Dried rhizome and root of Aralia racemosa (Fam. Araliacea). Alterative, Dia- phoretic. Average Dose: 30 grains (2 Gm.). Arbor Vnm,. See Thuja. Argentum CrEde. See CoUargol. ' Argonin. Silver-casein. Nearly white powder; 4.28 percent, silver. Sol- uble readily in water. Antigonorrheic, Astringent. Argyrol. Silver-vitellin. Black, hygroscopic scales; 20 to 25 percent, silver. Soluble freely in water or glycerin; insoluble in alcohol or oils. Antigonorrheic, Astringent, Antipyic. Used in 10 to 25 percent, solutions. SQUIBB'S MATERIA MEDICA 23 AWSTOCHIN. Aristoquin; Dlquinine Carbonic Ester. White, odorless, taste- less powder; 96 percent, quinine. Soluble in chloroform; in- soluble m water; difficultly soluble in alcohol, very sparingly in ether. Succedaneum for quinine sulphate. Dose: 2 to 15 grains (0.13 to 1 Gm.). .Incompatible with acids or alkalies. ArisTOLj Brand of Thymol Iodide. Arnica Flowers, Squibb Ground jor Percolation tin, lb. Arnica. Dried flower-heads of Arnica moniana (Fam. Com- posiia), especially free from sophistication with flowers of other plants. Produce galenicals of correct quality, odor and taste. Feeble Rubefacient, used chiefly as tincture. (See Fluid- extract; Tincture.) Arsenic Antidote. See Antidote, Arsenic. Arsenic Iodide, Squibb g. s. bottle, oz. Arseni lodidum. Asia; Arsenic TrIIodide. Orange-red, odor- less crystals or powder. 82.7 percent, iodine and 16.3 percent, arsenic. 1 Gm. dissolves in aboiit 12 mils (Cc.) water, with partial decomposition; soluble in alcohol, chloroform, ether. Alterative, in cancer (Internally and externally), scrdfula, leprosy, etc. Average Dose: 1/12 gr. (0.005 Gm.), in pills or tablets. Keep from light. (See also Tablets [Part II].) ©Arsenic Trioxide, Squibb (Acid Arsenous Powdered) bottle, 14 lb. ; oz Arseni Trioxidum; Arsenous Acid; AS2O3. Soluble in water, freely in glycerin, sparingly in alcohol or ether. Aqueous solubility is increased by tartaric or hydrochloric acid. Anti- periodic, Alterative, Caustic. Average Dose : 1/30 grain (0.002 Gm.). Antidotes: arsenic antidote, emetids; > milk -or eggs; magnesia in milk. Incompatible with tannic acid and infusion cinchona and other vegetable astringent infusions, tinctures and decoctions; also with salts of iron and magnesium, lime- water, etc. (See also Reagents, Part IV; Tablets [Part ll].) Arsenphenolamine-S. See Neoarsphenamine. Arsenobenzol. Brand of Arsphenamine (Salvarsan). © Arsphenamine. Name adopted by Federal Trade Commission for Diamino- dihydroxy-arsenobenzene Hydrochloride (first introduced as Salvarsar and also known as Ajrsenobenzol and Ehrllch's 606) as made in America. Yellow powder, containing about 31.5 percent arsenic. Readily soluble in water. Alterative and Antiluetic; succedaneum for arsenic, but used mainly in syphilis by Intravenous, Intramuscular or hypodermic injection. Dose (in lues) : men, 9 grains (0.6 Gm.) ; women, 6 grains (0.4 Gm.); children, 2 to 5 grains (0.13 to 0.3 Gm,). The Squibb products are recognized everywtiere as the Quality Standard. They are of uniform purity a,nd strength, hence therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 24 SQUIBB'S MATERIA MEDICA © ASAFETIDA. Asafatida. Gum-resin obtained by incising rhizome and roots of Ferula AsafmtiJa, F. fceiida, and other species of Ferula (Fam. Umbellifera). Soft mass; persistent, garUcky odor; bitter, acrid taste. Carminative, Sedative; in hysteria, asthma, etc. Average Dose: 4 grains (0.25 Gm.). (See also Tablets [fart II].) AsARUM. Asarum, N. F.; Canada Snake-root. Dried rhizome and roots of Asarum canadense (Fam. Aristolochiacea) . Carminative, Flavor; similar to ginger. Average Dose: 30 grains (2 Gm.). Asbestos Wool Reagent. See Reagents (Part IV). ASCLEPIAS. Asclepias, N. F.; Pleurisy Root. Dried roots of Asclepias iuberosa (Fam. Asclepiadacect) . Slight odor; bitterish, dis- agreeable, acrid taste. Domestic remedy for pleurisy; also used as Diaphoretic. Average Dose: 30 grains (2 Gm.). (See also Fluidextract.) AsPIDIUM. Aspidiumi Male Fern. Rhizome and stipes of Dr'gopterh Filix-mas or D. marginalis (Fam. Polypodiacea). Anthelmin- tic. Average Dose: 1 drachm (4 Gm.). ASPIDOSPERMA. Aspidosperma ; Quebracho. Dried bark of Aspidosperma Quebracho bianco (Fam. Apocynacea) . Respiratory Tonic. Antidyspneic ; chiefly in asthma and emphysema. Average Dose: 1 drachm (4 Gm.). (See also Fluidextract.) Aspirin. Brand name for Acetylsalicylic Acid. Atophan. See Acid Phenylcinchoninic. Atoxyl. Sodium Arsanilate. White, odorless powder; about 22 per- cent, arsenic. Soluble in water. Alterative, Antiluetic. Dose: !/3 to 3 grains (0.02 to 0.2 Gm.), hypodermically every second day. ©Atropine, Squibb ^-oz. vial, j lO-gr. vial, 5-gr. vial, V Alropina.. C17H23O3N. An alkaloid from Alropa Bella- donna and other plants of Solanacea. White, odorless, bitter, acrid crystals. I Gm. dissolves in '455 mils (Cc.) water, 2 alcohol 27 glycerin, 1 chloroform, 25 ether. Respiratory and Cardiac Stimulant; Antispasmodic, Antihydrotic, Antisialagogue, Average Dose: 1/120 gr. (0.0005 Gm.). Acts within J^ hour, eliminated within 3 hours. Applied locally as oleate. Anti- dotes: tannin, then emetics; morphine, pilocarpine, physostig- mine, aconitine. SQUIBB'S MA.TERIA MEDICA 25 © Atropine Sulphate, Squibb H-oz.vial, ; 10-gr.viaI, ; 5-gr.vial, Atropina Sulphas. (Ci7H2303N)2.H2S04. White, crys- talline, odorless, bitter powder. 1 Gm. dissolves in 0.4 mil (Cc.) water, 5 mils alcohol, 2.5 glycerin, 420 chloroform, 3200 ether. Uses same as alkaloid, but largely as Mydriatic, in Yz percent, solution. Average Dose: 1/120 grain (0.0005 Gm.) . Bacillus Bulcaricus Cijlture. Offered in liquid and tablet forms. Antizymotic internally, Antipyic topically. Dose : liquid, 7 mils (Cc.) ; tablets, I or 2, after meals. Baking Powder, Squibb tin, lb. ; 14 lb. After a formula approved by the U. S. Government, but with slight modification to enhance its effectiveness. Free from all injurious substances, hence perfectly harmless to health. Owing to the fact that this powder is made from the purest materials and thoroughly dried before putting up, it should be used with moderation; it is more active than most powders — a level tea- spoonful of Squibb's Baking Powder is equivalent to a heaping teaspoonful of the regular baking powders of the market. Keep the can well closed and in a dry place. Balm Gilead Buds. See Balsam Poplar Buds. Balsam Poplar Buds. Populi Cemmte, N. F.; Balm of Gilead Buds. Air-dried, closed winter leaf-buds of Populus nigra or P. halsamifera (Fam. Salicacea). Anticatarrhal, Expectorant; similar to cubeb or turpentine. Balsam Copaiba. See Copaiba. ' ^ Balsam, Friars' or Turlington's. See Tincture Benzoin Compound. ® Balsam Peru, Squibb bottle, lb. ; % lb. Balsamum Peruvianam, From Toluifera Pereird (Fam. Legu- /ni'nosffi). Soluble in alcohol and chloroform with not more than slight opalescence; partly in ether. Contains 50 to 56 percent, cinnamein. Thick, dark-brown liquid; vanilla-like odor; bitter, acrid taste. Sp. gr. 1.130 to 1. 1 60. Antiseptic, Alterative, Expectorant. Used chiefly extertially, on wounds, ulcers, chilblains, etc.; internally, in chronic catarrh, asthma, phthisis, etc. Dose:, I Q to 20 grains (0.65 to 1.3 Gm.). Incompatible with iodoform in substance, and hydrogen dioxide. Since we malse only one quality of eachi product, that best suited to the purposes intended, the specification "Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 26 iSQUIBB'S MATERIA MEDICA © Balsam Tolu, Squrbb " tin, lb. Balsamum ToluUmum. From Toluifera Bahamum (Fam. Legu- minostE). Free from rosin and copaiba and in other respects fully U. S. P. Yellow-brown, plastic solid, becoming brittle when old or dried or exposed to cold; vanilla-like odor; mild aromatic taste. Soluble in alcohol, chloroform, ether. Elxpec- torant; used chiefly as its syrup, a pleasant vehicle. Dose: 8 to 15 grains (0.5 to I Gm.). (See also Fluid; Syrup; Tincture.) Baptisia. Baptisia, N. F.; Wild Indigo. Dried roots of Baptisia tinc- ioria (Fam. Leguminose) . Used as Astringent. Average Dose: 15 grains (I Gm.). Barbital-Sodium (Sodium Diethylearbiturate) This is the name adopted by the Federal Trade Commission for the product known by various brand names, such as: Medi- nal, Veronal-Sodium, etc. White powder, of bitter-alkaline taste. Soluble in 5 parts water. Hypnotic; used also hypo- dermically and by rectum. Dose : 5 to 1 5 grains (03 to 1 Gm.) . Barberry. See Berberis. © Barbital. Name adopted by Federal Trade Commission for Diethylma- lonylurea or Diethylbarbituric Acid (first introduced under the trade name Veronal and also known as Malo-Urea) as made in America during the suspension of the German patents. White, crystalline, odorless, slightly bitter powder. Soluble in about 150 parts waier, readily in ether, slightly in chloroform. Hypnotic. Dose: 5 to 15 grains (0.3 to 1 Gm.), with a hot drink. Barium Acetate. Reagent. See Reagents (Part IV). Barium Carbonate Reagent. See Reagents (Part IV). Barium Chloride Reagent. See Reagents (Part IV). Barium Hydroxide Reagent. See Reagents (Part IV). Barium Nitrate Reagent. See Reagents (Part IV). Barium Sulphate for X-Ray Work, Squibb carton, lb. ; '/^ lb. BaS04. White, odorless, tasteless, quite bulky powder. In- soluble in usual organic solvents. Barium Sulphate has come into use for X-Ray work on the stomach and intestines. In- stances of poisoning that have occurred point out the necessi^ of employing only a perfectly pure grade free from soluble barium salts, which latter are the cause of toxic symptoms. The article here offered is perfectly free from these noxious soluble salts, and is especially prepared for X-Ray work. Being in- soluble in water, acids or alkalies, it passes through the system unchanged and imabsorbed. Hence no untoward action what- ever need be feared. Also suitible for use as Reagent. When ordering Barium Sulphate for X-Ray work specify "Squibb." Send for literature. Barker's Post-Partum Pills. See Pills Laxahve. Post-Partum. Bateman's Pectoral Drops. See Tincture, Pectoral. SQUIBB'S MATERIA MEDICA 27 Bayberry Bark. M^tica, N. F.; Candleberry; Wax Berry.' Dried bark of -' root of Myrica cerifera (Fam. M^ricacea): Used as Diges- tive, Carminative, Nerve Stimulant. Average Dose: 8 grains (0.5 Gm.). Bay Rum. See Spirit Myrcia Compound. Bearberry Leaves. See Uva Ursi. Belladonna Leaves, Squibb Ground for Percolation tin, lb. BellaJonncs Folia; Deadly Nightshade Leaves. Dried leaves and tops of Airopa Delladonna (Fam, Solanacetz^. Assays not less than 0.3 percent, alkaloids. Preparations made from this leaf may assay above official standard and must be adjusted accordingly. Anodyne, Antispasmodic, Antihydrotic. Aver" age Dose: 1 grain (0.065 Gm.). (See also Extract; Fluid- extract; Ointment; Tincture.) Belladonna Root. BelladonncB Radix. Assays not less than 0.45 percent, alka- loids. Average Dose: % grain (0.03 Gm.). (See also Ex- tract; (Fluid extract) Benzaldeliyde, , Squibb bottle, lb. ; !4 lb. BenzaldehyJum ; Benzoic Aldehyde; Artificial Essential Oil Almond. Contains not less than 85 percent. C7H0O. Color- less or yellowish liquid; odor of bitter almond; burning taste. Sp. gr. about 1.045. Miscible with alcohol, ether, oils; slightly, soluble in water. Non-poisonous substitute for oil bitter almond; also Flavoring. Average Dose: Yz minim (0.03 mil). Benzene. Benzol Medicinal. CgHe. From light oil of coal tar. Color- less liquid; strong" odor; burning taste. Soluble in alcohol, ether; insoluble in water. Used in Hodgkin's disease, leu- kemia, etc. Dose: 8 to 15 minims (0.5 to 1 mil [Cc.]) four times a day, in capsules or as emulsion. Use cautiously. Benzin, Petroleum, Purified. Benzinum Purificatiim ; Petroleum Ether. Purified distillate iFrom petroleum, consisting of hydrocarbons chiefly of marsh- gas series. Sp. gr. 0.638 to 0.660. Freely soluble in alcohol; miscible with chloroform,, benzene, and oils (excepting castor oil); insoluble in water.- Antiparasitic dermic; in scabies, pediculosis, barber's itch, etc.; but used chiefly pharmaceutically. Very inflammable. the founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and lalJored for thenn; and, in the Words of William Miller Bartlett, "the House of Squibb stands todjay as a living monument to the honor; mtegrity, zeal and devotion of its founder." 28 SQUIBB'S MATERIA MEDICA ® Benzoin, Squibb tin, lb. ; !4 lb. Benzoinum; Gum Benjamin; Gum Benzoin. Extra select Siam gum, in nice, clean tears; wholly different from the regular market article. Balsamic resin obtained from St^rax Benzoin and other species of Sfyrax (Fam. Styracacea). Yields less than 21/2 percent, ash, and especially rich in benzoic acid. Yellow- ish-brown, pebble-like tears; vanilla-like odor; slightly acrid taste. Soluble in solution sodium or potassium hydroxide, in 5 parts warm alcohol. Wound Antiseptic, 1 :5 ointment; Ex- pectorant, in inhalations. Used mainly technically and phar- maceutically. Average Dose: 15 grains (1 Gm.). (See also Fluid ; Tincture) . Benzoinated Cream, Squibb small jars per doz, ; oz. jars, per doz, J/^-oz. tubes, per doz. This medicated Cold Cream has been supplied for many years as a special laboratory product. It has been proved a most valuable article in cases where the action of ordinary cold cream is Insufficient to effect prompt relief. It differs from the ordinary article in being a therapeutic salve instead of a simple mechani- cal ointment. It is used for the same purposes for which cold cream is so generally employed, but being compounded with other remedial agents, it possesses valuable medicinal properties which permit of its wider and more beneficial use as a safe and healing application. It contains benzoin, camphor, expressed oil almond and natural beeswax. Emollient, Antiseptic and Antipruritic. Benzol (Benzene) Reagent. See Reagents (Part IV). Benzonaphthol. See Betanaphthol Benzoale. Benzosalin. Methyl Benzoylsalicylate. Fine, white crystals, of faint aro- matic odor. Soluble readily in chloroform, moderately in alcohol; insoluble in water. Intestinal Antiseptic. Dose: 8 to 15 grains (0.5 to 1 Gm.). Benzosol. Benzoyl-guaiacol; Guaiacol Benzoate. C6H4(OCH3).C6H5- CO2. White powder; slight odor and taste; 54 percent, guaia- col. Soluble in alcohol, chloroform; sparingly soluble in ether; insoluble in water. Intestinal and Urinary Antiseptic, Anti- diabetic. Dose: 3 to 10 grains (0.2 to 0.65 Gm.). @ Benzosulphinide. BenzosulphiniJum; Saccharin; Benzoylsulphonic Imide; Glu- side. C7H5O3NS. While, nearly odorless powder; intensely sweet taste. 1 Gm. dissolves in 290 mils (Cc.) water, 31 alcohol; slightly soluble in ether or chloroform; easily in am- monia water, alkaline hydroxide or sodium bicarbonate solution. About 500 times as sweet as cane sugar. Non-fermentable sweetener; corrigent of bitter or acrid drugs. Rarely medicinally, as acidiiier of urine in cystitis. Average Dose: 3 grains (0.2 Gm), well dfluted. (See also Tablets [Part II].) SQUIBB'S MATERIA MEDICA 29 •i © Benzosulphinide-Sodium. See Sodium Benzosulphinide. Berberis. Berberis, N. F.; Barberry Root; Oregon Grape Root. Dried hrizome and roots of Berberis aquifolium and other species of Berberis (Fam. Berberidacea) . Bitter Tonic, like Hydrastis. Average Dose: 30 grains (2 Gm.). (See also Fluidextract.) Bestuscheff's Tincture. See Tincture Iron Chloride, Ethereal. t Betaeucaine Hydrochloride. Beiaeacaina: H^drochloridum; Trimethylbenzoyloxypiperidine Hydrochloride. . Ci5H2iN02.HCl. "White, odorless powder. 1 Gm. dissolves in 30 mils (Cc.) water, 35 alcohol, 6 chloro- form. Incompatible with alkalies and their carbonates. Local Anesthetic; in 2 percent, solution for eye, 5 to 10 percent, solution for nose and throat. © Betanaphthol, Squibb • 1 -oz. vial Betanaphthol; Naphthol. C10H7OH. A monohydroxy- phenol occurring in coal tar, but usually made from naphtha- lene. Colorless or buff-colored, shining lamina:; faint, phenol- like odor; sharp taste. I Gm. dissolves in about 1000 mils (Cc.) water, 0.8 alcohol, 17 chloroform, 1.3 ether; soluble in glycerm, olive oiK alkali-hydroxide solutions. Antiparasitic Dermic; Intestinal Antiseptic, Anthelminthic. Internally, in typhoid fever, chronic diarrhea, etc.;. externally in psoriasis, scabies and other parasitic skin diseases. Also used as Reagent. Average Dose: 4 grains (0.25 Gm.). Applied in ^ to 10 percent, ointment. Incompatible on trituration with antipyrine, camphor, menthol or phenol, Betanaphthol Benzoate, Squibb l-oz. vial Benzonaphthol. C6H5CO2.C10H7. Creamy-white, nearly odorless and tasteless needles or powder; darkens with age. Soluble in alcohol, ether, chloroform. Intestinal Antiseptic. Dose: 3 to 8 grains (0.2 to 0.5 Gm.). Betanaphthol-bismuth. See Bismuth Betanaphtholate. Beth Root. See Trillium. ' Bismuth Betanaphtholate. Bismulhi Betanaphtholas ; Betanaphthol-Bismuth. Newly offi- cial. 15 percent, betanaphthol, 75 percent, bismuth oxide. Buff-colored to grayish -brown, almost odorless, tasteless powder, nearly insoluble in water, alcohol, chloroform, ether. Intestinal Antiseptic. Average Dose: 8 grains (0.5 Gm.). _ The Squibb Ideals have taken concrete forni in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 30 SQUIBB'S MATERIA MEDICA Bismuth Carbonate. See Bismuth Subcarbonate. Bismuth Citrate, Squibb bottle, oz. BiCeHsOy. Dropped from U. S. P. White, odorless, taste- less powderi When fresh or not too old,' soluble in ammonia water and solutions alkaline citrates; insoluble in water and alcohol. Stomachic, Astringent; also Reagent. Ordinary Dose: 2 grains (0.13 Gm.). Bismuth Citrate Soluble. See Bismuth and Ammonium Citrate. Bismuth Gallate Basic. See Bismuth Subgallate. Bismuth Magma, Squibb bottle, pint Magma BUmulhi; Milk of Bismuth. Yields 5.6 to 6.2 percent, bismuth oxide. Each fluidounce represents equivalent of about 40 grains bismuth subnitrate, suspended in plain distilled water. Antacid, Gastro-intestinal Astringent and Sedative. Average Dose: 1 fluidraqhm (4 mils [Cc.]). Keep protected against light; shake well before dispensing. Bismuth, Milk of. See Bismuth Magma. Bismuth Nitrate Reagent. See Reagents (Part IV). Bismuth Oxide Hydrated, Squibb bottle, oz. Bi(OH)3. White, bulkyi odorless powder. To make Cremor Bismuthi or Cream of Bismuth, mix 20 parts of this oxide with 80 parts water. Antacid, Gastric Protective, internally; As- tringent, locally. Also Reagent. Dose: 5 to 20 grains (0.3 to 1.3 Gm.). Bismuth Oxychloride, Squibb bottle, oz. Bismuthyl Chloride; Pearl White. Bi O CI. White, odorless, lustrous powder. Soluble in acids; insoluble in water. Used in face powders, etc. Bismuth Oxyiodide, Squibb bottle, oz. Bismuth Subiodide. BiOI. Brownish-red, odorless, tasteless powder, insoluble in ordinary solvents. Antiseptic, Vulnerary. Dose: 3 to 10 grains (0.2 to 0.65 Gm.). Bismuth Oxynitrate. See Bismuth Subnitrate. Bismuth Salicylate Basic. See Bismuth Subsalicylate. Bismuth Subcarbonate, Squibb bottle, lb. ; % lb. ; oz. Bismuthi Subcarbonas; Bismuth Carbonate (BiO)2C03. Yields not less than 90 percent, bismuth oxide, and free from alkalies, arsenic, alkaline earths and heavy metals. White, , odorless, tasteless powder. Insoluble in water, alcohol, ether, etc. Protective Vulnerary, Gastric Sedative, Intestinal Astrin- gent; also used as Reagent and in X-ray work. Average Dose: 8 grains (0 5 Gm.). Incompatible with sulphides, sul- phur, acids and acid salts. (See also Tablets [Part II].) , SQUIBB'S MATERIA MEDICA 31 Bismuth Stibgallate, Squibb bottle, lb. ; '/i lb. ; oz. Bismulhi Suhgallas; Basic Bismuth Gallate. Bi(OH)2C7H505. Yields 52 to 57 percent, bismuth oxide. Contains no free gallic acid. Bright-yellow, odorless powder. Soluble in solutions of alkali hydroxides; insoluble in ordinary solvents. Drying Antiseptic externally; Astringent internally. Average Dose: 8 grains (0.5 Gm.). Applied pure or as 10 to 20 percent, dusting-powder or ointment. Incompatible with acids, alkalies, sulphides and sulphur. (See also Tablets [Part II].) Bismuth Subiodide. See Bismuth Oxyiodide. Bismuth Subnitrate, Squibb bottle, lb. ; J4 lb. ! oz. Bismulhi Suhnitras; Magistery of Bismuth; Bismuth Oxy- nitrate. BiON03.H20 or Bi(OH)2N03. Pure, nice white and bulky. Not only fully meets the U. S. P. purity require- ments, but exceeds them. White, odorless, almost tasteless pow- der. Insoluble in ordinary solvents. Incompatible "with gallic, salicylic and tannic acids, solutions of alkaline carbonates, sul- phides and sulphur. Topical and Gastro-intestinal Astringent and Protective. Average Dose : 8 grains (0.5 Gm.) . (See also Reagents [Part IV]; Tablets [ParlTI].) Bismuth Subsalicylate, Squibb bottle, lb. ; '/i lb. ; oz. Bismulhi Suhsalic^las ; Basic Bismuth Salicylate, Bi(OH)2- C7H5O3. Yields 62 to 66 percent, bismuth oxide. White, or nearly white, odorless, tasteless powder. Insoluble in ord- inary solvents. External and internal Astringent and Anti- septic. Average Dose: 8 grains (0.5 Gm.). Topically used like iodoform. Incompatible with alcohol, alkali carbonates, and bicarbonates, tannin and iron salts. Note: The acid salicylate is nof official, and should not be dispensed when "salicylate" is called for in prescriptions. (See also Tablets [Part II].) Bismuth and Ammonium Citrate, Squibb bottle, lb. ; !4 It. ; o^- Bismulhi el Ammonii Cilras; Soluble Bismuth Citrate. A par- ticularly handsome and pure product, scaled with great care. Yields 46 to 52 percent, bismuth oxide. Shming, pearly, fador- ^ less scales; metallic taste; very soluble in water, sparingly solu- ble in alcohol. Stomachic, Astringent. Average Dose : 2 grains (0.13 Gm.). Injected in urethritis in 1 :500 solution. Keep well stoppered; becomes opaque, loses ammonia, and sacrifices its solubility on exposure. The- Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 32 SQUIBB'S MATERIA MEDICA Bitter Apple. See Colocynth. Bittersweet. Dulcamara, N. F. Dried stems and branches of Solanum Dul- camara (Fam. Solanacea). Used as Alterative. Average Dose: 60 grains (4 Gm.). Blackberry Bark. See Rubus. Black Cohosh. See Cimicifuga. Black Drop. See Vinegar Opium. Black Haw. See Viburnum Prunifolium. Black Wash. See Lotion, Black. Bladderwrack. See Fucus. Blancard's Pills. See Pills Iron Iodide. Blood, Occult, Test Tablets. See under Tablets (Part II). Blood=Root. See Sanguinaria. Blue Cohosh. See Caulophyllum, - Blue Flag. Iris Versicolor, N. F. Dried rhizome of Iris versicolor (Fam, Iridacca). Cathartic. Average Dose: 30 grains (2 Gm.). Blue Gum Tree. See Eucalyptus. Blue Mass or Blue Pill. See Mass Mercury. Blue Stone or Blue Vitriol. See Copper Sulphate. Blue Vervain. See Vervain. BoLDO. Boljo, N. F. Leaves of BolJu Boldus (Fam. Monimiacea). Aromatic, Mild Diuretic. Average Dose: 8 grains (0.5 Gm.). Boneset. See Eupatorium. Borax. See Sodium Bbrate. Bornyl Bromovalerate. See JBrovalol. Boroglycerin Qlycerite. See Glycerite Beroglycerin. Brayera. Brayera, N. F. ; Kousso ; Cusso. Dried panicles of flowers of Hagenia abyssinica (Fam. Rosacea), Teniacide. Average Dose: 240 grains "(16 Gm.). SQUIBB'S MATERIA MEDICA 33 Brometone. Tribrominated Tertiary Butyl Alcohol. C4H70Br3.. White crystals; camphor-like odor and taste. Soluble freely in al- cohol, ether, chloroform; slightly in water. Nerve Sedative, Antispasmodic' Dose: 5 to 10 grains (0.3 to 0.65 Gm,). Bromine. Bromum, N. F. Br. Heavy, dark brownish-red liquid, evolv- ing reddish fumes highly irritating to eyes and lungs; peculiar, suffocating odor; sp. gr. about 3.016. 1 mil (Co.) dissolves in about 90 mils water; free^ soluble in alcohol, ether, chloro- form. Caustic (pure). Antiseptic Inhalant (1 :500 water) ; used chiefly technically. Antidotes: ammonia by inha/lation; sodium carbonate, albumen. Must be kept in cool place and handled with great care. Its vapor is very irritating to mucosae. Bromipin. Bromine addition products of fatty acids of sesame oil. Yel- low, oily liquidsl 10 and 33]/^ per cent, bromine, respectively. Nervine. Dose: 10 percent., I to 4 fluidrachms (4 to 15 mils [Cc.]); 3314 percent;, 20 to 60 minims (1.3 to 4 mils [Cc.]). ■Bromoform. Bromoformum ; Formyl Tribrcmide; Tribromomelhane. CHBrg. Heavy liquid; ethereal odor, chloroform-like taste. Sp. gr, 2^95 to 2.620. Miscible with chloroform, alcohol, ether, oils; soluble in 80 parts glycerin; very slightly in water. Anti- spasmodic and Sedative, chiefly in whooping-cough. Average Dose: 3 minims (0.2 mil [Cc.]), in hydroalcoholic solution or emulsion. Antidotes : atropine or strychnine hypodermically ; amyl nitrite or ammonia by inhalation; oxygen. Bromoform is so extremely volatile that the vials are liable tp lose in weight rapidly on keeping. It is hence best ordered in small quantities, and should be kept in cool place protected against light. Bromural. Monobromisovalerylurea. White, almost tasteless needles. Sol- uble readily in hot water, ether, alcohol or alkalies. Nerve Sedative, Hypnotic. Dose: 5 to 10 grains (0,3 to 0.65 Gm.). Broom Tops, See Scoparius. Brovalol. Bornyl Bromovalerate. Colorless, oily, faintly aromatic liquid; 25.2 percent, bromine. Soluble in alcohol, chloroforin or ether; insoluble in water. Analeptic, Nerve Sedative. Dose: 4 to 12 grains (0.25 to 0.75 Gm.), in capsules. Ttiis house suppties only one quality of each product: that best suited to the purposes intended. The specification Squibb s is not open to various interpretations; it has a plain, posj- tive meaning. Therefore, when prescribing, specify SQUIBB S. 34 SQUIBB'S MATERIA MEDICA Bryonia. Bryonia, N. F.; Bryony. Dried root of Bryonia alba or B. Jioica (Fam. Cucurbilacete). Drastic Resinous Cathartic; used in dropsies, pleurisy, etc. Average Dose: I Gm. (15 grains). (See also Fluidextract ; Tincture.) Buchu, Squibb tin, lb. ; !4 lb. Bacha. Dried leaves of Barosma beiulina (Short Buchu) or of B. serratifolia (Long Buchu). (Fam. Rutacea). The article here listed is short buchu of best quality; in odor, taste, and other characteristics sahsfying the most exacting requirements. Diuretic, Anticatarrhal ; chiefly" in diseases of bladder and kidneys. Average Dose: 30 grains (2 Gm.), (See also Fluid- extract; Tablets [Part II].). BucKBEAN, See Menyanthes. Buckthorn Bark. See Frangula. Buckthorn Berries. Rhamnus Calharlica, N. F. Dried, ripe fruit of Rhamnus calharlica (Fam. Rhamnacea). Purplish-black externally; faint, unpleasant odor; sweetish, then nauseating, bitter taste. Cathartic. Average Dose: 15 grains (1 Gm.). Burdock. See Lappa. Burow's Solution. See Solution Aluminum Acetate. Butternut Bark. See Juglans. Cacao. See Cocoa. Cacao Butter. See Oil Theobroma. Cactus Crandiflorus. Cactus Crandiflorus, N. F.; Night-blooming Cereus. Fresh succulent stems of wild-growing Cactus grandifiorus (^Cereus grandiflorus ; Fam. Coclacea). Used in neurotic heart distur- bances; value doubted by many. Cadmium Iodide Reagent. See Reagents (Part IV). Cadmium^Potassium Iodide Reagent. See Reagents (Part IV). Cadmium Sulphate Reagent. See Reagents (Part IV). © Caffeine, Squibb carton, oz. Cafeina; Coffeine; Theine; Guaranine; Trimefhylxanthine. CSH10O2N4.H2O. Base from leaves of Thca sinensis (Fam. Ternstrcemiacea), or dried seeds of Coffea arabica (Fam. Ru- biacea). White, silky, bitter needles; efflorescent in dry air. 1 Gm. dissolves in 46 mils (Cc.) water, 66 alcohol, 5.5 chloroform, 530 ether. Aqueous solubility increased by potassium bromide, sodium benzoate, sodium salicylate. Diuretic; Cardiac, Res- piratory and Psychic Stimulant. Average Dose: 214 grains (0.15 Gm.). See also Tablets [Part II].) SQUIBB'S MATERIA MEDICA 35 Caffeine Citrated, Squibb bottle, oz. Caffeina Citrata. Unstable compound of caffeine and citric acid, containing whfen dried 48 percent, anhydrous caffeine. White, odorless powder; of slightly bitter, acid taste. Soluble in about 25 parts water, in mixture of equal volumes chloro- form and alcohol. Average Dose: 5 grains (0.3 Gm.). (See also Tablets [Part II].) Caffeine Citrated, Granular Effervescent. Caffeina Cilrala Effervescens. 4 percent, official citrated caf- feine. Average Dose: 60 grains (4 Gm.). Caffeine Hydrobromide, Squibb bottle, oz. ; J/^-oz. vial C8H10N4O2.HBr.2H2O. Large, white crystals, turning red- dish on exposure. Soluble in water, with decomposition. Caffeine and Sodium Benzoate, Squibb bottle, oz. ; V^-oz. vial Caff,ein'a>>> diacetylmorphine hydrochloride, with tincture sweet orange peel, spirit bitter almond, alcohol, glycerin, syrup and water. Stim- ulating Expectorant, Cough Sedative; chiefly in chronic pectoral affections. Average Dose: 1 fluidrachm (4 mils [Cc,]). ■Elixir Three Bromides. Elixir Trium Bromidorum, N. F. Each fluidounce con- tains about 36 grains each ammonium, potassium and sodium bromides, in compound elixir almond colored red. Nerve Sedative. Average Dose: 1 fluidrachm (4 mils [Cc.]).^ Elixir Vanillin Compound. Elixir Vanillini Composilum, N. F. Flavoring vehicle con- taining 2 vol. percent, compound spirit vanillin, with Httle glycerin, syrup and water. Elixir Viburnum Opulus, Compound. Elixir Virhurni Opuli Composilum, N. F.; Compound Elixir Cramp Bark. Each fluidounce represents 34 grains cramp bark, 68)/2 grains beth root and 34J^ grains aletris, with compound elixir taraxacum. Used as Uterine Tonic. Average Dose: I fluidrachm (4 mils [Cc.]). Elixir Viburnum Prunifolium. Elixir Vihurni Prurufolii, N. F.; Elixir Black Haw. Each fluidounce represents 57 grains viburniim prunifolium, with aromatic elixir and compound tincture catdamom Used as Uterine Sedative and Antispasmodic. Average Dose : 1 fluidrachm (4 mils [Cc.]). Elixir Vitriol. See Acid Sulphuric Aromatic. Elixir Yerba Santa Aromatic. See Elixir Eriodictyon Aromatic. Since we make only one quality of each product, that best suited to ^he purposes intended, the specification "Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 74 SQUIBB'S MATERIA MEDICA Elixir 2iNC Valerate. Elixir Zinci Valeratis, N. F. EacK fluidounce conlains 8 grains zinc valerate, with ammonium citrate, spirit bitter almond and aromatic elixir. Used as Nerve Sedative. Average Dose: 1 fluidrachm (4 mils [Cc.]). Elm. Ulmus; Slippery Elm. Bark of Ulmus fulva (Fam. Ulma- cca), deprived of outer corky layer and dried. Demulcent. (See also Troches.) © Emetine Hydrochloride. Emeiina Hydrochloridum. C30H44N2O4.2HCI+2H2O. Salt of an ipecac alkaloid. White to yellowish, odorless, bitter powder; darkens in light. Freely soluble in water, alcohol. Expectorant, Antamebic, Hemostatic; in bronchitis, amebic dysentery and pyorrhea alveolaris, hemoptysis, etc. Average Dose: Antamebic, I/3 grain (0.02 Gm.) hypodermically thrice daily for a week, then discontinued for a few days and resumed if necessary (injected into gums in 1 percent, solu- tion) ; expectorant I/12 to l/e grain (0.005 to 0.01 Gm.) ; hemostatic J/2 *° /^ g'^in (0.03 to 0.04 Gm.) subculaneously. Empyroform. Condensation product of birch tar and formaldehyde. Dark grayish-brown, nearly inodorous powder. Soluble in acetone or chloroform; insoluble in water, alcohol or ether. Antipruritic and Antiparasitic Dermic, in 5 percent, ointments, 10 to 20 percent, pastes or paints. Emulsions. No matter how well made, emulsions will not keep; hence, we do not carry them in stock, but we are prepared to supply them on special orders in quantities of 1 gallon or more. Emulsion Almond. Emulsum Amygdala; Milk of i^lmond. 6 percent, sweet almonds, with sugar, acacia and water. Demulcent, Vehicle. Emulsion Asafetida. Emulsum Asafalid'a; Milk of Asafoetida. 4 percent, eisafce- tida, with water. Sedative, Carminative; in hysteria, asthma, convulsions, etc. Average Dose: 4 fluidrachms (16 mils). Emulsion Castor Oil. Emulsum Olei Riclni, N. F. 35 percent, by volume castor oil, with tincture vanilla, syrup and water. Cathartic. Average Dose: V/2 fluidounces (48 mils [Cc.]). EiMULJION CoD-LlVER OiL. Emulsum Olei Morrhuce. 50 volume percent, of oil, and hold- ing flavor which efficiently masks the taste. Alterative Tonic, Nutrient. Average Dose: 2 fluidrachms (8 mils [Cc.]). SQUIBB'S MATERIA MEDICA 75 Emulsion Cod-Liver Oil with Calcium Lactophosphate. Emulsum Olei MorrhutE cum Calcii Lactophosphate, N. F. 50 volume percent, cod liver oil, with calcium lactophos- phate (23 grain; per fluidounce), syrup tolu and flavoring. Alterative, Reconstructive, Nutrient. Average Dose: 4 fluidrachms (16 mils [Cc.]). Emulsion Cod-Liver Oil with Calcium Phosphate. Emulsum Olei Morrhutt cum Calcii Lactophosphate, N. F. 50 volume percent, cod-liver oil, with calcium phosphate "( 1 6 grains per fluidounce), syrup tolu and flavoring. Alterative; Nutrient, Reconstructive. Average Dose: 4 fluidrachms (16 mils [Cc.]). Emulsion Cod Liver Oil with Egg. Emulsum Olei Morrhuts cum Vitello, N. F. 50 vol. percent, oil, 1 7J/2 glycerite yolk of egg, 1 syrup tolu. Average Dose : 4 fluidrachms (16 mils [Cc.]). Emulsion Cod-Liver Oil with Extract Malt. Emulsum Olei Morrhmg cum Malto, N. F. Each fluidounce contains 144 minims cod-liver oil and 260 minims extract malt. Nutritive," Tonic. Average Dose: 4 fluidrachms 16 mils [Co.]) Emulsion Cod-Liver Oil with Hypophosphites. Emulsum Olei Morrhua cum H^pophosphiiibus^ N. F. Each fluidounce contains 240 minims cod-liver oil, 4.6 grains cal- cium hypophospl^ite, 2.3 grains each potassium and sodium hypo- phosphites. Used, as Reconstructive Tonic, Nutrient. Average Dose: 2 fluidrachms (8 mils [Cc.]). Emulsion Cod-Liver Oil with Wild Cherry. Emulsum Olei Morrhua cum Pruno Virginiana, N. F. 50 volume percent, cod-liver oil and 30 grainsa wild cherry per fluidounce, with syrup tolu and flavoring. Alterative Tonic, chiefly in chronic respiratory affections. Average Dose: 4 fluidrachms (16 mils [Cc.]). Ejwulsion Oil Turpentine. Emulsum Olei Terebinthina. Each fluidounce contains 72 minims rectified oil turpentine and 24 minims expressed oil almond. Anthelmintic, Diuretic, Antiseptic. Average Dose: 30 minims (2 mils [Cc.]); as anthelmintic, y^ to I fluidounce (15 to 30 mils). Emulsion Petrolatum. ' Emulsum Peirolati; N. F. Each fluidounce contains about 103 grains petrolatum, 108 minims expressed oil almond; with syrup, tincture lemon peel, and water. Protective, Lubricant, Laxa- tive. Average Dose: 4 fluidrachms (16 mils [Cc.]), between meals. The founder of tlie House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William Miller Bartlett, ths House of Squibb stands today as a living monument to the. honor, integrity, zeal and devotion of its founder." 76 SQUIBB'S MATERIA MEDICA © Epinephrine. Active principle of suprarenal gland. Small, white crystals, sparingly soluble in water and prone to oxidize, hence supplied only in 1:1 000 solution of its hydrochloride in normal sail solution and generally containing a preservative. Vasco-con- strictor. Hemostatic; Tonic to heart muscle. Dose: 5 to 30 minims (0.3 to 2 mils [Cc.]) of the 1 :1000 solution; hypoder- mically, I to 15 minims (0.06 to 1 mil) diluted with sterile water. Applied in 1:1000 to 1:10000 solution. Epsom Salt, Pure. See Magnesium Sulphate. © Ergot. Ergota; Spurred Rye. Carefuly dried sclerotium of Claviceps purpurea (Fam. Hypocreacea) , replacing the grain of rye, Secale cereale (Fam. Craminea). All the well-known ergot products offered by this firm are made from yearly importations of new-crop Spanish ergot, which is immediately extracted and made up into the various preparations before deterioration of the active principles takes place. (For full descriptions of the various preparations, see the respective headings in this list.) Emmenagogue, Hemostatic, Circulatory Equalizer. Average Dose: 30 grains (2 Gm.) (See Extract; Fluidextract; Sterile Ergot; Tablets [Part II].) Ergot, Sterile, for Hypodermic Use. See Sterile Ergot. .Ergotin Bonjean. Purified Extract Ergot, analogous to the Squibb extract ergot. Ericin. See Mesotan. Eriodictyon (Yerba Santa), Squibb Ground for Percolation tin, lb. Eria<]ici\)on ; Mountain Balm; Consumptive's Weed. Dried leaves of Eriodictyon calif ornicum (Fam. H^drophyllacea) . Expectorant, but used chiefly as taste corrigent. Average Dose: 15 grains (I Cm.). (See also Fluid; Fluidextract; Syrup.) Erythroxylon. See Coca. Eserine. See Physostigmine. Essence Peppermint. See Spirit Peppermint Essence Pepsin, Squibb bottle, pint, gal. Of same drug strength as Elixir Pepsini el Rennini Compositum N. F., but differs in flavoring and vehicle and the lactic acid has been omitted because it is apt to interfere with action of the pepsin.~ Each fluidounce contains 10'/^ grains pepsin, 7^ grains rennin. Digestive; Vehicle for iodides and bromides. Average Dose: 2 fluidrachms (8 mils [Cc.]). SQUIBB'S MATERIA MEDICA 77 I Ether, Squibb (specially made for Anaesthesia). special tins, Ya ^• Squibb's Ether is furnished in tin cans of all the current sizes of the trade, but the smaller packages, such as the Y^ 'h. are especially recommended. One such can contains a quantity sufficient for an ordinary surgical operation ; and in opening an original package for each operation, the surgeon is absolutely sure of a fresh and otherwise correct supply. It is a de- plorable fact that in some instances our cans have been refilled with inferior ether. Surgeons will therefore see that the sealing cap is still intact. 1 /Ether; Sulphuric Ether; Ethylic Ether; Ethyl Oxide (€2145)20. The high-quality Anaesthetic Ether here listed is made in the Squibb laboratories by the original process de- vised by Dr. E. R. Squibb in 1853, and by continuous im- provement long ago brought to practical perfection, thus insur- ing a product of uniform purity, strength and efficiency. From the beginning to the present day all Squibb Ether has been made only in the Squibb laboratories. We make no ether for technical uses. This is in order to safeguard both surgeon and patient. The Squibb Ether is superior in vital respects to U. S. P; Ether, and by both laboratory tests and clinical experiences extending^ over more than sixty years, it has been proved to be the purest, best, safest and most economical anaesthetic ether made. Squibb*s Ether is put up only in soldered tins with soft metal caps, which can be readily cut out with a pocket knife and the tin then stoppered with a cork. _ These soldered cans are all carefully tested for leakage before they are sent. out. Sometimes, however, a weak spot is, not evident on testing, but yields to rough hai^dling during transportation, and the can will leak and be found short or even empty when received. In any such case we gladly furnish the purchaser with a new package if he will send the defective one to us. Soluble in about 10 times its volume water; miscible in all proportions with alcohol, chloroform, oils, petroleum benzin and benzene. Inhalation Anaesthetic, Anodyne, Stimulant, Anti- spasmodic; also Reagent. Average Dose per os: 15 minims (1 mil [Cc.]). Antidotes: artificial respiration; inversion of patient; ammonia; oxygen or fresh air. Ether is highly in- flammable. Its vapor, when mixed with air and ignited, ex- plodes violently. It should be kept in a cool place, and remote from lights and fire, and administered only by daylight or in electric light. (See also Inhaler; Spirit Ether Compound.) Ether Anhydrous, Reagent. See Reagents (Part IV). The Squibb Ideals have taken concrete form i,i the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general' Excellende and Reliability. Specify SQUIBB'S when prescribing or ordering. 78 SQUIBB'S MATERIA MEDICA Ether, Acetic, Squibb bottle, lb. ^iher Aceiicus, N. F.; Ethyl Acetate. C2H5C2H3O2. Dropped from U. S. P. An exceptionally pure product pre- pared in special apparatus, from high-grade material. Coloriess liquid; fragrant odor; acetous, burning taste. Sp. gr. 0.887 to 0.895. 1 Gm. dissolves in about 10 mils (Cc.) water; miscible with alcohol, ether, oils. Stimulant, Antispasmodic, Anodyne; in nervous affections, fainting, etc. Also Reagent. Average Dose: 15 minims (I mil). Etlier, Hydrobromic. See Ethyl Bromide. Ether, Sulphuric. See Ether. Ether Inhaler. See Inhaler. Ethyl Acetate. See Ether Acetic. Ethyl Bromide, Squibb ampul, oz. ; % oz. Monobromethane ; Hydrobromic Ether. C2H5Br. Great care is exercised to insure a product of correct specific gravity and high purity, factors upon which the successful and safe use of this article depends. Colorless, inflammable, volatile liquid, of burning taste and chloroform-like odor. Sp. gr. 1 .433 to 1 .457. Soluble in alcohol, chloroform or ether. Inhalation Anaesthetic, Nerve Sedative; used mainly in minor surgery. Dose: by in- halation, 150 to 300 minims (10 to 20 mils fCc.]); internally, 5 to 10 drops, on sugar or in capsules. On exposure to light it' is likely to become discolored from liberation of bromine. Keep from light, air and fire. Must not be confounded with poison- ous Ethylene Bromide. (See also Inhaler.) Ethyl CARBAMAtE. jEihylis Carbamas; Urethane; Ethyl Urethane. C3H7NO2. Ethyl ester of carbamic acid. Colorless, odorless crystals; cool- ing saline taste. I Gm. dissolves in 0.45 mil (Cc.) water, 0.8 alcohol, 2.5 glycerin, 0.9 chloroform, 1.5 ether, 32 olive oil. Mild and relatively harmless Hypnotic. Average Dose: 15 grains (1 Gm.). Incompatible in triturations with antipyrine, butylchloral hydrate, camphor, carbolic acid, menthol, naphthol, resorcin, salol or thymol; with acids or alkalies. Ethyl Chloride, Squibb 30 Cc. glass tubes with fine capillary delivery tube having auto- matic closing cap, for local anaesthesia, each 50 Cc. glass graduated tubes, with coarse capillary delivery tube having automatic closing cap, for general anaesthesia, each 60 Cc. glass tubes with fine capillary delivery tube having auto- matic closing cap, for local anaesthesia, - each jElhylls Chloridum; Monochlorethane. C2H5CI. Squibb's Ethyl Chloride is a true, pure Ethyl Chloride, eminently suited for General as well as Local Anaesthesia. Prepared and puri- fied in the Squibb Laboratories. Colorless, volatile, inflammable liquid, of agreeable odor and burning taste. Sp. gr. about 0.921 at 0°C.; boiling-point 12° to 13°C. Soluble readily in al- cohol or ether; slightly in water. Dose (by inhalation as gen- eral anaesthetic): 1 to 3 fluidrachms (4 to 12 mils [Cc.]). Keep from light and fire. Inflammable! SQUIBB'S MATERIA MEDICA . 79 Ethyl Chloride Inhaler. See Inhaler. t©ETHYLMORPHINE HYDROCHLORIDE. jEihylmorphinronchitis. Average Dose: 30 grains (2 Gm.). EuPHTHALMIN. -C17H25NO3.HCI. Mandelic acid derivative of eucaine. "White powder. Soluble readily in water or alcohol. Mydri- atic, in 5 to 10 percent, solutions. EUQUININE. Quinine Ethylcarbonate. C23H28N2O4. White, light, fleecy, acicular conglomerations, practically tasteless. Soluble readily in acohol, ether, chloroform; sparingly in water. Solutions are bitter. Succedaneum for quinine sulphate. Dose: 2 to 13 grains (0.13 to 1 Gm.). EuROPHEN. Diisobutylcresol Iodide. C22H29O2I. Bulky, yellow powder, of saffron odor; 28 percent, iodine. Soluble in alcohol, ether, chloroform, fixed oils; insoluble in water. Wound Antiseptic, Antisyphilitic. Bose: 2 to 5 grains (0.13 to 0.3 Gm.). EXTRACTS, SQUIBB The careful selection of prime drugs and the accurate prelim- inary assays to which they are subjected, combined with their complete exhaustion by the Squibb method, insure thoroughly reliable preparations. The solid extracts are made by evapora- tion at low temperatures, thus preventing the loss of the volatile constituents, chemical changes and the rendering insoluble of the active principles. These extracts will be found to be ex- ceptionally active, soluble and uniform in dosage. Those which are official in the pharmacopoeia are made to conform accur- ately, and absolutely with U. S. P. standards. A number of extracts not official are assayed and adjusted to a required strength. These instances are noted under the individual ex- tracts in the following list. All the solid extracts are put up in containers of the proper capacity, with sufficient room for the contents to expand under the ordinary changes of a tem- perate climate. They should not be sub;ecied to in unusual heat, however. SQUIBB'S MATERIA MEDICA 81 @ Extract Aconite Powdered*, Squibb toltle, oz. Extraclam Aconlll. Newly official. 1 Gm. represents about 4 Gm. drug. Required by U. S. P. to assay 1 .8 fo 2.2 percent, ether-soluble alkaloids. Physiologically assayed by U. S. P. method; minimum lethal dose not greater than 0.00001 Gm. per Gm. weight of guinea-pig. Circulatory Sedative, Sudorific, Antineuralgic. Average Dose: l/g grain (0.01 Gm.). Anti- dotes: emetics; atropine, digitalis or ammonia; small, frequent doses of stimulants; artificial respiration. Extract Aconite Root Soft, Squibb glass jar, ]/i lb. ; oz. From dried tuberous root of A coniiam Napellm. Assays 1 .8 to 2.2 percent, alkaloids. Dose: Ys to ]/^ grain (0.008 to 0.15 Gm.). ® Extract Aloes (Powdered), Squibb bottle, 14 lb- ; oz. Exlractum Aloes, N. F. 'Aqueous. I Gm. represents 2 Gm. drug. Cathartic; acts mostly on large intestine. Average Dose: 2 grains (0.13 Gm.). Extract Apples Ferrated. Exiracium Ferri Pomalum, N. F.; Crude Iron Malate. From fresh juice of sour apples and reduced iron. 'Contains about 10 percent. Fe. Mild Hematinic. Average Dose: 10 grains (0.65 Gm.). Extract Beef. ExlTactum Carnis, N. F! Residue left on evaporating fresh beef broth at low temperature. Yellowish-brown to dark-brown, pasty mass; meat-like odor and taste. Nutrient. Extract Belladonna Leaves Powdered, Squibb bottle, oz. Exiracium Belladonna Foliorum. Assays 1.18 to 1.32 percent, alkaloids. Anodyne, Antispasmodic, Antihydrotic. Average Dose: 14 grain (0.015 Gm.). Antidotes: emetics; morphine, pilocarpine, physostigmine or aconitine. ® Extract Belladonna Leaves Soft*, Squibb glass jar, J4 lb. ; oz. Exiracium Belladonna Foliorum. From dried leaves and tops of Alropa Belladonna. 1 Gm. represents about 4 Gm. drug. Assays 1.18 to 132- percent, alkaloids. Anodyne, Antispas- modic, Antihydrotic. Average Dose: 54 grain (0.015 Gm.). Antidotes; emetics; morphine, pilocarpine, physostigmine or aconitine. This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations ; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 82 SQUIBB'S MATERIA MEDICA Extract Black Cohosh. See Extract Cimicifuga. Extract Black Haw. See Extract Viburnum Prunifolium. Extract Calabar Bean. See Extract Physostigma. Extract Cannabis Powdered, Squibb 1-oz.viaI 1 Gm. represents 4 Gm. drug. Dose: I/3 to 1 grain (0.02 to 0.065 Gm.). Extract Cannabis Soft*, Squibb glass jar, oz. Exiractum Cannabis. From dried flowering tops of pistillate plants of Cannabis Saliva or C. Indica. 1 Gm. represents ' about 8 Gm. drug. Physiologically assayed according to U. S. P. Incoordination produced by 0.004 Gm. per Kgm. weight of dog. Narcotic, Sedative, Anodyne. Average Dflse: ]/(, grain (0.0 1 Gm.). Antidotes: emetics; atropine, strychnine or caffeine, hypodermically ; strong coffee. © Extract Cascara Sagrada (Powdered), Squibb bottle, . !4 lb. ; oz. Exiractum Cascara SagraJq: (Rhamni Purshianffi). 1 Gm. represents 3 Gm. thoroughly seasoned Cascara bark. Laxa- tive, acting mainly on colon ; has little tendency to produce . secondary constipation. Average Dose: 4 grains (0.25 Gm.). (See also Tablets [Part II].) Extract Cimicifuga (Powdered). Extractum Cimifuga ; Extract Black Cohosh. , From dried rhizome and roots of Cimicifuga racemosa. 1 Gm. represents about 4 Gm. drug. Used as Alterative, Stomachic and Anti- spasmodic. Average Dose: 4 grains' (0.25 Gm.). Extract Cinchona (Soft). Extractum Cinchona, N. F. Yields 22 to 26 percent, alkaloids. Average Dose: 4 grains (0.25 Gm.). Extract Colchicum Corm (Powdered). Extractixm Colchici Cormi. Not the soft, acetic extract of U. S. P. Vlllth Rev. 1 Gm. represents about 4 Gm. drug. Assays 1 .25 to 1 .55 percent, colchicine. Average Dose : 1 grain (0.065 Gm.). ©Extract Colocynth (Powdered), Squibb 1-oz. vial Extractum Co/oeynf/iiJis. From pulp of dried fruit of Cilrullus Coloc^nthis; not from entire fruit. 1 Gm. represents 4 Gm, drug. Drastic Cathartic. Average Dose: !/2 grain (0.03 Gm.). © Extract Colocynth Compound (Powdered) Squibb bottle, ; 14 lb. ; oz. Extractum Coloc^nthldis Compositum. From extract colocynth, aloes, cardamom, resin scammony and soap. Becomes impacted or caked on keeping, more rapidly when subjected to undue heat or moisture. When in this condition pressure of a spatula usually restores original powdered state. Drastic Cathartic. Average Dose: 4 grains (025) Gm.). SQUIBB'S MATERIA MEDICA 83 Extract Conium (Soft). Exlractam Conii, N. F. Assays 1 .8 to 2.2 percent. Conine. Anti- spasmodic, Sedative, Anodyne. Average Dose: J/2 grain (0.03 Cm.). Antidotes: tannin, emetics; atropine, strychnine, caffeine. Extract Culver's Root. See Extract Leptandra. Extract Dandelion. See Extract Taraxacum. Extract Digitalis Powdered, Squibb I-oz. vial 1 Gm. represents 4 Gm. drug. Dose: 1/xo to J/^ grain (0.006 to 0.012 Gm.). ® Extract Digitalis Soft, Squibb glass jar, ; J4 lb. ; oz. " Exiracium Digitalis, U. S. P. Vlllth Rev.; Extract Foxglove. Prepared from fluidextract. 1 Gm. represents 2J/2 Gm. digitalis, the dried leaves of Digitalis purpurea. Heart Tonic, Diuretic. Average Dose: i/e gfa™ (0.01 Gm.). Antidotes: tannin, emetics; strychnine or alcohol; morphine; rest in horizontal position. Extract Ergot Soft, Squibb glass jar, 14 lb- ; oz. in aseptic capsules holding 60 grs., 5 in a vial, per vial. Introduced over 30 years ago by Dr. E. R. Squibb, and since then the standard extract ergot of the world. Prior to U. S. P. Vlllth Rev. it was the official article, but for no satisfactorily explained reason the formula was changed in that revision and again in present edition. Almost entirely soluble in cold water. 1 Gm. represents 5 Gm. best Spanish ergot. Physi- ologically tested and proved of full activity, hence dependable. 5 Gm. dissolved in 20 mils (Cc.) water, filtered and made up to 25 mils by passing water through the filter, makes a solution of strength of official fluidextract and for many uses superior to latter, because free from alcohol and other irritating sub- stances. This solution is well adapted for hypodermic use and should be made up only as needed. Emmenagogue, Oxytocic, Hemostatic, Circulatory Equalizer, Average Dose: 4 grains (0.25 Gm.), (See also Sterile Ergot, for hypodermic use; Tablets.) Extract Ergot Powdered, Squibb bottle, oz. 1 Gm. represents 4 Gm. best Spanish ergot. Physiologically tested. Average Dose: 5 grains (0,3 Gm.). The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. They include containers, packing and boxing. When ordering or prescribing medicinal products. Specify SQUIBB'S. 84 SQUIBB'S MATERIA lyiEDICA Extract Euonymus (Powdered). Extracium Euonijmi. N. F.; Extract Wahoo. Prepared from fluidextract. 1 Gm. represents 4 Gm. euonymus, the dried bark of root of Euonymus atropurpureus. Cathartic of uncertain absorption; hence inadvisable. Average Dose: 2 grains (0.13 Gm.). Extract Gelsemium (Powdered). ,. Extracium Cehemii. Newly official. 1 Gm. represents 4 Cm. Gelsemium, the dried rhizome and roots of Celsemium sem- penirens. Antineuralgic, Nerve Sedative, Antispasmodic; in neuralgia, dysuria, hysteria, dysmenorrhea, delirium tremens, etc. Average Dose: i/e grain (0.01 Gm.). Antidotes: tannin, emetics; atropine or strophanthin subcutaneously ; stimulants. Extract Gentian Powdered, Squibb bottle, ; !4 lb- : oz- 1 Gm. represents 2 Gm. drug. Dose: 3 to 6 grains (0.2 to 0.4 Gm.). © Extract Gentian Soft*, Squibb glass jar, ; |/^ lb. ; oz. Exlracium Centianrs. Aqueous, 1 Gm. represents 2J/2 Gm, gentian, the dried rhizome and root of Centiana lutea. Bitter Tonic; Stomachic; Pill Excipient. Average Dose: 4 grains (0.25 Gm.). Extract Qlycyrrhiza Powdered, Squibb bottle, ; ]/4 \h, ; oz. Extract Licorice Powdered. I Gm. represents 2 Gm. drug. Lenitive, Demulcent. Ordinary Dose: 15 grains (1 Gm.). Used chiefly to cover taste of bitter drugs. Extract Glycyrrhiza Pure*, Squibb glass jar, 54 lb- ! oz. Extracium Cfpcjrr/iizffl Purum; Pure Extract Licorice. Pilu- lar. 1 Gm. represents 2.75 Gm. select licorice root. Demul- cent, Pectoral, Lenitive, sweetening agent, pill excipient. Or- dinary Dose: 15 grains (I Gm.). Keep cool; liable to get mouldy in warm place. Extract Golden Seal. See Extract Hydrastis. Extract, Goulard's. See Solution Lead Subacetate. EIxtract Hematoxylon (Powdered). Extracium Hamaloxyli, N. F.; Extract Logwood. Aqueous. I Gm. represents 16 Gm. hematoxylon, the heart-wood of Hama- ioxylon campechianum. Intestinal Astringent. Average Dose: 15 grains (I Gm.). Extract Henbane. See Extract Hyoscyamus. SQUIBB'S MATERIA MEDICA 85 Extract Hydrastis (Powdered). Extracium Hydrastis; Extract Golden Seal. Newly official. 1 Gm. represents about 4 Gm. Hydrastis, the dried rhizome and roots of Hydrastis canadensis ; assays 9 to 1 1 percent, ether-soluble alkaloids. Hemostatic, Alterative, Bitter Tonic; in uterine hemorrhage, catarrhal jaundice, etc. Average Dose: 8 grains (0.5 C^.). Extract Hyoscyamus Powdered, Squibb T-oz. vial Assays about 0.3 percent, alkaloids. Dose: Vz to VA grains (0.03 to 0.1 Gm.). Extract Hyoscyamus Soft*, Squibb glass jar oz. Extracium Hyoscyami ; Extract Henbane. I Gm. represents about 4 Gm. hyoscyamus, the dried leaves and flowering or fruiting tops of Hyoscyamus niger. Assays 0.22 to 0.28 per- cent, alkaloids. Antispasmodic, Sedative, Analgesic; in coughs, hysteria, emphysema, nervous headache, etc. Average Dose: 1 grain (0.065 Gm.). Antidotes: tannin, emetics; morphine, pilocarpine, physostigmine, aconitine. Extract Icnatia (Powdered), Exlractum Ignallas, N. F. Yields 5.4 to 6.6 percent, alkaloids. Nerve Stimulant, Gastro-intestinal Tonic. Average Dose: l/z grain (0.03 Gm.). Antidotes: tannin then apomorphine hypodermically ; chloral with bromides per rectum ; chloroform inhalation if necessary. Extract Jalap Powdered, Squibb bottle, ; J4 lb. ; oz. From dried tuberous root of Exogonium Purga, Adjusted to strength of 60 percent, total resin by milk sugar, which serves to keep it in powder as long as undue heat and moisture are avoided. Hydragogue Cathartic. Dose: 2 to 5 grains (0.13 to 0.3 Gm.). Extract Jalap Soft*, Squibb glass jar, oz. Extractum Jalapa, N. F. Average Dose: 15 grains (1 Gm.). Extract Krameria (Powdered). Extractum Krameria, N. F.; Extract Rhatany. Aqueous. I Gm. represents 4 Gm. krameria. Powerful Astringent; ex- ternally in leucorrhea, spongy gums, etc., in 2 to 10 percent, solutions; internally in diarrhea. Average Dose: 8 grains (0.5 Gm.). If difficulty Is experienced in procuring any Squibb product, in the original packages tiere listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 86 SQUIBB'S MATERIA MEDICA Extract Leptandra (Powdered), Squibb bottle, oz. Exlraclum Leptandra, N. F.; Extract Culver's Root. 1 Gm. represents 4 Gm. leptandra, the dried rhizome and roots or Veronica virginica. Cathartic, acting' somewhat like resin podophyllum. Average Dose: 4 grains (0.25 Gm.). Extract Male Fern. See Oleoresin Aspidium. Extract Malt, Squibb pint, ; gal. Exlraclum Malli. Syrupy. 1 Gm. represents 1.5 Gm. drug. Tonic, Digestive, emulsifying agent. Average Dose : 4 drachms (15 Gm.). Extract Musk Root. See Extract Sumbul. ©Extract Nux Vomica (Powdered), Squibb bottle, ; !4 lb. ; oz. Exlraclum Nucis Vomicce. Assays 15.2 to 16.8 percent, alka- loids (equivalent to about 8 percent, strychnine). One and three-fifths times as strong as former official product. Bitter Stomachic and Tonic. Average Dose: J4 grain (0.015 Gm.). Antidotes : tannin ; apomorphine subcutaneously as emetic ; chloral hydrate and bromides per rectum; chloroform by inhalation if necessary. t® Extract Opium (Powdered), Squibb bottle, oz. ; I/2 oz. Exlraclum Opii. Aqueous. Assays 19.5 to 20.5 percent, anhydrous morphine. Antispasmodic, Anodyne, Cerebrospinal Depressant. Average Dose: Yz grain (0.03 Gm.). Antidotes: potassium permanganate (2 grains in water), then emetics; hot strong coSee; atropine or strychnine; exercise. ©Extract Oxgall (Powdered), Squibb 1-oz. vial Exlraclum Fellis Bovis. Newly official. 1 Gm. represents 8 Gm. oxgall. Laxative, Cholagogue, Intestinal Digestive; in typhoid fever, intestinal indigestion, deficient biliary secretion, etc. Average Dose: 1)/2 grains (0.1 Gm.). (See also Oxgall Purified; Tablets.) Extract Physostigma (Powdered). Exlraclum Phssosligmalis ; Extract Calabar Bean. Assays 1 .7 to 2.3 percent, alkaloids. Antitetanic, Antineuralgic, Peristaltic. Average Dose: J/g grain (0.008 Gm.). Antidotes: emetics; atropine or strychnine hypodermically ; pilocarpine; chloral hydrate; stimulants. Extract Podophyllum (Soft). Exlraclum Podophylli, N. F. Slow but effective and rather irritant Cathartic' Average Dose: !4 grain (0.015 Gm:). SQUIBB'S MATERIA MEDICA 87 Extract Quassia (Powdered). Extraclum Quassia, N. F. Aqueous, I Gm. represents 10 Cm. drug. Bitter Stomachic. Average Dose: 1 grain (0.065 Gm.). Ejctract Rhatany. See Extract Krameria. Extract Rhubarb (Powdered), Squibb bottle, oz., Exiracium Rhei. The new U. S. P. recogriizes the potaierei extract, as against soft in preceding edition, f Gm. represents 2 Gm. drug. Laxative. Average Dose: 4 grains (0.25 Gm.). Extract Stramonium Powdered, Squibb bottle, oz. Exiracium Siramonii, Assays 0.9 to t.1 percent, alkaloids. Average Dose: i/e grain (0.01 Gm.). Extract Stramonium Soft*, Squibb glass jar, ; !4 lb. ; oz. Extractum Stramonii. From dried leaves of Datura Sb'amonium or of D, Tatula. \ Gm. represents about 4 Gm. drug. Assays 0.9 to I.I percent, alkaloids. Antispasmodic, Sedative, Analgesic. Average Dose: !4 gi'^in (0.01 da.). Antidotes: tannin; apo- morphine hypodermically as emetic; morphine; /unmonia by in- halation. Extract Sumbul (Soft). Exiracium Sumbul; Elxtract Musk Root. 1 Gm. represents about 43 Gm. drug. Used' as Antispasmodic and Nerve Tonic, in hysterical conditions, etc. Average Dose: 4 grains (025 Gm.). Extract Taraxacum Powdered, Squibb. I-oz.vial I Gm. represents about 3 Gm. drug. Dose: 10 to 20 grains (0.65 to 13 Gm.). Extract Taraxacum Soft*, Squibb glass jar, ; ^ lb. ; oz. Exiracium Taraxad; Elxtract Dandelion. 1 Gm. represents 3 Gm. Taraxacum, the dried rhizome and roots of Taraxacum oficinale. Bitter Tonic, Mild Laxative. Average Dose: 15 grains (I Cm.). Extract Valerian (Powdered), Squibb bottle, oz. 1 Gm. represents 4 Gm. valerian, the dried rhizome and root of Valeriana oficinalh. Used as Antispasmodic and Nerve Sedative, in hysteria and other nervous excitations. Dose: 5 to 15 grains (03 to I Gm.). The Squibb products are recognized everywtiere as the Quality Standard. They are of uniform purity and strength, nence therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 88 SQUIBB'S MATERIA MEDICA Extract Vanilla (Flavoring). See Tincture Vanilla. Extract Viburnum Prunifolium (Powdered). Exlractum Vibumi Prunifolii: Extract Black Haw. 1 Gm. represents 5 Gm. of dried bark of Viburnum pruni- folium or of V. Lentago. Used as Uterine Sedative in dys- menorrhea and habitual abortion. Average Dose: 8 grains ,(0.5 Gm.). Extract Wahoo. See Extract Euonymus. Fehling's Test Solution Elements, Squibb Copper Sulphate Solution 500 Cc. lOOCc. 50 Cc. Alkaline Tartrate Solution 500 Cc. Also supplied in a case, 50 Cc, of each 1 00 Cc. solution, together with two test tubes and 50 Cc, a 1 Cc. pipette. Price, per set, $1.00 Fennel, Squibb tin, lb. Fasniculum. Dried ripe fruit of true Faniculum Vulgare (Fam. Umbellifercc), carefully selected. Aromatic, Carminative. Average Dese: 15 grains (1 Gm.). Ferripyrine. Ferropyrine. Compound of 36 percent, ferric chloride and 64 percent, antipyrine. Yellowish-red powder, of acid-astrin- gent taste. Soluble in alcohol, 6 parts water; insoluble in ether, Hematinic, Styptic. Dose: 5 to 15 grains (0.3 to 1 Gm.). FiBROLYSIN. Sterilized 15 percent, solution thiosinamine and sodium sali- cylate. Resolvent, Discutient. Dose: by hypodermic^ intramus- cular or intravenous injection, one 2.3 Cc. vialful (= 0.2 Gm. [3 gr.] thiosinamine) daily or every second or third day. Fig. Ficus, N. F. Partially dried fruit of Ficus Carlica (Fam. Moracca). Nutrient, Laxative. Flaxseed. See Linseed. Flowers of Sulphur. See Sulphur Sublimed. Flowers of Zinc. See Zinc Oxide. Fluid Aloes for Tincture, Squibb pint, ; V4 pint. Three times strength of Tincture Aloes U. S. P. 100 mils (Cc.) represent 30 Gm. purified aloes and 60 Gm. licorice root. For conveniently making Tincture Aloes take: Fluid Aloes Squibb, Alcohol, and Water, equal volumes; mix the alcohol and water, then add the fluid aloes. SQUIBB'S MATERIA MEDICA 89 Fluid Bay Laurel, Squibb pint, ; % pint, A concentrated solution designed for the extemporaneous prep- aration of a superior bay rum. Take: Fluid Bay Laurel Squibb. 1 fl. oz.; Alcohol and Water, of each 32 6. ozs. Mix the alcohol and fluid bay laurel, and add the water. Fluid Benzoin for Tincture, Squibb pint, ; !4 pint. From best cpiality Siam gum benzoin. Especially designed for convenient preparation of Tincture Benzoin, by mixing 4 fl. ozs. of it with 12 fl. ozs. alcohol. Fluid Benzoin Compound for Tincture, Squibb pint, ; J4 pint. Twice strength of U. S. P. Tincture Benzoin Compound. Designed for rapid and convenient preparation of latter, by mixing vtrith an equal volume alcohol. Fluid Cantharides for Tincture, Squibb - pint, ; 54 pint. Prepared from best Russian Cantharides (CanOiaris vesica- toria). 2 mils [Cc.]) represent I Gm. drug. Designed for convenient preparation of Tincture Cantharides by diluting it with 4 volumes alcohol. Antidotes: flaxseed tea or other demulcents, then emetics subcutaneously; opium by rectum. Avoid oils! Fluid Cardamom Compound, Squibb pint, ; 14 pint. Designed for convenient preparation of Tincture Cardamom Compound as follows: Take Ffuid Cardamom Compound, Squibb, 4 fl. ozs. or 125 mils (Cc.); Glycerin, 288 min. or 18.75 mils; Diluted Alcohol, to make 16. fl. ozs. or 500 mils. Mix; filler if necessary. Fluid Cascara Aromatic (Non-Alcoholic) Squibb pint ; 3-oz. An improved, non-alcoholic preparation of Cascara, made from best quality, well-seasoned Cascara Sagrada bark, I mil (Cc.) representing I Gm. of drug. An efficient, pleasant Laxative, witk but little tendency to produce secondary constipation. Dose: 14 lo ' teaspoonful, after meals or at bedtime. Fluid Cinchona Compound for Tincture, Squibb pint, *; 14 pint. Each 100 mils (Cc.) represents 50 Gm. red cinchona, 40 Gm. bitter-orange peel and 10 Gm. serpentaria, and assays 2 to 23 Gm. of alkaloids. To reduce this product to strength of Tincture Cinchona Compound U. S. P., mix 200 mils of it with 60 mils glycerin, 540 mils alcohol and 200 mils water; filter if necessary. Since we make only one quality of each product, that best suited to the purposes intended, the specification "Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, speciW SQUIBB'S. 90 SQUIBB'S MATERIA MEDICA Fluid Eriodictyon Aromatic, Squibb pint, ; !/i pint. Fluid Verba Santa Aromatic. Each minim represents approxi- mately 1 grain Eriodictyon. Convenient for the extempora- neous preparation of Aromatic Syrup Eriodictyon (Syrup Cor- rigens) of National Formulary, by adding to 32 mils (Cc.) enough simple syrup to make 1000 mils. Fluid Qambir Compound, Squibb pint, ; !4 P'"*. So-called Fluidextrstct Catechu Compound. Specially intended for convenient preparation of compound tincture gambir. 100 mils (Cc.) represent 50 Gm. gambir and 25 Cm. Saigon cinna- mon. To conveniently make Tincture Gambir Compound take: Fluid Gambir Compound Squibb, I volume; Diluted Alcohol, 9 volumes. Fluid Ginger for Syrup, Squibb pint, ; !4 pi"'. Made from best quality of Jamaica ginger. Clearly soluble in simple syrup. Intended for the convenient and rapid prepara- tion of Syrup Ginger, by adding 2J4 fluidounces to 29)/g fluid- ounces of simple syrup. Fluid Qlycyrrhiza (Licorice) for Quinine, Squibb pint, ; Y'i P'"'' Intended especially for masking the taste of quinine and other bitter or nauseating remedies. It produces clear mixtures with syrup, glycerin or water. It is incompatible with acids. For conveniently making Syrup Licorice, take: Fluid Licorice Squibb, 2 fl. ozs.; Syrup, 14 fl. ozs. Fluid Golden Seal Colorless, Squibb pint, ; !/^ pint, Containing in each 16 fluidounces 20 grains hydrastine hydro- chloride, in non-alcoholic menstruum. Astringent and Anti- phlogistic topically; Tonic and Hemostatic internally. Used externally in gonorrhea, leucorrhea, endometritis, etc., usually in 1 to 2 in 1 6 dilution ; internally, in uterine hemorrhage, chronic dyspepsia, internal hemorrhoids, etc. Dose : 1 5 to 60 minims (1 to 4 mils [Cc.]). Incompatible with alkalies, borax or tannic acid. (The Squibb laboratories make also the official Fluidextract Golden Seal and Glycerite Hydrastis [so-called "non-alcoholic" fluidextract] .) Fluid Hydrastis. See Fluid Golden Seal Colorless. Fluid Lavender Compound for Tincture, Squibb pint, ; '/^ pint. From oil lavender flowers, oil rosemary, Saigon cinnamon, cloves, nutmeg and red saunders. Eight times strength of Tinc- ture Lavender Compound. For conveniently making latter, take: Fluid Lavender Compound, Squibb, 2 fl. ozs.; Alcobol, IOJ/2 fl. ozs.; Water, V/n fl. ozs. Mix the alcohol and water, then add the fluid lavender compound. SQUIBB'S MATERIA MEDICA 91 Fluid Licorice for Quinine. See Fluid Glycyrrhiza. Fluid Rliubarb Aromatic for Syrup, Squibb pint, ; % pint. For conveniently making Syrup Rhubarb Aromatic, take of this Fluid I fl. oz. and Syrup 19 fl. ozs. Fluid Rhubarb Aromatic for Tincture, Squibb pint, ; V4 pint. For conveniently making Tincture Rhubarb Aromatic, take: Fluid Rhubarb Aromatic Squibb, 5 fl. ozs'.; Alcohol, 5 fl. ozs.; Wafer, 4 fl. ozs.; Glycerin, 1 fl. oz. Mix the alcohol, water and glycerin, then add the fluid rhubarb aromatic. Fluid Rose Soluble, Squibb pint, ; |4 pint. Designed for the extemporaneous preparation of rose water, by diluting it with 31 volumes distilled water. Fluid Tolu for Syrup (1:19), Squibb pint, ; ]/4 pint. Solution Tolu for Syrup. For the easy manufacture of Syrup Tolu, by diluting it with 19 volumes syrup. Fluid White Pine Compound, Squibb pint, ; 14 pinfi 1000 mils (Cc.) represent 340 Gm. each white pine and wild cherry barks, 40 Gm. each spikenard root and balm gilead buds, 32 Gm. sanguinaria, 28 Gm. sassafras and 24 mils chloroform. Specially designed for conveniently preparing Syrup White Pine Compound, by mixing 1 volume of it with 3 volumes syrup. To make Syrup White Pine Compound ailh Mor- phine of N. F. strength, add l/s grain morphine sulphate per fl. oz. syrup while pine compound. Fluid Wild Cherry for Syrup, Squibb pint, ; V$ pi<>'> Specially designed for the convenient and rapid preparation of Syrup. Wild Cherry, by mixing 1 volume of it with 3 volumes syrup. Fluid Verba Santa Aromatic. See Fluid Eriodictyon Aromatic. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, irithe words of William Miller Bartlett, "the House of Squibl) stands today as a living monument to the honor, mtegnty, zeal and devotion of its founder." 92 SQUIBB'S MATERIA MEDICA FLUIDEXTRACTS. The constantly growing recognition of the certainty of thera- peutic action of the officially made fluidextracts, from properly selected material, urges us to be more pressing in the presenta- tion of these products. In a fluidextract the active principles are directly available, so that the value of these preparations in medicine is not in doubt. A selection of the most active drugs offered by the market or obtained by direct importation from best sources, and a thorough exhaustion of the assayed and tested drug, assure the production of fluidextracts of a standard strength, containing the maximum amount of active principle 'and accurately representing the drug. The process of extrac- tion employed is the well-known repercolaiion process, which originated in the Squibb Laboratories. ' The menstrua used are those which most effectively extract the medicinal ingredients of the drugs and thus are theoretically true solvents of them. The strength of the alcohol in these fluidextracts is fully equal to the requirements of the U. S. P., hence when deposits are discovered they may be considered as inert if all the self- evident precautions against evaporation, heat, etc., have been taken by the purchaser. In a considerable number of cases the pharmacopoeia prescribes a definite assayed alkaloidal strength of the fluidextracts, and to this standard they are therefore accurately adjusted. Otherwise, I mil (Cc.) repre- sents 1 Cm. of the drug. Fluidextract Cannabis is officially required to be assayed biologically; and we physiologically assay also those which the U. S. P. recommends being so tested. Fluidextract Aconite, Squibb pint, ; gal. FluiJextractam Aconili. From dried tuberous root of genuine Aconiium Napellus. Required by U. S. P. to assay 0.45 to 0.55 Gm. ether-soluble alkaloids per 100 mils (Cc). Physiologically assayed by U. S. P. method; minimum lethal dose not more than 0.0004 nor less than 0.00032 mil per Cm. weight of guinea-pig. Sedative, Febrifuge, Sudorific, Antineuralgic. Average Dose: Yi minim (0.03 mil). Antidotes: tannin, then emetics; atropine, digitalis or ammonia; smalK often repeated doses of stimulants; artificial respiration, if required. Fluidextract Adonis. FluiJexiracium Adonidis, N. F.; Fluidextract Bird's Eye. From dried root of Adonis vernalis. Cardiac Stimulant, of digitalis group^ Average Dose: 2 minims (0.13 mil [Cc.]). Antidotes: emetics; stimulants; opium to control gastro-intesKnal symptoms. Fluidextract Aletris, Squibb pint, ; % pint, Fluidexiracium Aleiridis, N. F.; Fluidextract Stargrass or Star- wort. From dried rhizome of Aleiris farinosa. Simple Bitter, also used as Uterine Tonic; in amenorrhea, rheumatism, flatu- lent dyspepsia, etc. Average Dose: 30 minims (2 mils [Cc.]). SQUIBB'S MATERIA MEDICA 93 Fluidextract Anceuca Root. Fluidextractum Angelica Radich, N. F. From dried rhizome and roots of Angelica atropurptirea (Fam. Umbellifera). Stimulating Elxpectorant, like tolu. Average Doge: 30 minims (2 mils [Cc.]). Fluidextract Apocynum. Fluidextraclum Apoc^ni, N. F.; Fluidextract Canadian Hemp. From dried rhizome of Apoc})num cannabinam. Cardiac Tonic, of digitalis group; unreliable as to rate of absorption. Average Dose: 12 minims (0.75 mil [Cc.]). Fluidextract Araua. Fluidextractum Aralia, N. F.; Fluidextract Spikenard. From dried root of Aralia racemosa. Used as Alterative, Dia- phoretic. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Arbor Vitae. See Fluidextract Thuja. Fluidextract Arnica Flowers, Squibb pint, ; }/i pint, Fluidextractum v4rme°(> Fluidextractum Asdepiadis, N. F.; Fluidextract Pleurisy Root. From dried root of Asclepiai tuberosa. Used as Diaphoretic; in pleurisy, bronchitis, colic, etc. Average Dose : 30 minims (2 mils [Cc.]). Fluidextract Aspidosperma, Squibb pint, ; !4 pint, . Fluidextractum Aspidospermatis ; Fluidextract Quebracho. From dried bark of Aspidosperma Quebracho bianco. Respira- tory Tonic, Antispasmodic; chiefly in asthma and emphysema. Average Dose: I fluidrachm (4 mils [Cc.]). The Squibb Ideals have taken concrete form in the Squibb Products: these are universally recognized as standards of uniform Purity and Efficacy, that is, genera) Excellence and Reliability. Speciftr SQUIBB'S when prescribing or ordenng. 94 SQUIBB'S MATERIA MEDICA Fluidextract Baptisia. > Fluidexiractum Baptisia, N. F.; Fluidextract Wild Indigo. From dried root of Baptisia tinctoria. Astringent. Used ex- ternally in ulcers, sore throat, etc.; internally, chiefly in typhoid fever. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Beareerry. See Fluidextract Uva Ursi. Fluidextract Belladonna Leaves, Squibb pint, ; J4 P>n'> From dried leaves and tops of Atropa Belladonna. Assays about 0.35 Gm. alkaloids in 100 mils (Cc.K Anodyne, Anti- spasmodic, Antithydrotic. Dose: 1 to 2 minims (0.06 to 0.13 mil). Antidotes: tannin, then emetics; morphine; pilocarpine; physotigmine ; aconitine. Fluidextract Belladonna Root, Squibb pint, ; J4 pi"*! Fluidexiractum Belladonna Radicis. Assays 0.405 to 0.495 Gm. alkaloids in 100 mils (Cc). Average Dose: 1 minim (0.06 mil). Fluidextract Berberis, Squibb pint, ; J4 pint, Fluidextractum Berheridis, N. F.; Fluidextract Barberry. From dried rhizome and roots of Berberis Aquifolium and other species of Berberis, Used as Bitter Tonic and Altera- tive; in anorexia, general debility, jaundice, etc. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Beth Root. See Fluidextract Trillium. Fluidextract Bird's Eye. See Fluidextract Adonis. Fluidextract Bittersviteet. Fluidextractum Dulcamara, N. F. From dried young branches of Solanum Dulcamara. Used as Alterative in skin diseases, leprosy, rheumatism, etc. Average Dose: I fluidrachm (4 mils [Cc.]). Fluidextract Blackberry. See Fluidextract Rubus. Fluidextract Black Cohosh. See Fluidextract Cimicifuga. Fluidextract Bladder-Wrack. See Fluidextract Fucus. Fluidextract Bloodroot. See Fluidextract Sanguinaria. Fluidextract Blue Flag. Fluidextractum Iridis V ersicoloris, N. F. From dried , rhizome of Iris Versicolor. Cathartic, similar to podophyllum. Average Dose: 30 minims (2 mils [Cc.]). SQUIBB'S MATERIA MEDICA 95 Fluidextract Boldo. Flwjexiractum Soldi, N. F. From dried leaves of Bolda foldus. Aromatic, mild Diuretic. Average Dose: 8 minims (0.5 mil [Cc.]). Fluidextract Boneset. See Fluidextract Eupatorium. Fluidextract Broom Tops. See Fluidextract Scoparius. Fluidextract Bryonia, Squibb pint, ; J4 pint, From dried roots of Bryonia alba. Draslit resinous Cathartic. Dose: 10 to 30 minims (0.6 to 2 mils [Cc.]). Fluidextract Buchu, Squibb pint, ; % pint, Fluidexlraclum Buchu. From best quality shorl buchu leaves (Barosrha beiulina). Diuretic, Anticatarrhal ; chiefly in urin- ary disorders. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Buchu Compound, Squibb pint. ; '/ipint, Fluidexiracium Buchu Compositum, N. F. Each fluidounce represents about 285 grains short buchu and 57 grains each of cubeb, juniper and uva ursi. Diuretic, Urinary Anticatarrhal. Average Dose: 30 minims (2 mils [Co.]). Fluidextract Buckthorn Bark. See Fluidextract Frangula. Fluidextract Buckthorn Berries. See Fluidottract Rhamnus Cathartica. Fluidextract Burdock. See Fluidextract Lappa. Fluidextract Butternut. See Fluidextract Juglans. Fluidextract Calendula. Fluidexiracium Calendula, N. F.; FluifJextract Marigold. From flowering herb of Calendula officinalis. Used externally, on bruises, wounds, etc. (pure or diluted). Fluidextract Calumba, Squibb pint, ; % pint, Fluidexiracium Calumha, N. F. ; Fluidextract Columbo. Dropped from U. S. P. From dried root of Jaleorrhiza pal- maia. Bitter Tonic, Stomachic. Average Oose: 30 minims (2 mils [Cc.]). Fluidextract Canadian Hemp. See Fluidextract Apocynum. The Squibb Label on a package is a positive guaranty for tlie uniform Purity and Reliability of ttie pr.oduct.- We niake only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 96 SQUIBB'S MATERIA MEDICA Fluidextract Cannabis Squibb pint, ; !4 pinl. Fluidexlractum Cannabis. From dried flowering tops of pistillate plants of Cannabis saiiva or variety indica. Physiologically assayed according to U. S. P.; incoordination produced by 0.03 mil (Cc.) per Kgni. weight of dog. Sedative. Anodyne. Average Dose: V/z minims (O.I mil). Antidotes: atropine; strychnine; caffeine; hot, strong coffee. Fluidextract Capsicum, Squibb pint, ; J4 pint, Fluidexlractum Capsici, U. S. P- Vlllth Rev. From dried ripe fruits o/ Capsicum frutescens. Carminative, Stomachic; occasionally used externally (diluted, in sore throat). Average Dose: I minim (0.06 mil [Cc.j), well diluted. Antidotes : demulcents, antiphlogistics ; morphine for pain, Fluidextract Cardamom Compound. See Fluid Car- damom Compound. pint, ; }/4 pint, Fluidextract Cascara Sagrada, Squibb pint, ; Vi pint, Fluidextracium Cascara Sagrada, From select, thoroughly seasoned, dried bark of trunk and branches of Rhamnus Purshiana, No additions or alterations have been made in this official fluidextract, for the purpose of enhancing its activity or masking oir eliminating its characteristic odor and taste — a not uncommon practice. Laxative, acting mainly on colon; has but little tendency to produce secondary constipation. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Cascara Sagrada Aromatic, Squibb pint, ; '/4 pint, Fluidextracium Cascara Sagrada Aromalicum. From thor- oughly seasoned Cascara Sagrada bark, sv^eetened and flavored. While all the active constituents are preserved, the disagreeable bitter principles are eliminated. It has not -had any other pur- gative agent added to it. Average Oose: 30 minims (2 mils). (See also Fluid Cascara Aromatic [Non-Alcohohc] .) . Fluidextract Castanea, Squibb. pint, ; % pint, Fluidexlraclum Castanea, N. F.; Fluidextract Chestnut Leaves. From dried leaves of Castanea dehlata. Astringent, but used chiefly in whooping cough. Average Dose : I _ fluidrachm (4 mils [Cc.]). Fluidextract Catechu Compound. See Fluid Gambir Com- pound. Fluidextract Catnep. Fluidextracium Calaria, N. F. From herb of Nepeta Cataria. Aromatic Carminative, similar to peppermint. Average Dose: I fluidrachm (4 mils [Cc.]). SQUIBB'S MATERIA MEDICA 97 Fluidextract Caulophyllum. ■' •' Fluidexlraclum Cauloph^llt, N. F.; Fluidextract Bhie Cohosh. From dried rhizome and rootlets of Caulophyllum ihaliciroides. Used as Diuretic and Emmenagogue. Average Dose : 8 minims (0.5 mil [Cc.]). Fluidextract Celery, Squibb pint, ; % pint, Fluidextractum Apii Fructus, N. F. From seed of Apium graveolens. Used as Emmenagogue. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Chestnut Leaves. See* Fluidextract Castanea. Fluidextract Chimaphila. Fluidextraclum Chimaphila, N. F.; Fluidextract Pipsissewa. From dried leaves of Chimaphila umbellata. Used as Tonic, Astringent, Diuretic. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Chionanthus. Fluidextractum Chionanthi, N. F.; Fluidextract Fringe: Tree Bark. From dried bark of root of Chionanthus virginica. Used as Alterative and Aperient. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Chirata. Fluidextractum Chirata, N. F.; Fluidextract Chiretta. From dried plant of Svtertia Chirayita, Bitter Stomachic, similar to gentian*. Average Dose: 15 minims (I mil [Cc.]). Fluidextract Citnicif uga, Squibb pint, ; !4 pint, Fluidextractum Cimicifuga! ; Fluidextract Black Cohosh. From dried rhizome and' roots ' of Cimicifuga racemosa. U«ed as Alterative, Sedative, Emmenagogue. Average Dose: 15 minims (1 mil [Cc.]). ' Fluidextract Cinchona, Squibb pint, ; % pint, Fluidextractum, Cinchona. Assays 4 to 5 Gm. alkaloids in ,100 mils (Cc); contains 10 vol. percent, glycerin. Antiperiodic, Bitter Tonic. Average Dose: 15 minims (I mil). Fluidextract Cinchona 'Aqueous, Fluidextractum Cinchona A^uosmiii' N. F. 100 mils ^Cc.) yield about 5 Gm. alkaloids. Bitter Tonic, Antiperiodic. Average Dose: 15 minims (1 mil [Cc.]). This house supplies oniy One quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations ; it has a plain, posi- tive meaning. Therefore, virhen prescribing, specify SQUIBB'S. B 98 SQUIBB'S MATERIA MEDICA Fluidextract Cinchona Red, Compound. See Fluid Cin- chona Compound. Fluidextraqt Cocillana. Fluidexiracium.Cocillana, N. F. From dried bark of Cuarea Rusbsi (Fam. Meliacea). Nauseant Expectorant, similar to ipecac. Average Dose: 15 minims (1 mil [Co.]). Fluidextract Coffee Roasted, Squibb pint, ; 14 pin'> FluiJexiracium Coffea, N. F. Designed for those desiring the Tonic and Stimulant effects of coffee in concentrated form. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Colchicum Root, Squibb pint, ; ]/4 pint, Fluidextracium Colchici Cofmi, N. F. From dried corm of Colchicum aatumnale. Assays 0.31 to 0.39 Cm. colchicine in each 1 00 mils (Cc.) (about Vsoo grain colchicine in , 1 minim) . Antipo^agric, Antineuralgic, Alterative. Average Dose: 3 minims (0.2 mil). Antidotes: tannin, then emetics; opiates for pain and diarrhea; hot, strong coffee and other stimulants. Fluidextract Colchicum Seed, Squibb pint, ; J4 pint. Fluidexlractum Colchici Seminis, Assays 0.36 to 0.44 Cm. colchicine in 100 mils (Cc.). Average Dose: 3 minims (0.2 mil). Antidotes: as of preceding. * Fluidextract Columbo. See Fluidextract Calumba. Fluidextract Condurango, Squibb pint, ; 14 P>nt> Fluidextracium Condurango, N. F. From dried bark of Mars- deriia Condurango. Bitter Stomachic; chiefly in ulcer and cancer of stomach. Average Dose: 1 fluidrachm (4 mils [Cc.]). Fluidextract Conium, Squibb pint, ; 14 pint, Fluidexlractum Conii, N. F.; Fluidextract Hemlock Seed. From fruit of Conium maculatum. - Assays 0.35 to 0.45 Cm. coniine in 100 mils (Cc). Antispasmodic, Sedative. Average Dose: 3 minims (0.2 mil). Antidotes: tannin, then emetics; atropine or strychnine hypodermically ; caffeine or other stimulants. Fluidextract Convallaria Flowers. Fluidextracium Convallaria Florum, N. F.; Fluidextract Lily of the Valley Flowers. , From flo>yers of Convallaria majalis. Cardiac Tonic, similar to digitalis. Average Dose: 8 minims (0.5 mil ICc]). SQUIBB'S MATERIA MEDLCA 99 Fluidextract CoNVALLARiA Root. .. ■;< t . Fluidexiraclum Convallatia Radicis, N. F.; Fluidextract Lily i of the Valley Root! Heart tonic, similar to digitalis. Aver- age Dose: 8 minims (0.5 mil [Cc.]). Fluidextract Coptis. ; Fluldexiracium Copiis, N,, F.; FIi«idextract Gold Thread. From dried plant oif Coptis irifoUa. Bitter Tonic. Average Dose : 30 minims (2 mils [Cc] ) . Fluidextract Corn Silk. See Fluidextract Zea. Fluidextract CoRNus. Fluidextracium Corni, N. F,; Fliiidextract Dogwood. From -bark of root of Cornui florida. Astringent, Antiperiodic; practically obsolete. Average Dose: 30 minims (2 mils ■ :.[Cc.]). Fluidextract Corydalis. Fluidexiraclum Corydalis, N. F., Fluidextract Turkey Corn. From dried tubers of Bicuculla canadensis. Used as Antiluetic, but considered useless and therefore harmful by Council on P. & C. of A. M. A. Average Dose: 10 minims (0.65 mil'. [Cc.]). Fluidextract Coto. See Fluidextract Paracoto. Fluidextract Cotton Root Bark, Squibb pint, ; % pint, Fluidexiraclum Coss^pil Corlicis, N. F.; Fluidextract Gossy- pium. From dried bark of root of Coss^pium herbaceam and other species of Cossypium. Used as Emmenagogue. Aver= age Dose: 30 minims (2 mils [Cc.]). Fluidextract Couch Grass. See Fluidextract Triticum. Fluidextract Cramp Bark. See Fluidextract Viburnum- Opulus. Fluidextract Cranesbill. See Fluidextract Geranium. Fluidextract Cubeb, Squibb pint, ; >4 ?>>>'> Fluidexiraclum Cubeba^ N. F. From dried fruits of Piper Cubeba. Diuretic, Sedative, Stimulating Expectorant. Average Dose: 15 minims (I mil [Cc.]). Fluidextract Culver's Root. See Fluidextract Leptandra. The prices of the Squibb Products are in all instances as low as ttie quality and quantity of ingredients and tfie expense of man- ufacture allow. Tliey include containers, pacl»t> Fluidextractum Dioscorea, N. F.; Fluidextract Wild Yam. From dried rhizome of Dioscorea villosa. Used in colic and other abdominal irritation. Average Dose: I fiuidrachm (4 mils [Cc.]). Fluidextract Dog Grass. See Fluidextract Triticum. Fluidextract Dogwood. See Fluidextract Cornus. Fluidextract Dogwood, Jamaica. See Fluidextract Jamaica Dogwood. Fluidextract Drosera. Fluidextractum Drosera, N. F.; Fluidextract Sundew. From air-dried flowering plant of Drosera rolundifolia, D. intermedia or D. longifolia (Fam. Droseracea). Usfed in respiratory diseases; no established indications for its use. Average Dose: 60 minims (4 mils [Cc] ) . Fluidextract Dulcamara. See Fluidextract Bittersweet.. Fluidextract Echinacea, Squibb pint, ; 14 pint, Fluidextractum Echinacea, N. F. From dried root of Echin- acea angastifolia. Used as Alterative and Antiluetic internal- ly. Antiseptic and snakebite antidote externally. Averag' Dose: 15 minims (I mil [Cc.]). SQUIBB'S MATERIA MEDICA 101 © Fluidextract Ergot, Squibb pint, ; |4 pint, oz. ; Yz °Z' The original Squibb Fluidextract Ergot, U. S. P., 1860. It has been proved that much of the value of fluidextract ergot .depends upon the selection of the best ergot obtainable .irre- spective of cost, its thorough cleansing and preparation, and care in percolation. Spanish rye ergot is very superior in activity to any other kind, and should be used exclusively. Ergot from barley, wheat or oats, although show- ing some activity, is much inferior to that from rye, and the peculiar atmospheric conditiolis of the Spanish peninsula tend to the more mature and better growth of this fungus. The cleansing of ergot is of greatest importance, since the .bags or cases in which the drug is imported often contain wormeaten and absolutely worthless material and dirt, nails, tacks, and hair pins, dropped apparently by the women who pick the ergot. After the worthUss and foreign matter is all removed, the ergot is ground and transferred to the percolators and the active prin- ciples extracted by the Squibb repercolaiion process, with men- struum of diluted alcohol and a little acetic acid, whereby a fluidextract is obtained which accurately represents the drug mil (Cc.) for Gm. Squibb's Fluidextract Ergot is physi- ologically tested by the method of Edmunds and Hale, and proved of standard activity; hence therapeutically dependable. Emmenagogue, Oxytocic, Vaso-constrictor, Circulatory Equal- izer. Average Dose : 30 minims (2 mils) . Acts in 1 5 minutes ; effect continues only about J/2 hour. ^ Fluidextract Eriodictyon, Squibb pint, ; % pint, Fluidexiractum Eriodicii)i; Fluidextract Yerba Santa. From dried leaves of Eriodictyon calitornicam. Used as Anticatarrhal, Expectorant; in coughs, genito-urinary inflammations, etc., but used chiefly to disguise quinine and other unpleasant drugs. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Eucalyptus. Fluidexiractum Eucalypti. From dried leaves of Eucalyptus Clobalus. Antiperiodic, Tonic. Average Dose: 30 minims (2 mils [Cc.])_. Fluidextract Euonymus. Fluidextractum Euonymi, N. F.; Fluidextract Wahoo. From root-bark of Euonymus alropurpureus. Cathartic. Average Dose: 8 minims (0.5 mil [Cc.]). If difficulty is experienced in procuring any Squibb product, in the original packages fiere listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 102 SQUIBB'S MATERIA MEDICA Fluidextract Eupatorium. Fluidextraclam Eupatorii, N. F.; Fluidextract Boneset, From dried leaves and flowering tops of Rupalorium perfolialum. Used as Diaphoretic. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Euphorbia Pilulifera. FluiJexiracium Euphorblte Pilulifera, N. F. From dried herb of Euphorbia pilulifera (Fam. Euphorbiacea) . Used mainly in asthma and chronic bronchitis. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract False Unicorn. See Fluidextract Helonias. Fluidextract Foxglove. See Fluidextract Digitalis. Fluidextract Frangula, Squibb pint, -, !4 pint> Fluidextractum Frangul>>t> Fluidexb'actum Zingiberis, From best Jamaica Ginger, the dried rhizome of Zingiber officinale. Aromatic, Carminative,. Gastro-intestinal Stimulant. Average Dose: 15 minims (I mil [Cc.]). Fluidextract Ginger, Soluble. See Fluid Ginger for Syrup.. ® Fluidextract Qlycyrrhiza (Licorice) , Squibb pint, ; !4 pint, . Exlraclum Clycyrrhiza Fluidum, U. S. P. 1890. Considered superior to present official product. From dried rhizome and roots of Cl^cyrrhiza glabra fypica or of G. glabra glandulifera,. known in commerce respectively as Spanish Licorice arid Russian Licorice: Demulcent, Expectorant. Average Dose: 30 minims (2 mils [Cc.]). Incompatible with acids. Fluidextract Goat's Rue. See Fluidextract Galega. Fluidextract Golden Seal. See Fluidextract Hydrastis. Fluidextract Gold Thread. See Fluidextract Coptis. Fluidextract Gossypium. See Fluidextract Cotton Root, Fluidextract Granatum. See Fluidextract Pomegranate. Fluidextract Grindelia, Squibb pint, ; J4 pi>i>> Fluidextractum Grindelia, From dried , leaves and flowering tops of Crindelia camporum, C, cuneifolia or C. squarrosa. Antispasmodic,. Anticatarrhal ; in asthma, whooping-cough, etc. Average Dose: 30 minims (2. mils [Cc.]). The Squibb products are recognized everywhere as the Quality Standard. They are of uniform purity and strength, hence threrapeuticaliy dependable. When ordering or prescribing med- icinal products, you will' do well always to specify SQUIBB'S. 104 SQUIBB'S MATERIA MEDICA Fluidextract Grindelia Soluble, Squibb pint, ; !4 pi"!' The {esinous matter has been rendered soluble by treatment with alkali, the finished fluidextract being miscible without precipita- tion with aqueous preparations, as syrups, elixirs, etc. Incom- patible with acids or acid salts. Same action and dose as preceding. Fluidextract Quarana, Squibb pint, ; !4 pint, ' Fluidexiractum Cuarana. Assays 3.6 to 4.4 Gm. "caffeine in 100 mils (Cc). Nerve Stimulant, Analgesic; chiefly in head- aches and narcotic poisoning. Average Dose: 30 miniins (2 mils) . Fluidextract Hamamelis Leaves, Squibb pint, ; J4 pint. FluiJexlraclum HamameliJis Folwrum, N. P.; Fluidextract Witch Hazel. Astringent. Average Dose : 30 minims (2 mils [Cc.]). Fluidextract Helianthemum. Fluidexiractum Helianlhfimi, N. F.; Fluidextract Frost-y/eed. Astringent, Alterative, Emetic. Average Dose : 1 fluidrachm (4 mils [Cc.]). Fluidextract Hellebore. See Fluidextract Veratrum Viride. Fluidextract Helonias. ..■..'. i.i Fluidextract Htloniadis, f4. F.; Fluidextract False ' Unicorn. From dried rhizome and roots of ChamtElirium- luteum^ As- serted Uterine Tonic, Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Hemlock Seed. See Fluidextract Conium. Fluidextract Hemp, Canadian. See Fluidextract Apocynum. Fluidextract Henbane. See Fluidextract Hyoseyamus. Fluidextract Hops. Fluid extracium Humuli, N. F. From dried strobiles of Humulu^ Lupulus. Arorhatic Bitter, Stomachic. Average Dose : 30 minims (2 mils [Cc.]). Fluidextract Horse-Nettle Berries. See Fluidextract Solanum. Fluidextract Hydrangea. Fluid extractum Hydrangea, N. F. From dried rhizome and roots of Hydrangea arborescem. Cathartic, Diuretic, Diaphor- etic. Average Dose: 30 minims (2 mils [Cc.]). SQUIBB'S MATERIA MEDICA 105 0Fluidextract Hydrastis, Squibb pint, ;i4pint, ■ ; Fluidexlracium Hydrastis ; Fluidextract Golden Seal. Assays 1.8 to 2.2. Gm. ether-soluble alkaloids in 100 mils ■ (Cc). riemostatic Astringent, Cholagogue, Antihydrotic. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Hydrastis, Aqueous. See Glycerite Hydrastis. Fluidextract* Hydrastis, Colorless, sp-called. See Fluid Golden Seal Colorless. Fluidextract Hydrastis Non-Alcoholic. See Qlycerite Hydrastis. Fluidextract Hyoscyamus, Squibb pint, ; J4 pint, Fluidextracium Hyosc^ami ; Fluidextract Henbane. From dried leaves and flowering tops of Hyoscyamus nigef. Assays 0.055 to 0D75 alkaloids in 100 mils (Cc). Antispasmodic Sedative, Analgesic; in coughs, nervous ailments, pains, etc. Average Dose: 3 minims (0.2 mil). Antidotes: tannin, emetics; morphine, pilocarpine, physostigmine, aconitine; stimulants by mouth. This fluidextract frequently deposits crystals of potas- sium nitrate, a salt always found in good hyoscyamus leaves. It is not a necessary element in the therapeutic efficiency of the preparation, and when found may be removed by decanta- tion, or by filtration. ® Fluidextract Ipecac, Squibb pint, ; % pint, Fluidexiractum Ipecacuanha. Assays 1.8 to 2.2 Gm. ether- soluble alkaloids in 100 mils (Cc.). Nauseant Ei(pectorant, Emetic, and Antamebic. Average Dose: Emetic, 15 minims (1 mil); Expectorant, 1 minim (0.06 mil). Fluidextract Iris. See Fluidextract Blue Flag. Fluidextract Jaborandi. See Fluidextract Pilocarpus. Fluidextract Jalap. Fluidextracium Jalapa, N. F. From dried tuberous root of Exogoniam- Purga. Hydragogue Cathartic. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Jamaica Dogwood, Squibb T , pint, ; J4 pio*> From root-bark of Piscidia Erythrlna, Hypnotic, Sedative, and dental ; Apodyne ; in nervous insomnia, ovarian pain, toothache, etc. Dose: I to 2. fluidrachms (4 to 8 mils [Cc.]). Since we make only one quality of each product, that best suited to the purposes intended, the specification "Squibb;s" is not open tb various interpretations; but has a .Plain, positive meaning. When ordering or prescribing, specify SQUIBB S. 106 SQUIBB'S MATERIA MEDICA Fluidextract Juclans. Fluidextractum Juglandis, N. F.; Fluidexlract Butternut. From inner bark of root of Juglans cinerea. Obsolescent Cathartic, similar to cascara. Average Dose: 1 fluidrachm (4 mils [Cc.]). Fluidextract Juniper, Squibb pint, ; 14 ?'•>•• FluiJexiractum Juniperi, N. F. From dried ripe fruit (berries) of Juniperas communis. Irritant Diuretic. Average Dose: 1 fluidrachm (4 mils [Cc.]). Fluidextract Kava. Fluidextractum Kava, N. F. From dried rhizome and roots of Piper methysticum. Mild Irritant, similar to cubeb; used chiefly in gonorrhea. Average Dose: 15 minims (I mil [Cc.]). Fluidextract Kola, Squibb pint, ; }A pint, Fluidextractum Kola, N. F. From dried~cotyledons of several species of Cola. Nerve and Muscle Stimulant, Diuretic, Average Dose: 1 fluidrachm (4 mils [Cc.]). Fluidextract Krameria, Squibb pint, ; !4 pint, ■Fluidextractum Krameria, N. F.; Fluidextract Rhatany. Dropped from U. S. P. From dried root of Krameria triandra, K. Ixina or K. argenlea. Powierful Astringent; chiefly in in- testinal catarrh and hemorrhage. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Ladies' Slipper. See Fluidextract Cypripedium. Fluidextract Lappa, Squibb pint, ; |4 pint, Fluidextractum Lappa, N, F,; Fluidexlract Burdock. From dried root of Arctium Lappa. Alterative. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Larkspur, Squibb pint, ; % pint. Acetic Fluidextract Larkspur. The use of Larkspur, Stavesacre and other varieties of Delphinium in ointments, lotions, etc., for the removal of body-parasites, has created a demand for a concentrated form which may be diluted with water and alco- hol at the time of using. A fluidextract made with 10 percent, acetic acid is best adapted for this purpose, as it contains all the virtues of the drug. To prepare parasiticidal lotion,' take; Fluidextract Larkspur Squibb, I fl. oz. ; gradually add alcohol \% fl. ozs. ; set aside 5 minutes, then add water 14f^ fl. ozs. Let stand 24 hours, then filter. Little used internally (dropsy, asthma, etc.). Dose: 3 minims (0.2 mil [Cc.]).< Antidotes: tannin, emetics-, ammonia or digitalis; brandy. ' Fluidextract Leptandra. Fluidextractum Leptandra; Fluidexlract Culver's Root. From dried rhizome and roots of Veronica virginica. Cathartic. Average' Dose : 15 minims (I mil [Cc.]). SQUIBB'S MATERIA MEDICA 107 Fluidextract Licorice. See Fluidextract Glycyrrhiza. Fluidextract Licorice for Quinine Mixtures. See Fluid tGlyeJjrrhiza. FtyiDEXTRACT LiFE RooT. See Fluidextract Senecio. Fluidextract Lily of the Valley Flowers. See Fluidextract Convallaria Flowers. Flliidextract Lily of the Valley Root. See Fluidextract Convallaria Root. Fluidextract Lobelia, Squibb pint, ; 14 pint< Fluidexiractuih Lobelia. The new U. S. P. has readopted the alcohplic' fluidextract and dropped the acetic product of Vlllth, Rev. , From' dried leaves and . flpweijiiig tops of Lobelia. in fiaia. Antispasmodic, Expectorant; in whooping-cough, asthma, etc. Average Dose: lYz minims (0.15 mil [Cc.]). Anti- dotes: tannin, emetics hypodermically ; brandy or ammonia; morphine. "^ » Fluidextract Lupulin. Fluidextraclum Lupulini, N. F. From glandular trichomes sep- arated from strobiles of Hamulus Lupulus. Bitter Tonic, simi- lar to gentian. Average Dose: 8 minims (0.5 mil [Cc]). Fluidextract Mandrake. See Fluidextract Podophyllum. Fluidextract Marigold. See Fluidextract Calendula. Fluidextract Matico. Fluidextraclum Matico, N. F. From leaves of Piper angustl- folium. Used as GenHlo-urinary Stimulant and Anticatarrhal ; similar to buchu, cubeb, etc., Average Dose: I fluidrachm (4 mils [Cc.]). Fluidextract Mezereum. Fluidextraclum Mezerei, N. F. Dropped from U. S. P. From dried bark of Daphne Mezereum, D. Cnidium or D. Laureola, Used as Antiluetic and Vesicant. Dose: 5 to 15 minims (0.2 to I mil [Cc.]), well diluted. Antidotes: demulcents; emetics. Fluidextract Mu;.lein Leaves. * Fluidextraclum Verbasci Foliorum, N. F. From dried leaves of V erbascum Thapsus "and other species of V erbascum. Demulcent, Anticatarrhal. Average Dose: 1 fluidrachm (4 mils [Cfc.]). The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal, and devotion of its founder." 108 SQUIBB'S MATERIA MEDICA Fluidextract Nux Vomica, Squibb pint, ; ^ pint, Flmiexlraclum Nucis Vomica. From dried ripe seeds of 5ftrycAnos Nux-vomica. Assays 2.37 to 2.63 Gm. alkaloids in 100 mils (Cc). Bitter Stomachic, Tonic. Average Dose: 1 minim (0.06 mil). Antidotes: tannin; apomorphine subculane- ously as emetic; chloral hydrate with bromides per rectum; chloroform by inhalation if required. Fluidextract Orange Peel, Bitter. Fluidexiracium Aurantii Amari. From dried rind of fruit of Citrus Aurantium amara. Aromatic Bitter Stomachic, taste corrigent. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Orange Peel, Sweet, Squibb pint, ; '/^ pint. From dried outer rind of ripe fruit of Citrus Aurantium. Flavoring ingredient. Fluidextract Paracoto. Fluldextractum Paracoto, N. F. From bark of an unidentified tree belonging to Lauracece. Intestinal Astringent, Average Dose: 5 minims (0.3 mil [Cc.]). Fluidextract Pareira. Fluldextractum Pareira, N. F. From dried root of Chondo- dendron lomenlosum. Bitter Tonic. Average Dose: 30 min- ims (2 mils [Cc.]). Fluidextract Parsley Root. Fluldextractum Petroselini Radicis, N. F. Carminative. Aver- age Dose: 30 minims (2 mils [Cc.]). Fluidextract Passion Flower, Squibb pint, ; Y4 pint. From dried leaves of Passiftora incarnata. Used as Nerve Sedative, in insomnia, restlessness, etc. Dose: 15 to 30 minims (1 to 2 mils [Cc.]). Fluidextract Phytolacca, Squibb. pint, ; 14 pint. Fluidextractum Phyiolaccie, N. F.; Fluidextract Poke Root. From dried root of Phytolacca decandra. Used as Emetic, Alterative, Cathartic. Average Dose: emetic, 15 minims (1 mil [Cc.]); alterative V/i minims (0.1 mil). Fluidextract Pichi, Squibb pint, ; J4 pint. From dried leaflets and twigs of Fabiana imbricala. Diuretic, Urinary Anticatarrhal. Considered contra-indicated in or- ganic renal disease. Dose: 30 to 60 minims (2 to 4 mils [Cc.]). SQUIBB'S MATERIA MEDICA 109 rluidextract Pilocarpus, Squibb pint, ; !4 pim. Fluid extraclum Pilocarpi; Fluidexlract Jaborandi. From dried leaflets of Pilocarpus Jaborandi or of P. microphallus. Assays 0.55 to 0.65 Gm. alkaloids in 100 mils (Cc). Sialagogue, Galactagogue, Diaphoretic; also used as stimulant of hair folli- cles. Average Dose: 30 minims (2 mils). Fluidextract Pink Root. See Fluidextract Spigelia.- Fluidextract Pipsissewa. See Fluidextract Chlmaphila. Fluidextract Pleurisy Root. See Fluidextract Asclepias. Fluidextract Podophyllum, Squibb pint, ; J4 pint,' Fluidexlractum Podophylli; Fluidextract Mandrake (May Apple). From dried rhizome of Podophyllum peltatam. Cathartic. Average Dose: 8 minims (0.5 mil [Co.]). Fluidextract Poke Root. See Fluidextract Phytolacca. Fluidextract Pomegranate. Fluidextraclum Cranaii. From dried bark of stems and roots of Punica Cranatum, and containing about 10 percent, glycerin. Anthelmintic, Astringent. Average Dose : 30 minims (2 mils [Cc.]). pLUIDEXTRAtT PricklY Ash Bark. See Fluidextract Xanthoxy- lum. Fluidextract Prunus Virginiana. See Fluidextract Wild Cherry. Fluidextract QuaSsia, Squibb pint, ; 14 P>nt' Fluidextraclum Quassice, N. F. Dropped from U. S. P. From wood of Picrasma excelsa or Quassia amara. Bitter Tonic, Teniafuge. Average Dose: 8 mipims^ (0.5 mil [Cc.]). FRiidextract Quebracho. See Fluidextract Aspidosperma. Fluidextract Queens Root. See Fluidextract Stillingia. Fluidextract Quercus. Fluidextraclum Quercus, N. F.; Fluidextract White Oak. From dried bark of Quercus alba; 10 volume percent, glycerin. Tannin-bearing Astringent like krameria. Average Dose : 1 5 minims (I mil [Cc.]). Fluidextract Red Clover. See Fluidextract Trifolium. Ttie Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that Is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. no SQUIBB'S MATERIA MEDICA Fluidextract Rhamnus Cathartica. Fluictexiractum Rhamni Calhartica, N. F.; Fluidextract Buck- thorn Berries. From dried, ripe fruit of Rhamnus cathartica. Cathartic. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Rhamnus Frangula. See Fluidextract Fran- gula. Fluidextract Rhamnus Purshiana. See Fluidextract Cas- cara Sagrada. Fluidextract Rhaiany. See Fluidextract Krameria. Fluidextract Rhubarb, Squibb pint, ; !4 pint, Fluidexlraclum Rhei. From prime quality Chipese root. Stom- achic, Laxative^ Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Rhus Glabra. Fluidexlractum Rhois Clahra, N. F.; Fluidextract Sumach Berries. From dried fruit of Rhus glabra, and containing 10 volume percent, of glycerin. Tannin-bearing Astringent, sim- ilar to krameria. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Rose. Fluidexlfactum Rosa. From dried petals of Rosa gallica, and containing 10 percent, by volume of glycerin. Mild Astringent; used chiefly as flavoring and for making syrup rose. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Rubus. Fluidextractum Ruhi, N. F.; Fluidextract Blackberry. Dropped from U. S. P. From dried bark of Rubus villosus, R. nigro' baccus or of R. cuneifolius. Intestinal Astringent. Average Dose: 15 minims (I mil [Cc.]). Fluidextract Rumex, Squibb pint, ; <4 pint, Fluidextractum Rumicis, T^. F.; Fluidextract Yellow Dock. From dried root of Rumex crispus. Alterative, External As- tringent. Average Dose: I fluidrachm (4 mils [Cc.]). Ex- ternally pure (in ulcers and skin diseases). Fluidextract Sabal, Squibb pint, ; l^ pint, Fluidextractum Sabal; Fluidextract Saw Palmetto. From par- tially dried berries of Serenoa serrulata. Used as Genito- urinary Anticatarrhal. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Sanguinaria. Fluidextractum Sanguinaria, N. F.; Fluidextract Bloodroot. Essentially the alcoholic product of U. S. P. 1890; not acetic, as per U. S. P. Vlllth Rev. From dried rhizome of San- Suinaria canadensis. Expectorant; large doses are -emetic. Average Dose: lJ/2 minims (0.1 mil [Cc.]). SQUIBB'S MATERIA MEDICA 111 Fluidextract Sarsaparilla, Squibb pint, ; !4 pint, Fluiiexlracium Sarsaparilla. From best grade of ofliciaE Sarsaparilla. Used as Alterative; in chronic rheumatism, skin, diseases, etc. Average Dose : 30 minims' (2 mils [Cc] ) . Fluidextract Sarsaparilla Compound, Squibb pint, ; ^ pint, Fluidextractum Sarsaparilla Composilam, Each mil (Cc.)' representing 1 Gm, mixture of sarsaparilla, licorice, sassafras, and mezereum, and carrying 10 volume percent, of glycerin^ Average Dose: 30 minims (2 mils). Fluidextract Sarsaparilla Compound for Syrup, Squibb pint, ; '/4 pint. For conveniently making Syrup Sarsaparilla Compound, take of this fluidextract 7 fl. ozs. and enough syrup to make 30 fi. ozs. Fluidextract Saw Palmetto.' See Fluidextract Sabal. Fluidextract Scoparius. Fluidextractum Scoparii, N. F.; Fluidextract Broom Tops. From dried lops of CsHsus Scoparius. Diuretic. Considered' contra-indicated in the presence of acute renal inflammation- Average Dose: 15 minims (I mil [Cc.]). Fluidextract Scullcap. See Fluidextract Scutellaria. Fluidextract Scutellaria. Fluidextractum Scutellaria, N. F.; Fluidextract Scullcap. From dried plant of Scutellaria lateriflora. Used as Nervine and Antispasmodic, chiefly in chorea and convulsions. Average Dose'i 15 minims (I mil [Cc.]). Fluidextract Senecio. Fluidextractum Senecionis, N. F.; Fluidextract Life Root. From dried overground portions of Senecio aureus. Used as- Tonic, Diuretic and Diaphoretic. Average Dose: I fluidrachm (4 mils [Cc.]). Fluidextract Senega, Squibb pint, ; !4 pint. Fluidextractum Senega; Fluidektract Seneka Snakerool.. Pharmacists and physicians frequently complain that this fluid- extract becomes "worthless" or "spoiled" by gelatinizing. Good' senega root contains a large amount of pectin, and the better the root the more it appears to contain. This physical properly is necessary to its proper therapeutic effects, and therefore it would npt be justifiable to select a root which is inferior ,in this- property. Unless the gelatinized clot is of too long standing, warmth applied, or at times a few drops of ammonia water with agitation, will restore it to its original fluid condition. Nauseam Expectorant. Average Dose: 1 5 minims (I mil [Cc.]). The Squibb Label on a package is a positive guaranty for tlie- uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low> as they can be made for that quality. Specify SQUIBB'S. 112 SQUIBB'S MATERIA MEDICA © Fluidextract Senna, Squibb pint, ; 14 ?»"•• Fluidextractum Senna. From best quality senna leaves, the dried leaflets of Cassia acatifolia or of C. angustifolia, known in commerce respectively as Alexandria Senna and India Senna. Cathartic. Average Dose : 30 minims (2 mils [Cc] )^ Fluidextract Serpentaria. Fluidextractum Serpentaria, N. F.; Fluidextract Virginia Snakeroot. From dried rhizome and roots of Aristolochia Ser- pentaria or of A. reticulata. Bitter, like gentian. Average Dose: 15 minims (1 mil [Cc.]). Fluidextract Solanum. Fluidextractum Solani, N. F.; Fluidextract Horse-Nettle Berries. From air-dried ripe fruit of Solanum carolincnse. Used as Antispasmodic and Sedative; in convulsions, epilepsy, etc. Average Dose: I fluidrachm (4 mils [Cc.]). - Fluidextract Spicelia. Fluidextractum Spigelie.; Fluidextract Pink Root. From dried rhizome and roots of Spigelia marilandica. Teniafuge. Average Dose: 1 fluidrachm (4 mils [Cc.]). Fluidextract Spikenard. See Fluidextract Aralia. Fluidextract Squill, Squibb ' pint, ; <4 pint, Fluidextractum Sci!/d standardized; minimum lethal dose not greater than 0.0006 mil (Cc.) per Gin, ' weight o'f frog. Rxpectorant, Diuretic ; large doses are Emetic. Average Dose: :1!^ minims (0.1 mil). Fluidextract Squill Compound, Squibb pint, ; 14 pint For- Syrup. Each mil (Cc.) represents 1 Gm. mixture of equal parts each squill and senega, and 0.01 25 Gm. tartar emetic. 160 mils with 840 mils syrup makes 1000 mils syrup squill compound. Fluidextract Staphisagria. Fluidextractum Staphisagria; Fluidextract Stavesacre. From ripe seed of Delphinium Staphisagria. Antiparasitic, Rube- facient; in scabies, rheumatism, etc. Applied in 1:16 dilution. Antidotes: tannin, emetics; chloral hydrate; chloroform by in- halation; ammonia, digitalis, brandy. Fluidextract Star Grass^ See Fluidextract Aletris. Fluidextract Stavesacre. See Fluidextract Staphisigria. SQUIBB'S MATERIA MEDICA 113 Fluidextract Stillingia, Squibb pint, - ; 14 pint, Fluidextractum SiilUngiai; Fluidextract Queen's Root. From dried root of Stillingia s^lvaiica. Sialagogue, Expectorant, Alterative. Average Doge: 30 minims (2 mils [Cc.]). Fluidextract Stillingia Compound, Squibb - ->■ ' pint, ; !4 pint, Fluidexiraclum Stillingia Composilum, N. F. Each mil (Cc.) represents I Gm.> mixture of stillin^a,' corydalis, iris, sambucus, chimaphila, coriander and xanthoxylum berries. Used as Alterative; in liver diseases, spring fever, etc. Average Dose: 30 minims (2 mils [Co.]).' Fluidextract Stramonium. . ,: Fluidextractum Slramonii, N. F. From leaves of Datura Stramonium or of D. Talula. Assays 0.22 to 0.28 Gm. alka- loids in 100 mils (Cc). AniUpasmodtc, Sedative, Analgesic. Average Dose: Lminin* (0.06 mij [Cc.]). Antidotes: tannin; apofnorphine hypodermically as emetic ;- morphine ; ammonia by inhalation. ; Fluidextract Sumach Berries. See Fluidextract Rhus Glabra.. Fluidextract Sumbul, Squibb pi>>t< ; !4piiit> _F,liaid§xtractum Sumful; Fluidextract Musk Root. From dried rhizome and roots of Ferula Sumf)ul. aiUsed as Antispasmodic, Nerve Tonic. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Sundew. See Fluidextract Drosera. Fluidextract Taraxacum, Squibb pint, ; % pint, Fluidextractum Taraxaei; Fluidextract Dandelion, From dried root of Taraxacum officinale. Bitter Tonic, mild Laxative. Average Dose: '2!4 fluidrachms (10 mils [Cc.]). Fluidextract Thuja. Fluidextractum Thuja, N. F.; Fluidextract .Arbor Vitae. From recently dried, leafy young twigs of Thuja occidentalis. Used as Febrifuge, Expectorant, Anthelmintic. Average Dose: 30. minims (2 mils [Cc.]). Fluidextract Thyme. Fluidexiraclum Th^mi, N. F. From dried tops of Thymus vulgaris. Antispasmodic, Carminative, Aromatic Stimulant. Average Dose: I fluidrachm (4 mils [Cc.]). This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations ; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 114 SQ|JIBB'S MATERIA MEDICA Fluidextract Trif olium, Squibb pint, ; (4 pint, Flaidextracium Trifolii, N. F.; Fluidextract Red Clover. From dried flowers of Trif olium pratense. Used as Alterative, Expectorant. Average Dose: 1 fluidrachm (4 mils [Cc.]). Generally administered in combination with other drugs. Fluidextract Trifolium Compound, Squibb pint, ; ]/i pint. Each mil (Cc.) represents I Cm. of mixture bf 8 parts red clover blossoms And 4 parts each of berberis, poke root, bur- dock root, cascara, stillingia, and prickly ash bark. Used as Alterative. Dose: I to 2 fluidrachms (4 to 8 mils [Cc.]). To prepare Syrup Trifolium Compound, lake of this Fluidextract 4 fluidounces, Potassium Iodide 128 grains, and Simple Syrup 12 fluidounces,. Fluidextract Trillium, Squibb pint, ; <4p>nt, Fluidexlract Trillii, N. F.; Fluidextract Beth Roof. From dried rhizome of Trillium ereclum. Used as Tonic, Astringent. Average Dose: 30 minims (2 mils [Cc.]). Fluidextract Triticum, Squibb pint,' ; 14 pi"'* FluiJextraclum Triiici; Fluidextract Couch Grass or Dog Grass. From dried rhizome of Agropyron repens. Diuretic, Demulcent; in cystitis and irritable bladder. Average Dose: 21/^ fluidrachms (10 mils [Cc.]). Fluidextract Turkey Corn. See Fluidextract Corydalis. Fluidextract Uva Ursi, Squibb pint, ; !4 pint, Fluidextractum Uvl ^^llium. saiivam (Fam. Liliaceee). Irritant Expectorant, similar to senega. Average Dose: 30 grains (2 Gm.). © Gelatin. Celatinum. From animal tissues (skin, ligaments and bones) by treatment with boiling water. Insoluble in cold water (but swells and softens when immersed in it), alcohol, chloroform, ether, oils; soluble in hot water, acetic acid, glycerin. Coagu- lated by tannin, chlorine, bromine and corrosive mercury chloride; formaldebyde rendefs it hard and insoluble. Nutri- ent, but used largely pharmaceulically. Gelatin Chondrus. Celatinum Chondri, N. F.; Irish Moss Gelatin. Evaporated, scaled decoction of Irish Moss. Demulcent, Nutritive. Gelatin GlycerInated. Celatinum Clycerinatum. '50 percent, gelatin. Base for throat lozenges and medicated suppositories and bougies. Gelsemium. Celsemium ; Yellow Jasmine Root. Dried rhizome and roots of Celsemium sempervirens (Fam. Loganiacea). Pronounced characteristic odor; slightly aromatic, bitter taste. Antineuralgic, Antispasmodic, Nerve Sedative; in migraine and neuralgia, in ovarian, uterine and rheumatic pain. - Average Dose : Y2 grain (0.03 Gm.). (See also Fluidextract; Tincture.) Gentian, Squibb Ground for Percolation tin, lb. Centiana; Gentian Root. Dried rhizome and roots of Cen~ tiana /uieo* (Fam. CeMlanatea). Simple Bitter, Stomachic. Average Dose: 15 grains (1 Gm). (See also Elixir; Extract; Fluidextract; Tincture.) Qentian Compound Ground, Squibb tin, lb. Mixture of ground Gentian, Bitter Orange Peel ' and Carda- mom, in proportions given in U. S. P. formula for Tincture Gentian Gottipound, and. used for preparing latter. Geranium. Geranium, N. F. ; Cranesbill. Dried rhizome of Ceramum maculatum, collected in late summer or autumn. Intestinal Astringent, like krameria. Average Dose : 15 grains ( 1 Gm.) . SQUIBB'S MATERIA MEDICA 119 Ginger, Squibb *Ground for Percolation tin, lb. Powdered tin, lb. ^ sprinkler-top tins, 4-oz., per doz. 2-oz., per doz. ; I -oz., per doz. Zingiber. CXried rhizome of Zingiber officinale (Fam. Zingberaceat) , The chief sources .of ginger are West Indies, Jamaica, Africa, Hindoostan and China. The rhizome is collected in the winter, cleaned,' scalded and rapidly dried, and is then known as Black Ginger. The process of preparation is carried still further with Jamaica Ginger and some that comes from the East Indies, by the removal- of this dark skin, thus leaving the roots yellowish-white in . color. As this variety commands a higher' price, the poorer qualities are sometimes made to resemble it by Ibleaching or covering with thin milk of lime or slaked lime. It has a warming, cordial effect when used as a. condiment, and also lends to prevent flatulence. The article here offered is strictly., pure and of best quality procur- able Average Dose: 15 grains (IGm.). (See also Fluid Ginger; Fluidextract; Oleoresin ; Tincture.) Ginger Soluble, for Syrup. ■ See Fluid Ginger for Syrup. Glauber's Salt. See Sodium Sulphate. Glucose Liquid. Clucosum. From incomplete hydrolysis of starch; consists chiefly of dextrose and dexfrins. Nearly colorless, odbrless, thick, sweet liquid. Very soluble in water, sparingly in alco- hol. Nutrient, but used lairgely pharmaceutically and techni- cally. Gluside. < See Benzosulphinide (Saccharin). Glusimide. Brand of Benzosulphinide (Saccharin). ©Glycerin, Squibb bottle, lb. ;J41b. Clycirinum; Glycerol. C3H6(OH)3. A liquid obtained by hydrolysis of vegetable or animal fats, or fixed oils. Most care- fully selected and subjected in our laboratories to the severest tests for purity. It is of proper density, stands the rigid sul- phuric acid test^ and is free from arsenic,' mineral impurities and acidic radicles indicative of contaminating salts. An especially acceptable article for internal use. Clear, thick, sweet liquid. Sp. gr. not below 1 .249. Soliible in all proportions of water or alcohol; insoluble in ether, chloroform or oils. Used chiefly technically and as a solvent, but also internally in place of 'sugar in diabetes imd as nutritive. Average Dose: I fliiidrachm (4 mils [Cc.]). Incompatible with cjiromic acid ap;l permanga- nates. -'(See also Suppositories.) "' ' .,. 1 ri.fi'r . ■ ; -J ..-1 .> "' .-■ The Squibb product^ are: /ecoaiized everywhere as the Quality Standard. They 'are of urtiforrii, purity and strength, nence thefaUpeutieatlytdepen-ddDle. ■ When orderihfe or prescribing thedi- cinai products, you will do well always to sp^cif^i SlQUIBB'S. 12p SQUIBB'S MATERIA MEDICA Glycerite Acid Carbolic. See Glycerite PhenoL Glycerite Acid Tannic, Squibb bottle, pint ; \^ pint Clycerilum Acidi Tannic!. 20 percent, tannic acid. Antiseptici Astringent paint, on fissured nipples, erysipelas, sores, etc.; rarely internally. Average Dose: 30 minims (2 mils [Cc.]). Glycerite Bismuth, Squibb bottle, pint ; J4 pint Clyceriium Bismulhi, N. F. I fluidr^chm contains about 16 grains bismuth and sodium tartrate; 100 mils (Cc.) yield about 12.8 Gm. bismuth oxide. Gastric Sedative, Intestinal Astrin- gent ; used mainly f o[ making elixirs. Ordinary Dose : 1 min- ims (0.65 mil [Cc.]). Glycerite Boroglycerin, Squibb bottle, lb. ; !4 lb. Clyceritum Boroglycerini U. S. P. is apt to become discolored during the process of making. We therefore increase the boric acid from 31 percent, to 35 percent, (equivalent to 56 per- cent, glyceryl borate or boroglycerin) and obtain a whiter and better article. Thick, sweet, colorless liquid. Soluble in water. Antiseptic. Glycerite Egg Yolk. Cl})cerlium VUelli, N. F.; Glyconin. 45 percent, egg yolk, 55 percent, glycerin. Protective, Emulsifier, Vehicle. Glycerite Golden Seal. See Glycerite Hydrastis. Glycerite Guaiac. Clycerilum- Caaiacl, N. F. Each fluidounce contains about 40 grains guaiac, with 30 minims solution potassium hydroxide. Al- terative, Emmenagogue. Average Dose: 30 minims (2 mils [Cc.]). Incompatible with mineral acids, ferric chloride, spirit nitrous ether. Glycerite Hydrastis. Cl^cerlium Hydrastis: so-called , Flqidextract Hydrastis Non- Alcoholic. Assays from 1.12 to 137 Gm. ether-soluble alka- loids in 100 mils (Cc.). An alcoholic percolate is made from powdered hydrastis, the alcohol removed by distillation, and resultant thick extract incorporated' with >vater and glycerin. Astringent, Antiphlogistic; topically and internally. Average Dose: 30 minims (2 mils [Cc.]). Glycerite Pepsin, Squibb bottle, pint ; % pint Clyceriium Pepslni, N. F.; Glycerol Pepsin. Each fluidounce contains about 40 grains of 1 :3000 pepsin and 5 minims hydro- chloric acid. Useful in making essence pepsin and where pepsin is desired in liquid form. Average Dose: 45 minims (3 mils [Cc.]). SQUIBB'S MATERIA MEDICA 121 Glycerite Phenol. Clyeeriium PhenoUs; Glycerite Carbolic Acid. Mixture of I volume liquefied phenol and 4 volumes glycerii;. External and, internal Antiseptic, Antipruritic. Average Dose: 5 minims (0.3 mil [Cc] ) , in water. Applied diluted with water, 1 :4 to 6. Glycerite Starch. Cl}^cerltum Amyli. 10 percent, starch well gelatinized. Vehicle for dermics; pill-excipient, etc. Glycerite Tar. Clgcerilum Ptcis Liquidte, N. F. 100 mils (Cc.) contain 6.3 Gm. tar, with glycerin, alcohol and water. Expectorant, Anti- septic. Average Dose: 1 fluidrachm (4 mils [Cc.]). Glycerite Tragacanth. Clyceritum Tragacantha,^. F. 100 mils (Cc.) contain about 12.5 Gm. tragacanth, with glycerin and water. Pill excipient. Glycerogelatins. Soft masses, melting at body temperature^ composed of gela- tin, glycerin, water and a medicztqient employed in skin dis- I eases, with or without the addition of zinc oxide. They are prepared with :glycerinafed gelatin (U. S.P.) as vehicle. The N. F. recogiiizes: G/jicerogc/aiin Satic^llc Acid, 10%; C/y- cerogelaiin Iodoform, 10%; Cl^cerogelalin Zinc Firm., \0% zinc oxide; Clscerogelatin Zinc Soft, 10% zinc oxide. Glycerol. See Glycerin and Glycerite. Glyconin. See Glycerite Egg Yolk. Glycopheno and Glycosine. Brands of Benzosulphinide (Sac- charin) . ©dlycyrrhiza Powdered, Squibb Clycyrrhiza. Licorice. Dried rhizome and roots of Clfcyrrhiza glabra glandulifera or of G. glabra fypica (Fam. Leguminosa) ; known in commerce respectively as Russian Licorice and -Spanish Licorice. Demulcent^ Expectorant; also absorbent in pill making. Average Dose: 30 grains (2 Gm.). (See also Eitract; Fluidextract ; Mixture; Powder; Troches [Part II].) Since we make only one quality of each product, that best fi?ted to the purpoies Intended, the specrfication 'Squibb s" fs not open to various interpretations, but has a plain positive meahing. When ordering or prescribing, speciftr SQUIBB'S. 122 SQUIBB'S MATERIA MEDICA Glycyrrhizin Ammoniated. G/ycjrr/ii'zinum Ammomalam. Sweet principle of glycyrrhiza (licorice root). Dark-brown' or brownish-red, odorless, sweet scales. Freely soluble in water; soluble in alcohol. Taste corrigent; Expectorant and Demulcent, in pectoral affections. Average Dose: 4 grains (0.25 Gm.). Incompatible with min- eral acids. Godfrey's Cordial. See Mixture Opium and Sassafras. Gold Chloride, Squibb 1 3-grain vial, AUHCI4.4H2O. Reddish-brown, very deliquescent crystals; approx. 49 percent, gold. Soluble in water, alcohol, ether. Used medicinally as Alterative, mainly in dipsomania and tuber- culosis. Used largely in photography. Dose : l/eo 'o Vl5 gra'" (0.001 to 0.004 Gm.) Keep well protected against air and light. Gold and Sodium Chloride, Squibb J/g-oz. vial, ; 15-gr. vial. Ami el Soiti ChloriJum. Mixture of equal parts anhydrous gold chloride and sodium chloride, containing 30 percent, gold. Orange-yellow, deliquescent, odorless powder; saline, metallic taste. Soluble freely in water, partially in alcohol. Average Dose: 1/12 grain (0.005 Gm.), in pills or tablets. Keep well stoppered, in dry place. (See also Tablets [Part II|.) Gold Thread. See Coplis. Golden Seal. See Hydrastis. / Goulard's Cerate. See Cerate Lead Subacetate. Granular Effervescent Salts, Squibb Grouped for convenience of reference. Skilfully made products, from purest ingredients, in accurate and proper proportions to secure the best results. They dis- solve rapidly with brisk effervescence. For d^criptions see re- spective titles. * Antilithic. See Sodium Phosphate Compound. Carlsbad Artificial bottle, lb. ;4oz. , per doz. Kissingen Artificial bottle, lb. ;4oz. , per doz. Lithium Citrate bottle, lb. ;4oz. , per doz. Magnesium Citrate bottle, lb. ;4oz. , per doz. Magnesium Sulphate bottle, lb. ;4oz. , pel* doz. Sodium Phosphate • bottle, lb. ;4oz. , per doz. Sodium Phosphate Compound 4oz. , per doz. Sodium Sulphate bottle, lb. ;4oz. , per doz. Vichy Artificial bottle, lb. ;4oz. , per doz. SQUIB B'S MATERIA MEDICA 123 Grindelia. , ^ Grindelia; Gum-plant. Dried leaves and flowering tops of Crindelia camporum or G. caneifolia or G. squatrosa (Fam. Composita). Balsamic odor; aromatic, bitter, resinous taste. Antispasmodic, Anticatarrhal. Average Dose: 30 grains (2 Gm.)^. (See also Fluidextract.) Griffith's Mixture. See, Mixture Iron Compound. Griffith's Pills. See Pills Iron Carbonate. Guaiac Resin, Squibb Whole tin, lb. * Ground for Percolation tin, lb. Caaiacum ; Guaiac. Resin of wood of Cuaiacum oftcinale or of Csancfum {Fam. Z^goph^llacea). Irregular, greenish-gray, brown masses or grayish powder, of balsamic odor and slightly acrid taste. Used as Alterative and Emmenagogue. Average Dose: 15 grains (1 Gm.). (See also Tincture.) Guaiac Wood. Cuaiaci Lignum, N. F.; Lignum Vitas. Heartwood of Caaiacum officinale or of C. sanctum (Fam. Z\)gophyllace• : oz. Ferri Phosphas; Iron Phosphate Soluble. Ferric Phosphate rendered soluble by sodium citrate. Slightly acid, green scales, cotttaining not less than 12 percent, iron. Freely soluble in water; insoluble in alcohol. Hematinic, only shghlly astrin- gent. Incompatible with acids, alkali carbonates and tannin* containing preparations. Averge Dose : 4 grains (0.23 Gm.) Iron Pyrophosphate, Squibb tin, lb, ; ^ lb. ; oz. Fcrri Pyrophosphas, N. F.; Iron Pyrophosphate with Sodiiun Citrate. Apple-green, odorless scales; acidulous, slightly saline taste; 10 percent. Fe. Freely soluble in water; insoluble in alcohol. Hematinic; used largely in elixirs. Average Dose: 4 grains (0.25 Gm.). Iron Subcarbonate, Squibb carton, lb. ; 14 lb. Ferri Subcarhonas, U. S. P. 1870; Iron Carbonate Precipi- tated. Consists chiefly of hydraled oxide, with small quantities of ferrous carbonate. Reddish-brown, odorless, tasteless pow- der. Insoluble in ordinary organic solvents. Hematinic. Dose: 5 to 10 grains (0.3 to 0.65 Cm.). Iron Subsulphate, Squibb bottle, ^4 lb. ; oz. Basic Ferric Sulphate; Monsel's Salt. Fe40(S04)g. Light, reddish-brown, deliquescent, powder; readily soluble in water, less irritating than normal ferric sulphate because of its defi- ciency in sulphuric acid, and possesses greater astringency. As- tringent, Styptic, Hemostatic. Dose: 2 to 5 grains (0.13 to 03 Cm.). Keep in dry place. Iron Sugar. See Iron Oxide Red, Saccharated. © Iron Sulphate (Cryst.), Squibb bottle, lb. ; 14 lb. Ferri Sulphas; Ferrous Sulphate; Iron Protosulphate; Green Vitriol. FeS04.7H20. Well-crystallized, and not less than 99.5 percent, pure. The crystals show no efflorescence and are free from uncombined acid and alkali metals. Bluish-green prisms; odorless, and of saline, styptic taste; efflorescent in dry air, and rapidly oxidizing on exposure to moist air, becoming coated with brownish-yellow basic ferric sulphate. 1 Gm. dis- solves in 1.4 mils (Cc.) water; insoluble in alcohol. Chalyb- eate Tonic, Astringent. Average Dose: II/2 grains (O.I Cm.). Keep well stoppered, in cool dry place. (See also Reagents [Part IV], under Ferrous Sulphate). SQUIBB'S MATERIA MEDICA 137 Iron Sulphate Dried, Squibb bottle, lb. ; 14 lb. Ferri Sulphas E^siccatus; Dried Ferrous Sulphate. Ferrous Sulphate deprived of its water by efflorescence and heating, whereby it loses 35 percent, of its weight. Grayish-white pow- der, completely soluble in water. Preferred to crystalline salt for administration in pill form. Average Dose: I grain (0.065 Cm.). Iron Sulphate Granulated, Squibb bottle, lb. ; '4 lb. Ferri Sulphas Cranulatus. FeS04.7H20. Pale-green,, crystal- line powder. Convenient form of ferrous sulphate for dis- pensing purposes. Action and dose, as iron sulphate crystals. Iron Sulphocarbolate. See Iron Phenolsulphonate. Iron and Ammonium Citrate, Squibb bottle, lb. ; !4 lb. ; oz. Ferri et Ammonii Cilras'; Soluble Iron Citrate; Ammonio- ferric Citrate. Garnet-red scales; odorless, saline, mildly ferruginous taste. Readily and completely soluble in water; insoluble in alcohol. Contains equivalent of ribt less than 16 percent, metal- lic iron. Hematinic. Average Dose: 4 grains (0.25 Gm.). Incompatible with mineral acids, vegetable astringent infusions, decoctions, etc. Iron and Ammonium Sulphate, Squibb battle, lb. ; !4 !!>• : oz. Ferri el Ammonii Sulphas, U. S. P. Vlllth Rev.; Ferric Ammonium Sulphate. FeNH4(S04)2.12H20. Violet, efflor- escent, styptic crystals. I Gm. dissolves in about 3 mils (Cc.) water; insoluble in alcohol. Hematinic, Astringent, Styptic^ Average Dose: 8 grains (0.5 Gm.). (See also Reagents [Part IV] under Ferric Ammonium Sulphate.) Iron and Ammonium Tartrafe, Squibb bottle, lb. ; !4 lb. ; oz. '~ Ferri ei Ammonii Jarlras, U. S. P. Vllth Rev. Garnet-red to reddish-brown, odorless scales; 13 percent, metallic iron. Very soluble in water; insoluble in alcohol. Non-astringent Chalybeate Tonic. Average Dose: 4 grains ^0.2^ Gm.). Iron and Manganese Peptonate. See Iron Peptonate and " Manganese. Since we make only one quality of each product, that best suited to the purposes intended, the specification Squibb s is not open to various interpretations, but has a plain positive meaning When ordering or prescribing, specify SQUIBB S. 1 38 SQUlfeB'S MATERIA MEDICA Iron and Potassium Tartrate, Squibb tin, lb. ; '/4 lb. ; oz. Fern el Polassii Tariras, U. S. P. Vllth Rev. Garnet-red to reddish-brown, odorless scales, of sweetish, ferruginous taste; 15 percent, metallic iron. Soluble freely in water; insoluble in alcohol. Non-astringent Hematinic. Average Dose: 4 grains (0.25 Gm.). Iron and Quinine Citrate (Soluble), Squibb bottle, lb. ; !4 lb. ; oz. , Ferri el Quinmee Cilras. The new U. S. P. has adopted this soluble salt and dropped the regular, difficultly soluble salt. Contains not less than 11.5 percent, anhydrous quinine, and 13 percent, iron. Greenish or golden-yellow scales; odorless; bitter, ferruginous taste; slightly deliquescent. Bitter and Chalybeate Tonic, Antiperiodic. Average Dose: 4 grains (0.25 Gm.). Iron, Quinine and Strychnine Citrate, Squibb bottle, lb. ; % lb. ; oz. Greenish, very bitter scales; 0.9 to 1 percent, strychnine. Sol- uble in water. Tonic; in anemia, chlorosis, convalescence, etc. , Dose: 2 to 5 grains (0.13 to 0.3 Gm.). Iron and Strychnine Citrate, Squibb bottle, lb. ; I4 lb. ; oz. Formerly official. Readily soluble, garnet-red scales; 0.9 to I percent, strychnine and 16 percent, iron. Nerve Tonic, Chaly- beate, Antiperiodic. Ordinary Dose: 2 grains (0.13 Gm.). ©Jaborandi. See Pilocarpus. Jackson's Pectoral Syrup. See Syrup Morphine and Acacia. © Jalap, Squibb * Ground for Percolation tin, lb. Powdered tin, lb. ; !4 lb. Jalapa. Dried tuberous root of Exogoniam Purga (Fam. Con' Volvulacea), Assays not less than 7 percent, total resin. Smoky, sweetish odor; sweetish, acrid taste. Hydragogue Cathartic, especially in dropsies; less'' irritant than other resinous cathartics. Average Dose: 15 grains (I Gm.). Acts in 3 hours, (See also Extract; Powder; Resin.) Jamestown Weed. See Stramonium. Janevi^ay's Pills. See Pills Aloes and Podophyllum Compound. JuGLANS. Juglans, N. F.; Butternut Bark. Dried inner bark of roots of Juglans cinerea (Fam. JuglanJacea) . Cathartic. Average Dose: 60 grains (4 Gm.). SQUIBB'S MATERIA MEDICA 439. Juniper BerrIes, i Juniperus, N. F. Dried ripe fruit of Juniperas commfinis (Fam. Pinacea). Odor aromatic; taste sweet, pleasant, tere- binthinate, slightly bitter. Irritant Diuretic. Average Dose: 60 graii\; (4 Gm.). (See also Fluidextracl.) Kaolin, Medicinal, Squibb carton, lb, Kaolinum, N. F. Offered in response to the demand from physi- cians for a pure, finely powdered, sterilized product, for :in- ternal use. Native aluminum silicate (H2Al2Si20g) . Grayish- yellow, fine powder; clay-like taste and odor; almost insoluble in ordinary solvents. Purified, dried and sterilized. Specially intended for medicinal use, as absorbent and eliminant .of patho- genic bacteria 'in diphtheria, typhoid fever, intestinal tubercu- losis; also used as dusting powder- in wounds and skin diseases, for clarifying liquids, and as pill-excipient for potassium per- manganate, . gold chloride and silver nitrate. Dose : 8 to 16 heaping teaspoonfuls one to three times daily, on empty stomach, suspended in a little water or oatmeal gruel. Topically, .for removing bacilli from throat, one-third teaspoonful is swallowed as slowly as possible every ten to fifteen minutes during the day until bacilli have completely disappeared, ' Kaolin Poultice. See Cataplasm Kaolin. Kava. "" Kava, N. F.; Kava Kava; Dried rhizome of Piper meihysli- cum (Fam. Piperaceo). Odor faint but characteristic; taste , aromatic, pungent, slightly bitter. Mild Diuretic, Genito- urinary Stimulant; similar to cubeb. Average Dose: 15 grains (1 Gm.). t Kelene. Brand of Ethyl Chloride. Kermes Mineral. See Antimony Sulphurated. ^i KlESELGUHR. See Silica. Kino. Kino. Spontaneously dried juice of Pterocarpus Marsupium (Fam. Leguminosa). Reddish-brown to reddish-black, brittle, odorless fragments; astringent taste. Slightly soluble in water; almost completely in alcohol ; nearly insoluble in ether. Intes- tinal and Pharyngeal Astringent. Average Dose: 8 grains (0.5 Gm.). (See also Tincture.) ' Kola. ^ Koia, N. F.; Cola. Dried cotyledons of several species of Cola (Fam. Slerculi(icea), yielding not less than 1.5- percent, caffeine. Odorless; slightly astringent tastes Stimulant, Muscle- invigorator. Average Dose: 60 grains (4 Gm.). The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and. in the words of William Miller Bartlett "the House of Squibl^ stands today as a living monument to the honor, integi-ity, zeal and devotion of its founder." 140 SQUIBB'S MATERIA MEDICA Kousso. See Brayera. Krameria, Squibb Ground for Percolation tin, lb. Krameria, N. F.; Rhatany. Dried root of Krameria irianJra, K. Ixina, eaid K. argenlea (Fam. Krameriacea) . Powerful Astringent; chiefly in diarrhea. Average Dose: 15 grains (1 Gm.). (See also Extract; Fluidextract; Syrup; Troches [Part 11].) Kumyss. Lac Fermentatum, N. F. Sweetened cow's milk fermented with yeast. Refrigerant Nutritive. Average Dose: 8 fiuidounces (240 mils [Cc.]). Lactophenin. Lactylparaphenetidin. C6H4OC2H5NH.COCH.OH.CH3. Colorless, odorless, faintly bitter powder. Soluble in 8.3 parts alcohol, 330 water. Aniipyrehc, Analgesic. Dose: 8 to 15 grains (0.5 to I Gm.). Lactose. See Sugar of Milk. Lactwcarium. Laciucariuin, Dried milk-juice of Laclaca virosa (Fam. Com- posila). Irregular, grayish-brovm pieces; opium-like odor; bitter taste. Partially soluble in alcohol or ether; practically insoluble in water. Nerve Sedative, Anodyne; in nervousness, irritative coiigh, etc. Average Dose: 15 grains (1 Gm.). , Ladies' Slipper. See Cypripedium. Lady Webster's Dinner Pills. See Pills Aloes and Mastic. Lafayette Mixture. _See Mixture Copaiba. Lamotte's Drops. See Tincture Iron Chloride Ethereal. Lanolin. See Wool-fat. Lappa. Lappa, N. T". ; Burdock. Dried root of Arctium Lappa (Fam. Composiice), Slight odor; taste mucilaginous, sweetish, sligntly bitter. Used as Alterative. Average Dose: 30 grains (2 Gm.) (See also Fluidextract.) Lard. Adeps. Purified internal fat of abdomen of hog (5u5 scrofa). Insoluble in water; very slightly soluble in alcohol, readily in ether or chloroform. Lard Benzoinated, Squibb tin, lb. Adeps Benzoinatus, Pure lard carefully benzoinated with I percent. Siam gum benzoin. Mildly Antiseptic. Emollient; Ointment Base. Liable to granulate on keeping; store in a very cool place. SQUIBB'S MATERIA MEDICA 141 Larkspur Seed. Delphinium,^ N. F. Dried seeds of Delphinium ConsoliJa ojr of D. Ajacis (Fam. Ranunculacete) , Faint odor; bitter then biting and acrid taste. Antiparasitic. (See also Fluidextract.) Larosan. Casein-Calcium. Light, white, almost odorless and -tasteless powder. Soluble in water. Addition to milk taken by infants suffering with diarrhea. Lassar's Dermatolocic Pastes. See under Paste. Laudanum. See Tincture Opium. Lavender Compound Ground, Squibb tin, lb. A mixture of the ground drugs Saigon cinnamon, cloves, nutmeg and red saunders, in the proportions called for in U. S. P. formula for Tincture Lavender Compound. © Lead Acetate, Squibb tin, lb. ; '/4 lb. Plumbi Acekis; Sugar of Lead, Pb(C2H302)2.3H20. Made by a special process devised in the Squibb Laboratories and which produces an exceedingly pure article, far superior to that commonly offered. -Colorless, granular crystals, of faintly acetous odor, and sweetish, astringent, metallic taste; efflores- cent and' absorbing carbon dioxide on exposure. 1 Cm. dissolves in 1 ,4 mils (Cc.) water, 38 alcohol, 5 glycerin. Astringent, Styptic; in conjunctivitis, gonorrhea, ivy poisoning, diarrhea, gastric hemorrhage, etc. Average Dose: I grain (0.065 Cm.). Incompahble with acids, tannin, vegetable astringent infusions and tinctures, carbonates, hydroxides, iodides, chlorides, sul- phates, etc. Antidotes : sodium or magnesium sulphate, emetics ; white of egg; demulcents. (See also Reagents [Part IV].) Lead Carbonate. Plumbi Carbonas, N. F. ; White Lead. Mixture of lead car- bonate and hydroxide. Heavy, white, odorless, tasteless pow- der.~ Insoluble in ordinary solvents. External Antiseptic; as dusting powder, ointment, etc. Lead Iodide. ' Plumbi lodidum, N. F.; Pbl2. Dropped from U. S. P. Heavy, yellow powder; odorless and tasteless. I Gm. dissolves in about 1300 mils (Cc). water; soluble in fixed alkali solu- tions, slightly in alcohol. Discutient, Alterative; externally in 10 to 20 percent, ointments, in indolent ulcers, swollen glands, etc.; internally in scrofula, phthisis, etc. Dose: J^/2 to I grain (0.03 to 0.065 Gm.) Lead Oxide Red, Reagent. See Reagents (Part IV). The Squibb Ideals have taken concrete form In the Squibb Products; these are universally^ recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 142 SQUIBB'S MATERIA MEDICA Lead Oxide, Yellow. Plumbi Oxidum; Litharge. PbO. Heavy, reddish-yellow, odorless, tasteless powder. Insoluble in ordinary solvents. Used pharmaceutically and technically. (See also Reagents [Part IV].) Lead Peroxide Reagent, See Reagents (Part IV). Lemon Peel. Limonis Cortex. Outer rind of fresh ripe fruit of Citrus medica Limonum (Fam. Rutacea). (See also Tincture.) Leptandra. Lepiandra, N. F.; Culver's Root. Dried rhizome and roots of Veronica virginica (Fam. Scrophulariacece) . Slight odor; taste bitter, slightly acrid. Cathartic, similar to podophyllum. Average Dose: 15 grains (1 Cm.). (See also Extract) Licorice Root Powdered, See Glychrrhiza. Life Root. See Seneeio. i Lily of the Valley Flowers. See Convallaria Flowers. Lily of the Valley Root. See Convallaria Root. © Lime, Squibb bottle, lb. Calx; Calcium Oxide; Quicklime; Burnt Lime. A well- burnt article, satisfactorily free from carbonate, containing no more than allowable impurities, and of not less than 95 per- cent. CaO. Hard, white, or grayish-white masses, on exposure attracting moisture and carbon dioxide and falling to a white powder; odorless; caustic taste. 1 Gm. dissolves in 840 mils (Cc.) water ; soluble also in glycerin and syrup ; insoluble in alcohol. With about half its weight of water it becomes heated and converted into calcium hydroxide (slaked lime). Antacid, Caustic, Depilatory. Given internally as lime water or syrup lime usually. Applied externally (to cancers, old ulcers, etc.) in substance or 25 percent, paste. Keep bottle securely stop- pered and in a dry place. (See also Reagents [Part IV], under Calcium Oxide.) Lime Chlorinated, Squibb bottle, lb. Calx Chlorinata ; Chlorinated Calcium Oxide; so-called "Chlo- ride of Lime"; Bleaching Powder. Indefinite composition, chiefly CaOCl2. Of unusually high test, assaying when fresh about 35 percent, of available chlorine, not only 30 percent, as U. S. P. requires. Since the value of chlorinated lime de- pends upon the amount of available chlorine which may slowly be given off, it will be found more economical to use this arti- cle than one of lesser strength. White or grayish-white powder, of penetrating odor, and repulsive saline taste ; gradually decom- poses on keeping. Partially soluble in water or alcohol. Used chemically and as bleaching agent, also General Disinfectant. Antidotes: ammonia by inhalation or by mouth; albumen; apo- morphine subcutaneously as emetic, if overdose was taken by moiith. SQUIBB'S MATERIA MEDICA 143 Lime Hydrated, Squibb For Lime Water 4-drachni vials, per doz. Pure Hydrated Lime specially designed for convenient prepara- tion of Lime Water. Add contents of vial to 1 gallon distilled water, shake briskly and repeat shaking several times during half an hour. The water will then be saturated, and the excess of lime will settle and should be allowed to remain in the bottle to insure constant saturation. Note: The entire contents of » vial should be used up at one operation; it will not do to employ a portion of them at a later date. Lime Sulphurated. See Calcium Sulphide Crude. Lime Juice. Succus Citrl, N. F. Expressed fresh juice of ripe fruit of Citrus medica acida (Fam. Huiacea). Each 100 mils (Cc.) contains 5 to 10 Gm. acids. Antiscorbutic, Refrigerant, Anti- septic. Lime Juice and Pepsin. Succus Citri et Pepsini, N. F, Glycerite pepsin 40 vol. percent., lime juice 60. Each fluidounce contains about 16 grains pepsin. Digestive. Average Dose: 2 fluidrachms (8 mils [Cc.]). Lime Water. See Solution Calcium Hydroxide. Liniment Aconite and Chloroform. Linimenlum Acottiti et Chloroformi, N. F. 100 mils (Cc.) contain 4.5 mils fluidextracl aconite and 12.5 mils chloroform, with soap liniment and alcohol. Anodyne embrocation. Anti° dotes: emetics; demulcents; atropine, digitalis, ammonia. © Liniment Ammonia. L'mimentam Ammonite; Volatile Liniment. I volume ammonia water and 3 volumes sesame oil. Stimulant and Anodyne embrocation. Liniment Ammonium Iodide. . , Linimenlum Ammonii lodidi, N. F. lodiiie, ammonia water, camphor, oils rosemary and lavender, and alcohol. Contains about 0.5 percent, ammonium iodide. Discutient. Liniment Belladonna. Linimentum Belladonna., 100 mils (Cc.) contain 5 Gm. cam- phor in fluidextract belladonna root. Anodyne. © Liniment Camphor, Squibb * bottle, pint Linimentum Camphorce; Camphorated Oil. 100 mils (Cc.) contain 20 Gm. camphor in cotton-seed oil. Anodyne, Rube- facient. The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE aualitv the SQUIBB quality; and our prices are as low as they can be r^ade for that quality. Specify SQUIBB'S. 144 SQUIBB'S MATERIA MEDICA Liniment Canada. See Liniment Opium Compound. Liniment Cantharides. bottle, pint Representing about 15 percent, cantharides in oil turpentine. Rubefacient, Counter-irritant. Antidotes: emetics; demulcents; morphine subcutaneously. © Liniment Chloroform, Squibb bottle, pint Lmlmcnlum Chloroformi. 3 volumes chloroform with 7 vol- umes soap liniment. Anodyne. Liniment Croto.n Oil. Linimenlum Tiglii, N. F. 13 vol. percent, croton oil, 43 oil cajuput and 44 alcohol. Counter-irritant, Rubefacient. Antidotes : emetics ; oil or mucilage ; atropine hypodermically ; cocaine. Liniment Croton Oil Compound. Llnlmentum Tiglii Compositam, N. F. 20 volume percent, each oils crolon, sassafras and turpentine, with 40 olive oil. Counter- irritant. © Liniment Lime. Linimenlum Calcis; Carron Oil. Equal volumes lime wafer and linseed oil. Emollient, Protective, Anodyne; in burns chiefly. Liniment Mustard Compound. Linimenlum Sinapis Composllum, N. F. Each 100 mils (Co.) contains 3 mils volatile oil mustard, 20 mils fluidextract meze- reum, 6 Cm. camphor, 1 5 mils castor oil, with alcohol. Counter- irritant, Rubefacient. Liniment Opium Compound. Linimenlum Opii Composilum, N. F.; Canada Liniment. 10 vol. percent, tincture opium, with camphor (1.75 percent.), oils turpentine and peppermint, ammonia water and alcohol. Ano- dyne. Antidotes: emetics; atropine or strychnine hypodermi- cally ; demulcents. © Liniment Soap, Squibb . bottle, pint Linimenlum Saponis; Liquid Opodeldoc; Camphorated Tinc- ture Soap. Each 1 00 mils (Cc.) contains 6 Gm. dried soap, 4.5 Gm. camphor, and 1 mil oil rosemary as perfume, with alcohol and water. Liniment Soap Camphorated. Linimenlum Saponalo-Camphoralum, N. F.; Solid Opodeldoc. A soft solid, containing soap, camphor, oils thyme and rose- mary, alcohol, and stronger ammonia water. Shmulating Anodyne. Liniment Soap Soft, Squibb bottle, pint Linimenlum Saponis Mollis; Tincture Green Soap. 100 mils (Cc.) contain 65 Gm. soft soap and 2 mils oil lavender, with alcohol. Detergent and Antipruritic, for use by surgeons and dermatologists, as well as for shampooing. Its alkalinity is very sHghl, merely sufficient to prevent rancidity. SQUIBB'S MATERIA MEDICA 145 Liniment Soap Soft, Compound. Linimentum Saponis Mollis Cpmpositum, N. F.; Compound Tincture Green Soap. 100 mils (Cc.) contain 15 Gm. soft soap, 2 mils oil cade, and alcohol. Antiparasitic Dermic. Liniment, Stokes'. See Liniment Turpentine Acetic. Liniment, St. Jolin Long's. See Liniment Turpentine Acetic. Liniment Turpentine. Ferti et Ammonii CUras; Soluble Iron Citrate; Ammonio- ferric turpentine. Counter-irritant, Rubefacient. Liniment Turpentine Acetic, Squibb bottle, pint Linimentam Terebinlhinos Acelicum, N. F.; Stokes' or St. John Long's Liniment; Linimentum Album. 40 vol. percent, oil turpentine, with egg, oil lemon,- acetic acid ^nd rose water> Counter-irritant, © Linseed. Linum; Flaxseed. Ripe seeds of Linum usitallssimum (Fam. Linacea). Demulcent, Emollient. Liquid Court Plaster. See Collodion Flexible. Liquid Petrolatum, Squibb Heavy (Califomian) 1 -pint bottles, per doz. Petrolatum Liqaidum; Mineral Oil, Heavy Calif ornian. Spe- cially repurified for medicinal use. Numerous comparative tests made by us show this Califomian oil to differ in essential respects from other American oils and to be superior to the best Rus- sian oils known to us. Therefore we have selected this Cali- fomian Heavy Oil, of high viscosity and high specific gravity, as the hest and now supply it on all orders. Concerning it the following facts are important; It is refined under our con- trol, and exclusively for us, by The Standard Oil Company of California. It is pure; free from paraffins, inorganic matter, organic sulphur compounds and all injurious hydrocarbons such as anthracene, phenanthrene, chrysene and oxidized acid and basic bodies, it is colorless, odorless and tasteless; has the Very high sp. gr. 0.886 to 0.895 at 15° C, or 0.881 to 0.890 at 25° C.; and it has" an exceptionally high natural viscosity — ■ which is of supreme importance because the value of liquid petrolatum is said to reside in lubrication; and true viscosity to be the chief index of lubricating power. Liquid Petrolatum Squibb is prescribed to prevent or relieve intestinal stasis, con- stipation, colitis and allied conditions; to prevent or relieve hemorrhoids; to regulate the mother's bowels during pregnancy and lactation, as its effect does not pass from mother to child. It is not a purgative, a cathartic, or a laxative, but a mechan- This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations ; if has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 146 SQUIBB'S MATERIA MEDIGA © Liquid Petrolatum, Squibb (Cont.) ical lubricant; It is not absorbed by the stomach or intestine, does not act on and is not acted upon by the fluids of the gastro-intestinal tract, and passes out of the body in exactly the same condition and quantity that it entered. During its pas- sage it lubricates the lumen of the gut, softens the feces, pre- vents injury of the mucous membrane by scybala, allows repair of an already abraded mucosa, relieves irritated or fatigued myenteric ganglia, and thus, by permitting a rapid passage of the intestinal contents, prevents the proliferation of bacteria and the production of toxins and a consequent auto-intoxication. In short, its use establishes and maintains a proper body drain- age, allowing better digestion and absorption of food. In surgery it is used as an aid in differentiating a surgical intes- tinal case from one non-surgical; also as a prophylactic to pre- vent the ascent of intestinal bacteria, thereby preventing sec- ondary infection of biliary and other ducts. In the peritoneal cavity it is used to prevent adhesions or, by Burrows' method, to forestall post-operative stasis. It is useful as a dressing for burns, also for nasal packings and spray. Liquid Petrolatum Squibb sprays better than does a light oil, and lubricates the nasal mucosa more thoroughly and the lubrication Is more last- ing. Dosage: As pure liquid petrolatum has no physiological action, it may be given in any quantity without harm. As i'. is not chemically active and resists chemical change, iris com- patible -with any medication indicated. However, certain facts about dosage are worthy of note. The length and calibre of the gastro-intestinal tract differ not only with age but in different individuals of the same age. Therefore the quantity of oil necessary for lubrication will vary. The conditions for which heavy liquid petrolatum is indicated are various, so the size and number of doses may vary. For instance, there must be considered the nature, amount, and consistency of the con- tents of the bowel; the pathological relaxation or hypertonicity of the intestinal walls; the degree of entero- or viscero-ptosis; the number, kind and place of adhesions, bands or kinks; also whether the life of the patient is active or sedentary. Larger and more frequent doses are necessary at the beginning of treatment than after a normal Intestinal condition has been established. In every case a minimum regulating dose should be determined and maintained, not because more oil would do harm, but because it would be wasted. Intestinal lubrication can be produced best when the tract is comparatively empty. The best time for administration, then, is between meals and at bedtime. However, individual preferences for other times may be gratified. An ordinary dose for adults is one table- spoonful between meals and two tablespoon fuls on going to bed. Children and infants need only smaller quantities. As Liquid Petrolatum Squibb is odorless and tasteless, flavoring or a menstruum is not necessary, although such may be added if desired. When prescribing mineral oil, specify Liquid Petro- latum Squibbt and thereby assure a pure, heavy, and viscous mineral oil of the highest quality. SQUIBB'S MATERIA MEDICA J47 Liquorice. See Glycyrrhiza. Litharge. See Lead Oxide Yellow. Lithium Benzoate, Squibb *From Synthetic Acid bottle, !4 lb. ; oz. From Natural (True) Acid bottle, !4 lb. ; oz. Ltlhi! Benzoas, U. S. P. Vllth Rev. LiC7H502. White powder or scales; odorless or faint benzoin odor; cooling, sweetish taste. Soluble in 3 parts water, 13 alcohol; aqueous solubility iiicreased by sodium benzoate and lessened by alco- hol. Used as Antirheumatic, Internal Antiseptic. Average Dose: 1 Gm. (15 grains). Litiiium Bromide, Squibb bottle, %\h. ; oz. Lithii Bromldum. LiBr. White, granular, odorless, very deli- quescent salt; sharp, slightly bitter taste. I Gm. dissolves in 0.6 mil (Cc.) water; freely soluble in alcohol, moderately in ether. Nerve Sedative. Average Dose: 15 grains (1 Gm.). Incompatible with alkaloidal salts in solution. Must be kept securely stoppered, in dry place. Lithium Carbonate, Squibb carton, lb. ; V^ lb. ; oz. LUhii Carbonas. Li2C03. White, light, odorless powder, of alkaline taste. 1 Gm. dissolves in 78 mils (Cc.) water, 140 boiling water; more freely soluble in water saturated with carbon dioxide; almost insoluble in alcohol. One of the most commonly employed salts of lithium. 'Systemic Antacid. Average Dose: 8 grains (0.5 Gm.). Lithium Citrate, Squibb bottle, 14 lb. ; oz. Lithii Ciiras. Li3C6H607.4H20. White, odorless powder; slightly deliquescent; cooling, faintly alkaline taste. I Gm. dissolves in 1.4 mils (Cc.) water; almost insoluble in alcohol or ether. Systemic Alkali, Diuretic. Average Dose; 8 grains (0.5 ,Gm.). Lithium Citrate, Granular Effervescent, Squibb bottle, lb. ; 4-oz. bottles, per doz. Sal Lithii Citratis Effervescens, N. F. Dropped from U. S. P. 5 percent, lithium citrate.' Average Dose; 120 grains (8 Gm.). Lithium Glycerophosphate, Squibb bottle, oz. C3H703PO(OLi)2. White water-soluble powder. Used . as Nervine, chiefly in gout with nervous debility. Dose : 3 to 10 grains (0.2 to 0.65 Gm.). Avoid hot solvents. Aque- ous solutions do not keep well; 1 minim chloroform to each fluidounce retards deterioration. The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. Theyinchjdecontainers,pacl«ing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 148 SQUIBB'S MATERIA MEDICA Lithium Salicylate, Squibb bottle, J4 lb. ; oz. Lithii Salicylas, N. F. Dropped from U. S. P. LiQHsOa. White or grayislr-white, odorless, sweetish powder. Very solu- ble in water or alcohol. Antirheumatic, Intestinal Antiseptic. Average Oose: 13 grains (I Gm.). Lithium Tartrate, Squibb bottle, oz. Li2C4H406.H20. White, crystalline powder. Soluble in water. Dose: 5 to 15 grains (0.3 to I Gm.). Litmus Paper, Squibb Blue, Red or Neutral. * strips, 1 00 in vial, ; box of 1 vials, sheets, 2 in tube. Liver of Sulphur. See Potassa Sulphurated. Lobelia, Squibb Ground jor Percolation tin, lb. Lobelia; Indian Tobacco. Dried leaves and flowering lops of Lobelia inflaia (Fam, Lobeliacea), Antispasmodic, Ex- pectorant; mainly in pectoral affections. Average Dose: 21/2 grains (0.15 Gm.). (See also Fluidextract; Tincture.) Logwood. See Hematoxylon. Lotion Ammoniated Camphor. Lolio Ammoniacalis Camphorata, N. F.; Aqua Sedativa, N. F. HI. Each 1000 mils (Cc.) contains 60 Gm. sodium chloride,- 60 mils ammonia water, 10 mils spirit camphor, with water. Topical Anodyne and Sedative. Shake well before dispensing. Lotion, Black. Lotio Nigra, N. F.; Black Wash. Each 1000 mils (Cc) contains 8.75 Gm. calomel, 15 mils water, lime water q. s. Antiseptic, Cicatrizant, Parasiticide. Shake well before dis- pensing. Lotion Lead and Opium. Lolio Plumbi ei Opii, N. F. Each 1000 mils (Cc.) contains 17.5 Gm. lead acetate, 35 mils tincture opium, water q. s. Antiphlogistic. Shake well before dispensing. Lotion, Yellow. Lotio Flava, N. F.; Yellow Wash. Each 1000 mils (Cc.) contains 3 Gm. corrosive sublimate, 35 mils water, lime water q. ». Topical Antiluetic, Vulnerary. Shake well before dis- pensing. Lugol's Solution. See Solution Iodine Compound. Lunar Caustic. See Silver Nitrate Moulded. SQUIBB'S MATERIA MEDICA 149 LUPULIN. Lupulinum, N. F. Dropped from U. S. P. Glandular trichomes separated from strobiles of Humulus Lkipalus (Hops). Granular, brownish-yellow to brown powder,- odor and taste of hops. Yields not less than 60 percent, of ether-soluble mat- ter. Bitter Tonic, asserted Antaphrodisiac. Average Dose: 8 grains (0.5 Gm.). Lycetol. Dimethylpiperazine Tartrate. White, odorless powder. Sol- uble in water. Diuretic, Uric-acid Solvent. Dose: 15 to 30 grains (I to 2 Gm.), in carbonated water. Lycopodium. L^copodlum, Spores of Lycopodium clavatum (Fam. Lyco- podiacece). Fine, light-yellow, very mobile, odorless, taste- less powder. Absorbent Dusting-powder; in intertrigo, etc. Also used pharmaceutically and technically. Mace Powdered, Squibb tin, lb. sprinkler-top tins, for table use, 4 oz., per doz. 2 oz., per doz. 1 oz., per doz. Macis, N. F. Being part of covering of nutmeg, it possesses similar properties. Yellowish-red; strong odor and taste; con- tains 7 to 9 percent, volatile oil. Condiment, Aromatic, Car- minative. Average Dose: 8 grains (0.5 Gm.). Macrotys. See Cimicifuga. Magma Bismuth. See Bismuth Magma, Magma Ferric Hydroxide. Magma Ferri Hydroxidi, N. F.; Ferric Hydroxide, .U. S. P. Vlllth Rev. Freshly prepared, brownish-red magma; insoluble in water. For chemical or pharmaceutical use. Magma Magnesia. See Magnesia Magma. Magnesia Alba. See Magnesium Carbonate. Magnesia Calcined, Heavy, Squibb tin, lb. ; 14 lb.- Magnesii Oxidum Pondsrosum; Ponderous Magnesia. MgO. A special, medicinal quality; not the regular market article. Action and dose as of following. if difficulty is experienced in procuring any Squibb product, n the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 150 SQUIBB'S MATERIA MEDICA © Magnesia Calcined, Light, Squibb tin, lb. ; '/^ lb. Magnesii Oxiium; Magnesia; Light Magnesia; Magnesia Usta. MgO. A special medicinal quality; not the regular market article. Prepared by thorough ignition of light carbonate. Almost insoluble in water; insoluble in alcohol. White, very bulky, fine, odorless powder; earthy taste. Absorbent dusting powder; Antacid, Laxative. Average Dose: 30 grains (2 Gm.) ; small doses are antacid, large ones laxative. Magnesia Magma, Squibb bottle, pint, ; Yi pint Magma Magnesia; Milk of Magnesia. Completely hydrated magnesium hydroxide in aqueous suspension. Yields 6.5 lo 7.5 Mg(HO)2; equivalent on average to 32 grains per fluid- ounce. Antacid, in conditions arising from gastric hyperacidity ~ and in milk modification for infant feeding; Neutralizing Denti- frice; Vehicle for salicylates, iodides, etc. Average Dose: TYz fluidrachms (10 mils [Cc.]). Magnesia Usta. See Magnesia Calcined, 'Light. © Magnesium Carbonate, Squibb carton, lb. Magnesii Carbonas; Light Magnesium Carbonate; Magnesia Alba. (MgC03)4.Mg(OH)2.5H20. A specially repurified, medicinal quality; not regular market article, which is vastly less costly. Yields upon ignition not less than 39.2 percent, magnesium oxide. Very light, white powder. Odorless; slightly earthy taste. Practically insoluble in water; jnsolubL in alcohol. Dustirig powder; Antacid, Laxative. Average Dose : 45 grains (3 Gm.) ; large doses are laxative. Magnesium Chloride. Magnesii Chloridam, N. F. MgCl2.6H20. Colorless, bitter, deliquescent crystals. 1 Gm. dissolves in about 0.6 mil (Cc.) water; readily soluble in alcohol. Saline Cathartic. Average Dose: 4 drachms (16 Gm.). Magnesium Chloride Reagent. See Reagents (Part IV). Magnesium Citrate, Oranular Effervescent, Squibb bottle, lb. ; 4-oz. bottles, per doz. Each drachm contains about 10 grains anhydrous magnesium citrate. Mild SaHne Laxative. Dose: 120 grains (8 Gm.). Magnesium Glycerophosphate, Squibb bottle, oz. MgOa.CsHTOgPO^ White powder. Sparingly soluble in water; soluble in dilute acids. Employed in neurasthenia, rickets, difficult dentition, etc. Dose: 3 to 6 grains (0.2 to 0.4 Gm.). Its solutions do not keep well; 1 minim chloroform to fluidounce is said to retard deterioration very, materially. Magnesium Hypophosphite, Squibb bottle, ; 14 lb. ; oz. Mg(H2P02)2.6H20. White crystals. Soluble in water. Used as Tonic. Dose: 3 to 10 grains (0.2 to 0.65 Gm.). Care should be observed' in dispensing this salt, as explosion is liable to occur when triturated or> heated with- nitrates, chlorates or other oxidizing substances. SQUIBB'S MATERIA MEDICA 151 Magnesium Oxide. See Magnesia Calcined. Magnesium Peroxide. Magnesium Dioxide. MgOa. White powder. Insoluble in water, but gradually decomposed by. it into hydrogen peroxide and magnesium hydroxide and former then decomposed by lat- ter with liberation of oxygen. Gastro-intestinal Antiseptic, Antacid. Dose: 4 to 8 grains (0.25 to 0.5 Gm.). Magnesium Phosphate, Squibb bottle, lb. ; !4 lb. ; oz. Magnesium Phosphate Dibasic. MgHP04+aq. White, crys- talline powder. Soluble in dilute acids'; slightly in water. Alterative, Antirheumatic. Dose: 10 to 20 grains (0.65 to 1.3 Cm.). Magnesium Salicylate, Squibb tin, lb. ; J4 'b. ; 1-oz. vial, Mg(C7H503).4H20. White, crystalline po\vder, containing about 74 percent, of salicylic acid. Soluble in about 5 parts water. Antirheumatic and Antifermentative, like Sodium Sa- licylate, but latterly recommended especially as an intestinal ■ Antizymotic. Dose : 5 to 30 grains (03 to 2 Gm.) three times daily, between meals. (See also Tablets [Part II].) © Magnesium Sulphate, Squibb (Granular) tin, lb. ; '/2 lb. ; !4'lb. Magnesii Sulphas; Epsom Salt. MgS04.7H20. A recrys- tallized, distinctive quality, almost free from the bitterness usu- ally found in the regular market article. Repurified by recrys- tallization, to remove dirt and mechanical impurities unavoid- ably present- in ordinary grade because of the crude method of its preparation on a large scale; It is carefully put up to pre- serve its cleanly condition, and will be found to make a clear solution wholly free from arsenic and. heavy metals. Small, colorless, odorless, slowly efflorescent granules, of cooling, saline, bitter taste. I Gm. dissolves in 1 mil (Cc.) water; insoluble in /alcohol. Active Saline Cathartic; latterly also used locally as an Antiphlogistic in erysipelas, ivy poisoning and cutaneous inflammation in general, a saturated aqueous solution being employed on compresses constantly kept moist with the lotion; also credited with Local Anesthetic and Antitetanic power when used by subarachnoid injection. Average Dose : 240 grains ( 1 6 Gm.) . Acts in I/2 to 1 hour' if taken before break- fast; in 2 to 4 hours if patient is in bed. (See also Reagents.) The Squibb products are recognized everywtiere as the Quality •Standard. They are of uniform purit;/ and strength, hence therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 152 SQUIBB'S MATERIA MEDICA Magnesium Sulphate Exsiccated, Squibb carton, lb. ; J4 "'• The foregoing crystalline magnesium suIpKate deprived of its water of crystallization. Action same as preceding granular salt, but twice as strong. Used also as Reagent. Average Dose: 120 grains (8 Gm.). Magnesium Sulphate, Granular Effervescent, Squibb bottle, lb. ; 4-oz. bottles, per doz. Contains 50 percent, magnesium sulphate. Dose; I/2 to -1 oz. tr. (16 to 32 Gm.). Magnesium and Ammonium Phosphate, Squibb bottle, lb. ; <4 lb. ; oz. Mg(NH4)P04.6H20. White, odorless, tasteless powder. Insoluble in ordinary organic solvents. Gastric Sedative and Protective, like bismuth salts; also used in gout, Dose: 10 to 30 grains (0.65 to 2 Gm.). © Male Fern. See Aspidium. Mallow Leaves. Malva Folia, N. F. Dried leaves of Malva s^lvestris and M. Toiundifolia, (Fam. Malvacee). Inodorous; mucilaginous, bland taste. Demulcent "herb tea,' Malt. Malium. Grain of HorJeum sativum (Fam. Craminea), partly germinated artificially, then dried. Yellow or amber grains; agreeable odor; sweet taste. 1 Gm. converts 5 Gm. potato starch into sugars. (See also Extract.) © Mandrake. See Podophyllum. Manganese Citrate Soluble, Squibb bottle, oz. Mangani Cilras Solubllis, N. F. Pinkish, glistening, odorless, slightly hygroscopic scales, containing about 13.5 percent, man- ' ganese. 1 Gm. dissolves slowly in about 4 mils (Cc.) water; nearly insoluble in alcohol. Hematinic, but designed especially for use in preparing Solution Iron Peptonate and Manganese. Manganese Dioxide Precipitated, Squibb oz. Mangani DioxlJum Pracipitalum ; Manganese Peroxide or Hyperoxide; Black Oxide of Manganese. Not less than 80 percent. Mn02, with small amounts of other oxides of man- ganese. Great care is observed in its manufacture, and it is proven to conform in all respects to U. S. P. requirements. Heavy, fine, black, odorless, tasteless, insoluble powder. Altera- tive and Emmenagogue internally; Dermic (10 to 25 percent^ ointment) externally. Average Dose: 4 grains (0.25 Gm.). (See also Reagents [Part IV]; Tablets [Part II].) SQUIBB'S MATERIA MEDICA 153 Manganese Glycerophosphate, Squibb bottle, oz. Mangani Clycerophosphas Solubilis, N. F. Yellowish to brownish or pinkish powder. Contains 70 to 75 percent. MnCsHiPOe, with citric acid. I Gm. dissolves in about 4 mils (Cc.) water. Used as Nerve Tonic; in neurasthenia, con- valescence, etc. Average Dose: 3 grains (0.2 Gm.). Its solutions do not keep well; 1 minim chloroform to each fluid- ounce retards their deterioration. Manganese Hypophosphite, Squibb bottle, lb. ;^lb. ; oz. Mangani Hypophosphis, N. F. Mn(PH202)2-H20. Pink, odorless, nearly tasteless salt. Freely soluble in water; almost insoluble in alcohol. Hematinic. Average Dose: 3 grains (0.2 Gm.). Manganese Oxide, Black. See Manganese Dioxide. Manganese Sulphate, Squibb bottle, lb. ; !4 lb. ; oz. Mangani Sulphas, N. F. ; Manganous Sulphate. Dropped from U. S. P. MnS04.4H20. Colorless or pale-pink, trans- lucent, slightly efflorescent, odorless, bitter-astringent crystals. 1 Gm. dissolves in about 1 mil (Cc.) water; insoluble in alco- hol. Used as Hematinic and Alterative internally; Dis- cutient externally (10 to 20 percent, ointment), in stiff joints from gout, rheumatisin, etc. Average Dose : 3 grains (0.2 Gm.) . (See also Reagents [Part IV] .) Manna. Manna. Dried saccharine exudation of Fraxinus Ornus (Fam. Oleaceai). Yellowish-white, irregular, elongated pieces or masses; slight, characteristic odor; sweet, slightly acrid taste. Mild Cathartic, Sweetener; usually prescribed with other purga- tives, and mostly for children. Average Dose: 4 drachms (16 Gm.). Marigold. See Calendula. Marsh Mallow Powdered. See Althaea Powdered. Mass, Blue. See Mass Mercury. Mass Copaiba. Massa Copaiba, N. F. ; Solidified Copaiba. 94 percent, copaiba, massed with 6 percent, magnesium oxide. Antica- tarrhal. Antiseptic, Cicatrizant. Average Dose: 15 grains (I Gm.). Since we make only one quality of eacii product, tiiat best suited to the purposes intended, the specification Squibb's" is not open to various interpretations, but has a plain, positive meaning When ordeVing or prescribing, specify SQUIBB'S. 154 SQUIBB'S MATERIA MEDICA © Mass Ferrous Carbonate, Squibb jar, lb. ; V^ lb. Massa Ferrl Carbonatis; Valiet's Mass. Containing nol less than 35 percent. FeCOs. Hematinic. Average Dose: 4 grains (0.25 Gm.). © Mass Mercury, Squibb *PiluIar jar, lb. ; !4 lb. Powdered bottle, Jb. ; J4 lb- Blue Mass; Blue Pill; Mercury Pill. Made by a special formula yielding a product superior to U. S. P. Massa HyJrar- gyri. Contains 33 percent, mercury, as ofEcially demanded, but the althaea, and glycerin are replaced by sugar which serves the purpose better. A specially devised shaker sub- divides the mercury until the globules are invisible under a lens magnifying ten diameters. Mercury mass has a tendency to harden on the surface by age, which, however, does not affect its efficiency. A small quantity of glycerin is placed on the surface to minimize this condition. H not too old the mass immediately under the surface will be found of the normal consistency. Cathartic, Antiluetic. Average Dose: 4 grains (0.25 Gm.), as pills or tablets. (See also Tablets [Part II].) Mass, Valiet's. See Mass Ferrous Carbonate. Mastic. Mastiche, N. F. Concrete resinous exudation from Pistacia Leniiscus (Fam. Anacqrdiacece) . Pale-yellow or greenish- yellow, transparent, brittle tears; slight, balsamic odor; mild, terebinthinate taste. Carminative, Corrigent. Average Dose: 30 grains (2 Gm.). Matico. Matico, N. F. Dropped from U. S. P. Dried leaves of Piper angustifollam (Fam. Piperacea). Genito-urinary Stimulant, similar to buchu. Average Dose : 1 drachm (4 Gm.) . Matricaria, Squibb tin, lb. Malricana; German Chamomile. Dried flower-heads of Mat- ricaria Chamomilla (Fam. Compositte). Carefully differentiated from English chamomile and other allied species. Popularly used as a Bitter and Aromatic tea and poultice. Average Dose: 240 grains (16 Gm.) May Apple, See Podophyllum. Meadow Saffron. See Colchicum. Medinal. Brand of Barbital-Sodium. • 'SQUIBB'S MATERIA MEDICA 155 Melilot. Meliloius, N. F.; Yellow Sweet Clover. Dried leaves and flowering tops of Melilotus officinalis (Fam. Legaminosa) . Tonka-like odor; sweetish, slightly pungent taste. Emollient; also used as Stimulant and Antispasmodic, in neuralgia. © Menthol, Squibb bottle, oz. Menthol; Peppermint Camphor. C10H19OH. A secondary al- cohol from oil peppermint. Colorless needles; strong peppermint odor ; warm aromatic taste, followed by ■ sensation of cold when air is drawn into mouth. Very slightly soluble in water or glycerin; freely, soluble in alcohol, ether, chloroform, or fixed oils. It iiquefies when triturated with about an equal weigh» of camphor, thymol, chloral hydrate, phenol, betanaph- thol or resorcinol. Counter-irritant, Anodyne, Anesthetic, ex- ternally, in headache, toothache, skin diseases, coryza, etc.; Carminative, internally, in vomiting, colic, etc. Average Dose: 1 grain (0.065 Cm.). Menthol Camphorated, Squibb 1-oz. vial Menthol Camphoralum, N. F.; Campho- Menthol. Lique- fied mixture of equal parts camphor and menthol with 5 percent, alcohol. Local Anodyne, Counter-irritant. MenyaNthes. Men^anthes, N. F.; Buckbean; Marsh Trefoil. Dried leaves of Menyanihes trifoliata (Fam. 'Centianacea'). Bitter. Average Dose: 15 grains ,(' Gm.). Mercurol. Mercury Nucleinate. Brownish-white powder; 10 percent mercury. Soluble in water; insoluble in alcohol. Astringent, Anlipyic, Antisyphilitic. Applied in '/i to 5 percent, solution. Dose: J4 to 2 grains (0.03 to 0.13 Cm.). © Mercury Repurifled, Squibb stone bottle, lb. HydrargSram; Quicksilver. Hg. Sp. gr. 13.5. A very pure grade, practically free from foreign metals. Eligible for dental use and for all other uses demanding a highly pure product. (See also Reagents [Part IV].) ©Mercury Ammoniated, Squibb , (Powdered) bottle, lb. ; % lb. Hpdrargsrum Ammofiiaiiim ; White Precipitate; Mercury and Ammonium Chloride; Sal Alembroth. HgNH2Cl., Whiter- amorphous, odorless powder; earthy, afterwards styptic, metallic taste. Insoluble in water or alcohol. Antiparasitic Dermic, in 1 to 10 percent, ointment. (See also Ointment.) The founder of ttie House of Squibb, Dr. Edward R. Squibb, ndt only had high ideals, but lived and labored for them; and, in the words of William Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder," 156 SQUIBB'S MATERIA MEDICA Mercury Bichloride or Perchloride. See Mercury Chlo- ride Corrosive. Mercury Biniodide. See Mercury Iodide Red. Mercury Bromide (Mercuric) Reagent. See Reagents (Part IV). © Mercury Chloride Corrosive, Squibb * Powdered or Granular bottle, lb. ; 54 lb- Hydrargyri Chloridum Corrostvum; Corrosive Sublimate; Mercuric Chloride; Mercury Bichloride or Perchloride. HgCl2. Heavy, colorless, odorless granules, or white powder; acrid, persistent metallic taste. 1 Gm. dissolves in 13.5 mils (Cc.) water, 3.8 alcohol, 12 glycerin, 22 ether. Antiseptic, Alterative, Antiluetic; wash for wounds, etc., in syphilis, "skin diseases, chronic rheiimatism, ' etc. Also Reagent. Average Dose: 1/20 grain (0.003 Gm.). Incompatible with alkalies, alkaloidat salts; with copper, iron and zinc salts, hypo- phosphites; infusions cinchona, calumba, oak bark or senna. Antidotes: white of egg, or flour stirred in milk; emetics; Dr. Fanlus's antidote (6 grains sodium hypophosphite with 4 grains sodium acetate, or 15 grains sodium hypophosphite with 2^/2 fluidrachms water and V/4 fluidrachms solution hydrogen perox- ide. If amount of poison taken is known Dr. F. gives 10 times as much sodium hypophosphite, followed at once by copious gastric lavage with 3 percent, solution sodium bicarbpnate to which may be added. 8 grains sodium hypophosphite. The en- tire procedure is repeated every 8 hours" until gastric contents are free from mercury by Vogel's test) ; castor oil. (See also Tablets [Part II]; Reagents [Part IV].) © Mercury Chloride Mild, Squibb bottle, lb. ; 14 lb. H^drargsri Chloridum Mi(e ;. Calomel ; Mercurous Chloride; Mercury Subchloride or Prbtochloride. HgCl. Odorless, tasteless, impalpable powder. Insoluble in ordinary solvents. Cholagogue Cathartic, Antisyphilitic, Alterative, Intestinal Anti- septic; also Reagent. Average Dose: laxative, 2Y2 grains (0.15 Gm.);- alterative, etc., 14 grain (0.015 Gm.). Incom- , patible with iodine, soluble iodides and bromides, alkalies, al- kaloidal Salts, etc. (See also Tablets Calomel [Part II] ; Reagents [Part IV].) © Mercury Iodide Red, Squibb bottle, lb. ; % lb. ; oz. Hydrarg^ri lodldum Rubrum; Mercury Biniodide; Precipi- tated Mercuric Iodide. Hgl2. Scarlet-red, amorphous, odor- less, nearly tasteless powder. I Gm. dissolves in 115 mils (Cc.) alcohol, 910 chloroform, 120 ether; also soluble in solutions of soluble iodides, mercuric chloride and sodium thiosulphate ; almost insoluble in water -or glycerin. Anti- syphilitic, Alterative; in syphilis, scrofula, obstinate skin dis- eases, etc. Also Reagent. Incompatible with alkalies, alkali carbonates, alkaloid^l salts, etc. Average Dose: 1/20 grain (0.003 Gm.). (See also Tablets [Part II].) SQUIBB'S MATERIA MEDICA 157 © Mercury Iodide Yellow, Squibb bottle, lb. ; J4 lb. ; oz. Hydrargyri lodiium Flavum; Yellow Mercurous Iodide; Mer- 'cury Protiodide. Hgl. Yellow, odorless powder. Practically insoluble in water; insoluble in alcohol or ether. Antisyphilitic, Alterative. Average Dose: }/(, grain (0.01 Gm.). Incompatible with alkali iodides, bromides and chlorides; with oxidizing^ agents, etc. (See also Tablets [Part II].) Mercury Mass. See Mass Mercury. Mercury Nucleinate. See Mercurol. Mercury Oleate. See Oleate Mercury. Mercury Oxide Red, Squibb bottle, lb. 5 % lb. ; cz. HydraTgyri Oxidam Rubrum; Red Mercuric Oxide; Red Pre- cipitate. HgO. Heavy, orange-red, crystalline scales or pow- der; odorless; slight metallic taste. Almost insoluble in water; insoluble in alcohol. Used only externally, in J4 '° '0 per- cent, ointment, as Parasiticide and Antiluetic. (See also Re- agents [Part IV].) © Mercury Oxide Yellow, Squibb bottle, lb. ; % lb. ; oz. Hydrargyri Oxidum Flavum; Yellow Precipitate. HgO. Orange-yellow, amorphous, heavy, odorless, impalpable pow- der; slightly metallic taste. Almost insoluble in water; in- soluble in alcohol. Employed in 0.5 to 10 percent, ointment as Parasiticide, Cicatrizant, Antipyic; in ophthalmia, ring- worm, pediculi, chancre, etc. (See also Ointment.) Mercury Protiodide. See Mercury Iodide Yellow. Mercury Protochloride. See Mercury Chloride Mild. © Mercury Salicylate, Squibb bottle, oz. Hydrargyrl Salicylas; Mercuric Salicylate. While or pinkish- white, odorless, teisteless powder; 54 to 59.5 per cent. Hg. Nearly insoluble in water or alcohol; soluble in solutions of fixed alkalies or their carbonates. Antiluetic, Gonococcicide (1:300 suspension). Antiseptic (10 percent, powder or oint- ment). Average Dose: l/ie grain (0.004 Gm.); by intra- muscular injection, I grain (0.065 Gm.) in suspension every fourth to second day. Incompatible with iodides. (See also Ampuls.) The Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 158 SQUIBB'S MATERIA MEDICA Mercury Subchloride. See Mercury Chloride, Mild.. Mercury Subsulphate Yellow, Squibb bottle, oz. H})Jrarg\)ri Subsulphas Flaviis, U. S. P. 1890; Turpelh Min- eral; Basic Mecuric Sulphate. HgS04.2HgO. Heavy, yel- low, odorless, almost tasteless powder. Soluble in about 2,000 parts cold water, 25 hot water, Antiluetic, chiefly subcutane- Emetic; in syphilis, croup, etc. Dose: alterative Ya^°Y2 g<^ain (0.015 to 0.03 Gm.); emetic (in children), 2 to 3 grains (0.13 to 0.2 Gm.). Mercury Succinimide. Hg[(CH2.CO)2N]2. .White powder. Soluble in about 75 parts cold water, 25 hot water. Antiluetic, chiefly subcutane- ously ; said to be non-irritating. Dose : J/^ to % grain (0.01 2 to 0.025 Gm.) daily. (See also Tablets, Hypodermic [Part II].) Mercury Sulphide Red, Squibb bottle, oz. Vermilion; Artificial Cinnabar. HgS. Bright-scarlet powder. Insoluble in water, alcohol or hydrochloric acid. Used mostly technically; sometimes by fumigation in syphilis, 30 grains (2 Gm.) on red-hot iron arvd fumes inhaled. Mercury Tannate, Squibb bottle, oz. Mercurous Tannate. 2Hg2.3 (C14H9O9) .OH. Greenish-gray powder; 50 percent, mercury. Insoluble in ordinary solvents, Antiluetic. Dose: I to 2 grains (0.065 to 0.13 Gm.). (See also Tablets [Part II]). Mercury and Ammonium Chloride. See Mercury Ammoni- ated. ® Mercury with Chalk, Squibb bottle, ]4 lb. ; oz. H})drargsrtim cum Crela; Gray powder. 38 percent, mercury, incorporated in a state of very minute subdivision with 57 per- cent precipitated chalk. We use latter instead of prepared chalk (officially prescribed), because it yields. a better prpduct. Light gray, rather damp powder; odorless, slightly sweetish taste. Intestinal Antiseptic, Mild Cathartic, Antiluetic. Aver- age Dose: 4 grains (0.25 Gm.). (See also Tablets [Part H]-) Mergal. Mixture of Mercuric Cholale 1 part, and Tannin Albuminate 2 parts, in capsule form. % grain mercuric cholate equals in mercury content B/22 grain corrosive sublimate. Insoluble in water, readily soluble in digestive fluids. Antiluetic. Dose: 2!/2 to 5 grains (0.15 to 0.3 Gm.). Mesotan. Ericin; Methyloxymethyl Salicylate. Yellowish, faintly aro- matic, oily liquid, sp. gr. 1.2. Soluble freely in oils, alcohol, ether, chloroform; sparingly in water. Local Antirheumatic and Anodyne, Applied with equal volume olive oil. SQUIBB'S MATERIA MEDICA 159 Methyl Acetate, Squibb bottle, lb. ; '/i lb. QHgOa. Colorless, fragrant liquid; sp. gr. about 0.950. Mis- cihle with alcohol or ethers moderately soluble in water. Used technically. Methyl Aminoxybenzoate. See Orthoform. Methylbenzoylecgonine. See Cocaine. © Methyl Salicylate, Squibb bottle, lb. ; !4 lb. Methylls Salic^las; Synthetic (Artifieial) Oil Wintergreen. CH3C7H5O3. Practically identical with oils gaultheria and birch. Colorless, yellowish or reddish liquid; wintergreen odor; sweetish, aromatic taste. Sp. gr. 1.180 to 1.165. Soluble freely in alcohol, ether, chloroform; sparingly in water. Anti- rheumatic, Antipyretic; Flavoring. Average Doge: 12 minims (0.75 mil [Cc.]). Methylene Blue, Medicinal. See Methylthionine Chloride. Methylmorphine. See Codeine. Methylthionine Chloride, Squibb bottle, oz. Methylihionince Chloridum; Methylene Blue Medicinal. C16H18N3CIS.3H2O. Aniline derivative, free from arsenic, commercial dye and mineral impurities. Specially prepared for medicinal use. Ordinary methylene blue contains zinc chloride and arsenic, and is not eligible for medicinal use. Dark- green, crystalline powder, or crystals of bronze-like lustre. Readily soluble in water or alcohol; less freely in chloroform. Urinary Antiseptic, Antiperiodic, Anodyne; in malaria, ' gonorrhea, cystitis, carcinoma, etc. Also Reagent. Average Dose: 2'/2 grains (0.15 Gm.) ; by injection, 1 grain (0.065 Gm.). Urine becomes greenish-blue during use of this drug. Incompatible with potassium iodide and reducing agents.' Mezereum. Mezereum; Mezereon. Dried bark of Daphne Mezereum, D. CniJium or D. Laureola (Fam. Th'S'neleacea) . Antiquated Antiluetic and Vesicant. MiLR Fermented. Lac Fermenlatam, N. F.; Kumyss. Cow's milk fermented with compressed yeast and sugar. Nutrient. Average Dose: 8 fluidounces (240 mils [Cc.]). Milk of Almond. See Emulsion Almond. Milk of Asafetida. See Emulsion Asafetida. The Squibb Label on a package is a positive guaranty for the uniform Piirity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 160 SQUIBB'S MATERIA MEDICA Magma Bismuth. See Bismuth Magma. Magma Magnesia. See Magnesia Magma. Milk of Bismuth See Bismuth Magma. Milk of Magnesia. See Magnesia Magma. Milk of Sulphur. See Sulphur Precipitated. Milk Sugar. See Sugar of Milk. Mineral Oil. See Liquid Petrolatum. Mixture Almond. See Emulsion Almond. Mixture Ammonium Chloride. Mislura Ammonii Chloridi, N. F. Each fluidounce contains about 1 1 ]/2 grains each ammonium chloride and pure extract licorice, with water. Expectorant. Average Dose: 2 fiuidrachms (8 mils [Cc.]). Mixture, Astringent. Mislara AJslringens, N. F.; Mixture Astringenl and Eschar^ otic; Villale's Solution. Prepared from solution lead sub- acetate, copper sulphate, zinc sulphate and diluted acetic acid; the resulting lead sulphate being removed. Astringent (diluted with 3 or 4 parts water) and Escharotic (pure). Mixture, Basham's. See Solution Iron and Ammonium Acetate, Mixture, Brown. See Mixture Glycyrrhiza Compound. Mixture Camphor Acid. Mislura Camphor a: Acida, N. F.; Hope's Mixture. Each fluid- ounce contains 8^ minims nitric acid, 5^ minims tincture, opium, with camphor water. Intestinal Astringent. Average Dose: 2 fluidrachms (8 mils [Cc.]), Mixture Camphor Aromatic. Mislura Camphora Aromalica, N. F. ; Parrish's Camphor Mixture. Each 100 mils (Cc.) contains 25 mils compound tincture lavender, 3.5 Gm. sugar, camphor wdter q. s. Aro- matic Carminative. Average Dose: 2 fluidrachms (8 mils). fMiXTURE Carminative. Mislura Carminativa, N. F.; Dalby's Carminative. Each fluidounce contains 30 grains magnesium carbonate, l|/2 grains potassium carbonate, 12 minims tincture opium, J/^ minim each oils caraway, fennel and peppermint, with syrup and water. Carminative. Average Dose: infants', 8 minims (0.5 mil). Mixture Chalk, Mislara Creta. Compound chalk powder 20 percent., cinna- mon water 40 vol. percent. Antacid, Antidiarrheal." Average Dose: 4 fluidrachms (15 mils [Cc.}). SQUIBB'S MATERIA MEDICA 161 Mixture Chloral and Potassium Bromide Compound, Squibb pint, ; 14 pint MisiuTa Chloralis el Potassii Bromidi Composiia, N. F. Each fluidrachm contains about 1 1 J^ grains each chloral hydrate and potassium bromide, and {/g grain each extracts cannabis and hyoscyamus. Nerve Sedative, Hypnotic, Antispasmodic. Average Dose: 1 fluidrachm (4 mils [Cc.]). Mixture Chloroform and Cannabis Compound, See Mixture' Chloroform and Morphine Compound. > t Mixture Choloform and Morphine Compound. Mistura Chloroformi ei Morphina Composiia, N. F.; for- merly Mixture Chloroform and Cannabis Indica Compound. Each fluidounce contains about 60 minims chloroform, 89 minims tincture cannabis, 12 minims tincture capsicum, 15.6 minims ether, and 1'/^ grains morphine sulphate. Analgesic, Carminative. Average Dose: 30 minims (2 mils [Cc.]). Mixture Copaiba. Mistura Copaibas. N. F.; Lafayette, Mixture, Each fluid- ounce contains I fluidrachm each copaiba, spirit nitrous ether and compound tincture lavender, 15 minims solution potassium hydroxide, with syrup and mucilage acacia. Genito-urinary Adticatarrhal, Diuretic. Average Dose: 2 fluidrachms (8 mils). Mixture Copaiba and Opium. Mistura Copaiba el Opii, N. F.; Chapman's Mixture. Each 100 mils (Cc.) contains 25 mils copaiba, 25 spirit nitrous ether, 6.5 compound tincture lavender, 3.2 tincture opium, 12.5 mucilage acacia, water q.s. Used as Genito-urinary Anti- catarrhal. Diuretic; mainly in gonorrhea. Average Dose: 1 fluidrachm (4 mils). Mixture, Diarrliea. See Tincture Opium Compound. Mixture Glycyrrhiza Compound, Squibb pint, Mistura Cl^crrhize Composiia; Brown Mixture; Licorice Mix- ture. Containing pure extract glycyrrhiza, acacia, camphorated tincture opium, antimony and potassium tartrate (J/g gr. per fl. oz.), and spirit nitrous ether, in syrup and water. Expec- torant. Average Dose: Zj/z fluidrachms (10 mils [Cc.]). Mixture, Griffith's. See Mixture Iron Compound. Mixture Guaiac. Mislura Cuaiaci, N. F. Contains 12.5 volume percent, tinc- ture guaiac, with honey and cinnamon water. Alterative in chronic rheumatism, gout, etc. Average Dose: 4 fluidrachms (16 mils [Cc.]). This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. B 162 SQUIBB'S MATERIA MEDICA Mixture, Hope's. See Mixture Camphor Acid. Mixture Iron Compound. Mislura Ferri Composita, N. F.; Griffith's Mixture. Should te freshly made when wanted. Contains nascent ferrous car- bonate suspended in myrrh emulsion. Only the green mixture should be dispensed; not when it has become darker, reddish- brown in color. Hematinic; in chronic skin diseases, chlorosis, and other chronic conditions attended by anemia. Average ' Dose: 4 fluidrachms (16 mils [Cc.]). Mixture, Lafayette. See Mixture Copaiba. Mixture Licorice. See Mixture Glycyrrhiza Compound. Mixture Magnesia, Asafetida and Opium. Mislara Magnesia, Asafalida el Opii, N. F.; Dewees' Car- minative. Each fluidounce contains about 23 grains mag- nesium carbonate, 36 minims tincture asafetida and 5 minims tincture opium. Carminative, Antidiarrheal. Average Doge: 2 fluidrachms (8 mils [Cc.]). Mixture Oil Tar. Mistura Olei Pier's, N. F. ; Tar Mixture. Containing oil tar (16.8 minims per fl. oz.), purified extract glycyrrhiza, sugar, chloroform, oil peppermint, alcohol and water. Expectorant. Average Dose: 2 fluidrachms (6 mils [Cc.]). Mixture, Oleo-Balsamic. Mistura Oleo-Balsamica, N. F. 1000 mils (Cc.) contain 4 mils each oils lavender, cinnamon, thyme, lemon and nutmeg, 4 eugenol, 16 balsam Peru, with alcohol. Carminative, Analep- tic. Dose: 10 to 30 minims (0.6 to 2 mils [Cc.]). Mixture Opium, Alkaline. See Mixture Opium and Sassa- fras. Mixture Opium and Chloroform Compound. See Tinc- ture Opium Compound. t Mixture Opium and Rhubarb Compound. Mislura Opii el Rhei Composila, N. F.; Sun Cholera Mix- ture. Mixture of I volume tincture capsicum, 1 tincture rhu- barb, 2 each tincture opium, spirit camphor, spirit peppermint and alcohol. Intestinal Astringent, Carminative. Average Dose: 30 minims (2 mils [Cc.]). Mixture Opium and Sassafras. - Mistura Opii et Sassafras, N. F.; Godfrey's Cordial; Alkaline Mixture of Opium. Each fluidounce contains 1 .6 grains opium, 4 grains potassium carbonate and 0.5 minim oil sassafras. Car- minative, Sedative; in colic, diarrhea, etc. Average Dose: (in- iants'): 5 minims (0.3 mil [Cc.]). SQUIBB'S MATERIA MEDICA 163 Mixture, Parrish's. See Mixture Camphor Aromatic. Mixture Pectoral (Stokes'), Squibb ' pint Misiura Pecioraiis Stores, N. F.; Stokes' Expectorant. EacK fluidounce represents 8 grains ammonium carbonate, 16 grains each senega and squill, and 84 minims cairiphorated tincture opium, with syrup tolu and water. Average Dose : I fluidrachm (4 mils [Cc.]). Mixture Rhubarb Alkaline, Squibb pint Misiura Rhei ADialina, N. F.; Syrup Rhubarb and Potassa Compound; Neutralizing Cordial. Each fluidounce represents^ about 7J/2 grains each rhubarb and potassium carbonate, and 3^ grains hydrastis, with tincture cinnamon, spirit peppermint, syrup and alcohol. Antacid, Stomachic. Average Dose: I fluidrachm (4 mils [Cc.]). Incompatible with acids or alka' loidal salts. Mixture Rhubarb and Potassium Compound. jSee Mixture Rhubarb Alkaline. Mixture Rhubarb and Soda. See Mixture Rhubarb Com- pound. Mixture Rhubarb Compound, Squibb pint, Misiura Rhei ComposHa, N. P.; Mixture Rhubarb and Soda. Each fluidounce contains about 16 grains sodium bicarbonate, 7.2 minims 'fluidextract rhubarb, 1 .4 minims fluidextract ipecac, 168 minims glycerin, 16.8 minims spirit peppermint. Incom- patible with acids and with solutions ol alkaloidal salts. Stom- achic, Antacid. Average Dose: 1 fluidrachm (4 mils ^Cc.]). (Note. — On request we will supply specially, in lots of 1 gal- lon or more Mixture Rhubarb Compound made in accordance with the original formula of Dr. E. R. Squibb. On such orders please specify "Original Squibb Formula.") Mixture Sassafras and Opium. See Mixture Opium andi Sassafras. Mixture Soda and Spearmint. See Solution Soda and Mint, Mixture Tar. See Mixture Oil Tar. Monobromethane. See Ethyl Bromide. Monobromisovalerylurea. See Bromural. Monochlorethane. See Ethyl Chloride. Monsel's Salt. See Iron Subsulphate. The prices of the Squibb Products are in atl instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. Theyincludecontainers, packing and boxing. When ordering Or prescribing medicinal products, specify SQUIBB'S. 164 SQUIBB'S MATERIA MEDICA Monsel's Solution. See Solution Iron Subsulphale. t© Morphine, Squibb J/J-oz. vial, Morphina. C17H19O3N.H2O. White, odorless, bitter prisms, needles or powder. 1 Gm. dissolves in 3340 mils (Cc.) water, 210 alcohol, 1220 chloroform, 6250 ether. Analgesic, Sedative, Hypnotic. Average Dose: Yt, grain (0.008 Gm.). Antidotes: potassium permanganate ; apomorphine hypodermically as emetic ; atropine; strychnine or caffeine; strong hot coffee; exercise. t Morpliine Acetate, Squibb !4-oz, vial, Morphina: Acetas, U. S. P. Vlllth Rev. C17H19O3N.- C2H4O2.3H2O. While or yellowish-white, bitter powder; faint acetous odor. Soluble in 2.23 parts water, 21.6 alcohol, 480 chloroform, 5.2 glycerin. Becomes less soluble onvexposure. Incompatible in solution with alkalies, tannin, borax, bromides, chlorates, iodides, spirit nitrous ether, or mercury bichloride. Average Dose: !4 grain (0.015 Gm.). Keep well stoppered. •f® Morphine Hydrochloride, Squibb Yi-oz. vial, Morphina Hydrochloridam. C17H19O3N.HCI.3H2O.- White, silky, odorless, bitter needles, cubes or powder. I . Gm, dis- solves in 17.5 mils (Cc.) water, 52 alcohol, 8 glycerin; insol- uble in ether or chloroform. t© Morphine Sulphate, Squibb Morphina Sulphas. (Ci7Hi903N)2.H2S04.5H20. White, feathery, silky, odorless, bitter flakes or cubes. 1 Gm, dis- solves in 15.5 mils (Cc.) water, 565 alcohol; insoluble in ether or -chloroform. Mountain Balm. See Eriodictyon. ■© Mucilage Acacia. Mucilago Acacia. 35 percent, acacia. Demulcent, but used chiefly pharmaceutically. Incompatible with alcohol, ether, ammonia and strongly alcoholic or ethereal fluidextracts and tinc- tures. Average Dose: 4 fluidrachms (16 mils [Cc.)]. Readily becomes sour or mouldy, hence should be made frequently. Mucilage Chondrus. Mucilago Chondri, N. F.; Mucilage. Irish Moss. 3 Gm. in 100 mils (Cc). Emulsifier, Demulcent. Mucilage Sassafras Pith. Mucilago Sassafras Medulla, N. F. 2 Gm. in 100 mils (Cc). Emollient, Demulcent, Refrigerant, Average Dose: 4 fluid drachms (16 mils). .SQUIBB'S MATERIA MEDICA 165 Mucilage Tracacanth. Mucilago Tragacantha. 6 percent, tragacanik, 18 glycerin, ExcipienI for troches, lozenges, etc. Mullein Flqwers. yerbasci Flores.J^. F. Dried corollas, with adhering stamens,, of Verbascum phlomoiJes or of F. ihapsiforme (Fam. Scro- phulgriacets) . Demulcent, Vulnerary. Average Dose: 2 drachms (8 Gm.). Mullein Leaves. Verbasci Folia, N. F. Demulcent, Anticatairrhal. Average Dose: I drachm (4 Gm.). Mulls. Mulls; Salve Mulls. Ointments of high fusing points,, spread on soft muslin or "mull." The following mulls are noted in N. F.:— Acid Salicylic: 10%; Creosote SalicylateJ: 20% creosote, 10% salicylic acid; Mercuric Chloride: 0.2%; Zinc: 10% zinc oxide. Musk. Moschus; Deer Musk; Tonquin Musk. Dried secretion from preputial follicles of Moschus moschifexas (Fam. Moschida). Irregular, blackish, stiiny grains; peculiar penetrating, per- sistent odor; bitterish taste. Soluble in water to about 50 per- cent.; in alcohol, 10 percent. Antispasmodic, Analeptic; used largely in perfumery. Average Dose: 4 grains (0.25 Gm.). Musk-root. See Sumbul. Mustard, Powdered, Squibb tin, lb. sprinkler-top tins, 4-oz., per doz. ' 2-oz., per doz. Sinapis Alba; White, Yellow, or English Mustard. Ripe seed of Sinapis alba, carefully reduced to a coarse powder. Free from adulteration or added coloring-matter. Emetic, Counter- irritant; Condiment. Average Dose: 150 grains (10 Gm.), in lukewarm water. In making mustard plaster cold mater, that is water at ordinary" room temperature, should be employed to obtain satisfactory results. Boiling water destroys the enzyme which produces the useful volatile oil of mustard; hence a plaster made with it will not be active. ' For making table mustard, take: Squibb's Powdered Mustard, 3 teaspoonf uls ; Table Salt, ^4 teaspoonful ; Powdered Sugar, I teaspoonful ; Cider Vinegar, 8 teaspoonfuls. Mix the first three ingredients . , well, then add the vinegar with constant stirring. If difficulty is experienced in procuring any Squibb product, in the original pacl^ P^^' Oleum Morrhute; Cod Oil. Fixed oil pbtained from fresh livers of Cadus morrhaa and other species of Gadus (Fam. Cadids)* A Norwegian oil, of highest purity obtainable; light-straw color, fresh and bland in taste, and extracted from the livers before decomposition has set in. It is consequently much superior medicinally to the dark-colored, rancid oils of common knowledge. It is imported from Norway in the colder months of the year and at once bottled in order , to avoid even the start of rancidity. -Therapeutically the Norway oil has been proved preferable to oils, obtained from any other part of the , world. Particular attention is called to the agreeable or rather not disagreeable odor and taste of this oil. Sp. gr. 0.918 to 0.922. Soluble readily in ether or chloroform, in 2 parts acetic ether, very slightly in alcohol. Alterative Tonic, Nutrient* Occasionally employed topically (in certain chronic skin dis- eases). Average Dose: 2J/2 fluidrachms (10 mils [Cc.]), two hours at'ler meals, or at bedtime. Oil Coriander. Oleam Cotiandrl. Volatile oil from ripe fruit of Coriandrum sativum (Fam. Umbellifera). Colorless or palecyellow; spicy odor and taste; sp. gr. 0.863 to 0.875. Soluble in 3 volumes 70-percent., alcohol. Aromatic, Carminative. Average Dose: 3 minims (0.2 mil [Cc.]). Oil Cotton=Seed, Squibb bottle, lb. Oleum Coss^pii Seminis, Fixed oil expressed from seed's of cultivated varieties of Cossypium herbaceum and other species of Coss^pium (Fam. Malvacea). An especially purified product, particularly adapted to pharmaceutical and medicinal uses. Pale-yellow, odorless liquid, of bland, nut-like taste. Sp. gr. 0.915 to 0.921. Readily soluble in' ether or chloroform, very sparingly in alcohol. Demulcent, Emollient, Nutrient; fre- quently used in place of olive oil in preparations for external use. Dose: 2 to 4 fluidrachms (8 to 16 mils [Cc.]). © Oil Croton. Oleum Tiglii. Fixed oil expressed from seeds of Crolon Tiglium (Fam. Euphorbiacea) . Pale-yellow or brownish- yellow; slightly viscid and fluorescent; slight, fatty odor; mild, acrid, burning taste. Produces pustular eruption when applied to skin. Sp. gr. 0.935 to 0.950. Freely soluble in ether, chloroform, oils; slightly soluble in alcohol. Drastic Cathartic, Rubefacient, Vesicant. Average Dose: 1 minim (0.06 mil [Cc.]), on sugar or in pills with bread or other absorbent. Antidotes: bland oils, mucilage, atropine, cocaine. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had higti id/eais,, but lived and labored for them; sand, in the words of William Miller Bartlett, the House of Squibb stands today, as. a living monument to the honor, integrity, zeal and devotion- pf itSifounder." 172 SQUIBB'S MATERIA MEDICA Oil Cubeb. Oleum Cubebtc. Volatile oil from unripe fruit of Piper Cubeba (Kam, Plperacea). Colorless, pale-green or yellow- ish-green; characteristic odor; warm, camphoraceous taste; sp. gf. 0.903 to 0.925. Soluble in about equal volume alcohol. Stimulating Antiseptic, Expectorant, Urinary AnticatarrhaL Average Doge: 8 minims (0.5 mil [Cc.]). Oil Cypress. Volatile oil from Cupressus sempefeirens. Yellowish liquid; pleasant odor; sp. gr. 0.88 to 0.89. Soluble in alcohol. Anti- spasmodic; chiefly in whooping-cough by inhalation, a table- spoonful of 1 :5 alcoholic solution being poured three or four times daily over pillow, gown and underwear. Oil Ethereal, Squibb g. s. bottle, oz. Oleum /Eihereum, N. F. Dropped from U. S. P. Not in- frequently the composite, indeterminate residue from the ether still, and a nondescript distillate from grapes, are marketed as "oil of wine." The Squibb product is prepared from pure materials in absolute compliance with N. F. process and fpi> mula, and none of it that is not of uniform best quality is al- lowed to leave the laboratory. Transparent, nearly colorless, volatile liquid; aromatic, ethereal odor; pungent, refreshing, bit- terish taste; sp. gr. about 0.905. An ingredient of Spirit Ether Compound (Hoffmann's Anodyne) ; not used by itself medi- cinally. '© Oil Eucalyptus. Oleum Eucalspii. Volatile oil from fresh leaves of Euca- lyptus globulus or other species of £uca/jjt)(us (Fata. Myriacea), yielding not less than 70 vol. percent, eucalyptol. Colorless or pale-yellow; spicy taste; sp. gr. 0.905 to 0.925. Soluble in 4 volumes 70-percent, alcohol. Antiseptic, Deodorant; largely used by inhalation as vapor or oil sprays in subacute and chronic inflammations of respiratory tract. Average Dose : 8 minims (0.5 mil [Cc.]). Oil Fennel. Oleum Funiculi. Volatile oil from ripe fruit of cultivated varieties of Fceniculum valgare (Fam. Umbelliferce). Color- ^less or pale-yellow; characteristic odor; mild, sweetish, spicy taste; sp. gr. 0.953 to 0.973. Soluble in 8 volumes 80-percent, alcohol. Aromatic Carminative, Corrigent of griping action of cathartics. Average Dose: 3 minims (0.2 mil [Cc.]). ■Oil Gaultheria. See Oil Betula and Methyl Salicylate. 'Oil Hyoscyamus Compound. Oleum Hyoscyami Composilam, N. F. 1000 mils (Cc.) con- tain 2 mils each oils lavender, peppemiint, rosemary and thyme, infused oil hyoscyamus q. s. Anodyne embrocation. SQUIBB'S MATERIA MEDICA 173 Oil Juniper. Oleum Juniperi. Volatile oil from ripe fruit of Junipexus com- munis (Fam. Pinacets). Colorless or faintly green or yellow; characteristic odor; warm, aromatic, slightly terebinthinate, bit- terish taste; sp. gr. 0.854 to 0.879. Soluble in 4 volumes alcohol (almost clearly). Irritant Diuretic, Carminative. Average Dose: 3 minims (0.2 mil [Cc.]). Oil Juniper Tar. See Oil Cade. Oil Lavende*. Oleum Lavandula. Volatile oil from fresh flowering tops of Lavandula Vera (L. oficinalis^ L. spica; Fam. Labiaiay. Colorless or yellow; fragrant odor; pungent, bitterish taste; sp. gr. 0.875 to 0.888. Soluble in 3 volumes 70 percent, alco- hol. Aromatic, Stimulant, Tonic; Flavor, Perfume. Average Dose: 3 minims (0.2 mil [Cc.]). Oil Lemon. Oleum Limonis, Volatile oil obtained by expression from fresh peel of ripe fruit of CUrus medica Limonum (Fam. Rutaceie). yielding not less than 4 percent, citral. Pale-yellow or greenish- yellow; fragrant odor; aromatic, slightly bitterish taste; sp. gr. 0.85 1 to 0.855. Stimulant, but used- mainly as flavoring and in perfumery. Average Dose: 3 minims (0.2 mil [Cc.]). An oil having a terebinthinate odor should not be dispensed. © Oil Unseed. . Oleum Lini; Raw Linseed Oil. Fixed oil expressed from linseed. Yellowish; slight odor; bland taste; thickens, dark- ens and acquires strong odor and taste on exposure; sp. gr. 0.925 to 0.935. Miscible with ether, chloroform, oil turpen- tine; slightly soluble in alcohol. Protective Emollient, Laxa- tive. Average Dose: 1 fluidounce (30 mils [Cc.]). Boiled linseed oil must not be dispensed for medicinal use. Oil Mineral. See Liquid; Petrolatum. ©Oil Mustard Volatile. Oleum Sinapis Volatile, From black mustard, or synthetically. Yields not less than 92 percent, allyl isothiocyanate. Colorless or pale-yellow; very pungent, irritating odor; acrid taste; sp. gr. 1.013 to 1.020. Miscible with alcohol or ether. Vesi- cant, Counter-irritant; Stimulant. Average Dose: J/g minim (0.008 mil [Cc.]), well diluted. Antidotes: demulcents; mor- phine for pain. The Squihb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of ijniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. i74 SQUIBB'S MATERIA MEDICA Oil Myrcia. Oleum Myrcia, N. F.; Oil Bay. Volatile oil distilled from leaves of Pimenia acris (Fam. M^Tlacea). Yellow or brownish yellow liquid ; pleasant, aromatic odor ; pungent; spicy taste. Spj gr. 0.962 to 0.990. Almost clearly soluble in equal volume alcohol. Used technically. Oil Myristica. Oleum Myrisiica; Oil Nutmeg. Volatile oil distilled from kernel of ripe seed of Myrisiica fragrans (Fam. Myristicacea). Colorless or pale-yellow; characteristic odor; warm, spicy taste; sp. gr. 0.859 to 0.924. Soluble in equal volume alcohol, 3 volumes 90 percent, alcohol. Aromatic Carminative; flavor- ing. Average Dose: 3 minims (0.2 mil [Co.]). Oil Neroli. See Oil Orange Flowers. Oil Nutmeg. See Oil Myristica. Oil Olive, Squibb special bottle, pint, ; ]/2 pint, ; ]/4 pint. Oleum Oliva. Fixed oil expressed from fruit of Olea europaa (Fam. Oleacea). The best quality of olive oil is obtained from olives picked before maturity ^ and immediately pressed. It is then called "virgin oil" and has a greenish tinge. The residue of crushed olives left after extraction of the virgin oil is thrown into boiling water, which drives out the remaining oil, and this, together with the oil extracted from wholly ripe olives, consti- tutes the common oil for culinary purposes and for making soaps. The Squibb oil is virgin oil of especially fine flavor, im- ported from known sources and absolutely free from adultera- tion. , Pale-yellow or light greenish-yellow; slight odor; nutty, oleaginous taste, with faintly acrid after-taste. Sp. gr. 0.910 to 0.915. Soluble readily in chloroform or ether, very sparingly in alcohol. Emollient, Laxative, Nutrient; latterly also recom- mended for restoring the opsonic index after narcoses and in other depressed conditions of the system. Average Dose: 1 fluidounce (30 mils [Cc.]), between meals; in hepatic colic, 3 to 6 fluidounces (90 to 180 mils) Oil Orange. Oleum Auranitl. Volatile oil expressed from fresh peel of sweet orange. Yellow; characteristic aromatic odor; orange taste ; sp. gr. 0.842 to 0.846. Soluble in . about 4 volumes alcohol. Carminative; aromatic flavoring. Average Dose: 3 minims (0.2 mil [Cc.]). An oil having a terebinthinate odor should not be dispensed. Oil Orange Flowers. Oleum Auraniii Floram, N. F.; Oil Nerolt. Volatile oil dis- tilled from fresh flowers of bitter orange. Citrus Auranlium amara (Fam. Huiacea). Pale-yellow oil; fragrant odor like orange blossoms; aromatic, sweet then bitter taste; sp. gr. 0.868 to 0.880. Soluble in equal volume alcohol, 2 volumes 80-percent, alcohol. Flavoring agent. , SQUIBB'S MATERIA MEDICA 175 Q Oil Peppermint, Squibb bottle, lb. ; 14 lb- ;oz. Oleum Mentha PiperUai. Volatile oil distilled from flowering^ plant of Mentha piperita (Fam. Lahiata), rectified by steam distillation. Colorless liquid; strong peppermint odor; marked aromatic, pungent taste, followed by sensation of cold when air is. drawn dirougb the mouth; sp. gr. 0.896 to 0.908. Soluble in. 4 volumes 70-percent. ' alcohol. Aromatic Carminative ; flavor- ing. Average Dose: 3 minims (0.2 mil [Cc.]), well diluted.. (See also Spirit.) Oil, Phenolated. Oleiim Phenolalam, N. F.; Carbolized Oil. Olive oil with 5 percent, phenol (Carbolic Acid). Mild Local Stimulantr Antipruritic. Oil Phosphorated. Oleum Phosphoratum, N. F. I percent, phosphorus in ex- pressed oil almond with little ether. Reconstructive, Anticachec- tic; chiefly in rickets. Average Dose: 1 minim (0.06 mil [Cc.]), Oil Pimenta. Oleum Pimenta-; Oil Allspice. Volatile oil distilled from fruit of Pimenta officinalis (Fam. M^rtacece) yielding not less than 65 vol. percent, eugenol. Colorless, yellow or reddish, becoming darker with age; allspice odor and taste; sp. gr. 1.018 to 1.048. Soluble in equal volume 90 percent, alcohol, 2' volumes 70-percent, alcohol. Carminative; flavoring agent. Average Dose: 3 minims (0.2 mil [Cc.]). Oil Pine Needles. Oleum Pini Pumilionis; Dwarf-Pine Oil. Volatile oil from fresh leaves of Pinus Pumilio (Pinus montana; Fam. Pinacea). Colorless or yellowish; pleasant odor; bitter, pungent taste; sp. gr. 0.853 to 0.869. Soluble in about 5 volumes alcohol. Anti- septic, Anticatarrhal, by inhalation or internally,' in tuber- culosis, chronic bronchitis, etc. Dose: 1 to 5 minims (0.06 to 0.3 mil [Cc.]). Oil Rosemary. Oleum Rosmarini, Volatile oil distilled from fresh flowering tops of Rosmarinus officinalis (Fam. Labiat^z), yielding not less than 10 percent, borneol. Colorless or pale-yellow; char- acteristic pungent odor; warm, camphoraceous taste; sp. .gr. 0.894 to 0.912. Soluble in 10 volumes 80-percent, alcohol; in ether. Carininative ; aromatic flavoring. Average Dose: 3 minims (0.2 mil [Cc.]). @ Oil Sandalwood. Oleum Santali; Oil Yellow Sandalwood. Volatile oil dis- tilled from wood of Santalum album (Fam. Santalacea), yielding not less than 90-percent, santalol. Pale-yellow, thick liquid ; ^aromatic odor ; pungent, spicy taste ; sp. gr. 0.965 to 0.980. Soluble in 5 volumes 70-,percent. alcohol. Urinary Disinfectant and Anticatarrhal. Average Dose: 8 minims (0.5 mil [Cc.]). The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 176 SQUIBB'S MATERIA MEDICA Oil Sassafras. Oleum Sassafras. Volatile oil distilled from Sassafras Varii- folium (Fam. Laaracea). Yellow or reddish-yellow; sassa- fras odor; warm aromatic taste; sp. gr. 1.065 to 1,077. Soluble in 2 volumes 90-pel-cent. alcohol. Aromatic Carminative; Rubefacient; flavoring. Average Dose: 3 minims (0.2 mil [Cc.]). Oil Sesame. Oleum Sesami; Benne Oil. Fixed oil from seeds of cultivated varieties of Sesamum indicum (Fam. Pedaliacea). Pale-yel- low ; almost odorless ; bland taste ; sp, gr. 0.9 1 6 to 0.92 1 . Mis- cible with ether, cholorform; slightly soluble in alcohol. Nutri- ent, Emollient; substitute for olive oil. Oil Spearmint. Oleum Mentha Viridis, Volatile oil distilled from flowering plant of Mentha spicata (_M. viridis; Fam. Lahiata), Color- less, yellow or greenish-yellow; strong, spearmint odor; hot, aromatic taste; sp. gr. Q.9I7 to 0.934. Aromatic Carminative; flavoring. Average Dose: 3 minims (0.2 mil [Cc.J). Oil Tar Rectified. Oleum Picis Liquida Reciificatum. Volatile oil distilled from tar. Thick; dark reddish-brown; strong, empyreumatic odor and taste; sp. gr. 0.960 to 0.990. Soluble in alcohol, ether. Antiparasitic Dermic, Ejcpectorant. Average Dose: 3 minims (0.2 mil [Cc.]). © Oil Theobroma, Squibb tin, lb. Oleum Theobromatis ; Cacao Butter. Fixed oil expressed from roasted seeds of Theobroma Cacao. Yellowish-white solid; faint, agreeable odor; bland, chocolate-like taste; melts at 30° to 35° C. Soluble readily in ether, chloroform, oils. Used pharmaceutically and technically; also as Emollient and Lubricant. Oil Thyme. Oleum Th^mi. Volatile oil distilled from flowering plant of Thymus vulgaris (Fam. Labialai), containing not less than 20 vol. percent, phenols. Colorless or reddish; strong th}rme odor; aromatic, pungent afterwards cooling taste; sp. gr. 0.894 to 0.930. Soluble in 2 volumes 80-percent, alcohol; in ether, chloroform. Rubefacient, Counter-irritant; Carminative. Average Dose : 3 minims (0.2 mil [Cc] ). Oil Turpentine. .Oleum Terebinlhina; "Spirits of Turpentine." Volatile oil distilled with water from concretft oleoresin obtained from Pinus paluslris or other species of Pinus (Fam. Pinacea). Colorless; inflammable; characteristic' odor and taste; sp. gr. 0.860 to 0.870. Soluble in 5 volumes alcohol. Rubefacient, Counter-irritant. (See also Liniment, and following oil.) SQUIBB'S MATERIA MEDICA 177 ©Oil Turpentine Rectified, Squibb bottle, lb. Oleum Terebinthina Reclificatum. For medicinal use. Care- fully selected, purified by thoroughly washing with solution of caustic soda and rectifying by distillation, only three-fourths of the oil being recovered. Only. this rectified product should be dispensed when oil turpentine is required for internal use, Sp. gr. 0.856 to 0.865. Anthelmintic, Diuretic, Antiseptic, Car- minative; in tympanitis, tapeworm, retention of urine, phosphorus poisoning, etc. Average Dose : 5 minims (0.3 mil [Cc] ) ; in tapeworm, 1 to 2 fluidrachms (4 to 8 mils). Oil Wine. See under Oil Ethereal. Oil Wintergreen. See Methyl Salicylate and Oil Betula. Oil Wintergreen, Synthetic. See Methyl Salicylate. Oil Wormseed, American. See Oil Chenopodium. Oils, Infused. Olea Infusa, N. F., are dirgbted to be made by macerating 10 Cm. dried drug with 10 mils (Cc.) alcohol and 0.2 mil ammonia water for 6 hours, then adding 1 00' Gm. sesame oil and warming the mixture on water-bath at 60° to 70° C. until the alcohol and ammonia are dissipated. Oil-Sugars. Oleosacchara, N. F., are directed to be made by triturating 2 mils (Cc.) of the volatile oil with 100 pm. sugar. Ointment (Simple). Unguenlum. 20 percent, white wax. with benzoinated lard. Ointment base. Emollient. Ointment Acid Boric, Squibb jar, lb. ; 1 -oz. tubes Unguentum Aciii Borici. 10 percent, boric acid, 5 paraffin, 85 white petrolatum. Antiseptic Vulnerary. Ointment Acid Carbolic See Ointment Phenol. Ointment Acid Tannic Unguentum Acidi Tannici. Simple ointment, with 20 percent, each tannic acid and glycerin. Astringent, Antiseptic. Ointment, Basilicon. See Cerate Rosin. @ Ointment Belladonna, Squibb ^ jar, lb. Unguentum Belladonna. 10 percent, extract belladonna leaves, withwool-fat and benzoinated lard. Anodyne. This house supplies only one quality of each product: that best suited to the purposes intended. The speclficatior. Squibb s is not open to various interpretations ; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 178 SQUIBB'S MATERIA MEDICA Ointment, Blue. See Ointment Mercury Diluted. Ointment, Brown. Unguenlum Fuscum, N. F.; Mother's Salve. 50 percent, cam- phorated brown plaster, 25 olive oil, 25 suet. Antiphlogistic, Discutient; in cellulitis, felons, boils, etc. Ointment Calamine. Unguentum Calamina, N. F.; Turner's Cerate. 17 percent, calamine, with simple ointment. Drying Antiseptic. Ointment Camphor. Unguenlum Camphora, N. F. 22 percent, camphor, with white wax and lard. Antipruritic,, Anodyne. Ointment Carbolic Acid. See Ointment Phenol. © Ointment Chrysarobin. Unguenlum Chrysarobini. 6 percent, chrysarobin, with ben- zoinated lard. Antiparasitic. Should not be used oh large surfaces; .toxic! Ointment, Citrine. See Ointment Mercury Nitrate. Ointment Diachylon, Squibb jar, lb. Unguenhim Diachylon ; Hebra's Lead Ointment. 50 percent, lead plaster, 49 white petrolatum, I oil lavender. Astringent Dermic. Ointment, Hebra's Itch. See Ointment Sulphur Compound. Ointment, Hebra's Lead. See Ointment Diachylon. Ointment Iodine. Unguenlum lodi. 4 percent, each iodine and potassium iodide, with glycerin and benzoinated lard. Discutient. Should not be dispensed unless recently prepared. Ointment Iodoform. Unguenlum loJoformi. 10 percent, iodoform, with benzoin- ated lard. Vulnerary. Ointment Lead Iodide. jar, lb. ; % lb. ; % lb. Unguenlum Plumbl lodidl, N. F. 10 percent, lead iodide, with benzoinated lard. Discutient, in indolent ulcers, swollen glands, etc. ' © Ointment Mercury, Squibb jar lb. ; J4 't. Unguenlum Hydrargyri; Mercurial Ointment. Mercury 50%, suet 35, lard 15. While the mercury content is as U. S. P. demands, a deviation from official formula has been made, to produce a better product. The oleate of mercury officially pre- scribed for extinguishing the mercury is omitted, as special ap- paratus accomplishes the desired result more effectually. As the rapid absorption of the mercury depends upon the fineness of subdivision, this mercurial ointment will be found to give particularly quick and reliable results. Endermic Antisyphilitic. Dose (by inunction) : I drachm (4 Gm.) , night and morning. SQUIBB'S MATERIA MEDICA 179 © Ointment Mercury Diluted, Squibb ' jar.'lb. ; !4 lb- i J/i-oz. tubes, Unguenlum HydrargpriDilulum; Blue Ointmenl, A thorough- ly eifected combination containing 30' percent, of metallic mer- cury (as against 33 percent, in U.S.P. Vllllh Rev.). Anti- parasitic, Antiluetic, Dose (by inunction): V/z drachms (6 Gm.) twice daily. / Ointment Mercury Ammoniated. Ungaentum H^drargyri Ammoniati; Ointment A^hite Precipi- tate. 1 parts ammoniated mercury, 50 white petrolatum, 40 hydrous wool^fat. Antiparasitic Dermic. Ointment Mercury Ammoniated, 2%, Squibb J/g-oz. lubes, per doz. Ointment Mercury Chlorjde Corrosive, Spread. See Mulls. Ointment Mercury Nitrate, Squibb jar, lb. ; !4 lb. Unguenlum H'sirarg^ri Nitratis; Citrine Ointment.- This ointment will become comparatively hard in consistence on keep- ing, but practically no reduction of the mercuric nitrate takes place. Hardening of this ointment is evidence of formation of solid elaidin, and therefore pfoof of the purity of, the ma- terials used. It only requires gentle warmth or addition of a few drops of lard oil to bring it into a condition to be readily dispensed. Antiparasitic Dermic; in tinea capitis, impetigo, psoriasis, porrigo, etc. Ointment Mercury Oxide Red. * Unguenlum H^drarg^ri Oxidi Rubri, N. F.; Red Precipitate Ointment. 10 percent, red oxide mercury, with hydrous wool- fat and petrolatum. Stimulant Vulnerary, Parasiticide; in eye diseases, indolent ulcers, etc. Ointment Mercury Oxide Yellow, Squibb jar,)b. ;!41b. Unguenlum H^drarg^ri Oxidi Flavi; Yellow Precipitate Oint- ment. 10 percent, yellow oxide of mercury, with wool-fat and petrolatum. In The Squibb Laboratories this ointment is made by precipitating a very finely divided yellow oxide of mercury from a solution of mercuric chloride. The precipitate is washed until it is free from chlorides, and the moist magma is used' in preparing the ointment. This process has the advantage of yielding an ointment in which the oxide is in an extremely finely divided state, a condition not obtainable when the dry chemical is used, regardless of the method by which the dry salt mayhaVe been produced). Stimulant Anti- septic, chiefly in eye diseases. The prices of the Squibb Products are ir» all instances as low as the quality and quantity of ingredients and the expense of n>an- ufacture allow. They include containers, pacl 5 grains (0.13 to 0.3 Gm^), with sodium bicarbonate. Externally, in fissured tongue and diphtheria, in 5 percent, glycerino-aqueous solution. Paper, Litmus. See Litmus Paper. Paper, Potassium Nitrate. Charla Polassii Nitralis, N. F. Strips of naper soaked with 20% solution potassium nitrate and dried. Burned, and fumes inhaled in paroxysms of asthma. Paprika Powdered, Squibb tin lb. ; 4-oz. sifter-top tins, per doz. ; 2-oz. sifter-top tins, per doz. ; I -oz. sifter-top tins, per doz. A variety of red pepper largely employed as spice; less pun- gent and of richer flavor than capsicum, Paracoto. ParacotOf N. F.; Goto. Bark of unidentified tree indigenous to Northern Bolivia. Strong odor; pungent, nutmeg-like taste. - Intestinal Astringent. Average Dose: 5 grains (0.3 Gm.). (See also Fluidextract.) Q Paraffin. Paraffmum. Purified mixture of solid hydrocarbons from petroleum. White, odorless, tasteless mass. Soluble freely in ether, benzin, carbon disulphide, volatile oils; insoluble in water or alcohol. Sp. gr. about 0.900; melting-point 50° to 57° C. Used in surgery for prosthetic purposes, and in phar- macy for raising melting-point of ointments. Paraffin Liquid. See Liquid Petrolatum. Paraformaldehyde. ParaformaUehydum; Paraform; Trioxymelhylene. (HCHO)8. White friable masses or powder; slight formaldehyde odor. Slowly soluble in water; insoluble in alcohol, ether. Intestinal Antiseptic, Escharotic (in 10 percent, suspension in collodion). Used chiefly to generate formaldehyde by heating, for disin- fection. Average Dose: 8 grains (0.5 Gm.). Note: Its in- ternal use seems inadvisable since it has produced serious results. SQUIBB'S MATERIA MEDICA 187 ©Paraldehyde, Squibb. bqtile, lb. ; y^ lb. ; oz. Paraldehsdam. C6Hi203. Polymer of acetaldehyde. Color- less, transparent liquid; strong, pungent bder; burning, cooling taste. Sp. gr. about 0.990. I Gm. , dissolves in 8 mils (Cc.) water; in all proportions alcohol, ether, chloroform, oils, Prompt, ' fairly active Hypnotic and Sedative, devoid of ser- ious side-effects; in nervous insomnia, alcoholism, asthma, in- sanity, etc. Average Dose: 30 mininis (2 mils [Cc.]), well diluted. ' Parathyroid Gland Dried. 1 Gm. represents 6 Gm. fresh gland. Light-yellow powder; peculiar odor. Partially soluble in water. Antispasmodic, Nervine; in tetany following removal of parathyroid i glands, paralysis agitans, chorea, etc. Dose: 1/20 *o VlO grain (0.003 to 0.006 Gm.) three or four times daily. Paregoric. See Tincture Opium Camphorated. Pareira. Pareira, Nl. F.; Pareira Brava. Dropped from U. S. P- Dried root of Chondodendron tomentosum (Fam. Menisper- maceffi). Of slight odor; bitter taste. Bitter Tonic; used also as Diuretic and Alterative. Average Dose: 30 grains (2 Gm.). Parrish's Camphor Mixture. See Mixture Camphor Aro- matic, Parsley Fruit Pelroselinum ; Parsley Seed, Dried ripe fruit of Pelroielinum sativum (Fam. Umbellifera) . Used as Emmenagogue in form of its oleoresin. '^ Parsley Root. ' Petroselini Radix, N. F. Dried root of Peiroselinum sallvum (Fam. Umbelli feral). Aromatic odor; sweetish, pungent taste. Carminative. Average Dose: 30 grains (2 Gm.). Passion Flower. Passiflora, N. F. Dried herb of Passiflora incarnata (Fam. Passifioracephylii, N. F.; Triplex Pills, N. F. III. 2 grains aloes, I grain mercury mass, |/4 grain resin podophyllum. Cholagogue Cathartic. Average Dose: I pill. Pills Aloes, Mercury and Scammony Compound. Pilula Aloes, H^drarg^T' 6' Scammonii Composita, N. F.; Francis's Triplex Pills ; Pills Scammony Compound. About % grain each aloes, resin scammony, and mercury mass; ^20 minim croton oil; ]/^ minim oil caraway; massed with tincture aloes and myrrh. Drastic Purgative, Cholagogue. Average Dose: I pill. , Pills Aloes and Myrrh. P.7u/ie Squibb Products are in all Instances as low as the quality aiid quantity of Ingredients and the expense of nran- ufacture allow. TheylncTudecontainers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 196 SQUIBB'S MATERIA MEDICA Pills Colocynth Compound. Pilulte Colocynthidis Compositte, N. F.; Cochia Pills. Con- tain l/e grain extract colocynth, 2 grains each aloes and resin scammony, % minim oil cloves. Hydragogue Cathartic. Aver- age Dose: I pill. Pills Colocynth and Hyoscyamus. Pilula ColocynthidU el Hyoscyami, N. F. Contain l/io grain extract colocynth, lJ/2 grains each aloes, resin scammony and extract hyoscyamus, ]/(, minim oil cloves. Cathartic. Average Dose: 1 pill. Pills Colocynth and Podophyllum. Pilula Coloc^nihidis ei Podophylli, N. F. Contain 2J/2 grains compound extract colocynth and ]/i grain resin podophyllum. Hydiragogiie Cathartic. Average Dose: I pill. PilLs Digitalis, Squill and Mercury. Pilula Digitalis, Scilla et Hsdrargyri, N. F.; Niemeyer's Diuretic Pills; Guy's Pills, I grain each digitalis, squill, mercury mass. Average Dose: I pill. Pills, Dinner. Pilula ad Prandium, N. F. Stomachic, Laxative. Average Dose.: I pill. The National Formularly describes the ioUowi'-.g: Chapman's: IJ/2 grains each aloes and mastip, 1 grain ipecac, ]/4 grain oil fennel. Cole's: V/5 grains each aloes, mercury mass and jalap, I/50 grain tartar emetic. HalVs: I grain each aloes, extract glycyrrhiza and soap. Lady Websler's: See Pills Aloes and Mastic. Pills, Ferruginous. See Pills Iron Carbonate. Pills, Francis 'sj Triplex. See Pills Aloes, Mercury and Scam- mony Compound. Pills Glonoin. See Pills Nitroglycerin. Pills, Griffith's. See Pills Iron Carbonate. Pills, Guy's. See Pills Digitalis, Squill and Mercury. Pills, Hall's See under Pills, Dinner. © Pills Iron Carbonate. Pilula Ferri Carbonails; Blaud's Pills; Griffith's Pills; Iron Pills ; Ferruginous or Chalybeate Pills. I grain ferrous car- bonate. Hematinic. Average Dose: 2 pills. Pills Iron Iodide. Pilula Ferri lodidi; Blancard's Pills. 1 grain ferrous iodide, with powdered extract licorice, sugar and acacia, coated with solution balsam tolu. Alterative, Hematinic, Average Dose: 2 pills. SQUIBB'S MATERIA MEDICA 197 Pills Iron, Quinine, Aloes and Nux Vomica. Pilula Ferri, Quinina, .. Aloes el Nads Vomica, N. F.; Quadruplex Pills, N. F. Ill; Pills Iron and Quinine Com- I pound. 1 grain each dried ferrous sulphate, quinine sulphate and aloes, ]/i grain extract nux vomica. Used as Tonic. Average Dose: 1 pill. Pills Iron, Quinine, Strychnine and Arsenic. Two strengths are recognized by National Formulary. (1) Stronger (Metallic Pills; Bitter Metallic Pills): 1 grain each reduced iron and quinine sulphate, ^20 graiii each strychnine and arsenous acid. (2) Mil J (Aiken's Tonic Pills) : % grain reduced iron,~ 1 grain quinine sulphate, ^60 grain each strych- nine and arsenous acid. Tonic, Average Dose; 1 pill. Pills, Janeway's. See Pills Aloes and Podophyllum Compound. Pills, Lady Webster's. See Pills Aloes and Mastic. Pills Laxative Compound. Pilala Laxtftiv'tB ComposUa, N. F. About '/s grain aloin, Vl30 grain- sfrychiiine, j/g grain extract belladonna leaves, 1/ie grain ipecac. Laxative. Average Dose: 2 pills. Pills Laxative Post-Partum. Pilula Laxaliva Posi-Partam, N. F.; Barker's Post-Partum Pills, 1^ grains compound extract colocynth, % grain aloes, ^/l2 grain extract nux vomica, V12 g'ain each resin podophyllum and ipecac, V/^ grains extract hyoscyamus. Cathartic for lying- in women. Average Dose : 1 pillr Pills Metallic. See Pills Iron, Quinine, Strychnine and Arsenic, Stronger. Pills, Niemeyer's Diuretic. See Pills Digitalis, Squill and Mercury. Pills, Niemeyer's Phthisis. See Pills Opium, Digitalis and Quinine. Pills Nitroglycerin. , . Pilalai Clycerylis Nilratis, N. F.; Pills Glonoin. VlOO grain nitroglycerin. Antispasmodio, Vaso-dilator. Average Dose: 1 pill fPiLLs Opium and Camphor. Pilula Opii el Camphora, N. F. 1 grain powdered opium, 2 grains camphor. Intestinal Astringent and Anodyne, Antispas- modic. Average Dose: 1 pill. If difficulty is experienced in procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 198 SQUIBB'S MATERIA MEDICA tPiLLs Opium, Digitalis and Quinine. Pilula Opii, Digitalis el Qainina, N. F.; Niemeyer's Phthisis Pills. About Yd grain powdered opium, 1 grain digitalis, 1 grain quinine sulphate. Average Dose: 1 pill. fPiLLs Opium and Lead. Pilala Opii el Plumbi, N. F. I grain each powdered opium and lead acetate. Antidiarrheal. Average Dose: 1 pill. Pills Phosphorus. Pilula Phosphori. ^/loo grain phosphorus. Nerve Stimulant, Reconstructive. Average Dose: I pill. Antidotes: potassium permanganate solution, emetics; charcoal. Pills, Plummer's. See Pills Antimony Compound. Pills Post-Partum, Barker's.- See Pills Laxative, Post-Partum. Pills Quadruplex. See Pills Iron, Quinine, Aloes and Nux Vomica. Pills Rhubarb. Pilula Rhei, N. F. About 3 grains rhubarb, 1 grain, soap. Bitter Tonic, Stomachic. Average Dose : 1 pill. . Pills Rhubarb Compound. Pilula Rhei Composila. 2 grains rhubarb, V/i grains aloes, 1 grain myrrh, with oil peppermint as corrective. Laxative. Average Dose: 2 pills. Pills, Rufus's. See-Pills Aloes and Myrrh. Pills Scammony Compound. See Pills Aloes, Mercury and Scammony Compound. Pills Triplex. See Pills, Aloes, Mercury and Podophyllum. Pills Vegetable Compound. See Pills, Cathartic, Vegetable. Pills, Warburg's. See Pills Aniiperiodic. © Pilocarpine Hydrochloride, Squibb 13-grainviaI, ; 1 0-grain vial, ; 5-grain vial, Pllocarpina Hyiirochloridum. C11H16O2N2.HCI. Colorless, odorless, faintly bitter, hygroscopic crystals. I Gm. dissolves in 0.3 mil (Cc.) water, 3 mils alcohol, 366 chloroform; in- soluble in ether. Indompalible with iodides, calomel, alkalies. Sialagogue, Galactagogue, Diaphoretic; Myotic externally. Average Dose: i/6_ grain (0.01 Gm.); hypodermic, 1/12 grain (0.005 Gm.). Antidotes: tannin, emetics; atropine; ammonia; brandy later. Keep well stoppered. ® Pilocarpine Nftrate. Pilocarplna Nilras. CHH16O2N2.HNO3. Colorless, odor- less, faintly bitter crystals. 1 Gm. dissolves in 4 mils (Cc.) water, 75 alcohol ; insoluljle in chloroform, ether. Dose : as preceding. SQUIBB'S MATERIA MEDICA !99 Pilocarpus. Pilocarpus; Jaborandi. Dried leaflets of Pilocarpus Jahorandi or P. microphallus (Fam. Rulacea). Assays not less than 0.6 percent, alkaloids. Diuretic, Diaphoretic^ Galactagogue. (See also Fluidextract.) Pimenta. See Allspice. PiMPINELLA. Pimpinella, N. F. Dried rhizome and roots of Pimpinella Saxifraga or of P. magna (Fam. Umbellifera). Aromatic odor; sweetish, pungent, acrid taste. Formerly used as Diur- etic Diaphoretic, Stomachic. Average Dose: 13 grains (I Gm.). Pineal Gland Dried. Pineal gland of young cattle, freed from connective and other tissue, dried and powdered. 1 Gm. represents about 7 Gm. fresh gland. Used in backward mental development of chil- dren, mongolism, etc. Dose: 1/20 to l/IO grain (0.003 to 0.006 Gm.) diree times daily. PiNKROOT. See Spigelia. PIPSISSEWA. See Chimaphila. Pituitary Body Desiccated. See Hypophysis Desiccated. Plaster, Adhesive. See' Plaster Rosin. Plaster Belladonna. Emplaslrum Belladonna. Adhesive plaster carrying 30 per- cent, extract belladonna leaves. Assays 0.35 to 0.4 percent, alkaloids. Anodyne. Plaster, Brown, Camphorated. Emplaslrum Fuscum Camphoralum, N. F.; Camphorated Mother Plaster. Red oxide lead, olive oil, wax and camphor. Anti- phlogistic, Discutient. Plaster, Blistering. See Plaster Canlharides. Plaster Cantharides. Emplasirum Cantharides ; Blistering Plaster. Cerate cantharides spread upon rosin plaster. Epispastic. Pi.ASTER Capsicum. Emplaslrum Capsici. Oleoresin capsicum spread over rubber plaster. Rubefacient, Counter-irritant. The Squibb products are recognized everyvKhere as the Quality Standard. They are of uniform purity and strength, hence therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 200 SQUIBB'S MATERIA MEDICA Plaster Diachylon. See Plaster Lead, Plaster, Elastic. Empltatrum Elasticum; Rubber Plaster; Rubber Adhesive Plaster. Mixture of rubber, resins and waxes, with a filler of absorbent powder such as orris root or starch, mechanically mixed and spread upon cotton cloth or other fabric. Plaster Lead. Emplaslrum P/umii,- Diachylon Plaster. Now made from lead oxide, olive oil and lard, instead of lead acetate and soap, as previously officially directed. Antiphlogistic. Plaster, Mother, Camphorated, See Plaster Brown Cam- phorated. © Plaster Mustard. Emplastrum Sinapis; Mustard Paper, Mixture of powdered black mustard and rubber solution, spread on paper, cotton cloth or other fabric. Rubefacient, Counterirritant. Plaster Rosin. Emplastrum Reslna; Adhesive Plaster; Rosin Adhesive Plas- ter. Mixture of rosin (14), lead plaster (80), and yellow wax (6). 1 Plaster Rubber Adhesive. See Plaster Eleistic. Plaster Soap. Emplastrum Saponis, N. F. 10 percent, soap, 90 percent, lead plaster.' Antiphlogistic, Discutient. Pleurisy Root, See Asclepias. Plummer's Pills. See Pills Antimony Compound. Podophyllin. See Resin Podophyllum. Podophyllum. Podophyillum ; Mandrake; May Apple Rhizome. Dried rhizome and roots of Podophyllum peliatum (Fam. Ser" heridacea) , yielding not less than 3 percent, resin. Slight odor; sweetish-bitter, acrid taste. Slow but effective and rather irritant Cathartic, (See also Fluidexlracl; Resin.) Poison Nut. See Nux Vomica. Poke Root. See Phytolacca. Pomegranate. Cranatum. Dried bark of stems and roots of Punka Crana- ium (Fam. Punicacea). Anthelmintic. Average Dose: 30 grains (2 Cm.). SQUIBB'S MATERIA MEDICA 20 1 Poppy Capsules. Papaveris Fruclus, N. F. Dried, fully grown, unripe fruit of PapaVer Somniferum (Fam. Papavcracea). Weak opiate. Average Dose: 60 grains (4 Gm.). Potassa. See Potassium Hydroxide. Potassa Sulphurated, Squibb bottle, lb. ; J4 '!>• Potassa Sulphurata; Pure Liver of Sulphur; so-called Potas- sium Sulphide. Hard, brown, brittle masses; od age Dose: 15 grains (1 Gm.), in sweetened solution. (See also Reagents [Part IV].) Potassium Benzoate, Squibb bottle, oz. KC7H5O2.3H2O. White,- crystalline powder. Soluble in water and alcohol. Mild Antiseptic. Dose: 10 to 20 grains (0.65 tp 1.3 Gm.). Potassium Bicarbonate, Squibb carton, lb. ; J4 lb. Potassli Bicarhonas. KHCO3. A recrystallized, especially pure quality, for medicinal and pharmaceutical uses. White, odorlessf granular salt ; saline, slightly alkaline taste. I Gm. dis- solves in 2.8 mils (Cc.) water ; almost insoluble in alcohol. Boiling changes it to carbonate. Mild Alkali employed in dys- pepsia, dropsy, jaundice, etc. Average Dose: 15 grains (I Gm.). (See also Tablets [Part II]; Reagents [Part IV].) Since we make orily one quality of each product, that best suited to the purposes intended, the specification "Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 202 SQUIBB'S MATERIA MEDICA Potassium Bichromate. See Potassium Dichromate. Potassium Binoxalate, Squibb bottle, lb. ; <4 lb- Sal Acetosella; Salt of Sorrel. KHC2O4.H2O. White crys- tals. Soluble in water. Used for technical purposes. An- tidotes: lime water, magnesia; emetics. . Potassium Bisulphate Reagent. See Reagents (Part IV). ^Potassium Bitartrate, Squibb (Powdered) tin, lb. ; !4 lb. Polassil Biiarlras; Cream of Tartar; Depurated Tartar. KHC4H4O8. This salt is frequently found largely adul- terated. The article here offered complies With the most rigid medicinal and pharmaceutical requirements. White, odorless powder; pleasant, acidulous taste. 1 Gm. dissolves in 155 mils (Cc.) water, 8820 alcohol. Boric acid or borax increases aqueous solubility. Diuretic, Aperient, Refrigerant. Average Dose : diuretic, 30 grains (2 Gm.) ; aperient, 1 20 to 240 grains (8 to 16 Gm.). (See also Reagent [Part IV].) Potassium Bromate Reagent. See Reagents (Part IV). Potassium Bromide, Squibb bottle, lb. ; % lb. Polassii Bromidum. KBr. White, odorless, granular powder; very salty taste. 1 Gm. dissolves in 1.5 mils (Cc.) water, about 250 alcohol, 4.6 glycerin. Incompatible with mineral acids; with salts of lead, mercury and silver; etc. Nerve Seda- tive, Antispasmodic; also Reagent. Average Dose: 15 grains (I Gm.). Absorbed and eliminated slowly, and when long continued should be omitted for a few days in -every month. Potassium Bromide, Granular Effervescent. Sal Polassii Bromidi Effervescens, N. F. About 16.6 percent, potassium bromide. Average Dose: 90 grains (6 Gm.). Potassium Bromide, Granular Effervescent Compound. Sal Poiassii Bromidi Effervescens Compositus, N. F.; formerly official as Potassmm Bromide Effervescent Granular, with Caf- feine. 8.3 percent, potassium bromide, 0-8 percent, caffeine, 4.2 percent, lithium carbonate. Average Dose: 90 grains (6 Gm.) Potassium Carbonate, Squibb (Powdered) bottle, lb.- ; 14 lb. Poiassii Carbonas; Sal Tartar. K2CO3. White, odorless, granular, very deliquescent powder; strongly alkaline taste. 1 Gm. dissolves in 0.9 mil (Cc.) water; insoluble in alcohol. Caustic, Antipruritic, Antacid. Used in acid dyspepsia, lithiasis, jaundice, etc. Average Dose: 15 grains (I Gm.). (See also Reagents [Part IV].) SQUIBB'S MATERIA MEDICA " 203 ffi Potassium Chlorate, Squibb , , (Graniii^r) tin, lb. ; 14 lb. Potassii Chloras. , KClOg. A special Squibb piroduct, repre- senting the U. S. P. market grade recrystallized and further purified ; ^ hence a distinctive product. White, odorless, gran- ules; saline taste. 1 Gm. dissolves in 11.5 mils (Cc.) water; soluble in glycerin; almost insoluble in alcohol. Alterative, Antisialagogue, Antiseptic, Astringent. Average Dose : 4 grains (0.25 Gm.). Applied externally in 3' to 5 perceiit. solution, or ointment or duisting -powder; as mouthwash and gargle, on ulcers,, etc.. Large doses are poisonous, causing disintegration of blood corpuscles. Incompatible with potassium iodide and tartaric acid. Dangerous explosions may occur when it is heated or subjected to concussion or trituration with organic substances (cork, tannin, sugar, etc.), or with sulphur, antimony sulphide, phosphorus or easily oxidizable substances. Antidotes : emetics; diuretics; ice; opium; pilocarpine; caffeine subcu- - taneously. (See also Tablets and Troches [Part II] ; Re- agents [Part IV].) I Potassium Chloride, Squibb bottle, 14 lb. Potassii Chloridum, N. F. KCl. White, odorless crystals or granules. I Gm. dissolves in 2.8 mils (Cc.) water; insoluble in alcohol. Uses technical. (See also Reagents [Part IV].) Potassium Chromate, Squibb bottle, !4 lb. K2Cr04. Yellow crystals. Soluble in water. Indicator in volumetric analysis. Antidotes: magnesia; emetics; alkaline carbonates. (See also Reagents [Part IV].) © Potassium Citrate, Squibb bottle, lb. . ; J4 lb. Potassii Citras. K3C6H607;H2P. White, odorless, granular powder; cooling, saline taste. 1 Gm. dissolves in 0.6 mi) (Cc.) water, 2 glycerin; sparingly soluble in alcohol. Systemic Al- kalis Diuretic, Diaphoretic ;, in, fevers, bronchial affections, rheu- matism, etc. Average Dose: 15 grains (1 Gm,)- ' © Potassium Citrate, Granular Effervescent. Potassii Citras Effervescens. 20 percent, potassium citrate. Average Dose: I drachm (4 Gm.). Potassium Dichromate Reagent. See Reagents (Part IV). Potassium Ferricyanide Reagent. See Reagents (Part IV). Potassium Ferrocyanide Reagent. See Reagents (Part IV). The founder of the House of. Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William ,l\/|iller Bartlett, the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 204 SQUIBB'S MATERIA MEDICA Potassium Glycerophosphate, 75%, Squibb bottle, % lb. ; oz. Concentrated aqueous solution of C3H703PO(OK)2- Yellow- ish, syrupy liquid. Soluble in water in all proportions. Used' as Nerve Tonic. Dose; 4 to 10 grains (0!25 to 0.65 Gm.)-. usually in combination with other glycerophosphates. Potassium Hydroxide, Squibb bottle, lb. ; !4 lb. Potassil Hydroxidum; Potassium Hydrate; Potassa; Caustic Potash. Assays not less than 83 percent. KOH. Small, crushed lumps; very acrid, caustic taste. 1 Gm. dissolves in 0.9 mil (Cc.) water, 3 mils alcohol, 2.5 glycerin. Caustic, Antacid. Dose: 1/2 •<> I grain (0.03 to 0.65 Gm.), welUdi- luted. Antidotes: water, then vinegar or lemon juice, emetics; demulcents. NoTE: On exposure potassium hydroxide readily absorbs carbon dioxide and moisture, and deliquesces. Hence keep well-stoppered, in dry place. (See also Reagents, Part IV; Solution.) Potassium Hypophosphite, Squibb bottle, lb. ; 14 lb. Potassil Hypophosphls. KPH2O2. White, opaque, odorless, deliquescent plates or masses, or granular powder ; pungent, saline taste. I Gm. dissolves in 0.6 mil (Cc.) water, 9 mils alcohol ; insoluble in ether. Used as Nerve Tonic. Average Dose: 8 grains (0.5 Gm;). Avoid triturating or heal- ing with oxidizing agents, such as nitrates and chlorates, as explosion is liable to occur, ; P,ota^sium Iodide, Squibb * Granulated or Crystals bottle, lb. ; 14 lb" ; oz. Polassii Jodidum, KI. Faint, iodine-like odor ; pungent, saline, afterwards bitter, taste. 1 Gm. dissolves in 0.7 mil (Cc.) water. 22 mils alcohol, 2 glycerin. Alterative, Resolvent, Antiluelic, Saline Expectorant. Average Dose: 5 grains (0.3 Gm.). Incompatible with alkaloidal salts, chloral hydrate, min- eral acids, etc. (See also Tablets [Part II] ; Reagents [Part IV].) Potassium Nitrate, Squibb * Granulated or Powdered tin, lb. Polassii Niiras; Saltpetre; Nitre. KNO3. Colorless, odorless granules ; or white powder ; cooling, saline, pungent taste. I Gm. dissolves in 2.8 mils (Cc.) water, 620 alcohol; soluble in glycerin. Diaphoretic, Diuretic; in fevers, asthma, dropsy, rheumatism, etc. Average Dbse; 8 grains (0.5 Gm.). Anti- dotes: stimulants; ice water; opiiim. (See also Reagents [Part IV].) SQUIBB'S MATERIA MEDICA 205 Potassium Permanganate, Squibb bottle, lb. ; !4 lb. ; oz. Polaisli Permanganas ; Potassium Hypermanganate. KMn04. An exceptionally pure salt; all large crystals, unlike regular so-called "large-crystal" grade. Slender, dark-purple, odorless prisms; sweet, afterwards disagreeable, astringent taste. I Cm. dissolves in.l3.5 mils (Cc.) water; decomposed by other sol- vents. Deodorant, Disinfectant, Elmmenagogue. Used mainly externally, in gonorrhea, leucorrhea, ulcers, tonsillitis, etc.; in- ternally in amenorrhea, zymotic diseases, morphine poisoning, etc. Average Dose: 1 grain (0.065 Gm.), in tablets, or in pills made with kaolin and petrolatum or with cacao butler. lis stains can be removed with oxalic or hydrochloric acid. Either in dry condition or in concentrated solution it should not be brought into contact with oi-ganic or readily oxidizable sub- stances; organic solvents should be avoided. (See also Tablets [Part II]; Reagents [Part IV].) Potassium Persulphate Reagent. See Reagents (Part IV). Potassium Phenolsulphonate, Squibb bottle, oz. Potassium Sulphocarbolate Powdered. An exceptionally pure article, free from sulphates, chlorides, and metallic impurities. Freely soluble in water. Used as Intestinal Antiseptic. Dose: 3 to 10 grains (0.2 to 0.65 Gm.). Potassium Sulphate, Squibb * Crystals • carton, lb. Powdered carton, lb. Poiassii Sulphas, N. F. K2SO4. White, odorless crystals or powder ; bitter, saline taste. I Gm. dissolves in 1 mils (Cc.) Water;' insoluble in alcohol.' Saline Cathartic, like sodium sul- phate. Average Dose: ace. to N. F., 15 grains (1 Gm.); as cathartic, up to 240 grains (15 Gm.). (See also Reagents [Part .IV].) Potassium Sulphide, so-called. See Polassa Sulphurated. Potassium Sulphocyanate Reagent. See Reagents (Part IV). Potassium Sulphocarbolate. See Potassium Phenolsulphonate. Potassium Tartrate, Squibb bottle, lb. ; J4 lb. Soluble Tartar., 2K2C4H4O6.H2P. Colorless, odorless crys- tals. Soluble freely in water; almost insoluble in alcohol. Refrigerant, Diuretic, Laxative. Dose: diuretic and refriger- ant, 15 to 30 grains (1 to 2 Gm.) ; laxative, 60 to 180 grains (4 to 12 Gm.). The Scruibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 206 SQUIBB'S MATERIA MEDICA Potassium and Sodium Tartrate, Squibb (Powdered) tin, lb. ; Yi lb. ; '4 lb. Polassil ei Sodii Tarlras; Rochelle or Seignette Salt; Tar- tarated Soda. KNaC4H40e.4H20. A recrystallized grade, free from calcium salts, more pleasant to the taste than ordinary product. I Gm. dissolves in 0.9 mil (Cc.) water; almost in- soluble in alcohol. Saline Cathartic. Average Doset 150 grains (10 Gm.). (See also Reagents [Part IV].) Poultice, Emollient. Species EmollienteSj N. F. Equal parts althaea leaves, mallow leaves, melilot, matricaria and linseed, powdered. Mixed with hot water for use. Poultice Spice. See Powder, Rubefacient Spice. Powder Acetanilid Compound, Squibb tin, lb. ; !4 lb. Puhls Acetanilldi ComposUus, N. F. Acetanilid 70 percent., caffeine 10, sodium bicarbonate 20. Analgesic, Antipyretic, Average Dose: 5 grains (0.3 Gm.). Powder Aloes and Canella. Pulvis Aloes el Canella, N. p.; Hiera Plcra. Contains aloes 80. percent., canella 20. Laxative. Average Dose: 5 grains (0.3 Gm.). Powder Alum Compound, Squibb per doz. tins. Surgical Powder. Introduced by Dr. E. R. Squibb in 1868, it has steadily grown in favor among the medical profession as an emergency dressing and wash. Ef&cacious and safe for external use. The ingredients are burnt alum, camphor and carbolic acid. Considered especially valuable as an Astrin- gent, Absorbent and Antiseptic dry dressing for wounds. The effect is sometimes a stinging sensation, but regularly followed by a rapid and continuous healing. It should be used freely, keeping the surfaces well covered with the powder as long as there is any discharge. Very useful also as a Styptic in bleed- ing cuts and wounds (dry powder) ; and as an Antiphlogistic in inflamed throat and other catarrhs of the mucous passages (strong warm solution). As the efficacy of this powder depends upon its perfect freedom from moisture, it is offered only in original, special tins, which should be kept well closed and in dry place when not in use. Powder, Antimonial. Pulvis Antimonialis, N. F.; James' Powder. 33 percent, anti- mony oxide, 67 percent, precipitated calcium phosphate. Dia- phoretic, Alterative. Average Dose : 3 grains (0.2 Gm.) . SQUIBB'S MATERIA MEDICA 207 Powder, Antiseptic (Soluble), Squibb bottle, lb. ; 1/i lb. Pubis Aniisepticxis, N. F.; Soluble Antiseptic Powder, Powdered salicylic acid 0.5 percent., carbolic acid 0.1, eucalyptol 0.1, menthol 0.1, thymol 0.1, zinc sulphate 12.5, boric acid 86.6. Antiseptic; as dusting powder or in solution (5 percent.). Powder, Aromatic, Squibb tin, lb. ; 14 lb. Palvis Aromaticus, 35 percent, each Saigon cinnamon and Jamaica ginger, 15 percent, each cardamom and nutmeg. Car- minative, Stomachic. Average Dose: 15 grains (1 Gm.). Powder BaVberry Compound. Pulvis Maries Composilus, N. F.; Composition Powder. 60 percent, bayberry root-bark, 30 percent, ginger, 5 percent, each capsicum and cloves. Carminative, Average Dose: 15 grains (1 Gm.). Powder Calomel and Jalap. Pulvis HydrargSTt Chlortdi Miiis el Jalapa, N. F. Calomel 34 percent., jalap 66. Drastic Cathartic. Average Dose: ,10 grains (0.65 Gm.). PovwjER Chalk Aromatic. X Pulvis Creta Aromaticus, N. F. Cinnamon 8 percent, nut- meg 6, cloves 3, cardamom 2, prepared chalk 25, and sugar 56. Antacid Carminative, Antidiarrheal. Average Dose: 30 grains (2 Gm.). t Powder Chalk Aromatic, with Opium. Pulvis Creta Aromaticus cum Opio, N. F. Powdered opium 2.5 percent., aromatic chalk powder 97.5. Anti- diarrheal. Average Dose: 15 grains (I Gm.). Powder Chalk Compound, Squibb tin, lb. ; 14 lb. Pulvis Creta Composilus. Prepared chalk 30 percent., acacia 20, sugar 50. Antacid, in diarrhea. Average Dose: 30 grains (2 Gm.). Powder, Composition. See Powder Bayberry Compound. Powder, Dover's. See Powder Ipecac and .Opium. Powder, Dover's, Liquid. See Tincture Ipecac and Opium. Powder, Effervescing Compound. See Powder Seidliiz. Ttie Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our' prices are as low as they-can be made for that quality. Specify SQUIBB'S. 208 SQUIBB'S MATERIA MEDICA Powder, Foot, See Powder Talcum Compound. Powder Gambir Compound, Pulvis Cdmbir Composiius, N. F, Gambir 40 percent., kino 20, krameria 20, cinnamon 10, nutmeg 10. Antidiarrheal. Average Dose: 20 grains (1.3 Gm.), Powder Glycyrrhiza Compound, Squibb. fin, lb. ; !4 lb. Pulvis ClycsTrhiza Composiius, U. S. P 1880; Compoimd Licorice Powder, Consists of licorice root 16 percent., senna 18, washed sulphur 8, ground fennel 8 and sugar 50, Considered therapeutically superior to present U. S. P. article, and also more stable and uniform. Laxative. Average Dose: 60 grains (4 Gm.), Powder, Gray. See Mercury with Chalk. Powder, Gregory's. See Powder, Rhubarb Compound, t Powder Ipecac and Opium, Squibb tin, lb. ; !4 lb. ; oz, Pulvis Ipecacuanha ei Opii; Dover's Powder; Compound Ipecac Powder. Contains ipecac and powdered opium (each ilO percent.), but the potassium sulphate (in U. S, P. 1870 formula) is retained in place of the milk sugar now prescribed. Considered a superior preparation. Squibb's- Dover's Powder has long been the standard, and is a product made by the eifercise of greatest thoroughness and manipulative skill. Ano- djTie, Antispasmodic, Diaphoretic, Average Dose: 8 grains (0.5 Gm.), Autidotes :' potassium permanganate solution, emetic hypodermically ; atropine or strychnine; hot, strong coffee; exercise. Powder Ipecac Compound. See Powder Ipecac and Opium. Powder Jalap Compound, Squibb tin, lb. ; % lb. Pulvis Jalaps Composiius. Jalap 35 percent., potassium bitar- trate 65. Hydragogue Cathartic; in dropsy of hepatic causa- tion, obstinate constipation, etc. Average Dose: 30 grains (2 Gm.). t Powder Kino and Opium Compound. Pulvis Kino et Opii Composiius, N, F.; Powder Kino Com- pound, N. F. III. Kino 75%, powdered opium 5%, Saigon cinnamon 20%. Intestinal Astringent, Average Dose: 15 grains (1 Cm.), Powder Licorice Compound, Squibb. See Powder Glycyrrhiza Compound. Powder Opium and Ipecac. See Powder Ipecac and Opium. SQUIBB'S MATERIA MEDICA 209 Powder Pancreatin Compound, Squibb bottle, !4 lb. ! oz. Pulvls Pancreatini Cotnposiius, N. F.; Peptonizing Powder. Pancreatin 20 percent., sodium bicarbonate 80. 25 grains suffi- cient t6 peptonize I pint fresh cow's milk. Powder, Peptonizing, See Powder Pancreatin G>mpound. Powder Rhubarb Compound. Pulvis Rhei Composiius; Rhubarb and Magnesia; Gregory's Powder. Rhubarb 25 percent., Jamaica ginger 10, magnesium oxide 65. Antacid, Carminative, Laxative; chiefly in children. Average Dose: 30 grains (2 Cm.). Powder Rhubarb and Magnesia, Anisated, Pulvis Rhei et Magnesia Anisaius, N. F,; Compound Anise Powder. Rhubarb 35 percent., heavy magnesia 65, with anethol as corrective. Carminative, Antacid, Laxative; largely in infants. Average Dose (infants): 5 grains (0.3 Cm.). Powder, Rubefacient Spice, Pulvis yiromaiicus Rubefaciens, N. F. Replacing Aromatic Plaster, N. F. III. 30% clove, 30% cinnamon, 20% ginger, 20% capsicum. Rubefacient poultice material. Powder, Seidlitz; Squibb bottle, lb, ; % lb. This effervescent saline mixture is Seidlitz Powder mixed together into a single powder, the constituents being all sep- arately well dried before being mixed. It consists of potassijum and sodium tartrate (Rochelle salt), sodium bicarbonate, tar- taric acid, and sodium chloride, the latter being added to en- hance its medicinal activity and palatability. As an Aperient the dose is one to three teaspoonfuls (5 to 15 Cm.) with or without sugar, stirred into three-fourths of a large glassful of cold water, eind drunk at once while the powder is suspended in the water. For use as an alkaline mineral water, or as a substitute for Rochelle salt, about Yz teaspoonful, stirred into the same quantity of water as above, and taken two or Aree times a day, may be sufficient. In the use of this powder the effervescence is inientionallp slight, or, if the water be very cold (as it should be) , is hardly perceptible, as the liberation of the carbonic acid is intended to take place slowly internally where it may be of service. Dampness should be carefully excluded. Powder, Soluble Antiseptic. See Powder, Antiseptic. Powder, Surgical. See Powder Alum Compound. This house supplies only, one quality of each product: that best suited to the purposes intended. The specification "Squibb's" Is not open to various interpretations; it has a plain, posi- tive meaning. When prescribing/ please specify SQUIBB'S. 210 SQUIBB'S MATERIA MEDICA Powder Talcum. See Talcum Powder. Powder Talcum Compound. ■ Pulvis Talci Compositus, N. F.; Powder Talc Salicylated, N. F. 111. Salicylic acid 3%, boric acid 10%, talcum 87%. Antiseptic, Deodorant, Antihydrotic dusting powder. Powder, Veterinary, Squibb tin, per doz. Used by the veterinary profession for many years, as an effica- cious, safe Antiseptic, Astringent and Absorbent dressing for wounds. The therapeutically, active ingredients are burnt alum, camphor, carbolic acid and charcoal. It should be used in-^ sufficient quantity to keep the wound surface dry. Serviceable also as a Styptic on incised and other bleeding wounds, applied freely in dry powder. Sold only in original tins, which should be kept well closed and in dry place when not in use. Precipitate, Red. See Mercury Oxide Red. Precipitate, White. See Mercury Ammonialed. Precipitate, Yellow. See Mercury Oxide Yellow. Prickly Ash Bark. See Xanthoxylum. Prickly Ash Berries. Xanthoxyli Fructas, N. F. Dried fruit of Xanthoxylum ameri- canum or of X. Clava-Herculh (Fam. Rutacea). Faint odor; warm, aromatic taste. Used as Sialagogue, Carminative, Alter- ative. Average Dose: 15 grains (I Gm.). Prince's Pine. See Chimaphila. © Procaine. Name adopted by Federal Trade Commission for novocain as made in America. Para-aminobenzo methylaminoethanol Hydrochloride. Colorless needles. Soluble in 1 part water, 30 alcohol. Local Anesthetic, like cocaine; solutions are sterilizable. Protan. Compound of casein and tannic acid (50 percent.) . Light- brown, tasteless, water-insoluble powder. Intestinal Astringent. Dose: 15 to 30 grains (1 to 2 Cm.). Protargentum, Squibb I oz. vial Compound of silver and protein, containing about 8 percent. Ag. Chocolate-brown, odorless powder; taste bitter and metallic. Soluble rather slowly but freely in water; insoluble in alcohol or oils. Solutions not precipitated by usual silver reagents, nor affected by cocaine hydrochloride in weak solutions. Used in urethritis and inflammation of eyes and nose, in t/^ to 5 per- cent, solutions, which should preferably be made fresh as wanted, (See also Solargenlum, containing 20 percent. Ag.) SQUIBB'S MATERIA MEDICA 211 Protarcol. Silver-proteid.^ Light-brown, bulky powder; 8.3 percent, silver. Soluble freely in water or glycprin; not precipitated by alkalies, albumen or chlorides. Bactericide, Antigonorrheit, Antipyic Incdmpatible in solution with lead acetate, zinc sulphate, copper sulphate, alum, or mercuric chloride. Its solutions should be made with cold water. Applied externally in acute cases in V4 to I percent, solutions; in chronic cases, in 3 to 10 percent, strengths. Dose ; I to 3 grains (0.065 to 0,2 Gm.) . (See also Protargentum.) Prune. Prunum, N. F. Partly dried, ripe fruit of Pranus Jomesi'ica (Fam. Rosacea). Laxative Nutritive. Prussian Blue, Insoluble. See Iron Ferrocyanide. Pulsatilla, Pulsatilla, N. F. Dried herb of .Anemone Pulsatilla, A. pratensis or ol A. Ludoviciana (Fam. Ranunculacea) . Nearly odorless; very acrid taste. Used as Alterative, Sedative, Anti- spasmodic. Average Dose: 5 grains (0.3 Gm.). Pumice. Pumex, N. F. Combination of complex silicates of aluminum, potassium and sodium, of volcanic origin. Abrasive, Polishing material; also used chemically. Pumpkin Seed. Pepo. Dried ripe seeds of cultivated varieties of Cucurbiia Pepo (Fam. Cucurbitacete) . Domestic Anthelmintic. Aver- age Dose: 1 ounce (30 Gm.). PUNICINE TannatE. See Pelletierine Tannate. Pyramidon. Dimethylaminoantipyrine. Small, white, nearly tasteless crys- tals. Soluble in about 1 1 parts water ; readily in alcohol or ether. Incompatible with ferric chloride and spirit nitrous ether. Anti- pyretic, Analgesic. Dose: 5 to 8 grains (0.3 to 0.75 Gm.). Pyrethrum. Psrethrum; Pellitory Root. Dried root of /4nacjicJus Py- rethrum (Fam. Composita). Sialagogue, Stimulant Mastica- tory, Local Irritant. Average Dose: 30 grains (2 Gm.). The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. Theyincludecontainfers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 212 SQUIBB'S MATERIA MEDICA Pyrogallol, Squibb (Acid Pyrogallic) tin, lb. ; 14 'b. ; oz. Pyrogallol; Trihydroxybenzene. CsHgCOHs). Light, white, odorless, bitter laminae or lieedles. t Gm. dissolves in 1,7 mils (Cc). water, 13 mils alcohol, 1.6 ether. Incompatible in trituration with antipyrine, camphor, carbolic acid, iodine, lead acetate or menthol. Antiparasitic Dermic, in 5 to 10 percent, ointment; also Reagent, and photographic developer. Pyroxylin. PyToxylinum ; Soluble Gun Cotton; Collodion Cotton; Colloxy- lin. Obtained by action of mixture of nitric and sulphuric acids on cotton. Consists chiefly of cellulose tetranitrate. Used for making collodion. Very inflammable I Quassia. , Clua&sia; Bitter Wood. Wood of Picrasma excelsa or of Quassia amara (Fam. Simarubace © Quinine Hydrochloride, Squibb • bottle, oz. Quinines HydTochloridum ; Quinine Hydrochlorate. C20H24- 02N2.HC1.2H^O. White, silky, odorless, very bitter needles. 1 Gm. dissolves in 18 mils (Cc.) vrater, 0.8 alcohol, 7 glycerin, 0.7 chloroform, 340 ether. Action and doee: as of quinine alkaloid, (See also Tablets [Part II].) If difficulty is experienced, in procuring any Squibb product, in the origiiial packages here listed, please notify us; we shall see that your wants are met promptly and- satisfactorily^ 214 SQUIBB'S MATERIA MEDICA CJuinine Hypophosphitd, Squibb . bottle, oz, Quininis Hy)pophosphis, N. F, C20H24O2N2.H3PO2.2H2O. Small, white, odorless, bitter crystals. 1 Gm. dissolves in about 35 mils (Cc.) water, 12.5 alcohpl, 27 chloroform; almost in- soluble in ether. Action and dose: like quinine alkaloid. Quinine Oleate. See Oleate Quinine. Quinine Salicylate, Squibb Quinince Salicslas. C20H24O2N2.C7H6O3 .H2O. Colorless, odorless needles, becoming pinkish on keeping. 1 Gm. dissolves ^ in 14 mils (Cc.) alcohol, 13 glycerin, 25 chloroform, 160 ether; slightly soluble in water. Bitter Tonic, Antineuralgic, Anti- periodic; in rheumatism, lumbago, typhoid fever, etc. Average Dose : tonic, 1 Y2 grains (0.1 Gm.) ; antiperiodic, at least 1 5 grains (I Gm.) daily. Quinine Sulphate, Squibb tin, 5 ozs., per oz. ; bottle, oz. Qainina Sulphas. (C2oH2402N2)2H2S047H20. White silky, flexible, glistening, ■ ' odorless, extremely bitter needles. I Gm. dissolves in 725 mils (Cc.) water, 1 07 alcohol, 30 glycer- in; sparingly soluble in chloroform or ether. Dilute acids increase aqueous solubility. Action and dose: as of quinine alkaloid.- Best given with or followed by an acid. (See also Tablets [Part II].) ® Quinine Tannate, Squibb bottle, oz. Quininie Tannas. C20H24O2N23C14H10O9.8H2O. Yellow- ish-white, odorless, nearly , tasteless powder; 30 to 35 percent, anhydrous quinine. Slightly soluble in water, chloroform or ether; more soluble in alcohol. Used mainly in children, be- cause of relative tastelessness. Average Dose: 3 grains (0.2 Gm.), in milk. Quinine Valerate, Squibb . bottle, oz. Quimna Valeras,. N. F. ,C2oH2402N2.C5Hio02.H20. White, shining crystals; valerian odor; bitter taste. Sparingly soluble in water, becoming less soluble with age; readily solu- ble in alcohol. Nervine, Antiperiodic; in hemicrania, hysteria and other neuroses associated with malaria. Average Dose: nervine, V/2 grains (O.I Gm.); antiperiodic, at least 15 grains (1 Gm.) daily. Quinine and Iron Citrate. ■ See Iron and Quinine Citrate. Quinine and Urea Hydrochloride, Squibb bottle, oz. 1 0-grain hermetically sealed tubes, box of 10, Quini'nffl et Urea HsJrochloridum ; Carbamidated Quinine Dihydrochloride. C2oH2402N2.HCl.CO.(NH2)2.HC1.5H20. Colorless, odorless, bitter crystals; about 58 percent, anhydrous quinine. 1 Gm. dissolves in 0.9 mil (Cc.) water, 2.4 mils alcohol. Subcutaneous Antiperiodic; Local Anesthetic with hemostatic action, in 1/2 to I percent solutions by injection and 10 to 20 percent, solutions topically. Average Dose: 15 grains (I Gm.). (See also Ampuls.) SQUIBB'S MATERIA MEDICA 215 Raspberries. Rubi Ida! Fructus, N. F. Fresh, ripe fruit of varieties of Rubus Idaus or of R. strigosus (Fam. Rosacea:). Reagents, Test Solutions, Volumetric Solutions and Indicators. See Part IV. Red Bark. See Cinchona, Red. Red Clover. See Trifolium. Red Saunders. See Sandal Wood, Red. Rennin, Squibb * bottle, oz. Renninum, N. F. Milk-curdling enzyme from stomach of calf; I part added to 25,000 parts fresh cow's milk heated to 105° F. produces a fine curd in ten minutes. Used for making liquid rennet, junket, essence pepsin, and similar preparations. Resin Guaiac. See Guaiac Resin. Resin Jalap, Squibb bottle, oz. Reslna Jdlapa. Yellowish-gray to yellowish-brown powder; slight, peculiar odor; acrid taste. Soluble in alcohol in all proportions; m about 5 parts ammonia water. Drastic Hydra- . gogue, Cathartic. Average Dose: 2 grains (0.13 Cm.). @ Resin Podophyllum, Squibb bottle, oz. Resina Podophyllv; Podpphyllin. An acid-precipitated, well- washed resin. Light-bro^n to greenish-yellow, faintly bitter powder; very irritating, to the nose and eyes. Soluble in alcohol. Slow hu\ effective and rather irritant Cathartic. Acts in 10 to 12 hours. Average Dose: J/6 grain (0.01 Gm.). Resin Scammony, Squibb (Powdered) bottle, oz. Resina Scammonla. Prepared from best quality Turkish true scammony root, the dried root of Convolvulus Scammonia; not from the cheaper, so-called "Mexican scammony root," Yellowish powder; faint odor and taste. Freely and completely soluble in alcohol; 95 percent, soluble in ether. Drastic Purgative. Average Dose: 3 grains (0.2 Gm.). The Squibb products are recognized everywhere as the Quality Standard. They are of uniform purity and strength, hence therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 216 SQUIBB'S MATERIA MEDICA © Resorcinol, Squibb ^Crystals bottle, oz. Powdered bottle, oz. Resorcinol; Resorcin; Metadihydroxybenzene. CeH4(OH)2. Nearly white needles or powder; faint odor; sweetish taste, bitter after-taste. 1 Gm. dissolves in 0.9 mil (Cc.) water or alcohol; easily soluble in ether or glycerin, very slightly in chloroform. Antiseptic externally; Antizymotic internally. Employed internally in sea-sickness, diarrhea, whooping- cough, cystitis, etc.; externally (in 5 to 30 percent, solutions or ointments) in skin diseases', gonorrhea, etc. Also Reagent. Average Dose: 2 grains (0.13 Gm.). Incompatible on tritura- tion with acetanilid, aritipyrine, camphor, euphorin, menthol, or urethane; with alkalies or spirit nitrous ether in solution. Turns pink on keeping and exposure. * Rhamnus Frangula. See Frangula. Rhamnus Purshiana. See Cascara Sagrada. Rhatany. See Krameria. Rhodalline. See Thiosinamine. Rhubarb, Squibb »WhoIe Select tin, lb. ; 14 lb. Fingers (Pressed) 80 to 1 lb., per lb. Ground for Percolation tin, lb. Powdered (100) rin, lb. ;!41b. Rheum, Dried rhizomes and roots of Rheum officinale, R. paU malum, and other species of Rheum (Fam. Pol^gonacea) . Prime quality of Chinese root, selected with great care, all im- perfect and bad pieces being rejected. Good sun-dried rhubarb is measurably injured by being sawed up into regular forms, and therefore no **cut rhubarb*' is offered in this list. Char- acteristic odor; bitter, astringent taste. Bitter Stomachic, pleas- ant Laxative. Average Dose: 15 grains (I Gm.). Acts in 7 to 8 hours. (See also Extract; Fluidextract; Mixture; Powder; Syrup; Tincture; Tablets [Part II].). Rhus GLAsaA. Rhus Clabra, N. F. Dried, ripe fruit of Rhus glahra (Fam. Anacardiacea) . Astringent, like krameria; in diarrhea, etc^ Average Dose: 15 grains (1 Gm.). Rochelle Salt. See Potassium and Sodium Tartrate. ©Rose (Red). Rosa Callica. Dried petals of Rosa gallica (Fam. Rosaceai), Used pharmaceutically. RosiN. Resina; Colophony. Residue left after distilling off volatile oil from gum turpentine. Freely soluble in alcohol, ether, ben- zene, oils. Used pharmaceutically. SQUIBB'S MATERIA MEDICA 217 RUBUS, Rubus, N. F.; Blackberry Bark. Dried bark of rhizome of Riibus villosus, R. nigrobaccus or of R, cuneifolius (Fam. Rosacea}. Tannin-bearing Astringent; in diarrhea. Average Dose: 13 grains (1 Gm.). RuFUs's Pills. See Pills Aloes and Myrrh. RUMEX. Rumex, N. F. Roots of Rumex crispas or of R, obUisifolius (Fam. Po/ygonaceffl). Alterative. Average Dose: 60 grains (4 Gm.). (See also Fluidextract) . Sabal. Sabal; Saw Palmetto Berries. Partially dried ripe fruit of Serenoa serrulata (Fam. Paimffi). Used as Stimulant of genito- urinary mucosa, like oil sandalwood. Average Dose: 15 grains (I Gm.). (See also Fluidextract.) Sabromin. Calcium Dibrombehenate. White, odorless, tasteless powder, containing '29 percent, bromine. ^'Soluble in ether;- insoluble in water, alcohol. Succedaneiim for alkali bromides, in same doses. Saccharin. See Benzosulphinide. Saccharin Soluble. See Sodium Benzosulphinide. Saccharinose, Saccharol. Brands of Saccharin. Saffron. See Crocus, is,' :, ... , Sajodin. Calcium Monoiodobehenate. (C2iH42lCOO)2Ga. White, odorless, tasteless powder; 26 percent, iodine, 4.1 percent, 'cal- cium. Succedaneum for alkali iodides internally. Dose: 5 to 15 grains (0.3 to 1- Gm.). Sal Acetosella. See Potassium Binoxalate. Sal Alentbroth. See Mercury Ammoniated. Sal Ammoniac, See Ammonium Chloride. Sal Tartar. See Potassium Carbonate. Salicin, Squibb bottle, oz. Salicinum. CigHigOy. Glucoside obtained from several species of Salix and Populus (Fam. Salicacece). Colorless, silky, shining needles or prisms, or white powder; odorless, very bitter. I Gm. dissolves in 23.5 mils (Cc.) water, 88.5 alcohol; insoluble in ether or chloroform. Antirheumatic, Anti- periodic, Bitter Tonic. Average Dose: 15 grains (I Gm.). Since we make only one quality of each product, that best suited to the purposfes intended, the specification Squibb's" is not open to various interpretations, but lias a plain, positive meaning. When ordering or prescribing,, specify SQUIBB'S. 218 SQUIBB'S MATERIA MEDICA Salicylquinine. See Saloquinine. Salipyrine. Antipyrine Salicylate. White, odorless powder; sweetish taste, bitter after-taste; about 58 percent, antipyrine, 32 percent, salicylic acid. Soluble in 200 parts water; readily in alcohol. Decomposed by acids and alkalies. Analgesic, Antipyretic, Dose: 8 to 30 grains (0.75 to 2 Gm.). Salol. See Phenyl Salicylate. Salophen. Acetamidosalol. White, odorless, tasteless powder; 51 per- cent, salicylic acid. Soluble in alcohol, ether, chloroform; insoluble in water. Decomposed by alkalies. Antirheumatic, Antipyretic, Antiseptic. Dose: 5 to 15 grains (0.3 to 1 Gm.). Externally in 10 percent, ointment. Saloquinine. Salicylquinine; Quinine Salicylic Ester. Whitish, tasteless, odorless powder. Soluble readily in chloroform, sparingly in ether or alcohol; insoluble in water. Antiperiodic, Antineural- gic. Antipyretic. Dose: 5 to 20 grains (0.3 to 1.3 Gm.). Salt, Bitter. See Magnesium Sulphate. Salt, Carlsbad Artificial, Powder, Squibb bottle, lb. ;!4lb. Sal Carolinum Factltium, N. F,: dried form. 2 percent, potas- sium sulphate, 18 sodium chloride, 36 sodium bicarbonate, 44 dried sodium sulphate. 16 grains dissolved in 7 fluidounces water represents same volume of Carlsbad Sprudel water. Saline Laxative. Salt, Carlsbad Artificial, Granular Effervescent, Squibb bottle, lb. ; 4 oz. bottles, per doz. Sal Carolinum Factltium Effervescens, N. F. 26.6 percent, dried artificial Carlsbad salt. Average Dose: 90 grains (6 Gm.). Salt, Epsom. See Magnesium Sulphate. Salt, Glauber's. See Sodium Sulphate. Salt, Kissingen, Artificial, Squibb bottle, lb. Sal Kissingeme Factitium, N. F. About 3 percent, potassium chloride, 66 sodium chloride, 1 1 anhydrous magnesium sul- phate and 20 sodium bicarbonate. Solution of 24 grains in 7 fluidounces water represents same volume of ICissingen water (Rakoczi spring). Alterative. SQUIBB'S MATERIA MEDICA 219 Salt, Kissingen, Artificial, Granular Effervescent, Squibb bottle, lb. ; 4-qz. bottles, per doz. Sal Kisiingense Factitiam Effervescem, N. F. Contains about 40 percent, artificial Kissingen salt. . Alterative. Solution of 80 grains in 6 fluidounces water^ represents equal volume of Kissin- gen water. Average Dose: 80 grains (5.5 Gm.). Salt, Monsel's. See Iron Subsulphale. Salt, Rochelle or Seignette. See Potassium and Sodium Tartrate. Salt, Vichy, Artificial, Squibb bottle, lb. Sal Vichsanum Factitium, N. F. Contains about 85 percent, sodium bicarbonate, 4 potassium carbonate, 4 anhydrous mag- nesium sulphate, and 7 sodium chloride. Solution of 16 grains in 7 fluidounces water represents dqual volume of Vichy water (Grande Grille spring). Antacid. Salt, Vichy, Artificial, Granular Effervescent, Squibb bottle, lb. ; 4-oz. bottles, per doz, Sal Vich^anum Facliilam Effervescens, N. F. Contains 25 percent, artificial Vichy salt. Solution of 60 grains in 7 fluid- ounces water represents same volume-QJf Vichy water (Grande Grille spring). Average Dose: 60 grains (4 Gm.). Salt, Vichy, Artificial, GranulAr Effervescent, with Lithium.' Sal Vich^anum Factitiam Effervescens cum Lithio, ■ N. F. Contains 25 percent, artificial . Vichy salt and 8.3 percent, lithium citrate. Antacid.' Average Dose: 90 grains (6 Gm.). Salt, Volatile. See Ammonium Carbonate. Saltpetre. Seb Potassium Nitrate. Salvarsan. Brand of Arsphdnamine. Salts, Granular Effervescent, Squibb Skilfully made products, from purest ingredients, in accurate and proper propbrtions to secure the best , results. They dis- solve rapidly with brisk effervescence. We make: Salt Cdrlsbadi' Artificial ; Salt Kissingen, Artificial; Lithium Citrate; Magnesium Citrate; Magnesium Sulphate; Sodium Phosphate r Sodium Phosphate Compound; Sodium Sulphate; Salt Vich'S, Artificial. (See these titles.) The founder of the House of Squibb, .Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 220 SQUIBB'S MATERIA MEDICA Sambucus. Sambucus, N. F.; Elder Flowers. Air-dried flowers of Sam- hacas canadensis or of S. nigra (Fam. Caprifoliacece). Faintly sweet, aromatic odor; slightly bitter taste. Used in dropsy; large doses are said to act as Hydragogue Cathartic. Average Dose: 60 grains (4 Gm.). Sandal Wood. Sanialum Album, N. F.; White or Yellow Sandal Wood. Heartwood of Sanialum album (Fam. Sanialacea). Aromatic, persistent odor; strongly aromatic taste. Source of oil sandal wood. Sandal Wood, Red. Sanialum Rubrum; Red Saunders. Heart-wood of Plero- carpus sanlalinus (Fam. Leguminosa), Brownish-red chips or powder; nearly odorless and tasteless. Coloring for alco- holic liquids. Sanguinaria, Squibb Ground for Percolation tin, lb, Sanguinaria; Blood Root; Telterwort, Dried rhizome and roots of Sanguinaria canadensis (Fam. Papaveracea). Of slight odor; persistent, acrid bitter taste. Expectorant, Emetic, Errhine. Average Dose: Expectorant, 2 grains (0.13 Gm.); emetic, 15 grains (1 Gm.). Santonin, Squibb 'Crystals bottle, oz. Powdered bottle, oz. Sanloninum. Anhydride or Lactone of Sanlonic Acid. CisHigOs. From Santonica {Arlemisid pattciftora) , Colorless, shining, flattened, odorless prisms, or white powder; nearly tasteless at first, then becoming bitter. Turns yellow on exposure to light. I Gm. dissolves in 43 mils (Cc.) alcohol, 1 .7 chloro- form, 110 ether; very slightly soluble, m water; soluble in alkalies and most oils. Vermicide, especially against ascaris. Average Dose: 1 grain (0.065 Gm.). Antidotes: chloral hy- drate by enema, cold affusions. Santyl, Sanlalol Salicylate; Salicylic Ester of Sanlalol. Yellowish oil; faint balsamic odor and taste; sp. gr. 1.07. Soluble in about 10 parts alcohol; insoluble in water. Anticatarrhal, An- tiseptic. Dose: 8 to 24 minims (0.5 to 1.5 mils [Cc.]), in capsules. Sarsaparilla, Sarsaparilla ; Radix Sarsa; Sarsaparilla (Fam. Liliaceai). Formerly used as Alterative in chronic rheumatism, skin dis- eases, syphilis, etc.; now employed mainly as taste corrigent. Average Dose: 30 grains (2 Gm.). (See also Fluidextract; Syrup.) SQUIBB'S MATERIA MEDICA 221 Sassafras, Squibb tin, lb. Sassafras. Dried bark of root of Sassafras Variifolium (Fam. Lauracea), collected in early spring or autumn, and deprived of outer corky layer. Mild Aromatic and Carminative; but used chiefly as flavoring. Average Dose: lYz drachms (10 Gm.). Sassafras Pith. Sassafras Medulla, N. F. Dried pith of Sassafras variifolium (Fam. Lauracea), Faint, sassafras-like odor; mucilaginous taste. Demulcent. Saxin. Brand of Benzosulphinide (Saccharin). ScAMMONY Root. Scammoma_ Radix, - Dried root, of Convolvulus Scammonia (Fam. Convo/vu/aceffi), yielding not less than 8 percent, total resin. Hydragogue* Cathartic. Average Dose: 4 grains (0.25 Gm.). (See also Resin.) Scarlet R Medicinal; Toluylazobetanaphthol. Dark brownish-red powder. Nearly insoluble in water; soluble in chloroform, oils, fats. Cicatrizant, ' Antipyic; in suppurating wounds, chronic ulcers, etc., in 4 to 8 percent, ointments. , SCOPARIUS, Scbparius, N. p.; Broom Tops.' Dried lops of Cylisus scoparius (Fam. Leguminosie) . Diuretic. Average Dose: 15 grains (1 Cm.), ® Scopolamine Hydrobromide, Squibb 1 5-grain vial, ; 5-graiQ vial, Scopplamina Hpdrobromidurn. C17H21O4N.HBr.3H2O. Oflicially considered identical with hyoscine ' hydrobromide. Colorless, odorless, slightly efflorescent crystals. I Gm. dis- solves in 1.5 mils (Cc.) water, 20 alcohol; slightly soluble in chloroform; insoluble in ether. Hypnotic, Sedative, Mydriatic (in ]/i percent, solution; also used as preliminary to anaesthesia, and combined with morphine, to produce "twilight sleep." Average Dose: 1/200 grain (0.0003 Gm.); in the insane larger doses are given. Antidotes: tannin, emetics; pilocarpine or moiphine subcutaneously ; chloral hydrate. (See also Tab- lets [Part II].) Scopolamine, Stable. Scopomannit. Aqueous solution scopoleunine hydrobromide pro- tected against decomposition by addition of 10 percent, man- nit.. I mil (Cc.) contains 0.0003 Gm. (V^OO grain) drug. The Squibb -Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of .uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 222 SQUIBB'S MATERIA MEDICA ScuLLCAP. See Scutellaria. Scutellaria. Scutellaria, N. F.; ScuUcap;- Hoodworl. Dried plant of Scutellaria lateriflora (F am. Lahiata). Bitter taste; contains several proximate principles. Used as Nerve Sedative, Anti- spasmodic; in chorea, convulsions, neuralgia, etc. Average Dose: 15 grains (1 Gm.). Seidlitz Powder. See Powder, Seidlitz. Senecio. Senecio Aureus, N. F.; Life Root. Dried, overground por- tions of Senecio aureus (Fam. Composite'). Aromatic odor; bitter, slightly astringent, acrid, pungent taste. Vied as Tonic, Expectorant, Diaphoretic, Diuretic. Average Doge: 60 grains (4 Gm.). Senecio. 5enecio, N. P.; Life Root. Dried overground portions of Senecio aureus (Fam. ComposiitB). Used as Tonic, Diuretic, Expectorant, Diaphoretic. Average Dose: 60 grains (4 Gm.). Senega. Senega; Senega Snakeroot. Dried root of Polsgala Senega (Fam. Polygalacea) ; of correct identity and purity. , Odor slight, nauseating; taste' svfeetish, afterwards acrid. Nauseant Expectorant. Average Dose: 15 grains (1 Gm.). (See also Fluidexlract; Syrup.) © Senna, Squibb *WhoIe tin, lb. Ground for Percolation tin, lb. Powdered tin, lb. Senna. Alexandria and India senna, respectively the dried leaflets of Cassia aculifolia and C. anguslifolia (Fam. Legum- inosa). Cathartic. Average Dose: 60 grains (4 Gm.). Acts in 4 to 5 hours. (See also Confection; Fluidexlract; Syrup.) Serpentaria. Serpenlaria; Virginia Snakeroot. Dried rhizome and roots of Arislolochia Serpeniaria and A. reticulata (Fam. Aristoloch- iacetc). Bitter, similar to gentian. Average Dose: 15 grains (1 Gm.). Serum Antidiphtheritic and Serum Antitetanic. See Part III, Biological Products. Silica. 7'erra Sllicea Purificata; Plirified Kieselguhr; Purified Infusor- ial Earth. Si02 consisting of frustules and fragments of di- atoms purified by boiling with hydrochloric acid. Fine, bulky, white or light-gray, odorless, tasteless, insoluble powder. Fil- tering medium, particularly for acid solutions. SQUIBB'S MATERIA MEDICA 223 Silver Citrate. White, odorless, heavy powder. Soluble in about 3800 parts water. Astringent and Bactericide, like silver nitrate. Silver Colloidal. See Solargentum. © Silver Nitrate, Squibb Crystals or ^Granulated bottle, oz. Argenii Nilras, AgNOs. Colorless, transparent, odorless, crystals or granules; bitter, caustic, metallic taste. Darkens on exposure to light. 1 Gm. dissolves in 0.4 mil (Cc.) water, 30 mils alcohol. Incompatible with alkahes, bromides, iodides, chlor- ides, hypophosphites, alkaloidal salts, tannic acid in solution ; with vegetable -infusions, tinctures, and decoctions; with all organic substances and reducing agents. Dispense solutions in black bottles. Escharotic, Astringent, Antiseptic. Average Dose: l/e grain (O.OI Cm.). Antidotes; White of egg or. milk; emetics subcutaneously ; sodium or ammonium chloride. (See also.Reagents [Part IV]; Tablets [Part IIJ.) Silver Nitrate 1% Solution, Squibb box of 1 dozen Ampuls, For prevention of ophthalmia neonatorum, 1 or 2 drops being instilled into each eye. Silver Nitrate Crayons, Squibb bottle of 100, Small crayons of pure silver nitrate, about ^/le in. thick and I/4 in. long. Especially designed for genito-urinary surgeons, and affording a convenient, sanitary means of cauterization, each crayon serving for one application only. Used in an applicator. Silver Nitrate Mitigated, Squibb bottle, oz. Argenii Nitras Miligaius, U. S. P. Vlllth Rev.; Silver Nitrate Diluted. 66.7 percent, potassium nitrate, 33.3 percent, pure silver nitrate. Its constituents retain the solubility in water and in alcohol characteristic respectively of silver nitrate and potassium nitrate. Being , made from pure materials, the pro- duct is free from all prohibited contaminations. Used ex- ternally where moulded silver nitrate is too powerful. m Silver Nitrate Moulded, Squibb bottle, oz. Argenii Nitras Fusus; Lunar Caustic. Pure silver nitrate melted with approximately 4 percent, hydrochloric acid and moulded into small cones. Caustic, on warts, sluggish ulctrs. The Squibb Label on a package is a positive guaranty for, the uniform Purity and Reliability of the product. We mal Average Dose : 4 grains (0.25 Gm.) . : Explosion may occur when sodium chlorate is heated or subjected to concus- sion or trituration with organic substances (cork, tannic acid, sugar, etc.), or with sulphur, antimony sulphide, phosphorus, or other easily oxidizabli substances. Antidotes: emetics, diuretics; ice; opium; pilocarpine; caffeine subcutaneously. (See also Re- agents [Part IV].)«» The prices of the Squibb Products are in all instances as low as ttie quality and quantity of ingredients and the expense of man- ufacture allow. Theyinchjdecontainers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 228 SQUIBB'S MATERIA MEDICA Sodium Chloride, Squibb bottle, lb. Sodil Chloridum. NaCI., Highly purified, for use in transfu- sion, hypodermoclysis, and other cases where an especially pure product is required. The chlorides and sulphates of calcium and magnesium, and other impurities, have been removed, I Gm. dissolves in 2.8 mils (Cc.J water, 10 glycerin; almost in- soluble in alcohol. Occasionally used as Emetic. Average Dose: 240 grains (15 Gm.). (See also Reagents [Part IVJ ; Tablets, Salt IPart II].) Sodium Citrate, Squibb bottle, lb. ; ^ lb. Sodii Cilras. Na3C6H507.2H20. White, odorless, granu- lar powder; efflorescent in dry air; cooling, saline taste. I Gm. dissolves in 1 3 mil (Cc.) water ; insoluble in alcohol. Systemic Alkali, Diuretic. Average Dose: 15-grains (I Gm.). (See also Reagents [Part IV]; Tablets :[Parf II].) Sodium 'Cyanide. Soda Csanidum. Newly official. NaCN. White, opaque pieces; or white, granular powder; odorless when dry, but ex- haling odor of hydrocyanic acid when damp. Freely soluble in water. Cough Sedative, Antispasmodic. Ordinary Dose: Ve grain (0.01 Gm.). Antidotes: chlorine water or chlor- inated-soda solution, emetics; solution hydrogen peroxide hypo* dermically; ammonia; artificial respiration. Sodium Cyanide Reagent. See Reagents (Part IV), Sodium Diethylbarbiturate. See Barbital-Sodium. Sodium Dimethylarsenate. See Sodium Cacodylate. Sodium Glycerophosphate (Dry), Squibb bottle, lb. ; % lb. ; oz, Sodii Clipcerophosphas. Hydrated Sodium Glycerophosphate containing not less than 68 percent, anhydrous Na2C3H7POe. White, odorless powder; saline taste. Soluble freely in water; almost insoluble in alcohol. Used as Nerve Tonic, and usually given with other glycerophosphates. Average Dose: 4 grains (0.25 Gm.). (See also Elixir; Solution; Tablets [Part II]). Sodium Glycerophosphate 50%. See Solution Sodium Gly- cerophosphate. Sodium Qlycocholate, Squibb 1 -oz. vial, ; J/J-oz. vial, One of the bile ssilts. Greenish-black, very bitter granules; peculiar odor. Soluble in water or alcohol with turbidity. Cholagogue. Dose: 5 to 15 grains (0.3 to I Gm.), as tablets. (See also Tablets [Part II].) ~ SQUIBB'S MATERIA MEDICA 229 ® Sodium Hydroxide, Squibb ' bottle, lb. ; Y^, lb. Soiii H^droxidum; Sodium Hydrate; Soda; Caustic Soda. NaOH. Electrolytic-; exceptionally pure, and assays liigher than U. S. P. requirements of 90 percent. Small, white, crushed lumps. 1 Gm. dissolves in 0.9 mil (Cc.) water; very soluble in alcohol. Caustic, Antacid. Dose: l/z 1° ' grain 0.03 to 0.065 Gm.) well diluted, Aotidoies : water, then vinegar or lemon juice, followed by emetics; demulcents. Note: On exposure sodium hydroxide deliquesces, absorbs carbon dioxide and becomes coated with carbonate. Hence keep well-stop- pered, in dry place. (See also Reagents [Part IV] ; Solution.) Sodium Hypophosphite, Squibb bottle, lb. ; % Ih. i oz. Sodii Hypophosphis. NaPH202.H20. Small, colorless plates, or white granular powder; odorless; bitterish-sweel, saline taste; deliquescent in moist air. I Gm. dissolves in. 1 mil (Go:) water, 2 mils glycerin; soluble in alcohol; insoluble in ether. Ingredient of hypophosphite mixtures used as Tonics. Average Dose: 13 grains (1 Gm.).^ Care should be observed in dispensing this salt, as explosion may occur when it is tritur- ated or heated with nitrates, chlorates or other oxidizing agents. Sodium Hyposulphite. See^odium Thiosulphate. ' Sodium Iodide, Squibb bottle, oz. Sodii lodidum, Nal. Made by a specif Squibb process. White, odorless, crystalline powder; saline, slightly bitter taste; deliquescent in moist air. ) Gm. dissolves in 0.33 mil (Cc.) water, about 2 mils alcohol, I glycerin. Alterative, Resolvent, Saline Expectorant, like potassium iodide. Average Dose: 5 grains (0.3' Gm.). Incompatible with many alkaloidal salts, spirit nitrous ether, potassium chlorate, acids, bismuth and ferric salts, etc. Sodium Nitrate, Squibb bottle, lb. Cfiili Saltpetre. NaNOa. Dropped from U. S. P. pdorless, greuiular salt; cooling, saline, slightly bitter taste; hygroscopic in moist air. Soluble in about 1.1 parts water, 100 alcohol. Rarely used in human medicine, at present; in intestinal catarrhs, rheumatism, dropsy, etc. Ordinary Dose: 15 grains (1 Cm.) well diluted. Externally (in rheumatism), in 1 :3 solu- tion. Antidotes: stimulants; ice water; opium. (See also Reagents [Part IV]..) If difficulty is experienced in procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 230 SQUIBB'S MATERIA MEDICA ® Sodium Nitrite, Squibb bottle, !4 lb. ; oz. Sodii Niiris. 95% NaN02. White granules; odorless; mild, saline taste. I On. dissolves in 1.5 mils (Cc.) water; slightly soluble in alcohol. Vaso'-dilator, similar to nitroglycerin but slower and more prolonged. Average Dose : 1 grain (0.065 Gm.). Incompatible in solution with acetanilid, aniipyrine, hypophosphites, iodides, vegetable infusions, decoctions or tinc- tures, or mercur}( salts. Keep well stoppered; on exposure it ijeliquesces and is oxidized to nitrate. (See also Reagents [Part IV].) Sodium Nitroprusside Reagent. See Reagents (Part IV). Sodium Oxalate Reagent. See Reagents (Part IV). Sodium Perborate. Sodii Perboras. NaB03.4H20. While, granular, odorless salt. Soluble in water, decomposing into hydrogen peroxide -and sodium metaborate. Antiseptic, Deodorant, Bactericide; in 2% solution or as dusting powder, on purulent wounds, etc. Sodium Peroxide Reagent, See Reagents (Part IV). Sodium Phenolsulphonate, Squibb bottle, oz. Sodii Phenolsulphonas ; Sodium Sulphocarbolate. CgHsO.- S03Na,2H20. It is a very difficult matter to make an article of correct chemical identity and satisfactory purity. The product quoted contains the officially required 99 percent, pure sodium paraphenolsulphonate. White or nearly while powder; cool- ing, saline, bitter taste; slightly efflorescent. I Gm. dissolves in 4.2 mils, (Cc.) water, 140 alcohol, about 5 glycerin. Used as Intestinal Antiseptic; mostly internally in typhoid fever, fermentative dyspepsia,* phthisical diarrhea, etc. Average Dose: 4 grains (0.25 Gm.). Externally in % to 1 percent, solution; in gonorrhea, putrid wounds, etc. S Sodium Phosphate, Squibb (aranular) tin, lb. ; l/^ lb. ; % lb. boltle, lb. ; J/i lb. ; '/^ lb. Sodii Phosphas; Disodium Orthophosphate. Na2HP04.12H20. Much of the sodium phosphate on the market contains arsenic in quantities sufficient to render its use dangerous. The article here listed has been recrystallized and purified until no trace of arsenic can be detected in 5 Gm. by the Marsh-Berzelius test in 1/2 hour. Colorless; odorless; cooling, saline taste. Very efflorescent. 1 Gm. dissolves in 2.7 mils (Cc.) water; insoluble in alcohol. Incompatible with solutions of alkaloidal salts, and, on trituration, with antipyrine, phenol, chloral hydrate, resorcin, salicylic acid or sodium salicylate. Keep well closed, in cool place. Saline Cathartic, similar to magnesium sulphate (epsom salt). Average Dose: 60 grains (4 Gm.); as much as 240 gfains (16 Gm.) is often given. (See also Reagents [Part SQUIBB'S MATERIA MEDICA 231 Sodium Phosphate, Acid, Squibb bottle, lb. ; !4 lb. ; oz. Sodium Biphosphate; 'Monosodium Dihydrogen Phosphate. NaH2P04-)-aq. Colorless, slightly hygroscopic granules; acid reaction. '^'Soluble in less than 1 part water; insoluble in al- cohol. Urine-acidifier, usually given in conjunction with hexa- methylenamine as urinary bactericide administered two hours before latter drug. Dose: 15 to 20 grains (1 to 1.3. Gm.), in sweetened, flavored solution, as often as required to render urine acid, © Sodium- Phosphate, Granular Effervescent, Squibb bottle, lb. ; 4-oz., per doz. SoJii Phosphas Effervescens. 20 percent, exsiccated sodium phosphate. Average Dose: 150 grains (10 Cm.). Sodium Phosphate Compound, Granular Effervescent, Squibb 4-oz. bottles with dose-measures, per doz. Formerly called G. E. Antilithic. Suggested by Dr. H. H. Tinker, of New York, as an agreeable and efficient Eliminant in gout, rheumatism and all conditions connected with the uric acid diathesis. . Each drachm contains 5 grains Dried Sodium Phosphate, and 1 grain each Sodium Benzdate and Sodium Salicylate True, all of the Squibb quality. Ordinary Dose : 2 drachms (8 Cm.). Sodium Phosphate Exsiccated, Squibb bottle, lb. ;^ilb. Soda Phosphas Exsiccaius; Dried or Anhydrous Sodium Phos- phate. Na2HP04. Crystalline sodium phosphate is very apt to effloresce and become uncertain in dosage. This disadvantage, combined with the largeness of the dose, has created a prefer- ence for the dried salt, the dose of which % only one-half that of the granular salt. Exceedingly hygroscopic, hence must be kept well stoppered and in a dry place. Sodium Phosphate Liquefied. See Solution Sodium Phos- phate Compound. Sodium Pyrophosphate, Squibb _ tin, lb. - ; % lb. ; oz. SoJi! Psrophosphas, U. S. P., Vlllth Rev. Na4P2O7.10H2O. Colorless, odorless, transparent prisms, or white powder, of cooling, saline, feebly alkaline taste; slightly efflorescent. Sol- uble in about 1 1 .5 parts water ; insoluble in alcohol. Laxative, similar to sodium phosphate. Average Dose: 30 grains (2 Gm.). ® Sodium Salicylate, Squibb * From Synthetic Acid, Powdered ' tin, lb. ; % lb. ; oz. Soda Salicylas. NaCYiHsOs. White or faintly pinkish pow- The Squibb products are recognized everywhere as the Quality Standard. They are of uniform purity and strength, hence therapeutically dependable. When ordering or prescribing me- dicinal products, you will do well always to specify SQUIBB'S. 232 SQUIBB'S MATERIA MEDICA ®Sodium Salicylate, Squibb (Cont.) der; odorless or nearly so; sweetish, saline taste. I Cm. dis- solves in 0.9 mil (Cc.)' water, 9.2 alcohol; soluble also in glyycerin. Antirheumatic, Antineuralgic, Antiseptic. Avef age Dose: 15 grains (1 Cm,). Incompatible with ferric salts, acids, and acid salts, quinine salts in solution, etc. (See also Tablets [Part II].) Sodium Salicylate from Natural (True) Acid, Squibb (Powdered) bottle, lb. ; 14 'b. ; oz. Prepared with natural (true) salicylic acid derived from pure oil betula. Believed by many physicians to be better borne and more efficient than sodium salicylate, prepared from synthetic acid; according to Council on Ph. & C. of A. M. A., not superior to latter. (See also Tablets [Part II].) Sodium Sulphate, Squibb tin, lb. ; ^4 !!>• Soda Sulphas; Glauber's Salt. Granular. Na2SO4.I0H2O. Colorless,, transparent, efflorescent granules; odorless; of bitter, saline taste. I Gm. dissolves in about 1 mil (Cc.) water; soluble in glycerin; insoluble in alcohol. Saline Cathartic; more unpleasant than magnesium sulphate. Average Dose: 240 grains (15 Cm.). Keep well stoppered; very efflorescent. (See also Reagents [Part IV].) Sodium Sulphate Dried, Squibb bottle, lb. ; % lb, Na2S04.H20. The crystalline salt deprived of water of crys- tallization. Therapeutically twice strength of crystals or granu- lar %alt, besides having the advantage of being more uniform and stable. Sodium Sulphate Anhydrous, Reagent. See Reagents (Part IV). Sodium Sulphate, Granular Effervescent, Squibb bottle, lb. ; 4 ozs., per doz. Contains 30 grains sodium sulphate per drachm. Dose: 2 to 8 drachms (8 to 30 Gm.). @ Sodium Sulphite Dried, Squibb tin, lb. ; J4 lb. -Soda Sulphis Exsiccalus. Na2S03. Granular salt, made from high-quality crystalline sulphite by depriving it of its crystal water. Readily and almost perfectly soluble in water; very sparingly soluble in alcohol. Antiseptic, Antizymotic; used mainly as mouthwash in stomatitis, in. 1 :16 solution. Average Dose: 15 grains (1 Gm.). Incompatible with mineral acids. Keep well-stoppered, in cool place. Sodium Sulphocarbolate. See Sodium Phenolsulphonate. Sodium Tartrate, Squibb bottle, 54 lb. White, odorless, almost tasteless crystals. Freely soluble in .water. Succedaneum for Rochelle and Epsom salts. Dose: purgative, 4 to 8 drachms (15 to 30 Gm.) ; diuretic and refrig- erant, 15 to 45 grains (1 to 3 Gm.). SQUIBB'S MATERIA MEDICA 233- Sodium Thiosulpfaate, Squibb tin, lb. Sodli Thiosulphas. NaaSaOs.SHaO. More commonly but in- correctly called "Sodium Hyposulphite." Colorless, granular salt; cooling, afterwards bitter taste; efflorescent in warm air, slightly deliquescent in moist air. I Gm. dissolves in 0.5 mil (Cc.) water; insoluble in alcohol. Antiparasitic, Antizymotic, Cathartic. Used largely in photography ; also to remove iodine and silver nitrate stains,^lc. Average Dose: 13 grains (I Gm.). Incompatible with acids, iodine, chlorine, solutions of nitrates, silver or lead salts. ICeep can well closed, in cool place. (See also Reagents [Part IV].), Sodium and Ammonium Phosphate Reagent. See Re-' agents (Part IV). Sodium and Potassium Tartrate. See Potassium and Sodium Tartrate. SoLANUM. Solamim, N. F.; Horse-nettle Berries. Air-dried ripe fruit of Solanum cafoUnense (Fam. Solanacea) . Pepper-like odor ; bitter, acrid taste. ^ Used , as Sedative, in convulsions , and epi- lepsy. Average Dose: 60 grains (4 Gm.). Solargentum, Squibb bottle, lb. ; 14 lb. ; oz. Brownish-black, lustrous, odorless granules, containing 19 to 23 percent, silver in colloidal formt associated with an organic protective colloid. Nonhygroscopic under ordinary conditions. Freely and quickly soluble in water; neutral and perfectly non- irritating in any strength; not precipitated from its 5oluliq§s by sodium chloride, and does not coagulate albumin. Non-irritant Antiphlogistic and Germicide; in gonorrhea, and in inflainmation of the eyes, e^r, nose and throat. Used chiefly in I to 23 percent, or stronger solutions; also in bougies and suppositories. [CAUTION. — There are a number of colloid silver preparations on the market, of dif- fering descriptions. It is therefore necessary to specify "Solargentum, Squibb" when this product is desired.] Q Solution Acid Arsenous. Liquor Acidi Anenosi; frequently erroneously designated as "Solution Arsenic Chloride." Containing I percent, arsenic trioxide in solution with dilute hydrochloric acid and water. Alterative, Antiperiodic. Average Dose: 3 minims (0.2 mil [Cc.]), in water. Antidotes: arsenic antidote, or magnesia in milk; then emetics. Incompatible with iron in solution, with vegetable astringent infusions, tinctures or decoctions. Since' we make only one quality of eacfi proi3uct,, tliat best suited to the purposes intended, ttie specification Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 234 SQUIBB'S MATERIA MEDICA Solution Acid Carbolic (Crude), Squibb quart 2 percent, solution of crude 90 percent, carbolic acid. Used for general Disinfectant and household purposes. It may, with- out injury or staining, be freely sprinkled upon bedding, clothing, carpets, floors, furniture, etc., or, when further diluted, may be applied to the body. This dilute solution may be safely entrusted to hands unskilled in the use of powerful medicinal agents, and yet is strong enough fA most useful purposes. Antidotes: alcohol or whiskey freely at once; emetics hypo- dermically; raw white of egg, or other demulcents. Solution Aluminum Acetate, Squibb bottle, pint. Liquor Alumlni A.ceialis, N. F.; Burow's Solution; not Solu- tion Aluminum Acetate, N. F. III. Made by interaction of lead acetate and aluminum sulphatca Contains 4.5 to 5.5 Cm. neutral aluminum acetate in 1 00 mils (Cc.) . External Antiseptic and Astringent; used diluted with I to 3 parts water. Solution Aluminum Aceto-Tartrate. Liquor Alumini Acelico-Tartralis, N. F. Contains about 50 percent, aluminum aceto-tartrate made extemporaneously. Ex- ternal Astringent, Antiseptic. ® Solution Aluminum Subacetate. Liquor Alumini Subaceiatls, N. F.; formerly officially known as Solution Aluminum Acetate. Contains 7^5 to 8 percent, basic aluminum acetate. External Antiseptic and Astringent; used diluted with I to 3 parts water. I © Solution Ammonium Acetate. • Liquor Afnmonii Acelatis; Spirif of Mindererus. 7 percent. Clear, colorless liqui the House of Squibb stands today as a Living monument to the honor, integrity, zeal and devotion of its founder." 236 SQUIBB'S MATERIA MEDICA Solution Carmine. Liquor Carmini, N. F. Each 100 mils (Cc.) contains 6.5 Gm. carmine, 36.5 mils each ammonia water and glycerin, and water. Coloring. Solution, Channing's. See Solution Mercury and Potas- sium Iodide. / Solution Chlorine Compound, Liquor Chlori Composilus, N. F.; Chlorine Water. G.35 Cm. chlorine in 100 mils (Cc). Yellow liquid; strong odor and taste of chlorine. Disinfectant, Antizymotic; Reagent. Aver- age Dose: 1 fluidrachm (4 mils), well diluted. Very, unstable; should not be dispensed unless recently made. Solution, Clemens. See^Solution Arsenic, Clemens'. Solution Coal Tar. Liquor Picis Carbonls, N. F. Each 100 mils (Cc.) contains 20 Gm. coal tar dissolved by aid of 10 Gm. quillaja. Stimu- lating Antiparasitic and Antipruritic Dermic. Q Solution Cresol Compound, Squibb bottle, pint Liquor Cresolis Composiius. 50 percent, pure cresol, held in solution by soap produced from' linseed oil and sodium hy- droxide. Light-amber liquid; phenol-like odor, _ Soluble in warm water in ail proportions. Darkens with age, but this does not affect its antibacterial action. Superior succedaneum for carbolic acid (phenol), having carbolic acid coefficient of about 3, hence three times as powerful as latter. Powerful Antiseptic, Disinfectant, Deodorant and Parasiticide. Does not precipitate albumen, attack instruments, nor slain linen. Used in I to 3 percent, solution, best made with ^yarm water. Solution, Dobell's. See Solution Sodium Borate Compound, Solution, Donovan's. See Solution Arsenic and Mercury^ Iodide. Solution, Fehling's, See under Fehling's Test Solution Ele- ments. ® Solution Formaldehyde. Liquor FormaUeh^Ji; Formalin; Formol. Aqueous solution containing not less than 37 percent. CH2O. Clear, colorless liquid; pungent odor; caustic^ taste; irritating vapor; sp. gr, 1.075 to 1.078; miscible with water or alcohol. General Disin- fectant, Deodorant, Antihydrolic ; hardener of microscopical specimens. Used m Y2 \o 2 percent, solution medicinally; in weaker solurions for hygienic purposes. Incompatible with al- kalies, ammonia, and oxidizing agents. Antidotes: solution am- monium acetate; ammonia by inhalation. Solution Fowler's. See Solution Potassium Arsenite. SQUIBB'^ MATERIA MEDICA 237 Solution Glycerophosphates Compound, Squibb (No Sugar) bottle, pint, Each fluidounce contains 8 grains calcium glycerophosphate, 16 grains sodium glycerophosphate (75%), 1J4 grains iron gly- cerophosphate, I grain manganese glycerophosphate, Yl grain quinine glycerophosphate, and l/l6 grain strychnine glycero- phosphate. Employed as Nerve tonic, where the correspond- ing elixir glycerophosphates compound is considered ob- jectionable on account of the sugar. Ordinary Dose: 1 fluid drachm (4 mils [Cc.]), in water, before meals. (See also- Elixir; Tablets [Part 11].) Solution Gold and Arsenic Bromide, Squibb g. s. bottle, pint, ; ^ pint, ; oz. Liquor Auri ei Arsen! Bromidt, N. F. III. Owing to the im- possibility of procuring bromauric acid, called for in present N. F., these laboratories continue to supply the N. F. Ill pro- duct. Each 10 minims contains I/32 grain gold li-ibromide and V40 grain arsenous acid. Used as Alterative, Antidiabetic, Antiepileptic. Average Dose: 3 minims (0.2 mil [Cc.]). Solution Gutta Percha. Liquor Culta Percha, N. P.; Traiiniaticin. 16 Gm. gulta percha dissolved in 100 mils (Cc.) chloroform. Protective,, like collodion. Solution, Half's, See Solution Strychnine Acetate. Solution Hydrastine Compound. Liquor H'sdraslina Compositus, N. F. ; Colorless Hydrastine Solution. Each fluidounce contains about l^^g grains each hydrastine hydrochloride, aluminum chloride, calcium chloride, and magnesium chloride, I/2 grain potassium chloride, 240 minims glycerin, and water. Antiseptic Astringent externally; Tonic and Hemostatic internally. Average Dose : I fluidrachnt (4 mils [Cc.]). ® Solution Hydrogen Peroxide, Squibb bottle, lb. ; J/1 lb, ; % lb. Liquor Hydrogenii Dloxidi; Solution Hydrogen Dioxide. 3 percent. H2O2, equivalent to 10 volumes available oxygen. Made by an improved process which insures high purity and excellent keeping properties. Free from acetanilid and alcohol. A harmless, non-staining Antiseptic, Disinfectant and Deodor- izer; on cuts, wounds, etc.; as an antiseptic mouth wash; de- odorizer of the body, utensils, etc. Used pure 0/ diluted with 1 to 3 parts water. Used also as Reagent. Average Dose : I fluidrachm (4 mils [Cc.]). Keep in cool place and quiet; occasionally remove the cork. The Squibb Ideals have taken concrete form in the Squibb- Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 238 SQUIBB'S MATERIA MEDICA Solution Hypophosphites. Liquor Hypophosphitum, N. F. Each fluidounce contains about I6I/4 grains calcium hypophosphite, 9 grains sodium hypophosphite, SVs grains potassium hypophosphite, in water; unsweetened. Alterative Tonic, Average Dose; 1 fluidrachm (4 mils [Cc.]). (See also Syrup.) Solution Hypophosphites Compound, Squibb (No Sugar) pint. Liquor Hypophosphiium ComposHus, N. F. Each fluidounce contains about 4 grains each calcium and potassiunr hypophos- phites, 1 grain each sodium, quinine and manganese hypophos- phites, 2 grains ferric hypophosphite, and V32 grain strychnine hypophosphite. Used in place of Syrup Hypophosphites G>m- pound where sugar is objectionable. Average Dose: 1 fluid drachm (4 mils [Cc.]), after meals, © Solution Hypopliysis, Squibb box of 6X1 Co. ampuls, . box of 6X0-5 Cc. ampuls, Liquor Hy/pophssis; Solution of Pituitary Body. Prepared under aseptic conditions from posterior lobes of fresh pituitary gland from cattle, and carefully standardized and sterilized. Stimulant and Constrictor of unstriped muscle, especially that of the uterus and blood vessels; used in second stage of labor, uterine atony with post-parfum hemorrhage and other forms of uterine bleeding, shock and other conditions of low blood pressure, certain cases of pulmonary hemorrhage, post-operative intestinal paresis, etc. Average Dose: 16 minims (1 mil [Cc.]) hypodermically, repeated in 30 to 60 minutes if necessary. Solution Iodine Compound. Liquor lodi Composiius; LugoVs Solution. Aqueous liquid containing about 5 percent, iodine and 10 percent, potassium iodide. Alterative. Average Dose: 3 minims (0.2 mil [Cc.]), diluted. Solution Iodine Phenolated. Liquor loJi Phenoldius, N. F. ; Boulton's Solution. Each 100 mils (Cc.) contains 1 .5 mils compound solution iodine, 0.6 mil liquefied carbolic acid, 1 6.5 mils glycerin, water q. 9. Antiseptic. Solution Iron Acetate. Liquor Ferrl Aceiaiis, N. F. 31 percent, anhydrous ferric acetate, equivalent to 7.5 percent. Fe. Hematinic, Hemostatic. Average Dose: 5 minims (0.3 mil [Cc.]). Solution Iron Albuminate, Squibb pint. Of same Iron Albuminate strength as the Liquor Ferri Albu- minati, N. F., but made by a process'^ielding a better article. Each fluidounce contains 2.4 grains metallic iron as albuminate. Hematinic. Average Dose: 2 fiuidrachms (8 mils [Cc.]). SQUIBB'S MATERIA MEDICA 239 Solution Iron Chloride, Squibb g. s. bottle, pint Liquor Petri Chloridi. About 29 percent, anhydrous ferric chloride (equivalent to, 10 percent, iron). Reddish-brown liquid; acid, strongly styptic taste; acid reaction. Sp. gr. ] .29 to 1 .32. Astringent, Styptic, Hematinic ; but used mainly pharmaceutically. Average Dose: V/z minims (0.1 mil [Cc.]), well diluted. Solution Iron Citrate. Liquor Ferri Cilratls, N. F. Aqueous solution containing ferric citrate corresponding to 7.25 percent. Fe.- Hematinic. Aver» age Dose: 10 minims (0.65 mil [Cc.]). Solution Iron Hypophosphite. 'Liquor Ferri Hspophosphitis, N. F. Each fluidrachm contains about 1 grains iron hypophosphite, in glycerin and water. Hematinic. Average Dose: 15 minims (I mil [Cc.]). Solutionjron Iodide, Squibb 1 -oz. ampuls, 2 in box, per box. Designed for convenient preparation of Syrup Iron Iodide. Contains about 81 Gm. iron iodide (ferrous) in 100 mils (Cc). Sp. gr. about 1 .73. One volume with 1 1 volumes syrup makes syrup iron iodide of official strength. Solution Iron Nitrate, Squibb ^ lb. Liquor Ferri Nilratis,. N. F, Contains about 6 percent, an- hydrous salt, or about 1.3 percent, metallic iron. Clear, red- dish Iiqui,d; sp. gr. about 1,060. Astringent, Styptic, Hematinic. Average Dose: 5 minims (0.3 mil [Cc.]). Solution Iron Oxychloride, Squibb pint Liquor Ferri Ox^chloridi, N. F. Contains ferric oxychloride corresponding to about 3 percent, metallic iron, dissolved in mixture of glycerin and water. Hematinic, Astringent, and Ar- senic Antidote, but used mainly for preparing Solution Iron Albuminate. Solution Iron Peptonate, and Solution Iron Pep- tonate with Manganese. Average Dose: 30 minims (2 mils [Cc.]). ' Solution Iron OxysUlphate. Liquor Ferri Oxysulphalis, N. F. 100 mils (Cc.) contain product of interaction of 16.5 Gm. each ferrous sulphate and nitric acid. Astringent. Solution Iron Peptonate, Squibb pint Liquor Ferri Peptonati, N. F. Each fluidounte contains about 2Y4 grains metallic irqn as peptonate, Hematinic. Average Dose: 2 fluidrachms (8 mils [Cc.]). The Squibb Label on a package is a positive guaranty for ttie uniform Purity and Reliability of the product. We malyeight warm alcohol; almost com- pletely soluble in ether; insoluble in water. Antiparasitic Der- mic, Expectorant. Average Dose: 15 grains (I Gm.). © Stramonium. Stramonium ; Thornapple Leaves; Jamestown, or Jimson, Weed. Dried leaves of Datura Stramonium or of D. Talula (Fam. Solanacece), assaying not less than 0.25 percent, alkaloids. Odor heavy, narcotic; taste nauseous. Nerve Sedative, Anti- spasmodic, Anodyne. Average Dose: 1 grain (0.065 Gm.). Antidotes: tannin; apomorphine hypodermically ; morphine; ammonia by inhalation. See also Extract; Fluidextract; Tincture.) Strontium Acetate, Squibb bottle, lb. ; % lb. ; oz. Sr(C2H302)2.!^H20. White, crystalline powder. Soluble in water. Anthelmintic ; also Reagent. Dose : 40 grains (2.6 Gm.); in water and glycerin, twice daily for five days. Strontium Arsenite, Squibb bottle, oz. Sr(As02)2'-4H20. White powder. Soluble difficultly in water. Alterative, Antiperiodic ; in chronic skin diseases, malaria, etc. Dpse': 1/so to I/15 grain (0.002 to 0.004 Gm.), thrice daily. Antidotes: arsenic antidote or magnesia and milk; emetics ; stimulants. Strontium Bromide, Squibb (Crystals) bottle, lb. ; '/Tib- ! oz. Stroniii BromiJum. SrBr2.6H20. Free from barium. Color- less, odorless, bitter-saline crystals. 1 Gm. dissolves in 0.35 mil (Cc.) water; soluble in alcohol; insoluble in ether. Nerve Sedative, similar to sodium bromide; also Reagent. Aver- age Dose: 15 grains (1 Gm.). Incompatible in solution with mineral acids, alkaloidal salts, and salts of heavy metals. Strontium Carbonate. Stroniii Carbonas, N, F. SrCOg. White, odorless, tasteless powder, insoluble in ordinary solvents. Used technically. Strontium Iodide, Squibb g. s. bottle, J4 ">• ; °z. Strontii lodiJum, Srl2.6H20. Almost colorless, odorless, bit- ter-saline, deliquescent, hexagonal plates, darkening on expo- sure. 1 Gm. dissolves in 0.2 mil (Cc.) water; soluble in alcohol, slightly soluble in ether. A deeply colored article should not be dispensed. Alterative, like potassium iodide; Expectorant. Average Dose: 5 grains (03 Gm.). Incom- patible in solution with alkaloidal salts, chloral hydrate, mineral acids, alkalies and metallic salts generally. SQUIBB'S MATERIA MEDICA 253 Strontium Lactate, Squibb bottle, !4 lb. ; oz. * White, granular powder; slightly bitter taste. Soluble in 4 parts water; in alcohol. Used as Alterative, Vermicide, Anti- catarrhal; in rheumatism, chorea, worms, nephritis, etc. Dose: 5 to 15 grains (0.3 to I Gm.); vermicide, 30 grains (2 Gm.) twice daily for 5 'days. Strontium Salicylate, Squibb bottle, lb. ; ^i lb. ; oz. Sironlii Salicslas, Sr(C7H503)2.2H20. White, crystalline, odorless, powder; sweetish, saline taste. I Gm. dissolves in 19 mils (Cc.) water, 61 alcohol. Antirheumatic, Intestinal Antiseptic. Average Dose: 15 grains (1 Gm.). Incompatible in solution with ferric salts, , mineral acids, quinine salts, silver nitrate and lead acetate. ' Q Strophanthin, Squibb 5-grain vial Slrophanlhinum. Glucoside (or mixture of glucosides) from Strophanlhus. Exceedingly powerful and poisonous, hence great caution should be used in handling if. White or faintly yellowish, crystalline, intensely bitter powder. Soluble freely in water or diluted alcohol; nearly insoluble in chloroform or ether. Heart Stimulant, lilie digitalis, but acts more rapidly and is excreted sooner; hence preferred in emergencies, used hypodermically. Absorption from alimentary canal variable, hence oral use inadvisable. Average Dose: by mouth, l/eo grain (0,001 Gm.) ; intravenously, l/so grain (0.00075 Gm.). Antidotes: emetics; atropine or pilocarpine subcutaneously ; picroloxin; camphor or brandy as stimulants. Strophanthin Crystallized or G-Strophant^in. See Ouabain. ffi Strophanthus. Strophanlhus. Dried ripe seeds of Strophanthus Kombe or of S, hispiJus (Fam. >lpoci;nanu5 Laclucarii, ]0 vol. percent, tincture lactucarium (1 :2), 20 glycerin, 5 orange-flower water. Used as Cough Seda- tive. Average Dose: 2J/^ fluidrachms (10 mils [Cc.]); Syrup Lemon. See Syrup Acid Citric. Syrup Licorice. See Syrup Glycyrrhiza. Syrup Manna. Syrupus Manna, N. F. Each fluidounce represents 57 grains manna. Laxative. Average Dose: 2 fluidrachms (8 mils [Cc.]). SQUIBB'S MATERIA MEDICA 263 Syrup Morphine and Acacia. Syfupus MorphiniB ei Acacia, N. F.; Pectoral Syrup; Jack- son s Pectoral (or Cough) Syrup. Each fluidounce contains ^14, grain morphine hydrochloride, with mucilage acacia and oil sassafras. Average Dose: 1 fluldrachm (4 mils [Cc.]). Syrup Orange, Squibb pint Syrupus Aurantii. 5 mils (Cc.) tincture sweet orange peel and 0.5 Gm. citric acid in 100 mils. Flavoring vehicle. Syrup Orange Flowers. Syrupus Aurantii Florum. Sugar dissolved in orange-flower water. Flavoring vehicle. Syrup, Pectoral. See Syrup Morphine and Acacia. Syrup Phosphates Compound., -r S^upHs Phosphalam Compositus, N. F. ; Chemical Food. 50 vol. percent, solution phosphates compound with syrup and glycerin, colored red with tincture cudbear. Antiquated Tonic. Average Dose: 1 fluidrachm (4 mils [Cc.]). Syrup Phosphates with Quinine and Strychnine. Syrupus Phosphaium cum Qulnina el Strychnina, N. F.; Syrup Hydrochlorophosphates. Each 1000 mils (Cc.) contains 500 mils solution phosphates compound, 4.4 Gm. quinine hydro- chloride, 0.14 Gm. strychnine nitrate, with glycerin and syrup. Used as General Tonic. Average Dose: 1 fluidrachm (4 mils). Syrup Poppy. S^Tupus PapaVeris, N. F. Representing 10 Gm. poppy capsules in 100 mils (Cc). Mild Opiate, Sedative. Average Dose: 1 fluidrachm (4 mils [Cc.]). Syrup Quinidine. iSj^rujDus Quinidinn' Tivctura CincbontE. Assays 0.8 to 1 Gm. alkaloids in 100 mils (Cc). Astringent Bitter Tonic. Average Dose: 1 fluid drachm (4 mils). Tincture Cinchona Compound, Squibb pint ; '/4 pint Tinctura Cinchona Composlta. 100 mils (Cc.) represent 10 Gm. red cinchona, 8 Gm. bitter-orange peel, and 2 Gm. ser- pentaria. Assays 0.4 to 0.5 Gm. alkaloids in each 100 mils (Cc). Aromatic Astringent Bitter. Average Dose: 1 fluid drachm (4 mils). Tincture Cinnamon. Tinctura Cinnamomi. 20 Gm. Saigon cinnamon, and 7.5 Gm. glycerin in 100 mils (Cc). Carminative, Antidiarrheal. Average Dose: 30 minims (2 mils). Tincture Cocculus Indicus. , Tinctura Cocculi Indici, N. F.; Tincture Fish Berries. 10 Gm. drug to 1 00 mils (Cc) ; menstruum, diluted alcohol. External Parasiticide. Antidotes : none known. It is advised to give emetics, copious draughts of warm water and to treat symptoms as they arise. © Tincture Colchicum Seed, Squibb pint ; 54 P'"' Tinctura Colchici Seminis, Assays 0.036 to 0.044 Gm. colchi- - cine in 100 mils (Cc). Antipodagric, Antineuralgic. Average Dose: 30 minims (2 mils). Tincture Coto. See Tincture Paracoto. Tincture Cubeb. Tinctura Cubeha, N. F. 20 Gm. Cubeb in 100 mils (Cc.) Carminative, Expectorant, Genito-urinary Anticatarrhal. Aver- age Dose: 1 fluidrachm (4 mils [Cc]). Tincture Cudbear, Squibb pint ; % pint Tinctura Persionls, N. F. Cftloring-agent where a bright-red tint is desired, particularly in acid liquids. Tincture Cudbear Compound, Squibb ^ pint ; ]/i pint Tinctura Persionis Composita, N. F. Contains cudbear and caramel. Brownish-red coloring agent. SQUIB B'S MATERIA MEDICA 275 Tincture Delphinium. See Tincture Larkspur. © Tincture Digitalis, Squibb pint ; !4 pint Tinctura Digitalis, 10 Gm. digitalis in 100 mils (Cc). Physiologically assayed according to U. S, P. and standard- ized; minimum lethal dose not more than 0.006 mil (Cc.) per Gm. weight of frog. Also assayed biologically by "Cat Meth- od" of Dr. Hatcher. Cardiac Stimulant, Diuretic; in cardiac decompensation ; most effective when heart action is rapid and very irregular; effective in edema only when latter is due' to impaired circulation. Average Dose: 8 minims (0.5 mil). Very slowly absorbed and< eliminated. Shows no positive effect on circulation within 36 or 48 hours and no diuretic influence within 72 hours. Antidotes: tannin, emetics; nitroglycerin, strychnine or alcohol; morphine; rest in horizontal position. Tincture Digitalis Fat=Free, Squibb pint ; Ya pint ; oz. From digitalis leaves deprived of their fat by a process which does not destroy or remove any proximate principles. Phys- iologically assayed and standardized by "Cat Method" of Hatcher ; each, mil (Cc.) represents 1 cat unit. Direct Cardiac Stimulant, Diuretic. Average Dose: 8 minims (0.5 mil). Tincture Dover's Powder. See Tincture Ipecac and Opium. Tincture Ergot Ammoniated. Tinctura Ergota Ammoniata, N. F. 25 Gm. drug in 100 mils (Cc). Menstruum, ammonia water (10%), alcohol and water. Vasoconstrictor, Parturient. Average Dose: 1 fluid drachm (4 mils). Tincture Ferrated Extract Apples. Tinctura Ferrl Pomata, N. F.; Tincture Iron Malate (Crude). 10 Gm. ferrated extract apples, 10 mils (Cc.) alcohol, 80 mils cinnamon water. Mild Hematinic. Average Dose: t fluidrachm (4 mils), containing about !/g grain metallic iron. Tincture Qambir Compound, Squibb pint ; |4 ?■"' Tinctura Cambir Composita. 5 Gm. gambir and 2.5 Gm. Sai- gon cinnamon in 100 mils (Cc). Intestinal and External As- tringent. Average Dose: 1 fluidrachm (4 mils). Tincture Gelsemium, Squibb pint ; % pint Tinctura Celsemii; Tincture Yellow Jasmine. 10 Gm. drug in 100 mils (Cc.) ; assays about 0.03 Gm. alkaloids in TOO mils. Antineuralgic, Antispasmodic, Nerve Sedative. Average Dose: 4 minims (0.25 mil). Antidotes: emetics; atropine or strophan- thin subcutaneously ; stimulants. The prices of the Squibb Products ars in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. They include containers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 276 SQUIBB'S MATERIA MEDICA Tincture Gentian Compound, Squibb pint ; Ya pint Tinclura Ceniiana Composlta. 10 Gm. gentian, 4 Gm. bitter- orange peel and 1 Gm. cardamom, in 100 mils (Cc.). Bitter Tonic, Stcraachic. Average Dose: I fiuidrachm (4 mils). © Tincture Ginger, Squibb pml ; 14 P'">' Tinclura Zingiberis. 20 Gm. ill 100 mils (Co.). Made from best Jamaica ginger obtainable. Aromatic Carminative, Gastro- intestinal Stimulant. Average Dose: 30 minims (2 mils). Tincture Golden Seal. See Tincture Hydrastis. Tincture Green Soap. See Liniment Soap Soft. Tincture Guaiac, Squibb pint ; !4p>>>t Tinclura Cuaiaci, 20 Gm. guaiac in 100 mils (Cc.). Altera- tive; in chronic rheumatism, gout, etc. Average Dose: 1 fluidrachm (4 mils). Incompatible with water. Tincture Guaiac Ammoniated, Squibb pint ; ]4 pin* Tinclura Cuaiaci Ammoniala. 20 Gm. guaiac with aromatic spirit ammonia to produce 100 mils (Cc.). Alterative, Em- menagogue. Average Dose : 30 minims (2 mils) , Incompatible with water. Tincture Guaiac Compound. Tinclura Cuaiaci Composila, N. F. ; Dewees's Tincture of Guaiac. Each fluidounce represents about 37 grains guaiac, 2^/4 grains potassium carbonate and 14.6 grains pimenta. Alterative, Emmenagogue. Average -Dose : 1 fluidrachm (4 mils [Cc.]). Tincture Henbane. See Tincture Hyocyamus. Tincture Hops. Tinclura Humuli, N. F. 20 Gm. liops in 100 mils (Cc.). Bitter Stomachic. Average Dose: I fluidrachm (4 mils). Tincture Hydrastis, Squibb pint ; % pint Tinclura Hydrastis ; Tincture Golden Seal. Assays 0.36 to 0.44 Gm. elher-soluble alkaloids in 100 mils (Cc.). Bitter Tonic. Astringent, Alterative. Average Dose: 1 fluidrachm (4 mils). ® Tincture Hyoscyamus, Squibb pint ; J4 pi°' Tinclura H^osc^ami; Tincture Henbane. Assays 0.0055 to 0.0075 Gm. alkaloids in 100 mils (Co.). Sedative, Antispas- modic, Anodyne. Average Dose: 30 minims (2 mils). Anti- dotes: morphine, pilocarpine, physostigmine, aconitine; stim- ulants. SQUIBB'S MATERIA MEDICA 277 Tincture Icnatia. Tinclura Ignatia, N. F. Assays 0.18 to 0.22 Gm. alkaloids in 100 mils (Cc.).. Nerve Stimulant, Bitter Stomachic; in chronic constipation, neuralgia, nervous depression, etc. Aver- age Dose: 10 minims (0.6 mil [Cc.]). Antidotes: tannin, then emetics; chloral hydrate with bromides per rectum; chloroform by inhalation, if required. © Tincture Iodine, Squibb g. s. bottle, pint ; J4 P'n* Tinciura loJi. 7 Gm. iodine and 5 Gm. potassium iodide in 100 mils (Cc.). Antiseptic, Discutient, Counter-irritant, Al- ' terative. Average Dose: I'/z minims (0.1 mil). Externally undiluted or with equal volume alcohol. Antidotes: apomor- phine hypodermically ; starch paste or flour in warm water; demulcents. Tincture Iodine Stronger, Squibb (Churchill's Tincture) g. s. bottle, pint ; ]4 pint Tinclura lodi Foriior, N. F. 100 mils (Cc.) contains 16.5 Gm. iodine and 3.3 Gm. potassium iodide. Dose: Yl to ' minim (0.03 to 0.06 niil). Tincture Iodine Decolorized. Tinctura lodi Decolorata, N. F. Practically an alcoholic solu- tion of sodium and ammonium iodides for external use as Discutient. Contains 8.3 Gm. iodine per 100 mils (Cc.) in combined form, no free iodine, t Tincture Ipecac and Opium, Squibb pint ; J4pint Tinciura Ipecacuanha el Opii, N. F.; Liquid Dover's Powder; Tincture Dover's Powder. Made from a depurated solution of opium, and hence contains only the valuable anodyne and hypnotic principles of opium, beside the ipecac constituent. 100 mils (Cc.) represent 10 Gm. each deodorized opium and ipecac. Diaphoretic, Anodyne, Antispasmodic. Average Dose: 8 minims (0.5 mil) (containing nearly l/jo grain mor- phine). Antidotes: potassium permanganate solution (2 grains in water), then emetics; atropine or strychnine hypodermically. © Tincture Iron Chloride, Squibb g. s. bottle, pint, ; 1/^ pint; ; oz. Tinclura Ferri Chloridi; Tincture Iron Per- or Sesqui-chloride. Contains 35 volume percent, solution ferric chloride (equal to 13 percent, ferric chloride, or 4.48 percent, iron), with alcohol. Styptic, Astringent; Hematinic. Average Dose: 8 minims (0.5 mil [Cc.]), well diluted. Incompatible with alkalies, alkali benzoates, antipyrine, tannin, and vegetable infusions, tinctures or decoctions. If difficulty is exp'erienced in procuring any Squibb product, in the original paclBred for them; and in the words of William Miller Bartlett, "the House of. Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 284 SQUIBB'S MATERIA MEDICA © Tincture Valerian Ammoniated, Squibb pint ; Y^ pint Tinctura Valeriana Ammoniata, 20 Gm. valerian, with aro- matic spirit ammonia, in 100 mils (Cc.). Nerve Sedative, Anti- spasmodic. Average Dose : 30 minims (2 mils) . Tincture Vanilla, Squibb pint ; 14 pi°> Tlnciura Vanilla, N. F. Dropped from U. S. P. A pure and genuine product, made from choicest Mexican vanilla beans, 10 Gm. per 100 mils (Cc.). Free from adulterant of any nature, so commonly used in the so-called "Extracts of Vanilla." Flavoring. Tincture Vanillin Compound, Squibb pint ; 14 pint Tinctura Vanillini Composifa, N. F. III. Dropped from pres^ ent N. F., but still in common use as a flavoring agent. 0.65 Gm. vanillin and 0.04 Gm. coumarin, in 100 mils (Cc.), with alcohol, glycerin, syrup and compound tincture cudbear. Tincture Veratrum Viride, Squibb pint ; % pint Tinctura Veratri Viridis. 10 Gm. drug in 100 mils (Cc). Cardiac and Circulatory Depressant, Diaphoretic. Average Dose: 8 minims (0.5 mil [Cc.]). Antidotes: tannin, emetics; morphine with atropine, hypodermically ; stimulants. Tincture Viburnum Compound, Squibb pint ; Ya pint Tinctura Vibumi Opull Composita, N. F. Each fluidounce represents about 16^ grains viburnum opulus, 16j4 grains dioscorea, 4J^ grains scullcap, 23 grains clove, 30 grains cin- namon. Used as Uterine Tonic and Antispasmodic, in mens- trual disorders. Average Dose: 1 fluidrachm (4 mils [Cc.]). Tincture, Warburg's. See Tincture Antiperiodic. Tincture Zedoary Bitter. 7'inc(ura Zedoaria Amara, N. F.; Compound Tincture Zedoary. Each fluidounce . represents 11% grains zedoary, 5^/lO grains aloes, 2^ grains each rhubarb, gentian, agaric and saffron, with glycerin, alcohol and water. Bitter Stomachic, Laxative. Average Dose: 1 fluidrachm (4 mils [Cc.]). Tolii, Soluble. See Fluid Tolu. © Tragacanth, Squibb 'Ribbons tin, lb. ; '/J lb. Powdered tin, lb. ; 14 lb. Tragacanlha. Gummy exudation from stems of Astragalus gummifer or other species of Astragalus (Fam. L,eguminosa^ : First quality, free from foreign gums and starchy adulterants. Demulcent; Emulsifier, Adhesive. SQUIBB'S MATERIA MEDICA 285 Tribromomethane. See Bromoform. Triferrin. Iron Paranucleinate. Reddish, tasteless powder; 22 percent, iron, 2.5 percent, phosphorus in organic combination. Insoluble in ordinary solvents. Hematinic. Dose: 5 grains (0.3 Gm.). Trifolium. TrifoUum, N. F.; Red CloVer. Dried flowers of Trifolium pratense (Fam. Leguminosa), Used in Antiluetic and Altera- tive compounds, also as Expectorant; considered inert by many. Average Dose: 60 grains (4 Gm.). Given chiefly as fluid- extract, which see. Trihydroxybenzene. See Pyrogallol (Acid Pyrogallic). Triiodomethane. See Iodoform. Trikresol. Brand of Cresol. Trillium. , Trillium, N. F.; Beth Root. Dried rhizome of Trillium erecium (Fam. Liliacea). Obsolescent Astringent. Tonic, Average Dose: 2 Gm. (30 grains). (See also Fluid extract.) Trimethylxanthine. See Caffeine. Trinitrophenol. Trinitrophenol; Acid Picric. C6H3N3O7. NewIy offi- cial. Yellow, odorless, very bitter crystals. 1 Gm. dissolves in 78 mils (Cc.) water, 12 alcohol, 35 chloroform, 65 ethrf. Explodes when heated rapidly or subjected to percussion. An- tiseptic and Keratoplastic, in burns . (0.5 to 1 % solu- tion), erysipelas (2 to 6% hydroalcoholic solution), wounds (}/4 to 1% solution), etc.; Antiperiodic, internally. Also Re- agent. Average Dose: 1 grain (0.065 Gm.). Antidotes: white of egg, then emetics; sodium sulphate; transfusion with alkaline sodium chloride solution. Note: Should be applied cautiously, owing to the danger from absorption. Trional. Brand of Sulphonethylmethane. Trioxymethylene. See Paraformaldehyde. i Triticum. Triticum; Couch Grass; Dog Grass. Dried rhizome of Agropyron repens (Fam. Cramrneffi). Odor slight; taste sweet. Used as Diuretic, in cystitis and irritable bladder. Average Dose: 120 grains (8 Gm.). (See also Fluidextract.) The Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that isv general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 286 SQUIBB'S MATERIA MEDICA Trituration Elaterin. Trtlaraiio Elalerini. 10 percent, elaterin. Powerful Hydra- gogue Cathartic. Average Dose: Yz grain (0.03 Gm.). Troches, Squibb. See end of Tablet list (Part II). t Tropacocaine Hydrochloride. Benzoylpseudotropeine Hydrochloride. C8H14NO.C7H5O.- HCl. Colorless, acicular crystals. Soluble freely in water. Local Anesthetic, like cocaine. Trypsin. Proteolytic enzyme of the pancreas. Light-yellow powder; faint odor; meaty taste. Slowly and incompletely soluble in water. Digestive, solvent of false membranes ; also been used on malignant tumors. Dose: 1 to 2 grains (0.065 to 0.13 Cm.) with sodium bicarbonate. Turlington's Balsam. Tincture Benzoin Compound. ©Turpentine. Terebinthina, N. F. Concrete oleoresin from Pinus palustris and other species of Pinus (Fam. Pinaced). Yellowish, opaque, sticky masses; characteristic odor and taste. Freely soluble in alcohol, ether, chloroform. Source of oil turpentine. Turpentine, Venice. Terebinthina Laricis, N. F. ; Larch Turpentine. Viscid oleoresin from Larix europaa (Fam. Pinacea). Yellowish or greenish, thick liquid; distinctive odor; bitter, characteristic taste. Soluble In alcohol, chloroform; insoluble in water. Rubefacient externally; Anticatarrhal internally. Dose: 3 to 5 grains (0.13 to 0.3 Cm.). Turpeth Mineral. See Mercury Subsulphate Yellow. Unguentum Crede. • See under Collargol. Unicorn Root. See Alelris. Unicorn Root, False. See Helonias. Unna's Dermatolocical Pastes. See Pastes. Uranium Nitrate. Umnii Nitras. U02(N03)2.6H20. Light-yellow, odorless, bitter, astringent, slightly efflorescent .crystals. 1 Gm. dissolves in 1.2 mils (Cc.) water; freely soluble in ether or alcohol. Used in diabetes and cancer. Average Dose: ]/(, grain (0.01 Gm.). (See also Reagents [Part IV].) SQUIBB'S MATERIA MEDICA 287 Urea Apparatus, Squibb For the estimation of urea in urine. Complete in box, with materials for making Solution Chlorinated Soda and full direc- tions for use.. For those who prefer to employ Solution Sodium Hypobromlte (rather than Solution Chlorinated Soda) as a reagent with this apparatus, we offer the materials for its manufacture, viz: lOQCc. 500 Cc. Solution Sodium Hydroxide (28.50/o) Solution Bromine (l2.5'^/o) (These solutions mixed in equal .proportions produce Solution Sodium Hypobromite.) Urease, Squibb 10 Gm. vial, ; 0.1 Cm. Tablets, bottle of 100, Soluble urea-splitting enzyme of the Jack Bean, compounded with potassium phosphates in proportion to produce the quick- est and most complete activity according to the researches of Dr. D. D. Van Slyke. An improved agent for the rapid estimation of urea in urine, blood, spinal fluid, etc. Its urea- splitting power is greater than that of urease from the soya bean, and it contains less foreign protein in proportion to its enzymatic activity when tested by the absolute method of Van Slyke. Write for complete literature. Uritone and Urotropin. brands of Hexamethylenamine. UvA Ursi. Uva Ursi; Bearberry Leaves. Dried leaves of Arciostaphylos Uva-ursi (Fam. Ericaced). Diuretic, Urinary Anticatarrhal. Average Dose'^ 30 gf-ains (2 Cm.). (See also Fluidextract.) © Valerian. Valeriana. Dried rhizome and roots of Valeriana officinalis (Fam. Vahrianacea). Odor unpleasant; taste camphoraceous, somewhat bitter. Used as Nerve Sedative, Antispasmodic; in hysteria and other nervous excitations. Average Dose: 30 grains (2 Gm.). (See also Tincture.) Valervldiethylamide. See Valyl. Valipoi. Menthol Valerate with 30 percent, free menthol. Colorless, thick liquid; mild, pleasant odor; cooling, slightly bitter taste. Soluble readily in alcohol, ether, chloroform, or oils; insoluble in water. Nerve Sedative, Analgesic, Carminative. Dose: 10 to 20 drops. The S'quibb Label on a package is a positive guaranty for tire uniform Purity and Reliability of ttie product. We make only ONE quaUty: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 288 SQUIBB'S MATERIA MEDICA Vallet's Mass. See Mass Ferrous Carbonate. Valyl. Valeryldiethylamide. Colorless liquid; pungent odor; burning, valerian-like taste. Soluble in about 25 parts water, easily in alcohol or ether. Nerve Sedative, Antineuralgic. Dose: 2 to 6 minims (0.13 to 0.4 mil [Cc.]). Vanilla. Vanilla, N. F.; Vanilla Bean. Cured, full-grown, unripe fruit of Vanilla planifolia (Fam. Orchidacea) . Flavoring. Vanillin, Squibb bottle, oz. Vanillinum. CgHgOs. Methylprotocatechuic Aldehyde, ob- tained from vanilla, or synthetically. Occasionally used as Stimulant and Aphrodisiac, but chiefly as Flavoring. Aver- age Dose: J/2 grain (0.03 Gm.). Venice Turpentine. See Turpentine, Venice. Veratrine. Verairina. Natural mixture of alkaloids from seed of sabadilla {AsagrtEO oficinalis; Fam. Liliacea). White or grayish- white, amorphous, odorless, sternutatory powder; taste acrid, leaving tingling and numbness on tongue. 1 Gm. dissolves in 1760 mils (Cc.) water, 2.8 alcohol, 0.7 chloroform, 4.2 ether. Topical Anodyne ; as oleate (2 percent.) or ointment (4 per- cent.). Antidotes: tannic acid, emetics; morphine with atropine hypodermically; demulcents; stimulants by mouth. Verbena. Verbena, N. F.; Blue Vervain. Dried, overground portion of Verbena hastata (Fam. Verbenacece). Heavy odor; disagree- able, bitter taste. Expectorant, Diaphoretic, Tonic. Average Dose: 15 grains (1 Gm.). Veratrum Viride, Squibb Ground for Percolation tin, lb. Veratrum Viride; Green Hellebore; American Hellebore. Dried rhizome and roots of Veratrum viride (Fam. Liliaceai). When powdered, it is strongly sternutatory; taste, bitterish acrid. Cardiac Depressant, Diaphoretic. Average Dose : I grain (0.065 Gm.). See also Fluidextracl; Tincture.) Vermilion. See Mercury Sulphide, Red. Veronal. See Barbital. Veronal-Sodium. See Barbital-Sodium. Vervain. See Verbena. SQUIBB'S MATERIA MEDICA 289 Viburnum Opulus. Viburnum Opulus, N. F.; Cramp Bark. Dried bark of Vibur- num Opulus var. americanum (Fam. Caprifoliacete). Strong odor; astringent bitter taste. Used as Uterine Antispasmodic and Tonic. Average Dose: 30 grains (2 Gm.). (See also Fluidextract; Tincture.) Viburnum Prunifolium. Viburnum Prunifolium ; Blac^ Haw. Dried bark of Vibur- " num prunifolium or of V, Lentago (Fam. Caprifoliacea). Slight, peculiar odor; bitter, very astringent taste.. In vogue as Uterine Sedative and Tonic, in dysmenorrhea and habitual abortion. Average Dose: 30 grains (2 Gm.). (See also Fluidextract.) Vienna Caustic or Lime. See Potassa with Lime. Vinegar, Aromatic. Aceium Aromaiicumi N. F. Containing oils of lavender, rose- mary, juniper, peppermint, cinnamon, lemon and clove, in alcohol, acetic acid and water. Cooling, stimulating application in fever; Condiment, t Vinegar Opium. Aceium Opii, N. F.; Black Drop; Acetated Tincture Opium. About 10 percent, granulated opium, in acetic acid menstruum, with sugar and nutmeg. Anodyne, Antispasmodic. Average Dose: 8 minims (0.3 mil [Cc.]). Antidotes: potassium per- manganate (2 grains in water), emetics; atropine or strychnine hypodermically ; hot, strong coffee; exercise. Vinegar Squill, Squibb bottle, pint Aceium Scilla. 10 percent, squill, with dilute acetic acid. Yellow to reddish-brown liquid. Physiologically assayed according to U. S. P. and standardized; minimum lethal dose not greater than 0.006 mil (Cc.) per Gm. weight of frog. Expectorant, Diuretic. Average Dose: 15 minims (I mil [Cc.]). Vinegar Tarragon, Squibb bottle, pint. Prepared by macerating tarragon herb (^Ariem'isia Dracunculus) in cider vinegar for three months. Used in place of cider vinegar in salad dressings, etc. ViOFORM. lodochloroxyquinoline; Nioform. Greenish-yellow, nearly odorless, voluminous powder. Insoluble in ordinary solvents. Antiseptic Vulnerary. ^ This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations: it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 290 SQUIBB'S MATERIA MEDICA Vitriol, Blue. See Copper Sulphate. Vitriol, Qreen. See Iron Sulphate. Vitriol, White. See Zinc Sulphate. Vleminckx' Lotion or Solution. See Solution Sulphurated Lime. Volumetric Solutions. See under Reagents (Part IV). Wahoo. See Euonymus, Warburg's Tincture. See Tincture Antiperiodic. Wash. See Lotion. Water Almond Bitter. Aqua Amygdala Amara. 0.1 volume percent, oil bitter al- mond. Cough Sedalive; Vehicle. Average Dose: I fluidrachm (4 mils [Cc.]). Water Ammonia. See Ammonia Water. Water Anise. Aqua Anisi. 0.2 volume percent, oil anise. Aromatic Car- minative; Vehicle. Average Dose: 4 fluidrachms (15 mils [Cc.]). @ Water Camphor. Aqua Camphora. 0.8 percent, camphor. Nerve Stimulant, Antispasmodic; Vehicle for collyria. Average Dose: lYi fluidrachms (10 mils [Cc.]). @ Water Chloroform. Aqua Chloroforml. About I/2 percent, chloroform. Carmina- tive, Gastric Anodyne ; Vehicle. Average Dose : 4 fluidrachms. (15 mils [Cc.]). ® Water Cinnamon. Aqua Cinnamomi. 0.2 volume percent, cinnamon. Carminative; Aromatic Vehicle. Average Dose: 4 fluidrachms (15 mils [Cc.]). Water Creosote. Aqua Creosoii. 1 vol. percent, creosote. Antiseptic, Anti- tubercular, Antizymotic: Dermic. Average Dose: 2!/2 fluid drachms (10 mils [Cc.]). © Water Distilled. Aqua Destillata. Water, H2O, purified by distillation. Neu- tral; free from sulphate, chloride, calcium, metals, organic sub- stances, and carbon dioxide. SQUIBB'S MATERIA MEDICA 291 ^Water Fennel. ' Aqua Faniculi. 0.2 vol. percent, oil fennel. Carminative; Vehicle. Average Dose: 4 fluidrachms (15 mils [Cc.]). Water Hamamelis. Aqua Hamamelidis ; Wilch-Hazel Water; Distilled Extract Witch-Hazel. Saturated aqueous liquid obtained by distilling with steam or water, the bark, twigs or whole shrub of Hamamelis virginiana (Fam. Hamamelidacea), and adding 15 mils alcohol to each 85 mils distillate. Clear; colorless; characteristic odor and taste; sp. gr. 0,979 to 0.982. Cooling Astringent lotion. Water Hydrogen Dioxide. See Solution Hydrogen Dioxide. Water Javelle. See Solution Potassa Chlorinated. Water Lead. See Solution Lead Subacetate Diluted. Water Lime. See Solution Calcium Hydroxide. Water Orange Flower. Aqua Aurantii Florum. Equal volumes distilled water and stronger orange-flower water. Flavoring. Water Orange Flower, Stronger. Aqua Aurantii Florum Foriior. Water saturated with volatile oil fresh orange flowers, obtained by distilling fresh orange flowers with water. @ Water Peppermint. Aqua Mentha Piperita. 0.2 volume percent, oil peppermint. Aromatic Carminative; Vehicle. Average Dose: 4 fluidrachms (15 mils [Cc.]). ® Water Rose. ' Aqua Rosa. Equal volumes stronger rose water and distilled water. Flavoring, Perfume. Water Rose, Stronger. Aqua Rosa Foriior. Water saturated with volatile oil rose petals and distilled. Water Spearmint. Aqua Mentha Viridis. 0.2 volume percent, oil spearmint. Carminative. Average Dose: 4 fluidrachms (15 mils [Cc.]). © Wax, White. Cera Alha. Yellow wax bleached. The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. Th6yinc(Udecontainers,pacl pound. See Tablets Ammon^ Salicylate and Acetanilid Comp. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 300 SQUIBB'S MATERIA MEDICA t Tablets Acetanilid and Bromide Compound, Squibb (Neuralgic Headache, Dr. Myers) -, C. T. Acetanilid Sodium Bromide Morphine Sulphate Caffeine Citrated Extract Hyoscyamus Igr. 5 gr. Vso gr. 1/2 gr. Per 1000 Per 500 Per 100 These tablets are used in mi- graine, headaches due to con- gestion or to irritation of the sensory nerves and neuralgic pains in general. Dose : 1 tablet, repeated in half an hour if necessary, but not oftener than four times in succession. (NoTE. — In the use of these tablets the possible formation of the morphine habit should be guarded against.) ' Tablets Acetanilid and Caffeine Compound, Squibb (Dr. Hubbard) Per 1000 Per 500 Per 100 31/2 gr., "I These tablets are employed as 1 gr. > an analgesic and nerve seda- 71/2 gr. J tive, chiefly in nervous head- ache. Dose : 2 tablets with a glass of water, repeated in four hours if required. Tablets Acetanilid and Cannabis Compound, Squibb (Neuralgic Improved) Per 1000 Per 500 Per 100 This combination of gesics and nervines has C. T. Acetanilid Caffeine ' ' Sodium Bromide C. T. Acetanilid Ext. Cannabis Quinine Sulphate Ext. Hyoscyamus Acid Arsenous Sfrychnine>SuIphate 2gr.] 1/4 gr. 2gr. 1 ,^'2 ^'■ VlOO gr. i/eo gr. . anal' been employed with reputed suc- cess in the treatment of mi- graine and various other types of neuralgia, and ii is said to be particularly useful in cases of a periodical character, whether due to malarial infection or to other causes. Care should be taken in thos-e patients who do not tolerate acetanilid well or who show an idiosyn- crasy toward cannabis. Dose : 1 tablet, repeated in half an hour if required, then every two or three hours until the con- dition is relieved. Tablets Acetanilid and Gelsemin Compound, Squibb 1000 Per 500 Per 100 Antipyretic, Analgesic and Depressant. The well-known action of acetanilid is here augmented by gelsemin. The combination has been used with reputed success in neuralgia, pleurisy and pneumonia. In dysmenorrhea and ovarian neural- gia it is credited with good results, but is deemed especially useful in neuralgia affecting the dental branches of the fifth nerve. It should be cautiously-administered, as certain patients show a peculiar idiosyncrasy to its depressant effects. Dose: I tablet every 2 or 3 hours, /or not more than three doses. C. T. P Acetanilid Gelsemin Caffeine Citrated 21/2 gr. ^/lO gr. Igr. SQUIBB'S MATERIA MEDICA 301 t Tablets Acetanilid and -Morphine Compound, Squibb (Analgesic Compound) C. T. Per 1000 Per 500 Per 100 Acetanilid 2 3/] 11 gr- Sodium Salicylate 1^%2gr. Caffeine 5/22 gr. Sodium Bicarbonate l^/n gr. Capsicum I/20 gr. Our Tablets Acetanilid and Sodium Salicylate Compound bave generally been found use- ful in relieving pain of a re- flex or spasmodic character. In some cases, however, phy- sicians have found it advis- able to add small doses of morphinefpulphate, which increase the anodyne effect, and a little capsicum, to stimulate the mucous membrane of the stomach. Dose: 1 or 2 tablets with water every hour or two until relieved. (Note. — ^These tablets should be used cautiously, and the possibility of the formation of th« morphine habit guarded against.) Tablets Acetanilid and Quinine, Squibb C. T. Per 1000 Per 500 Per 100 Acetanilid 2^2 gf- 1 This formula has been found Quinine Sulphate 2^12 gr. j useful in the treatment of re- flex pains of neuralgic origin in sthenic patients where there is no cardiac weakness. It pos- sesses marked antipyretic and emalgesic properties, and good results have been obtained with it in cases of migraine, influenza and other painful conditions. We call particular attention to the rapidity with which these tablets and similar combinations here listed disintegrate in water or in fluids of the body, thereby minimizing any possibility of cumulative action, as each dose promptly produces its effect. Dose : 1 tablet with water every two hours for three or four doses, then every four hours. f Tablets Acetanilid and Quinine Compound, Squibb C. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) This is a combination of remedies that has been ex- tensively used in the treat- ment of grip and the early ^ stages of colds. The usual precautions against the use of acetanilid must be observed in its administration, although the depressing effect is somewhat guarded against by the camphor and quinine. Its action as a sudorific will be greatly increased by hot' drinks during the treatment. Dose: 1 tablet every 2 hours, but for not more thah three consecutive doses. Acetanilid 2gr. Quinine Sulphate V2 gr- Camphor 14 gr. Capsicum V4gr. Podophyllin ^/so gr. Aconite Root ^20 gr. Morphine Sulphate V120 gr. The Squibb Ideals have taken concrete form in the Squibb, Products; these are universally recognized as standards bf uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 302 SQUIBB'S MATERIA MEDICA Tablets Acetanilid and Salol, Squibb C. T. Per 1000 Per 500 Per 100 Acetanilid 2^/2 gr. \ The acetanilid acts as an Salol 21/2 gr. J Analgesic and Antipyretic; the salol as. an Antirheumatic and Intestinal Antiseptic. Together ihey are commonly used in acute rheumatism, gouty attacks, myalgia, sciatica and neuralgic pains of rheumatic origin. In the early stage of grip and sudden colds they have been found to relieve pain and muscular sore- ness promptly, and usually without bad after-effect. Great care is observed in all of Squibb's tablets to prevent decomposi- tion, and to present *he medicaments in their natural activity, unchanged by the process of manufacture; hence they can be relied on for prompt and uniform action. Dose.: I tablet every hour or two until pain and fever are relieved. Caution : Tab- lets containing salol should not be exposed to direct sunlight or kept in a warm place, as the chemical melts at about 106° F, Tablets Acetanilid and Sodium Salicylate Compaund, Squibb (Analgesic No. 2) Per 1000 Per 500 Per 100 This is a slight modification of the following formula, sodium salicylate being substituted for the strontium salt. The indi- cations . for its use and the dose are the same as those of the next combination. Tablets Acetanilid and Strontium Salicylate Compound, Squibb (Analgesic) Per 1000 Per 500 Per 100 C. T. Acetanilid 2V2 gr- 1 Neuralgic and rheumatic Strontium Salicylate 2 gr. I pains, the muscular soreness Caffeine I/4 gr. [ attending grip, headaches and Sodium Bicarbonate I gr. J reflex pains arising from de- layed digestion are usually relieved by these tablets. They act as an analgesic and anti- pyrehc, and are rarely followed by bad after-effects. Dose: 1 or 2 tablets every three or four hours until relieved, but not oftener -than four times in succession. Tablets Acetanilid Compound, Squibb (Migraine) C. T. Per 1000 Per 500 Per 100 Acetanilid 2 gr. 1 This formula is used in ■ the Camphor Monobrom. I/2 gr. > treatment of neuralgic pains, , Caffeine I/4 gr. J particularly in pains of a re- flex or spasmodic character; hence it is most frequently employed for the prompt relief of C. T. Acetanilid 21/2 gr. Sodium Salicylate 13 4gr. Caffeine 1/4 gr. Sodium Bicarbonate Igr. SQUIBB-S MATERIA MEDICA 303 Tablets Acetanilid Compound, Squibb (Cont.) headache. The rapidity with which the tablets disintegrate in- sures prompt therapeutic action and prevents cumulative effect. Doser I or 2 tablets with water, every hour if necessary, for four or five doses; it is deemed advisable to discontinue the tablets after the fifth consecutive dose. Tablets Acetanilid Compound No. 2, Squibb (Migraine No. 2) Per 1000 Per 500 Per 100 C. T. Acetanilid 3 gr. 1 This is a modification of the -C. T. Acetanilid Caffeine Sodium Bicarbonate 31/2 gr. 1/2 gr. Igr. Camphor Mcnobrom. 2 gr. > preceding formula, the quantity Caffeine I/2 gr. J of each of the ingredients be- ing increased. It is used under the same conditions. Dose: 1 tablet every hour for three doses, then every 2 or 3 hours until the condition is relieved. Tablets Acetanilid Compound No. 3, Squibb (Migraine No. 3) Per 1000 Per 500 Per 100 These tablets are used for promptly controlling reflex pains arising from disturbance of nerve function. They com- bine the analgesic" and antipyretic action of acetanilid with the antacid properties of sodium bicarbonate. They have been found useful in nervous and sick headache due to ' mental strain or disordered digestion, and for the relief of neuralgia and reflex pains with fever. Dose: 1 tablet with water every hour if necessary for three doses. If not relieved after the third dose, it is advised to wait three hours before resuming. Tablets Acetanilid Compound No- 4, Squibb (Migraine No. 4) Per 1000 Per 500 Per lOO C. T. Acetanilid 3 gr. | These tablets are more power- Caffeine V2 gr- I ful than those of the regular Camphor Monobrom. 1 gr- f Acetanilid Compound formu- Sodium Bicarbonate 1 gr. J la. They are used chiefly in the. treatment of neuralgia and spasmodic pains in robust patients- Dose : 1 tablet with water every hour for three or four doses. The Squibb Label on a package Is a positive guararrty for ttie uniform Purity and Reliabiiity of tfie product. We mai . this way the therapeutic action of the drugs is not changed or destroyed. Dose : 1 tablet with water or diffused in water to which about five drops of glycerin may be added, every hour until relieved. SQUIBB'S MATERIA MEDICA 311 Tablets Aconite and Colchicum Compound, Squibb (Sciatica) T. T. Per 1000 Per 500 Per 100 Tr. Aconite U.S.P.'90 8/4 min. 1 Deranged functions of the Tr. Colchic, U.S.P.'90 8/4 min. I nerves and secretory organ's Tr. Bellad, U.S.P.'90%min. f are the indications for these Tincture Cimicif uga 8/4 min. J tablets, which act as a seda- tive to the nerves and relieve pain. By their action upon the circulation they tend to improve nutrition of the nervous system and aid in the elimination of waste products through the skin, the kidneys and the bowels. In sciatica their effect is usually prompt. Dose: 2 tablets every three hours until pain is relieved. * Tablets Aconite and Mercury Compound, Squibb (Tonsillitis) T. T, Per 1000 Per 500 Per 100 Tr. Aconite U.S.P.'90 Vg min. 1 Aconite given in the early Mercury lod. Red ^100 gr. I stage of tonsillitis, when the Tincture Bryonia 1/iomin. f skin is hot and dry, causes a Tr. Bellad, U.S.P.*90 VlO min. J copious perspiration, relieves the chilliness and muscular soreness, and reduces the inflammation and fever. Bella- donna lessens its depressant effect. Bryonia acts as a stimu- lant to the mucous membrane. Red iodide of mercuty re- duces the swelling and inflammation. Dose: 1 tablet, on the tongue, every twenty minutes for three doses, then every half hour for two doses; afterwards at hourly intervals until the pain and inflammation are relieved. Tablets Aconitine 1/500 gr., Squibb C. T. Per 1000 Per 500 Per 100 Aconitine is used for neuralgic and sciatic pains, and is con- sidered especially useful in trifacial neuralgia^ Some patients show an idiosyncrasy to its use, and it should therefore be given cautiously, more particularly where weak heart exists, beginning with the smaller dose and grsKlually increasing until the systemic effect is observed. Qose t I tablet every three or four hours until effective. Tablets Agaricin 1/10 gr., Squibb C. T. Per 1000 Per 500 Per 100 Agaricin (Agaricic Acid) appears to act directly upon the sweat glands and not through the nerve centers. It has been used for the excessive sweating of gouty patients, but it is prin- cipally employed to control night sweats in phthisis. The action of agaricin is slow, four or five hours elapsing before its effects are apparent; hence the dose should be timed accordingly. Dose: 1 tablet, after supper, repeated at bedtime if required. If difficult is experienced in procuring any Squibb product, in tlie original pacloges liere listed, please notify us; we siiall see that your wants are met promptly and satisfactorily. 312 SQUIBB'S MATERIA MEDIGA Tablets Agaricin Compound, Squibb (Antihydrotic; Night Sweat) C. T. Per 1000 Per 500 Per 100 Agaricin Vi2 gr. 1 These tablets are used for Picrotoxin VfiO gr. \ controlling excessive sweating Atropine Sulphate l/l20 gr- J in phthisis and in rheumatic ' and gouty subjects. Dose; 1 tablet at bedtime, repealed in two hours if required. ^Tablets Aiken's Tonic. See Tablets Quinine and Iron Comp. Tablets Aiken's Tonic Laxative. See Tablets Quinine and Iron Compound with Cascarin. Tablets Aloes and Mastic, Squibb (Dinner) Per 1000 Per 500 Per 100 Chocolate=coated (C. C. T.) Aloes Purified 2 gr. <\ This is a favorite laxative in Mastic 1/2 gr. • dyspepsia with habitual con- Red Rose '■.-• ■'■/2 8r. J stipation. Aloes acts chiefly upon the lower bowel and rectum ; its action is slow, but not lessened by habitual use. Where not contraindicated by piles, these tablets are considered a useful laxative that may be taken as long as constipation exists. Dose: 1 or 2 tablets after dinner, or 1 to 3 tablets at bedtime. Tablets Aloes, Mercury and Podophyllin, Squibb (Triplex) Per 1000 Per 500 Per 100, C. T. Cliocolate=coated (C. C. T.) Aloes Purified 2 gr, ^ The same combination as ^he Mercury Mass 1 gr. \ N. F. IV pills of the same Podophyllin I/4 gr. J name. It is used in constipa- ' tion with hepatic congestion. Dose: 1 or 2 tablets with water, after meals or at bedtime. * Tablets Aloin and Belladonna* Compound, Squibb. T. T. PerlOQP Per 500 ' Per 100 Chocolate°coated {C. C. T.) Aloin 1/5 gf. 1 Aloin is conceded to bei a Extract Belladonna ^8 gr. f valuable remedy in constipaT Strychnine Sulphate ^leoW-i t>°°> i'^ action being almost wholly confined to the large intestine and rectum, but also possessing a slight stimulating effect upon the liver. The addition of the belladonna and strychnine serves to increase peristalsis, overcome muscular atony and pre- vent griping and tenesmus. The formula' is deemed an excellent one in habitual constipation attended with indigestion and hepatic torpor; one particularly adapted for persons of seden- tary habit. Its use, it is maintained, may be continued without debilitating the bowels. Dose : ' 1 or 2 tablets at night, followed by a glass of water and repeated the following morning if necessary. SQUIBB'S MATERIA MEDICA 313 Tablets Aloin and Belladonna Compound No. 2, Squibb Per 1000 Per 500 Per 100 T. T. Chocolate-coated (C. C. T.) Aloin 1/g gr.i1 This tablet is similar in com- Extract Belladonna l/g gr. j- position and action to the Strychnine Sulphate Vl20 gr- J preceding formula, but con- tains half as much strychnine. Dose: I or 2 tablets at bedtime, followed next morning by 1 tablet every three or four hours until effective. Tablets Aloin, Belladonna and Strychnine with Cas- cara, Squibb Per 1000 Per 500 Per 100 C. T. Chocolatccoaied (C. C. T.) Vsgr. Aloin Extract Belladonna Strychnine Sulphate Extract Cascara 1/. /16 gf' I /eo gr- I This formula is a modifica- tion of our Aloin and Bella- donna Compound. The ' change consists in a reduction of the quantity of extract of belladonna and the addition of extract of cascara sagrada, a tonic laxative, the use of which is said not to cause habituation, but rather to tend to restore the normal functions. Dose : 1 or 2 tablets, at night, with water, repeated next morning if required. Tablets Aloin and Cascarin Compound, Squibb (Dr. Duncan) Per 1000 , Per 500 C. T. Chocolate-coated (C. C. T.) Per 100 Aloin 5gr. Cascarin 'k gr. Extract Belladonna % gr- Strychnine Sulphate , Veogr. This Laxative tablet is very popular with physicians for use in indigestion with slug- gish liver and habitual con- stipation. It acts pleasantly without griping, and its continued administration is not known to debilitate the bowel. It has proved very useful as a laxative in atonic conditions of the intestines. Dose: 1 or 2 tablets, at bedtime, with water, repeated the following morning if necpssary. The Squibb products are recognized everywhere' as the Quality Standard. They are of uniform purity and strength, nence theraupeutically dependable. When ordering or prescribing medi- cinal products, you will do well always to specify SQUIBB'S. 314 SQUIBB'S MATERIA MEDICA Tablets Aloin and Podophyllin Compound, Squibb (Catharric) Per 1000 Per 500 Per 100 Chocolafe-coated (C. C. T.) Aloin l/io gr. Podophyllin l/lO gf' Ext. Colocynth Comp. VlO gf Ext. Nux Vomica ^/lo gr. Crolon Oil 30 gr- Oleoresin Capsicum ^/256 gr- increase the irritation. Dose : bowels move; or 1 to 3 at bedtime. These tablets are an active Cathartic, used in conditions where prompt and thorough action of the bowels is de- sired. They should not be used, however, where inflam- mation of the intestines is present, as they are liable to I tablet every two hours until * Tablets Aloin and Strychnine Compound, Squibb Per 1000 Per 500 Per 100 T. T. Chocolate°coated (C. C. T.) Aloin Strychnine Sulphate Extract Belladonna Ipecac Vsgr. Veo gr. V] 16 gr. In congested states o£ the system due to failure of the bowels to perform their nat- ural functions this formula is used with good effect. It is said to act upon the entire alimentary tract; for while aloin alone affects the lower bowel almost entirely, the added bella- donna, strychnine and ipecac stimulate the peristaltic action and overcome the atonic condition of the intestinal tract and cause a more thorough evacuation of its contents. Tablets Aloin and Strychnine Compound Squibb are used in indigestion with hepatic congestion and constipation. Dose : 1 or 2 tablets, at bedtime, followed by 1 after breakfast and dinner the following day -if required. Tablets Aloin and Strychnine Compound No. 2, Squibb Per 1000 Per 500 Per 100 C. T. Chocolate-coated (C. C. T.) Aloin Vsgr. 1 This formula is a modifica- Strychnine Sulphate 1/eo gr. 1 tion of the previous one, the Ej£tract Belladonna ^/x6 gr. j quantity of extract belladonna Ipecac l/l6 gr. J being reduced one-half. Il is intended specially for those patients in whom an idiosyncrasy for this drug exists. ' Dose : I or 2 tablets, at bedtime, followed by I after breakfast if required. SQUIBB'S MATERIA MEDICA 315 Tablets Aloin and Strychnine Compound No. 3, Squibb (Laxative No. 5, Dr. W. B. Pierson) Per 1000 Per 50b Per 100 Chocolate-coafed (C. C. T.) Aloin 1/4 gr. "I This is a slight modification Strychnine Sulphate l/go gr. I of our Alpin and Strychnine Extract Belladonna l/ig gr. f Compound formula, adapted Ipecac I/18 gr. J to those patients requiring a larger dose of aloin and who show an undue susceptibility to the action of belladonna. The tablets are used in cases of habitual constipation with hepatic torpor, usually the result of atony of the digestive functions. They act pleasantly without gripiing, and their Continued use is not known to debilitate the bowels. Dose: 1 or 2 tablets at night, and 1 after breakfast next morning if needed. Tablets Aloin Compound, Squibb Per 1000 Per 500 Per 100 T. T. ChocoIafe=coated (C. C. T.) Aloin l/g gr. I In sthenic patients where no Podophyllin l/s gf- j inflammatory condition of the bowels, exists, and where a decided stimulation of the liver is . needed, these tablets have been found to act with decided benefit. Podophyllin is both cholagpgue and cathartic, stimulating the flow of bile as well as producing free action of the bowels, but apparently acting ^ chiefly, upon the stnall intestine. The action of aloin is laxative or purgative, depending upon the ,dose, and seems to be exerted mainly upon the large intestine and rectum. These drugs usually act well together, but they have a tendency at times to cause griping. Dose: 1 to 4 tablets at bedtime, gradually decreasing the dose as the normal condition of the bowels returns. Tablets Aloin Compound No. 2, Squibb Per 1000 Per 500 Per 100 T. T. Chocolate°coated (C. C. T.) Aloin 1/4 gr. ] Dose : I or 2 tablets at bed- Podophyllin I/4 gr. j time, reducing the ' dose as the condition improves. Tablets Amenorrhea (Anemic). See Tablets Manganese Compound. Since w/e make only one quality of each product, that best suited to the purposes intended, the specification "Squibtj's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 316 SQUIBB'S MATERIA MEDICA Tablets Ammonium Bromide 5 gr., Squibb Per 1000 Per 500 Per 100 C. T. As is known, anlmonium bromide efficiently acts as a Sedative in nervous excitement, whether caused by irritation of the brain, the sexual system or the spinal cord; it allays reflex irritability. It is used in epilepsy, mania, sexual excitement, seasickness, sleeplessness from overwork or worry and in various phases of nervous exaltation. It is believed to be less depressing than the sodium or potassium salt, yet, on account of its pungent and dis- agreeable taste, it is not so frequently employed. Long-con- tinued use often causes an acne-like eruption and a depressed mental condition; but these symptoms usually disappear upon withdrawal of the medicine. Dose : I to 3 tablets, with water, repeated in an hour or two if required. Tablets Ammonium Chloride 3 gr., Squibb Per 1000 Per 500 Per 100 C. T. Ammonium chloride is a stimulant expectorant, and is useful in bronchial catarrhs where the secretion is viscid, tenacious and difficult to dislodge, and also in intestinal catarrh, catarrhal jaun- dice and in certain forms of neuralgia. As a bronchial stimu- lant it is usually combined with other remedies, and usually given with some demulcent, as extract licotice, which modifies its unpleasant taste. Dose: as a bronchial stimulant, 1 or 2 tablets every two^ or three hours, allowed to dissolve in the mouth or taken with a wineglass of water or milk. For intes- tinal catarrh and neuralgia, 5 tablets dissolved in a wineglass of water, every three or four hours. Tablets Ammonium Chloride 5 gr., Squibb Per 1000 Per 500 Per 100 C. T. Dose: as an expectorant, 1 or 2 tablets dissolved on the tongue every two or three hours; as a hepatic stimulant, 2 to 4 tablets in half a glass of water every three or four hours. Tablets Ammonium Chloride and Hyoscyamus Com- pound, Squibb Per 1000 Per 500 Per 100 C.T. Ammonium Chloride 1 gr. Extract Hyoscyamus l/e gf- Tartar Emetic I/24 gr. This combination is employed as an Anodyne Expectorant, in painful cough with absent or only scanty expectoration. Dose: 1 tablet after each meal, or every three or four hours if required. SQUIBB'S MATERIA MEDICA 317 Tableits Ammonium Chloride and Licorice, Squibb Per 1000 Per 500 Per 100 C. T. Ammonium Chloride - 1 gr. Extract Licorice 3 */4 gr. Oil Anise I/20 ™in. These tablets represent an agreeable and efficient remedy in bronchial affections with hoarseness and -thick, scanty sputum difficult of expectoration. Dose : I or 2 tablets every two or three hours. f Tablets Ammonium Chloride and Sanguinarine Com= pound, Squibb (Anodyne Expectorant, Dr. Bolton) Per 1000 Per 500 Per 100 T. T. Ammonium Chloride I gr. 1 In bronchial affections where Sanguinarine Nitrate VlOO gf- I 'lie sputum is thick and Tartar Emetic I/30 gr. f scanty and expectoration is Morphine Sulphate I/50 gr, J accomplished with difficulty and often painful, this combi- nation usually gives reliefs Sanguinarine, although not now used as often as formerly, acts as a powerful stimulant to the bronchial mucous membrane, and where the dose is hot excessive is not depressing. In combination with the well-known expec- torants, ammonium chloride and tartar emetic, it generally pro- duces a more fluid and copious secretion from the bronchi. The action of the morphine quiets the cough, relieves pain and soreness of the pectoral muscles, and contributes a sudorific action to the other remedies. Dose : 1 or 2 tablets every 2 or 3 hours. In the use of these tablets the possibility of the for- mation of the morphine habit should be borne in mind and . guarded' against. Tablets Ammonium, Chloride and Squill Compound, Squibb (Cough Persistent, Dr. Brewer) Per 1000 Per 500 Per 100 C. T. Ammonium Chloride 2 gr. Ext. Squil) Acetic I/4 gr. Ipecac 1/4 gf • Fluidexl. Senega I min. These tablets are used in subacute bronchitis with thick, viscid mucus, difficult ex- ~ pectoration and obstinate cough, to stimulate the secre- tion of bronchial mucus, and to render it more fluid, less tenacious and more easily expeclora(ed. Owing to the nause- ating tendency of the squill and ipecac, they are not adapted for patients with sensitive stomachs. Dose: 1 tablet every two ^ or three hours. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideais, but lived and labored for them; and, in the words of William Miller Bartlett, the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 318 SQUIBB'S MATERIA MEDICA t Tablets Ammonium Chloride and Squill Compound, with Heroin, Squibb (Cough Persistent, with Heroin) C. T. Ammonium Chloride Ext. Squill Acetic Diacetylmorphine (Heroin) Ipecac Fluidexl. Senega Per 1000 1?g'-l V4gr. ^/25 gr. 1/4 gr. 1 min. Per 100 s a stim- and An- d eem e d Per 500 These tablets act ulant Expectorant odyne, and are especially useful in subacute and chronic bronchitis when the cough is obstinate and painful and the expectoration scanty. Nausea is apt to be incited by these tablets at times. Dose : 1 tablet every hour or two, depending upon the severity of the symptoms. In the use of these tablets the possibility of the formation of the morphine habit should be borne in mind and guarded against, (Note. — We also make this com- bination with D'lacetslmoTphine, the U. S. P. name for heroin, and can offer them at lower prices than those charged for the tablets containing the trademarked product.) Tablets Ammonium Chloride Compound, Squibb T. T. Per 1000 Per 500 Per 100 Elxtract Licorice Cubeb VlOgr. Vs gr. useful in the early stage of bronchitis, acting as a mild stimulating Expectorant. Dose: I or 2 tslblets dissolved on the tongue every fifteen or twenty minutes until relieved, t* Tablets Ammonium Chloride Compound with Co=- deine, Squibb T. T. Ammonium Chloride Codeine Extract Licorice Cubeb Per 1000 Per 500 Per 100 1/. 4gr. ^/25 gr- VlO gr- l/s gr- This formula acts as an Ex- pectorant and mild Anodyne. It has been found useful in the early stage of bronchitis, with frequent and painful cough and before the secreting stage is well established. Dose: 1 tablet, dissolved on the tongue, every fifteen minutes to half hour until reheved. t* Tablets Ammonium Chloride Compound with Heroin, Squibb T. T. Pe Ammonium Chloride I/4 gr. Diacetylmorphine (Heroin) Extract Licorice Cubeb VlOO gr. ^/lO gr. Vs gr. 1000 Per 500 Per 100 This combination is employed ' in the early stage of coughs and colds, to relieve the irri- tation and soreness of ~ the throat, facilitate expectoration, and allay cough. Dose: 1 tablet, dissolved in the mouth every fifteen minutes to half an hour until 4 have been taken, then every hour or two until relieved. The possibility of the formation of the morphine habit should be. borne in mind when prescribing these tablets, and guarded against. SQUIBB'S MATERIA MEDICA 319 t Tablets Ammonium Chloride Compound with Heroin, No. 2, Squibb (Cough, Infants') T. T. Ammonium Chloride I/4 gr. Diacetyjmorphine (Her- oin) Hydrochlor. Eluidextract Ipecac Tr. Belladonna Licorice Oil Anise V200 gr- 1/0 min, 1/5 ™'n' q.s. .1000 Per 500 Per 100 The addition of ammonium chloride and ipecac serves to produce an increased secre- tion from the bronchial mucous membrane. Bella- donnav in addition to its anti- spasmodic effect, acts as a respiratory stimulant. The oil anise and licorice make the tablets palatable, and hence they are readily taken by children. Dose: for young children, a tablet may be dissblved in water before administering and given at hourly intervals until relieved; older children take I or more tablets at a dose. The bottle should be kept well corked and in a dry place. The possibility of the formation of the morphine habit should be borne in mind, when prescribing these tablets, and guarded against. t Tablets Ammonium Salicylate and Acetanilid Com-< pound, Squibb Per 1000 Per 500 Per 100 C. T. This formula is used in the early stages of coryza and grip. It usually acts promptly, allaying pain, controlling the febrile symptoms, and, if taken early enough, frequently Dose: 1 or 2 tablets every two or three See Tablets Acetanilid and Strontium 2gr.] I|/2gr. lV2gr. V2 gr. Igr-J Ammonium Salicylate Acetanilid Dover's Powder Camphor Caffeine aborting an attack, hours, with water. Tablets Analgesic. Salicylate Compound. Tablets Analgesic No. 2. _ See Tablets Acetanilid and Sodium Salicylate Compound. Tablets Analgesic Compound. See Tablets Acetanilid and Morphine Compound. ~ Tablets Anemia. See Tablets Blaud's and Manganese Comp. Tablets Anodyne. See Tablets Morphine, Camphor and Hyoscyamus. Tablets Anodyne. Expectorant (Dr. Bolton). See Tablets Ammonium Chloride and Sanguinariife. Compound. Tablets Anodyne, Infants' (Dt. Waugh). ' , See Tablets Codeine and Nickel Compound. The Squibb Ideals have taken concrete form In the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordenng. 320 SQUIBB'S MATERIA MEDICA Tablets Anorexia. See Tablets Gentian and Nux Compound. Tablets Anorexia No. 2 (Dyspeptic). See Tablets Strych- nine and Ipecac Compound, Tablets Antiasthmatic. See Tablets Potassium Iodide and Belladonna Compound. Tablets Antiasthmatic No. 2. See Tablets Potassium Iodide and Lobelia Compound, Tablets Anticonstipation. See Tablets Cascara Comp. No. 4. Tablets Antidyspeptic. See Tablets Rhubarb and Sodium Bicarbonate Compound. Tablets Antif ermentative. See Tablets Sodium Salicyl. Cbmp, Tablets Antihydrotic. See Tablets Agaricin Compound, Tablets Antimony and Ipecac, Squibb (Dr. Fowler) T. T. Per 1000 Per 500 Per 100 Tartar Emetic Vioo gr. ] Tartar emetic in small and Ipecac VlOO gr, j repeated doses acts as an Expectorant and Diaphoretic; in larger quantities it causes nausea, vomiting and great prostra- tion. It is deemed useful in the early, stage of bronchitis before the secretion is well established. In combination with ipecac it is' regarded as an excellent remedy in acute affections of the bronchi with hard, painful cough, deficient secretion and fever. Dose: I tablet every hour or two, stopping the remedy on the appearance of nausea. Tablets Antimony and Ipecac No. 2, Squibb C. T. Per 1000 Per 500 Per 100 ' Tartar Emetic Vioo gr. 1 This formula is a modification Ipecac V4 gr. J of the prescription of . Dr. Fowler; it contains a larger proportion of ipecac, which increases the expectorant action without producing* subsequent depression. It is indicated in bronchial congestion with fever, where the cough >s hard and painful and the secretion scanty. Dose: 1 tablet every hour or two as required. Tablets Antipyrine 1 gr., Squibb T. T. Per 1000 Per 500 Per 100 Pains of a reflex or spasinodic character as seen in locomotor ataxia, migraine, and neuralgia are commonly relieved by anti- pyrine. Good results have also been obtained in asthma and in whooping-cough. Its antipyretic properties are well known, but it should be cautiously used. (See note under Tablets Acetani- lid 1 gr.) Dose: for children, I tablet every hour until tem- perature falls, or pain is relieved; for whooping-cough 1 tablet every two hours. SQUIBB'S MATERIA MEDICA 321 Tablets Antipyrine 5 gr., Squibb Per 1000 Per 500 Pet 100 C. T. -Dose: as an Antipyretic, 1 tablet every two or three hours while fever is high; as an Analgesic, I every hour for three doses, or 3 at one dose, depending upon the condition. t Tablets Antipyrine and Heroin Compound, Squibb (Whooping-Cough) Per 1000 Per 500 Per 100 T. T. Antipyrine I/2 gr. Diacetylmorphine (Her- oin) Hydfoehlor. V200 gr- Tincture Drosera 1 min. Tr. Bell..U5.P. '90 1/5 min. Ipecac V200gr- Oil Anise q. s. Antipyrine is quite generally conceded to be a useful rem- edy in whooping-cough. It is combined in this formula with respiratory stimulants and antispasmodics) which increase its efficiency. The combination is palatable and readily taken by children. Dose: 1 tablet every hour or two until relieved, and then at' longer intervals. Tablets Antirheumatic. See Tablets Potassium Iodide- and Phytolacca Compound. Tablets Antirheumatic No. 2. See Tablets Acid Salicylic and Colehicum Compound. Tablets Antirheumatic No. 3. See Tablets Sodium Salicy- late and Colehicum Compound No. 2. Tablets Antiseptic, Bernays'. See Tablets Mercury Bi- chloride Compound, Bernays'. Tablets Antiseptic, Detergent. See Tablets Borax and Sodium Salicylate Compound. ' Tablets Antiseptic, Detergent, Improved. See Tablets Borax and Sodium Salicylate Compound, Improved. Tablets" Antiseptic Intestinal. See Tablets Zinc ^ulpho- carbolate Compound. Tablets Antiseptic, Wilson's. See Tablets Mercury Bi- chloride Compound, Wilson's. Tablets Aphrodisiac. See Tablets Nux and Phosphorus Comp. The Squibb Label on a package is a positive guaranty for tlie uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as -low as they can be made for that quality. Specify SQUIBB'S. 322 SQUIBB'S MATERIA MEDICA f Tablets Apomorphine Hydrochloride 1/100 gr., Squibb Per 1000 Per 500 Per 100 C. T. Apomorphine hydrochloride, according to physiologists, at first stimulates the respiratory centers, and if the dose be sufficient to nauseate, causes marked depression; small doses given by the mouth act as an Expectorant and are useful in early stages of inflammation of the bronchi, where a hyperemic condition of the mucous membrane exists, and the secretion is viscid and difficult to expectorate. In larger doses it is an active Emetic, but must be given with caution, as it occasions marked depression. As an emetic it is used principally in case of poisoning and where a prompt and certain effect is wanted. For thjs purpose it is gen- erally given hypodermically. Dose: I tablet every three or four hours. f Tablets Apomorphine Hydrochloride 1/20 gr., Squibb Per 1000 Per 500 Per 100 C. T. Dose: 1 tablet as an emetic, repeated cautiously until effective. f Tablets Apomorphine Hydrochloride 1/10 gr., Squibb Per 1000 Per 500 Per 100 C. T. Dose : 1 tablet as an emetic in case of poisoning or choking due to presence of foreign body in the esophagus. Tablets Arsenates Triple. See Tablets Triple Arsenates. Tablets Arsenic and Iron. See Tablets Iron and Arsenic, Tablets Arsenic Iodide 1/50 gr., Squibb Per 1000 Per 500 Per 100 C. T. This remedy is employed in cutaneous eruptions of a chronic character and some forms of malarial poisoning. Small doses are commenced with, and if gastric distress or reddening of the eyelids occur, the drug is withheld until the symptoms disappear and then resumed. Good effects have been observed in psoriasis, chronic eczema and other obstinate skin diseases. Dose: 1 or 2 tablets after eating. Dispense in glass. Tablets Arsenic Iodide 1/25 gr., Squibb Per 1000 Per 500 Per 100 C. T. Dose: 1 tablet with water after each meal. To be discontinued if pain or fulness of the stomach occur. Dispense in glass. SQUIBB'S MATERIA MEDICA 323 ♦Tablets Arsenic Sulphide Red 1/50 gr., Squibb T. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Arsenic Sulphide Red is used in acne, eczema, psoriasis, and in suppurativis skin diseases. The effect of arsenic is observed in nutrition, the patient gaining in weight and the skin becoming soft and smooth. In combination with sulphur it is reported especially useful in suppurative skin diseases and excellent re- sults have been obtained in the treatment of boils and carbuncles. As with all arsenical prep^ations, its effect upon the system must be watched. The dose is generally increased to the point of toleration, . when, if gastric symptoms or reddening of the eyelids occur, it is lessened or the remedy withdrawn for a short time and then resumed. Dose: 1 tablet, gradually increased to 3 or 4, after meals. * Tablets Arsenic Sulphide Red 1/30 gr., Squibb T. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: I tablet after meals, gradually increased. Tablets Arsenous Acid. See Tablets Acid Arsenous. Tablets Asafetida 2 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose : I or 2 tablets after meals and at bedtime. Tablets Asafetida 3 gr., Squibb Per 1000 Ppr500 Per 100 Chocolate-coated (C. C. T.) ' ' Dose: 1 or 2 tablets after meals and at bedtime. Tablets Asafetida 5 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.> These tablets act as an Antispasmodic and Nerve Sedative, and have been found useful in hysteria, hypochondriasis and other functional nervous disorders, as well as in flatulent dyspepsia. Dose: 1 or 2 tablets after meals and at bedtime. Tablets Asafetida and Nux Vomica, Squibb Chocolate-coated (C. C. T.) Per 1000 Per 500 Per lOO Asafetida Powdered 3gr. 7 The addition of nux vomica Extract Nux Vomlc^ Vl S'* J '° asafetida increases its value in atonic conditions of the alimentary tract. The combination has been found useful in hysterical and neurasthenic subjects who suffer much abdominal distress after meals, due to flatulence and fermentation. Dose: I or 2 tablets after meals and at bedtime. Squibb's Tablets are made from the Squibb quality of ingredients and by improved processes that insure accurate dosage and rapid and complete disintegration^ or solution in the system, hence prompt and full therapeutic effect. Specify SQUIBB'S. Asafetida Powdered 1 gr. Extract Valerian I gr. Elxiract Sumbul 1 gr. 324 SQUIBB'S MATERIA MEDICA Tablets Asafetida,and Valerian Compound, Squibb (Sedative No. 3, Dr. Baer) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) These tablets are used as an antispasmodic and sedative in mild -cases of nerve disorder accompanied by flatulence and intestinal disturbance. They are well adapted for relieving the nervous manifestations seen in hysteria and melancholia occurring specially in women. Of late years it has grown more and more difficult to secure asafetida of ,the proper stand- ard, and many samples have been condemned by our control laboratory. The asafetida used in these tablets is of the highest quality, and great care is exercised so that its properties are not impaired during the process of their manufacture. Dose: 1 tab- let after meals and at bedtime. Tablets Aspirin. See Tablets Acid Acetylsalicylic. Tablets, Astringent Gargle. See Tablets Hydrastis and Alum Compound. Tablets Astringent, Vaginal. See Tablets Zinc Sulphate and Tannic Acid Compound. [ Tablets, Astringent Wash. See Tablets Lead and Zinc Compound. Tablets Atropine Sulphate 1/200 gr., Squibb T. T. Per 1000 Per 500 " Per 100 Dose: 1 tablet every hour until throat feels dry, but not for more than four consecutive doses. Tablets Atropine Sulphate 1/150 gr., Squibb T. T, Per 1000 Per 500 Per 100 Dose: ] tablet every hour until dryness of throat occurs, but not for more than four , doses in succession. * Tablets Atropine Sulphate 1/100 gr., Squibb T. T. Per 1000 Per 500 Per 100 Atropine is used as a cardiac and respiratory stimulant and for its effect upon the glands. It arrests and even suppresses the action of the mammary, sudoriparous and salivary glands. Ad- vantage of its action in controlling sweating has been taken in the treatment of nigKt-sweats in phthisis, and of its effect of reducing the secretions of the mucous membrane in acute coryza. In addition, it possesses antispasmodic properties, which are shown in the relief afforded in spasm of the sphincter of the bladder, neuralgia, asthma and whooping-cough. Dose: I tablet every hour until throat becomes dry, but for not more than three doses. SQUIBB'S MATERIA MEDICA 325 Tablets Atropine and Morphine. See Tablets Motphine and Atropine. Tablets Belladona and Aconite. See Tablets Aconite and Belladonna. t Tablets Belladonna and Aconite Compound. See Tablets Aconite and Belladonna Compound. ' Tablets Belladonna, Nux land Cubeb, Squibb (Incontinence) C. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Tr. Bell. U.S.P. "90 2 min. Tr. Nux Vom. " 1 min. Tr. Cubeb 2 min. Tr. Rhus Aromat. I min. Tr. Cascarilla 2 min. Incontinence of urine In chil- dren is often corrected by the administration of these tablets, especially when due to irritable bladder. To overcome the acidity and concentration which are often the exciting causes, considerable water should be taten during the day, but the quantity should be restricted towards evening. Dose: 1 or 2 tablets at night, for a child six to eight years. Tablets Betanaphthol Compound, Squibb " Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Betanaphthol I gr. 1 Betanaphthol is a reliable Bismuth Salicylate 1 gr. \ remedy in morbid conditions Aromatic Chalk Powd. I gr. J of the alimentary tract, as ^ seen in diarrhea and dysen- tery, as well as in dilated stomach, where the contents of that organ are not completely emptied, and fermentation is a prom- inent symptom. Bismuth salicylate (subsalicylate) acts as a sedative and astringent to the mucous membranes; aromatic chalk powder as a carminative and antacid. Doser I tablet, with a glass of water, half an hour before meals, repeated in two hours if required; for diarrhea I tablet every two or three hours until relieved. ' Tablets Bismuth and Cascara, Squibb (Dyspeptic No. 2) Per 1000 Per 500 Per 100 C. T. Bismuth Subgallate 5 gr. \ The tonic laxative effects of Extract Cascara I gr. ) cascara are here combined with bismuth subgallate. The latter is considered an excellent remedy in flatulent dyspepsia, but at times it causes constipation. The cascara overcomes this objection and together they generally give marked relief, Dose: I tablet after meals, with water. This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations; it has a plain, posi- tive meaning. When prescribing, please specify SQUIBB'S. 326 SQUIBB'S MATERIA MEDICA t Tablets Bismuth and Cerium Oxalate Compound, Squibb (Nausea No. 2) Per 1000 Per 500 Per 100 C. T. Bismuth Subnitrate Cerium Oxalate 2 gr. 1 These tablets are used for the 2 gr. > relief of vomiting in pregnacy. Cocaine Hydrochlor. Vl2 gf • J <^'"' sickness, seasickness, and nausea. On account of the contained cocaine they should be given with caution lest a habit be formed. Where the nausea is excessive and much liquid cannot be given, the tablet may be placed in a spoon with a few drops of water, when it will disintegrate at once. Dose: 1 tablet in a teaspoonful of water every hour. Tablets Bismuth and Magnesia No. 1, Squibb Per 1000 Per 500 Per 100 C. T. Bismuth Subnitrate 15gr. 1 This formula affords a com- ' Magnesia Calcined 1 gr. j bination having the properties of an Antacid, Stomachic, Gastro-intestinal Astringent and Antizymotic. It is a favorite with many surgeons as a means of preventing as well as com- bating the formation of flatus after operations. Dose: I tablet about two hours after meals, or every three or four hours. Tablets Bismuth and Magnesia No. 2, Squibb Per 1000 Per 500 Per 100 C. T. Bismuth Subnitrate 1 5 gr. 1 Action and uses essentially Magnesia Calcined 5 gr. J same as preceding ; more Astringent and less Antacid. Dose : 1 tablet about two hours after ineals, or every three or four hours if required. Tablets Bismuth and Magnesia No. 3, Squibb Per 1000 Per 500 Per 100 C. T. Bismuth Subnitrate 10 gr. 7 Dose: 1 tablet about two Magnesia Calcined 1 gr. j hours after meals, or every three or four hours if required. Tablets Bismuth and Sodium Bicarbonate, Squibb Per 1000 Per 500 Per, 100 C. T, Bismuth Subnitrate lOgr. 1 This combination is prescribed Sodium Bicarbonate lOgr. j as an Antacid, Antizymotic and Gastrointestinal Astrin- gent, in acid dyspepsia, flatulence and diarrhea. Dose: 1 tablet about two hours after meals, or every three or four hours if required. SQUIBB'S MATERIA MEDICA 327 Tablets Bismuth Compound. Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Bismuth Subcarb. 1 Vsg'- Betanaphthol 3/io gr. Salol 1/2 gr. Creosote V2 gf- Oil Cloves q. s, Astringent, Antizymotic, Pre phylaclic. Morbid conditions of the aliinentary tract due to fermentative decomposition or to septic infection are indi- cations , for" the use ~ of these tablets. They combine a number of well-known antiseptics, which, by preventing putrefactive changes, allow digestron to proceed in a normal manner. ' Dose : 1 or 2 before or after meals, repeated in two hours if required. For diarrhea and in typhoid, 1 every two or three hours. Tablets Bismuth Compound No. 2, Squibb Per *1 000 Per 500 Per 10O T. T. Bismuth Subnitrate Vag'-l This is a mild sedative to ' Cerium Oxalate J-/2 gr. ) mucous surfaces, used in siinple nausea, and in some cases of infantile, diarrhea with nausea as a disturbing symptom. These tablets are so made that they disintegrate at once in water. Where a child or- older person cannot swallow a tablet, or where nausea exists, one or more may be placed in a spoonful of water, when they will instantly crumble to powder. Dose: 1 or 2 tablets repeated hourly until jiausea is relieved. Tablets Bismuth Oxide Hydrated 5 gr., Squibb Per 1000 Per 500 Per 100 C. T. This addition to our list has been made at the. request of many physicians who desired a tablet for the extemporaneous prep- aration of Milk of Bismuth (Magma Bismuthi). The tablets disintegrate at once in water, and eight tablets added to an ounce pf water and shaken slightly form a milky mixture from which' the bismuth oxide separates on standing, but quickly mixes again to a perfectly homogeneous liquid upon slight agitation. The bismuth oxide seems to possess the power of coating a much larger surface than the subnitrate or subcarbonate. The indi- cations for its use are the same as those for the subnitrate or subcarbonate. Dose: I to 3 tablets repeated every half hour until relieved, swallowed with a little water or diffused in a spoonful of water before- taking. The prices of the Squibb Products are ir^ alt instances as low as the quality and quantity of Ingredients and the expense of man- ufacture allow. They Include containers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 328 SQUIBB'S MATERIA MEDICA Tablets Bismuth Salicylate 1 gr., Squibb Per 1000 Per 500 Per 100 C. T. Bismuth salicylate (subsalicylate) acts as an Astringent and Sedative to the mucous membranes and possesses Antiseptic properties. It is found useful in all catarrhal conditions of the alimentary canal, checking fermentation, allaying inflammation and acting as a tonic and astringent. In diarrhea, dysentery and typhoid its use has been followed with good results. Dose: 1 tablet every hour until symptoms improve. Tablets Bismuth Salicylate 5 gr., Squibb Per 1000 Per 500 Per 100 C. T. Dose: I tablet with water every two or three hours until re- lieved. In fermentative dyspepsia, 1 tablet half an hour before meals and 1 tablet two hours afterwards. Tablets Bismuth Subcarbonate 5 gr., Squibb Per 1000 Per 500 ' Per 100 C. T. Bismuth subcarbonate is preferred by some practitioners to the subnitrate. It acts as an Antacid and Astringent, and is con- sidered valuable in flatulent dyspepsia, diarrhea, pyrosis, nausea, vomiting and gastric pain and inflammation. Dose: 1 or 2 tablets, repeated every half hour or two until relieved, in nausea, flatulent dyspepsia, pyrosis and diarrhea. Tablets Bismuth Subgallate 1 gr., Squibb Per 1000 Per 500 Per 100 T. T. Bismuth subgallate has been highly recommended in fermenta- tive dyspepsia. In addition to the Sedative and Antiseptic properties of bismuth, it has Astringent action owing to the pres- ence of the gallic acid. It has been used with advantage in the treatment of fermentative disorders of the stomach aiid bowels, accompanied with nausea, flatulence, pyrosis and diarrhea; in acute and chronic catarrhal conditions of the alimentary tract. Dose: for children, 1 tablet every hour or two, to control vomiting and diarrhea. Tablets Bismuth Sub£;allate 3 gr., Squibb Per 1000 Per 500 Per 100 C.T. Dose : for diarrhea, 1 or 2 tablets every two or three hours until relieved. As a gastric sedative, 1 or 2 tablets before meals, repeated in an hour or two if required. SQUIBB'S MATERIA MEDIGA 329 Tablets Bismuth Subgallate 5 gr., Squibb ' C.T. Per 1000 Per 500 Per 100 Dose : for gastric dyspepsia 1 tablet' before meals, repeated in two hours if necessary ; for diarrhea, 1 to 3 tablets every two or three hours until relieved, preferably in combination with betanaphthol ' or zinc~sulphocarbolale. (See Tablets Zinc Sul- phocarbolate Compound.) Tablets Bismuth Subgallate Comi>ound, Squibb (Dr. Aulde) C.T. Per 1000 Per 500 Per 100 . Bismuth Subgallate 5 gr. 1 In slow and imperfect gastric Pepsin 1 gr. [■ digestion of food due to an Extract Nux Vomica ^li gr. J atonic condition of the sto- mach, these tablets have been found to give Inarked relief. Bismuth subgallate acts as a tonic and astringent to the mucous membrane; pepsin supplies the gastric ferment where that .agent is deficient in quantity or weak , in digestive power ; nux vomica acts as a stimulant to the 1 peptic cells of the stomach, and is considered one of the best remedies in enfeebled states of that organ, enabling the stomach to tolerate and digest food and affording relief in the various distressing symptoms arising from faulty digestion. Dose: I tablet with a swallow of water before meals, repeated after meals if required. Tablets Bismuth Subgallate Compound No. 2, Squibb (Dr. Aulde) C.T. Per 1000 Per 500 Per 100 Bismuth Subgallate 3^/2 gr. 1 The purpose of this formula Pancreatin I ^(2 gf • \ is to assist the digestion of Extract Nux Vomica ^4 g""- J starchy and fatty foods. , The pancreatin used in these tablets conforms to the U. S. P. requirements and is present in an active fofiii. Fermentative dyspepsia with flatulence and diarrhea due to undigested food in the intestines, is the indi- cation for these tablets. Dose: 1 tablet before meals, repeated in two hours if necessary. t Tablets Bismuth Subgallate Compound No. 3, Squibb (Diarrhea Fermentative, Dr. J. W. Hyde)' Per 1000 Per 500 Per .100 This has proved an excellent combination in acute attacks C.T. P, Bismuth Snbgallate Igr. Salol - Igr. Cerium Oxalate Igr. Dover's Powder 2sr. Oil Anise q,s. . of summer diarrhea, with flat- ulence, fermentation, cramps and frequent discharges from the bowels./ It arrests fer- mentation, allays the irritation and pain, and checks the dis- If difficulty is experienced in procuring any SquiblJ product in the original packages here listed, please notify us; we shall see that your wants are met promptly arid satisfactorily we 330 SQUIBB'S MATERIA MEDICA t Tablets Bismuth Subgallate Compound No. 3, Squibb (Cent.) charge. Its action is Antiseptic, Anodyne and mildly Astringent. Dose: for adults, 1 tablet, every two or three hours; for chil- dren, I tablet in a tablespoonful of water and a teaspoonful of the solution given every two or three hours, stirring well before each dose. Tablets Bismuth Subnitrate 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 Bismuth subnitrate is used in dyspepsia, to control nausea and vomiting and to prevent flatulence and pyr&sis. It is fouiid use- ful in the chronic gastritis of alcoholics, in gaslralgia and in ulcer of the stomach. It acts as a Sedative and Astringent in inflamed conditions of the mucosae of the stomach and the intestines, especially when of a catarrhal nature. Tablets Bis- muth Subnitrate Squibb disintegrate at once in the presence of water, and yield more rapid therapeutic effects than capsules or cachets. If, as sometimes happens in nausea, it is inad- visable to give much liquid, a tablet may be placed in a spoon and a few drops of water added. Dose: I tablet every hour or two, in diarrhea and vomiting in infants. Tablets Bismuth Subnitrate 2 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: I tablet- every half hour for three or four doses, in stomach and intestinal indigestion. Tablets Bismuth Subnitrate 5 gr., Squibb — C.T. Per 1000 Per 500 Per 100 Dose: for nausea and indigestion, 1 or 2 tablets after meals; for diarrhea, I or 2 tablets every three hours until relieved. Tablets Bitter Tonic (Dr. Frank E. West). See Tablets Nux and Ipecac Compound. Tablets Blank, Squibb Per 1000 Per 500 Per 100 White, Pink or Yellow (T. T.) These tablets are made from Squibb's {>ure milk sugar. They contain no medicinal ingredient whatever. The pink and yellow tablets are prepared with vegetable colors which are perfectly harmless. Tablets Blaud's 1 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) The iron and alkali carbonate exist in these tablets in the un- combined state; in presence of moisture, as in the stomach, reaction takes place, which results in the formation of ferrous carbonate. Nascent ferrous carbonate is universally conceded to be one of the best forms in which iron can be administered; SQUIBB'S MATERIA MEDICA 331 Tablets Blaud's 1 gr., Squibb (Cont.) '■- it is rapidly acted upon by the stomach, easily utilized, produces a marked increase in the quantity of hemoglobin and the red corpuscles, and rarely causes any constitutional disturbances; in anemia and debility its effects are soon apparent in the bettered nutrition and the altered state of the blood. Dose: for chil- dren, I or 2 tablets after meals, continuing the treatment as long as necessary. Tablets Blaud's 3 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dos^e: 1 or 2 tablets three tiines a day, after meals, until the condition is improved. Tablets Blaud's 5 gr., Squibb Per 1000 Per 500 Per 100 Chocolate°coated (C. C..T.) Dose: 1 tablet three times a day, after meals. Tablets Blaud's and Manganese Compound, Squibb (Anemia) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Blaud's Mass 3 gr. 1 Expierience has shown that of Manganese Dioxide - 1 gr- r the many forms of iron intro- Acid Arsenous ^/go gr. J duced to the medical pro- fession, ferrous carbonate in the nascent condition is one that is best borne and one that yields the most rapid results; its administration is rarely fol- lowed by headache^ or disturbance of the digestive functions. The arsenous acid and manganese are believed to enhance the therapeutic action of the iron. They are employed in ane- mia, debility and menstrual irregularities. Dose: 1 or 2 tab- lets with water, after meals. Tablets Blaud's Mass and Aloin Compound, Squibb (Blaud's Tonic Laxative) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Pink-coated (P. C. T.) Blaud's Mass 3 gr. Aloin VlO gr- Quinine Sulphate V2 gr- Extract Nux Vomica l/lO gf • . These tablets have been used with good effect in anemic and chlorotic conditions with disturbance of the menstrual functions. The aloin serves — to relieve the constipation present in certain patients. Dose: 1 or 2 tablets, three times a day, after meals. The Squibb products are recognized everywiiere as ttie Quality Standard. Ttiey are of uniform purity and strength!, hence therapeutically dependable. When ordering or prescribing med. icinal products, you will- do well always to Specify SQUIBB S. 332 SQUIBB'S MATERIA MEDICA Tablets Blaud's Pill Compound, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Blaud's Mass 3 gr. ) 'Tlhe arsenous aictd in tliis Acid Arsenous ^60 g)*' 3 formula is added to increase its therapeutic value, the combination of the two remedies producing a more rapid and pronounced effect upon the blood. It is indicated in anemia, debility and chlorosis. Dose: 1 tablet three times a day, with water, after meals. Tablets Blaud's Pill Comiiouiid No. 2, Squibb / Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Blaud's Mass 5 gr. 7 Same indications as preceding. Acid Arsenous ^40 gr- ) Dose : I tablet, after meals, with water. Tablets Blaud's Pill Compound No. 3, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Blaud's Mass 5 gr. 1 These tablets are employed in Mercury Bichloride VsO gr- I anemia, chlorosis cmd general Strychnine Sulphate Ved gr- f debility. Dose: 1 tablet Acid Arsenous I/50 gr. J three times a day, after meals, with a swallow of water or other beverage. i Tablets Blaud's Pill Compound No. 3, Half Strength, Squibb Per 1000 Per 500 - Per 100 Chocolate-coated (C. C. T.) Blaud's Mass 21/2 gr. Mercury Bichloride V16O. gr- Strychnine Sulphate I/120 gr. Acid Arsenous Vldo gr. For indications, see preceding. Dose: 1 or, 2 tablets jthree times a day, after meals. Tablets Blaud's Pill Compound No. 4, Squibb (Tonic, Children's) Per 1000 Per 500 Per 100 Pink-coated (P. C. T.) The effects of iron in anemic and debilitated conditions are here intensified by alteratives, and other tonic remedies, thereby effecting improvement of the appetite, assimilation and nutrition, while the anemic condition gradually disappears. Dose: 1 or 2 tablets, according to age of child, after meals. Blaud's Mass , 1 -gr. Quinine Sulphate l/io gr. Acid Arsenous ■'/soo gf- Strychnine Sulph. ^/soo gr- Corrosive Sublim. ^/4oo gr. SQUIBB'S MATERIA MEDICA 333 Tablets Blaud's Pill Compound Improved, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Blaud's Mass 5 gr. Acid Arsenous I/50 gr Extract Nux Yomica l/g gr Extract Cascara Sagr. J/2 &• As a well-made tablet con- taining Blaud's Mass rarely produces constipation, the addition of extract cascara sagrada in ^ this formula might seem unnecessary. However, occasionally there are cases where obstinate constipation exists in anemic patients, and in such these tablets are used to special advantage. Dose : 1 tabrel. Tablets Blaud's Tonic Laxative. See Tablets Blaud's Mass and Aloin Compound, Tablets Blue Mass 5 gr., Squibb Per 1000 Per 500 Per 100 C. T. These tablets are made from the Well-known Squibb Massa Hydrargyri, in which special care is taken to thoroughly -sub- divide the mercury, and upon which the efficiency and uniform action of the product depend. The mass is in no way altered by the process of transforming into tablets. Squibb's Blue Mass Tablets are to be pr^jcrred to pills of blue mass because they do not harden with age; moreover, they disintegrate promptly in water, and retain their therapeutic action indefinitely. Dose : 1 or 2 tablets at night, followed next morning by a saline cathartic. > Tablets Borax and Sodium Salicylate Compound, Squibb (Antiseptic Detergent) Bots. of 50 Per 500 Per 100 Per doz. C.T. These tablets are a convenient means for preparing antiseptic solutions. They contain sodium bicarbonate (4^/2 gr.), sodium borate (41/2 gr.), sodium salicylate (Vll gf-)' eucalyptol, men- thol and methyl salicylate. ' They are non-poisonous and when dissolved in the proportion of I tablet in 2 fluidounces of water, yield a bland "detergent fluid with mild antiseptic powers, which is a slight modification of the solution originally proposed by Dr. Carl Seiler. They have been found very efficacious as a spray or douche in acute or chronic catarrh, as a gargle in sore throat, and as a mouth wash. Since we make only one quality of each product, ttiat best suited to the purposes intended, the specification 'Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribine, specify SQUIBB'S. 334 SQUIBB'S MATERIA MEDICA Tablets Borax and Sodium Salicylate Compound, Improved, Squibb (Antiseptic Detergent Improved) Bots. of 50 C.T. Per 500 Per 100 Per doz. These tablets are preferred where a slight astringent effect upon the mucous membrane is desired. . They contain in addition to the ingredients of the preceding antiseptic tablets, sanguinarine nitrate (l/eo gf-) a""! hydrastirie hydrochloride (l/l20 gf^J these lend stimulating and astringent properties to the combina- tion. For preparing a spray, nasal douche or mouth wash, dissolve I tablet in 2 fluidouiices of water. Tablets Bromides Compound. (Dr. Hubbard). See Tablets Morphine and Hyoscine Hydrobrbmides Compound. Tablets Bromides, Triple. See Tablets Triple Bromides. Tablets Bronchitis, See Tablets Dover's Powder and Bella- donna Compound. Tablets Bronchitis No. 2- (Acute). See Tablets Aconite and Belladonna Compound No. 2. t* Tablets Brown Mixture, Squibb (One teaspoonful) Per 1000 Per 500 Per 100 Brown Mixture has long been a popular remedy in treatment of coughs with hot, dry skin, scanty expectora- tion, hoarseness and difficult breathing. It owes its virtue largely to the small quantity of tartar emetic it contains, which by its action upon bronchial mucous membrane and the skin tends to relieve the cough and expression and to increase expectoration. These tablets are used chiefly in children over two years old. Dose: 1 tablet every hour until the acute symptoms are relieved or slight nausea occurs, and then at longer intervals. t Tablets Brown Mixture Compound, Squibb Per 1000 Per 500 Per 100 C.T. Brown Mixture 1 fl. dr. ] The addition of ammonium Ammonium Chloride 1 gr. j chloride to this formula serves to increase its expectorant effect and to counteract in a measure the depressant action of the tartar emetic. It is considered an excellent remedy in coughs and colds with painful and Scanty expectoration of viscid mucus. Dose: 1 tablet, allowed to dissolve in the mouth or taken with a swallow of water, every hour or two until symp- toms improve, and then at longer intervals. T. T. Extract Licorice VlOgr Camphor V25 gr Acid Benzoic Vas gf Oil Anise - 1/25 niin Opium Powdered V25 gr T^irtar Emetic Veo gr SQUIBB'S MATERIA MEDICA 335 Tablets Buchu Compound, Squibb (Infusion Buchu Compound) Per 1000 Per 500 Per 100 C. T. Each tablet represents: Infusion Buchu 3 dr. Tr. Hyoscyam. \JS.P. '90 20 min< Potassium Bicarbonate 6 gr. Irritable conditions of the bladder and urethra, and cystitis with acid urine, are reported to be markedly re- lieved by the use of these tablets; the bicarbonate of potassium neutralizing acidity, re- ducing inflammation, increasing the action of the kidneys and exerting a solvent action upon uric acid calculi. Hyoscyamus allays pain and tenesmus, and quiets the irritable state of the bladder. Buchu is regarded as a diuretic and stimulant to the mucous membranes of the genito-urinary organs. It is said to reduce inflammation, to increase the secretion of the kidney when scanty, and to render it bland and non-irritdtihg. Tab- lets Buchu Compound Squibb havie been found useful and to afford prompt relief in vesical and urethral inflammation with strongly acid iirine; in mild disorders caused by cold or disturbed digestion with painful and frequent micturition; in subacute gonorrhea and enlarged prostate ; and in the atonic conditions of the bladder in elderly men, with incontinence or retention of urine, Dose : 1 or 2 tablets, with a : glass of hot water, every three or four hours. Tablets Caffeine 1 gr., Squibb Per 1000 Per 500 Per 100 T. T. Caffeine is believed to strengthen the cardiac contractions and increase arterial pressure; also to act directly upon the kidneys. Hence it is used as a Cardiac and Renal Stimulant, as a stim- ulant to the cerebral functions, and also as an antidote in mor- phine poisoning. Dose: I tablet three or four times a day. Tablets Caffeine Citrated 1 gr., Squibb Per 1000 Per 500 Per 100 -T. T. Dose: 1 tablet three or four times a day, as a Cardiac and Renal Stimulant. The founder of the House of Squibb, .Dr. .Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William, Miller Bartlett, "the House of Squibb stands today gs a living monument to the honor, integrity, zeal and devotion of its founder." 336 SQUIBB'S MATERIA MEDICA Tablets Caffeine Compound, Squibb Per 1000 Per 500 Per 100 T. T. Caffeine Citrated I gr. \ This combination is used with Nitroglycerin V200 gr. j good effects in cardiac diiata- ' tion and in affections of the kidneys. According to clinical observation, it supports the heart, lowers arterial tension and increases the urinary secretion, and is useful in relieving the headaches in contracted kidney and in increasing the flow of urine in acute parenchymatous nephritis. Dose : I tablet three or four times a day. Tablets Calcium Sulphide 1/20 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Calcium sulphide (so-called; more correctly, sulphurated lime) is said to check suppuration and inflammation, and has been used in the lre,atment of boils, acne, carbuncles, discharges from the ear, conjunctivitis, enlarged glands, chronic bronchitis with purulent secretion, etc. As the drug is unpleasant to the taste and smell, the tablets are offered in chocolate-coated form only. Dose: I to 3 tablets after meals. Tablets Calcium Sulphide 1/10 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: 1 or 2 tablets every two or three hours, for boils, car- buncles and other suppurative conditions. Tablets Calcium Sulphide % gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose : 1 or 2 tablets ' every two or three hours. Tablets Calcium Sulphide % gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: 1 tablet three or four times a day, ^or boils, carbuncles, etc. Tablets Calcium Sulphide 1 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: 1 tablet three or four times a day, for boils, carbuncles, etc. SQUIB.B-S MATERIA MEDICA 337 * Tablets Calomel 1/100 gr., Squibb . . >J Per 1000 Per 500 Per 100 T. T, Small doses of calomel are regarded as valuable in disordered states of the alimentary canal, whether associated with diarrhea or with constipation. In diarrhea with clay-colored feces, di- gestive disturbance and febrile symptoms it has ■ been found to act remarkably well, changing (he ccilor and character of the stools, relieving the dyspepsia, and allaying the restlessness and fever. Small doses repeated until the desired effect is obtained seem to accomplish as much as larger ones, wifti less systemic disturbance. Careful trituration is one of the prominent features of Tablets Calomel Squibb, resulting in accurate dosage and uniform therapeutic action. Dose: for an infant, 1 tablet every hour or two until symptoms improve. * Tablets Calomel 1/20 gr., Squibb Per 1000 Per 500 Per 100 T. T. Dose : 1 tablet every hour until bowels act and character of the secretions changes. Tablets Calomel 1/10 gr., Squibb Per 1000 Per 500 Per 100 T. T. or C. T. ; Plain, Pink, Rose or Wintergreen Flavor Dose: I tablet every hour for adults or children, for ten doses or until the bowels move freely, as an Hepatic Stimulant and Corrective. ♦Tablets Calomel:^ gr., Squibb Per 1000 Per 500 'Per 100 T. T., Plain or Winter- green Flavor Dose: 1 tablet every hour until bowels move or until eight have been taken, followed by a saline cathartic. * Tablets Calomel 1/6 gr., Squibb Per 1000 Per 500 Per 100 T. T., Plain or Winter- green Flavor Dose: I tablet every hour until six tablets have been taken; the last dose being followed by a saline cathartic. The Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellence and Reliability. ■ Specify SQUIBB'S when prescribing or ordering. 338 SQUIBB'S MATERIA MEDICA *TabIets Calomel 1/5 gr., Squibb Per 1000 Per 500 Per 100 T. T., Plain or Winter- green Flavor Dose: 1 tablet every hour until bowels move freely; the last dose being followed by a saline laxative, * Tablets Calomel J4 gr., Squibb Per 1000 Per 500 Per 100 T. T., Plain or Winter- green Flavor Dose; I tablet every hour or two until laxative action is ob- tained, followed by a saline cathartic. In dyspepsia with coated tongue, 1 or 2 at night followed by a saline cathartic next morning. * Tablets Calomel y^ gr., Squibb Per 1000 Per 500 Per 100 T. T., Plain or Winter- green Flavor Dose; 1 tablet every hour or two until effect is produced, fol- lowed by a saline cathartic. * Tablets Calomel 1 gr., Squibb Per 1000 Per 500 Per 100 T. T., Plain or Winter- green Flavor „,, , Dose; 1 tablet every two or three hours until laxatiye action is obtained, followed by a saline cathartic. Tablets Calomel 2 gr., Squibb Per 1000 Per 500 Per lOQ T. T., Plain or Winter- ^ green Flavor Dose: I or 2 tablets at night, followed next morning by a saline cathartic. Tablets Calomel 5 gr,, Squibb C. T. Per 1000 Per 500 Per 100 Dose; 1 tablet at night, followed by a saline cathartic next morning. . ' - * Tablets Calomel and Bismuth Compound, Squibb (Corrective Infants', Dr. Ives) Per 1000 Per 500 Per 100 Attacks of indigestion in chil- dren due to overeating, with coated tongue, foul breath and fever, have been quickly re- lieved by the use of this formula. Calomel and ipecac' are intended t» increase the: activity of the liver, and by their T. T. P Calomel ^/20 gr Bismuth Subnitrate Igr Sodium Bicarbonate Vz gr Ipecac VsO gr Oil Anise q. s SQUIBB'S MATERIA MEDICA 339 * Tablets Calomel and Bismuth Compound, Squibb (Cont.) action upon the bowels to relieve the overburdened system. Bismuth subnitrate and sodium bicarbonate tend to correct the dyspepsia aiid . hyperacidity. Dose : 1 tablet in a leaspoonful of water every hour or two until relieved. t Tablets Calomel and Morphine Compound, Squibb (Diarrhea No. 2) Per 1000 Per 500 Per 100 Chocolate-coated (C.C. T.) Calomel ' l/s gr- Morphine Sulphate * Vl6 g'- Capsicum l/ig gr. Ipecac 1/32 gr. Camphor V18 gr- . This formula has been in use many years in the treatment of summer diarrhea, especially where after expulsion of the exciting irritants, the discharge continues, and where a condi- tion bordering on dysentery exists. Dose: I tablet with water every hour for three, or four doses, then every two or three hours until relieved. Tablets Calomel and Santonin. See Tablets Santonin and Calomel. Tablets Calomel and Soda, Sguibb Per 1000 Per 500 Per 100 C. T. Chocolate-coated (C. C. T.) Calomel ^/2-gi'' 1 The combination of calomel Sodium Bicarbonate 3 gr. J with an alkali is a favorite method of administering this remedy in attacks of diarrhea in children where the movements -are slimy and green-colored. These tablets are used also as a stimulant to the liver in sluggishness of that organ in adults. Dose : for, children with diarrhea, 1 tablet every two hours, until the character of the discharges changes; for adults, 1 or 2 tablets at night. * Tablets Calomel and Soda No. 2, Squibb Per 1000 Per 500 Per 100 T. T. Calomel I/4 gr. \ This formula is largely used Sodium Bicarbonate 1 gr. j in deranged and congested • conditions of the liver where the symptoms of poor appetite, coated- tongue, bad breath, headache and constipation are present. Dose i 1 : tablet every hour until laxative effect is produced. The Squibb Label on a paekage is a positive guaranty for tha» uniform Purity and Reliability of tlie product. ^\fJe mal calomel is intended to increase Sodium Bicarbonate I gr. J its usefulness in disorders of the stomach, in that condition known as "biliousness." These tablets are employed in indi- gestion, with coated tongue, headache and constipation. Dose : 1 or 2 tablets, after meals, with an occasional dose of a saline aperient in the morning — enough to produce a free movement, but not sufficient to purge. Tablets Camphor and Hyoscyamus Compound, Squibb ' (Nervine) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Camphor- 1 gr. Ext. Hyoscyamus I/2 gr- Ext. Valerian I/2 gr. This formula acts as an Ano- dyne and Sedative to the ner- vous system. It is used in controlling mild mental excite- ment, quieting the sexual system and for inducing sleep in in- somnia due to cerebral stimulation caused by overwork or worry ; also to allay pain and restlessness due to vesical irritation. Dose: I tablet every half hour for three or four doses, then every two hours -until effect is produced. Tablets Camphor and Opium. See Tablets Opium and Camphor. Tablets Camphor, Hyoscyamus and Sumbul Compound, Squibb (Sedative No. 2) Per 1000 Per 500 Per 100 White-coated (W. C. T.) Camphor I gr. ) For nervous and excited |tates Ext. Hyoscyamus I/2 gf. I of the system caused by over- Ext. Sumbul V2 gr. [ work, loss of sleep or worry ; Valerian I/2 gr. J in mild forms of melancholia and hysteria; and to allay sexual excitement. Dose: 1 tablet after meals and at bedtime. SQUIBB'S MATERIA MEDICA 343 Tablets Cannabis Extract ^ gr., Squibb T. T. Per 1000 Per 500 Per 100 Cannabis h^s been employed as a Sedative, Anodyne and Hypnotic, in cases where opium does not agree with the patient. Unlike tlie latter, it causes neither nausea nor constipation. It produces at first a mental stimulation, which is later followed by a calmer mood and finally by sleep. It is used in acute and chronic mental derangements, in neuralgia, migraine, gout and rheumatism. In combination with the bromides (see. Tab- lets Triple Bromides and Cannabis Compound) it is employed in hysteria, delirium tremens and mild cases of mania., AH patients do not respond to it alike; and while no doubt idiosyn- crasy plays a great part, yet the quality of the drug has much to do with its constitutional effect. In all our preparations of this drug the best quality of hemp is used. The results will be found uniform and reliable. Dose: 1 tablet every 2 or 3 hours. f Tablets Cannabis and Aconite Compound, Squibb (Neuralgic, Brown-Sequard) Per 1000 Per 500 Per 100 Chocolate coated (C. C. T.) This is a combination of powerful antispasmodics and sedatives, and should be used with caution. All of the ex- tracts are accurately standard- ized and carefully incorpo- rated in the tablets which rep- resent the full therapeutic efficiency of the formula. 1 tablet cautiously repeated every three or four hours; discontinued after the third 4°'e. Extract Cannabis Extract Aconite Extract Hyoscyamus Extract Conium Extract Ignatia Extract Opium Extract Stramonium Extract Belladonna Dose to be V4gr.] ^/s gr- % gr- % gr- V2gr. ^k gr. JBgr. ^/6 gr. J t Tablets Cannabis Strength, Squibb (Neuralgic, Chocolate -coated Extract Cannabis Extract Aconite Extract Hyoscyamus Extract. Conium Extract Ignatia Extract Opium Extract Stramonium Extract Belleidonna and Aconite Compound, Half Brown-Sequard, Half Strength) Per 1000 Per 500 Per 100 (C.C.T.) ^/s'gr. ' ^le gr- ^/3 gr- % gr. 1/4 gr. V4 gr. VlO gr. Vl2 gr. J These tablets are half the strength of the preceding and are intended for patients of less robust constitution. Dose: 1 tablet every three or four hours with a swallow of wafer, but to be discontinued after the third doser This house supplies only one quality of each product: that best suited to the purposes intended. The specification Squibb's" is not open to various interpretations; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 344 SQUIBB'S MATERIA MEDICA t Tablets Cannabis and Hyoscyamus Compound, Stquibb (Croup, Spasmodic) Per 1000 Per 500 Per 100 These tablets are employed for the relief of laryngeal ' spasm as seen in croup in chil- dren.~ The formula is an old one and has been added to our list in response to repeated demands from physicians who have used it with good results. Dose: I teaspoonful of a mixture of eight tablets diffused in twenty-five teaspoonfuls of hot water every fifteen minutes until relieved, for a child six months; older children in propor- tion. Tablets Cannabis and Strychnine Compound, Squibb Per 1000 Per 500 Per 100 Green-coated (G. C. T.) C. T. Extract Cannabis ^ho gr- Ext. Hyoscyamus 1/20 gr. Paregoric Syrup Ipecac Ext. Licorice 5 min. 5 min. 2gr.. This combination has been used largely as a nerve tonic and stimulant. It is indicated in anemic and debilitated con- ditions of the system, accom- panied with lack of nervous energy and of vital powers. Dose; I tablet after meals and at bedtime. Extract Cannabis VlO gr- Strychnine Phosphate ^40 gr. Zinc Phosphide 1/10 gr. Avenin I/200 gr- Tablets Capsicum and Nux, Squibb (Capsicum Compound, Dr, Lindsley) Per 1000 Per 500 Per 100 T.T. Chocolate-coated (C. C. T.) Capsicum ^/lO gr. ) Capsicum stimulates the mu- Nux Vomica ^4 gr* 3 cous membranes of the mouth and the stomach. Nux vomica is of value in all atonic conditions of the alimentary canal. To- gether they are deemed an excellent combination for disordered digestion in persons of sedentary habits, and in gastritis due to abuse of alcohol. Dose : 1 or 2 tablets half an hour before' meals, repeated if necessary at half hourly intervals for three doses after eating. Tablets Capsicum and Quinine. See Tablets Quinine and Capsicum. Tablets Capsicum Compound (Dr. Lindsley). See Tab- lets Capsicum and Nux. Tablets Cardiac (Dr. Waldstein). See Tablets Sparteine Comp. Tablets Cardiac Asthma. See Tablets Heroin and Digi- talis Compound. SQUIBB'S MATERIA MEDICA 345 Tablets Cascara and Bismuth. Cascara. See Tablets Bismuth and Tablets Cascara Compound, Squibb C.T. ' Per 1000 Chocolate-coated (C. C. T.) Ext. Cascara Sagrada ' 2 gr, Podophyllin 1/g gr Per 500 Per 100 Ext. Belladonna l/ie gr. The laxative action of cascara sagrada is here increased by the addition of podbphjrllin, an active cathartic and hepatic stimulant, and modified by extract belladonna, which prevents griping. These tablets are employed as a Laxative in cases of constipation with inactive liver, where no ' inflammation of the bowels exists. Dose: 1 or 2 tablets at night. Tablets Cascara Compound No. 2, Squibb (Dr. Hinckle) Per 1000 Per 500 C. T. Piak-coated (P. C.T.) Cascarin l/4gr.l Aloin 1/4 gr. Podophyllin Vegr. Ext. Belladonna Vs gr. Strychnine Sulphate Voo gr. Gingerin ^8 gr. J Per 100 the intestinal All paxts of tract are said to be acted upon by this combination; it stim- ulates the liver and the inles- inal glands; increases peris- taltic action and operates thor- oughly without griping or causing tenesmus. As a remedy in habitual constipation, with torpid liver and indigestion, it has proved very efficacious and its continued use is not known to debilitate the bowels. Dose: I or 2 tablets at bedtime, repeated after breakfast and dinner if needed; as the bowels resume their normal functions the intervals are lengthened. Tablets Cascara Compound No. 3, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Ext. Cascara Ssigrada I/2 gr. Aioin ^/g gr. Podophyllin l/io gr. Oil Peppermint q. s. Habitual constipation with hepatic torpor is usually cor- rected by this formula; the activity of th^ liver is in- creased by the' action of the podophyllin, while all parts of the bowel are affected. At times griping is produced, although the carminative effect of the oil of peppermint tends to correct this. In many cases the addition of belladonna is an improvement, and the practitioner is directed to these various combinations under their several titles. Doge: 1 or two tablets at bedtime, repealed after break- fast if necessary. The prices of the Squibb Products are in ail instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. They include containers, pacl"• This formula is used to allay irritation of the mucous mem- brane, prevent fermentation and increase tolerance of food in nausea due to gastric inflammation, ~ in seasickness, vomiting in pregnancy, etc. Dose: 2 tablets, followed by 1 tablet .every hour for three or four doses. In the use of these tablets the possibility of the formation of the cocaine habit should be remembered and guarded against. Tablets Charcoal 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Charcoal is a well-known Absorbent and Antiseptic, It is used in dyspepsia with acid eructations, fermentation, nausea and vomiting; checking production^of gas in the stomach and bowels, and relieving the various unpleasant symptoms arising therefrom. The best willow charcoal is used in these tablets, and they will be found pleasant to the taste; they may be eaten or swallowed with a little water, as preferred. Dose: 1 or more tablets after meals, or oftener if required. Tablets Chloramine=T 4.6 gr., Squibb Per 1000 Per 500 Per 100 Convenient for preparing disinfectant solutions according to Dr. Dakin's method. 1 tablet dissolved in 1 fiuidounce of water makes a 1 percent, solution, and 2 tablets in a fiuidounce a 2 percent, solution; these are the ordinary strengths used for wound disinfection. In the nose and thfoat chloramine-T is employed in 14 per cent, solution, obtained by dissolving I tablet in 4 fiuidounces of water. SQUIBB'S MATERIA MEDICA 349 t Tablets Chlorodyne, Squibb C.T. Chocolale-coated (C. C. T.) Morphine^Hydrochlor. l/e gr. Per 1000 Per 500 Per 100 Extract Cannabis Nitroglycerin Ext.'Hyoscyamus Oleoresin Capsicum Oil Peppermint An active and well known ^li gr. combination of Antispas- Vsoo gr- ; modics and Anodynes is ^h gr. presented here. It is used ■"•/lO gr. in the treatment of cramps, /lO min. J colic and diarrhea, and for the relief of pain generally. In diarrhea produced by change of drinking water or by ex- posure to sudden reduction of temperature, with severe abdominal pains, it is reported to afford prompt relief. Dose: 1 tablet every hour if necessary for pain; discontinued after the third dose for three hours, and then resumed if not entirely relieved. For diarrhea, I tablet every three hours until effective. t Tablets Chlorodyne No. 2, Squibb Per 1000 C.T. ChocoIate°coated (C. C. T.) Morph. Hydrochlor. l/l2 gr. Extract Cannabis 1/g gr. Nitroglycerin l/dnn er. Ext. Hyoscyamus Oleoresin Capsicum ' Oil Peppermint Per 500 Per 100 V4 gr. V20 gr. 1/20 min. Dose: 1 tablet every hour for three doses if necessary for pain ; discontinued after the third dosfe for three hours, then' resumed^ For diarrhea, 1 tablet every two or three hours until relieved. Tablets Cholera Jnf antum. See Tablets Zinc Sulpho- carbolate and Calomel Compound. ,-:,,:!; Tablets Chromium Sulphate 4 gr., Squibb Per 1000 Per 500 Per 100 C.T. Chocolate-coated (C. C. T.) Chromium Sulphate has been introduced of late years as an Alterative and Nervine for use chiefly in' the treatment of neuras- thenia, locomotor ataxia and exophthalmic goiter; and latterly it has also been proposed as a remedy in hypertrophy of the prostate gland. The reports are somewhat conflicting, but in response to a large demand we have added the tablets to our list. Dose : 1 or 2 tablets three times a day after meals. The Squibb products are recognized everywhere as the Quality Standard. They are of uniform purity and strength, hence therapeutically dependable. When ordering or prescribing me- dicinal products, you will do well always to specify SQUIBB'S. 350 SQUIBB'S MATERIA MEDICA t Tablets Cocaine Hydrochloride 1% gr., Squibb (For Solutions) Per 100 Per tube of 25 C.T. These tablets are convenient for preparing soluilans of any strength: 1 tablet dissolved in 1 fluidrachm of water yields approximately a two-percent, solution; dissolved in 2 fluidrachms of water a one-percent, solution. 2 tablets dissolved in I fluid drachm of water yield a four-percent, solution, etc. Distilled or sterile water should always be used in preparing solutions; and if for hypodermic use, the solution should be passed through absorbent cotton. Antidotes: Chloral hydrate; amyl nitrite by inhalation; caSeine or morphine; stimulants, t Tablets Cocaine Hydrochloride 2% gr., Squibb (For Solutions) Per 1 00 Per tube of 25 C.T. For Preparing Solutions: I tablet dissolved in 1 fluidrachm of water yields approximately a four-percent, solution, r t Tablets Codeine ^ gr., Squibb Per 1000 Per 500 Per 100 T.T. Codeine is used to allay pain, relieve restlessness and quiet cough; its action being that of a mild Anodyne and Sedative. The indications for its use are similar to those for morphine, but it is said to cause less nausea and not to create a habit, in view of which it is employed in place of the latter where pain is not too pronounced a symptom. Codeine is very frequently used in diabetes, to check the inordinate «ppetile, reduce the urinary secretion and allay the thirst. Dose; 1 tablet three or four times a day and 1 at bedtime. t Tablets Codeine 14 Sr., Squibb Per 1000 Per 500 Per 100 T.T. Dose: 1 tablet every three or four hours, as a mild anodyne, to allay cough and to relieve symptoms in diabetes. Used also in combating the opium or morphine habit. t Tablets Codeine % gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose: 1 tablet every three or four hours, to allay pain and restlessness, to relieve the cough of phthisis, to combat the opium habit and in diabetes. SQUIBB'S MATERIA MEDICA 351 t Tablets Codeine and Nickel Compound, Squibb (Anodyne Infants', Dr. Waugh) ^^PerlOOO Per 500 Per 100 T.T. Codeine Sulphate ^/ey gr. Nickel Bromide ■'•/l34 &• Ipecac I/1S4 gr. Lithiun^ Carbonate 4/25 gr.^ Oil Anise Vl34 gf • These tablets are used to relieve colic and allay [Sain . and restlessness in very young children. Dose: 1 or 2 tab- lets, dissolved in a little hot water, every fifteen to thirty minutes until relief is obtained. t Tablets Codeine Phosphate Ys gr., Squibb Per 1000 Per 500 Per 100 T.T. ^, ■ , Dose: 1 or 2 tablets every three or four hours as a mild Ano- dyne, Cough Reliever , and Nerve Sedative. t Tablets Codeine Phosphate % gr., Squibb Per 1000 Per 500 Per 100 T.T. Codeine phosphate possesses the properties of the alkaloid, but is a^ very soluble salt, and probably is more readily absorbed. Dose : 1 tablet every three or four hours. t Tablets Codeine Phosphate ^ gr., Squibb Per 1060 Per 500 Per 100 T.T. Dose: 1 tablet every three or four hours., f Tablets Codeine Sulphate % gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 or 2 tablets every three or four hours, as a mild Ano- dyne and Sedative, to allay cough, quiet restlessness, and to con- trol the unpleasant symptoms^ in diabetes. t Tablets Codeine Sulphate % gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose and uses as of Tablets Codeine (alkaloid) I/4 gr. t Tablets Codeine Sulphate % gr., Squibb Per J 000 Per 500 Per 100 T.T. Dose and indications similar to those of Tablets Codeine (alka- loid) 1/2 gf. ^ Since we make only one quality of each product, that best suited to the purposes intended, the specification _ Squibb s is not operr to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB S. 352 SQUIBB'S MATERIA MEDICA t Tablets Codeine Sulphate 1 gr., Squibb T.T. ^ Per 1000 Per 500 Per 100 Dose: 1 tablet three or four times a day as required, as an ' Anodyne and Soporific. I TabI.ets Colchicine 1/100 gr., Squibb T.T. Per 1000 Per 500 Per 100 Colchicine is largely used in goujt and rheumatism. It is reported to act upon the nerves, the skin and the bowels; allaying pain, inciting free perspiration with a subsidence of the fever and inflammation, and producing free evacuations from the bowels. Some observers state that it acts also as a diuretic, but this is denied by Garrod and others. Certain patients show more susceptibility to its action than others, and it is hence deemed best to begin with small doses and gradually, increase until the systemic effect is observed. Dose: I tablet every three hours until bowels move or symptoms are relieved. Tablets Colchicine 1/50 gr., Squibb T.T. Per 1000 Per 500 Per 100 Dose: 1 tablet three times a day; less frequently if the bowels move too freely. In overdoses colchicine is an active poison. Tablets Cold. See Tablets Dover's Powder and Aconite Comp. Tablets Cold No. 4. See Tablets Aconite and Camphor Compound. Tablets Cold No. 5. See Tablets Aconite . and Calomel Compound. Tablets Colic No. 2, Infantile. See Tablets Sodium Bi- carbonate Compound. Tablets Compound Licorice Powder, Squibb Put up in 1-oz packages containing 22 tablets, 16 packages to the carton, per lb. A pleasant and efficient laxative confection containing the Squibb special compound licorice powder. Doge : I or 2 tablets at bedtime, eaten as a confection. Tablets Copaiba and Salol. See Tablets Salol and Co- paiba. * Tablets Copper Arsenite 1/200 gr., Squibb T.T. Per 1000 Per 500 Per 100 • Copper arsenite is considered a valuable remedy in acute and chronic diarrhea in children ox adults and as useful also in intestinal indigestion with flatulence, fermentation and disordered bowels. Dose: for children, 1 tablet every three or four hours until diarrhea is checked; for adults, 1 tablet every two or three hours. SQUIBB'S MATERIA MEDICA 353 * Tablets Copper Arsenite 1/100 gr., Squibb '^ T.t Per 1000 Per 500 Per lOQ. Dose : for children, I tablet, dissolved in half a glass of water and a teaspoonful given every half hour until the symptoms improve; adults, a lablespoonful of the same solution. Tablets Copper Sulphate 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 These tablets are made from pure copper sulphate and hence dissolve completely and yield clear solutions with distilled water. They should be, kept well stoppered as the salt is very efflorescent. They are employed for the preparation of astrin- gent and cicalrizant solutions for use on sluggish ulcerations, chancroids, etc. Directions: Dissolve 2 to 4 tablets in a fluid ounce of distilled water. Tablets Corrective. See Tablets Strontium Salicylate and Charcoal Compound. Tablets Corrective, Infants'. See Tablets Calomel and Bismuth Compound. Tablets Corrosive Sublimate 1/100 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: in diarrhea and dysentery, 1 tablet every hour or two until the discharges change in character or are controlled; as an Antiluetic in children, I tablet after each meal. Tablets Corrosive Sublimate 1/60 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: in diarrhea and dysentery, 1 tablet every hour or two until the character of the discharges changes; as an Antiluetic, I tablet three times ^ day. Tablets Corrosive Sublimate 1/50 gr., Squibb " Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: as an Intestinal Antiseptic, 1 tablet every two hours; as an Antiluetic, 1 tablet three times a day., Tablets Corrosive Sublimate 1/30 gr., Squibb C.T. Per 1000 Per 500 Per J 00 Dose: 1 tablet after meals, gradually increased until systemie effect is observed, in syphilis and scrofula. The founder of the House of Squibb', Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William. Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 354 SQUIBB'S MATERIA MEDICA Tablets Corrosive Sublimate and Ammonium Chloride. See Tablets Mercury Bichloride Compound, Wilson's. tablets Corrosive Sublimate and Citric Acid. See Tablets Mercury Bichloride Compound, Bernays'. Tablets Coryza. See Tablets Quinine and Camphor Com- pound No. 3. Tablets Coryza No. 2. See Tablets Quinine and Camphor Compound No. 4. Tablets Coryza No. 3. See Tablets Quinine and Camphor Compound. Tablets Coryza No. 5. See Tablets Quinine and Calnphor Compound No. 2. Tablets Coryza Modified. See Tablets Quinine, Camphor and Hybscyamus Compound, Tablets Coryza with Heroin. Set Tablets Quinine i^an^ Camphor Compound No. 5. Tablets Cough, Infants'. See Tablets Ammonium Chloride Compound with Heroin, l*4o.' 2. ij-,i, ." Tablets Cough, Persistent. See Tablets Ammonium Chlo- ride and Squill Compound. •' I ' i ' i ,■ . ts^i , i Tablets Cough, Persistent, -with Heroin. See- Tablets Ammonium Chloride and Squill iCompound with Heroin. Tablets Cough Sedative. See Tablets Terpin Hydrate and Heroin Compound. 'Tablets Creosote 1 min., Squibb -:;!'i Per 1000 Per 500 .Per 100 Chocolate-coated (C. C. T.) Creosote has been used with good results in chronic bronchitis and in phthisis, also as an intestinal antiseptic. It is reported to improve nutrition, increase appetite, diminish expectoration and cause an increase in weight; It is recommended to give the remedy in gradually increasing dose until the point of toler- ance is reached. Should, however, gastric disturbances arise, its use is discontinued or the dose reduced until the irritation subsides. Tablets Creosote Squibb are made from the purest wood creosote, and are prepared so that they disintegrate quickly in the stomach and cause little or no gastric irritation. Dose: 1 tablet immediately after meals, with water or milk, gradually increased as tolerance is established. Tablets Creosote 2 min., Squibb ' Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: 1 or more tablets after meals; in chronic bronchitis, phthisis, tuberculous diarrhea and as an intestinal antiseptic generally. SQUIBB'S MATERIA MEDICA 355 Tablets Croup, Spasmodic. See Tablets . Cannabis and Hyoscyamus Compound. Tablets Cystitis. See Tablets Acid Boric and Buchu Compound. t Tablets Diaceiylmorphine 1/24 gr., Squibb T.T. Per 1000 Per 500 Per 100 Diacetylmorphine is considered a remedy of much valuej as a stimulant to the respiration in dyspnea and emphysema and as a sedative in the treatment of bronchial and tubercular cough, and to be preferable to morphine as a cough sedative because it does not disturb digestion readily. In asthma its action is reported to be prompt and prolonged, not only diminishing the severity of the attacks, but preventing their recurrence. Com- bined with expectorants it is deemed useful in bronchitis, pneu- monia and grip, and it is also used as a mild anodyne. Accord- ing to some authorities, .diacetylmorphine (or heroin) is more toxic than morphine and les| valuable for the relief of pain; it is equally habit forming. Antidotes: Same as of morphine. Dose: I or 2 tablets after meals and at bedtime, for the relief of cough and pain. t Tablets Diacetylmorphine 1/12 gr., Squibb . T T. Per 1000 Per 500 Per 100 Dose: I tablet after meals and at bedtime. f Tablets Diacetylmorphine 1/6 gr., Squibb T.T. Per 1000 Per 500 Per 100 Dose: 1 tablet as required, cautiously repeated. f Tablets Diacetylmorphine Hydrochloride 1/24 gr., Squibb Per 1000 Per 500 Per 100 T. T. Dose: I or 2 tablets after meals and at bedtime, for the relief of cough and pain. f Tablets Diacetylmorphine Hydrochloride 1/12 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose': 1 tablet after meals and at bedtime. "f Tablets Diacetylmorphine Hydrochloride 1/6 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 tablet as required, cautiously repeated. The Squibb Ideals -have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, general Excellehce and Reliability. Specify SQUIBB'S when prescribing or ordering. 356 SQUIBB'S MATERIA MEDICA Tablets Diarrhea (Dr. Sullivan). See Tablets Opium, Cam- phor and Lead. Tablets Diarrhea No. 2. See Tablets Calomel and Mor- phine Compound, Tablets Diarrhea Fermentative. See Tablets Bismuth Subgallate Compound No. 3 Tablets Digestive. See Tablets Pepsin and Pancrealin Compound No. 3. Tablets Digestive Absorbent. See Tablets Papain and Charcoal Compound. Tablets Digestive Aromatic. See Tablets Pepsin, Pan- crealin and Lactic Acid Compound. =*' Tablets Digitalin (Cerman) 1/100 gr., Squibb Per 1000 Per 500 Per 100 T.T. According to authorities, digitalin is a direct Cardiac Stimulant and Diuretic, particularly useful in cardiac decompensation, where the heart action is rapid and very irregular (auricular fibrillation). Its effects are produced slowly, but they are prolonged and cumulative, especially where the urinary secre- tion is not increased. The direct diuretic action . of digitalin is stated to be small, and the drug to be effective in dropsy only when the latter is due to impaired circulation. Dose: I tablet every three or four hours. * Tablets Digitalin (German) 1/60 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 tablet every three or four hours, as a Renal and Cardiac Stimulant. If headache or digestive disturbaikce occur, the in- tervals between the doies are increased. ^ Tablets Digitalis Fluidextract 1 min., Squibb Per 1000 Per 500 Per 100 C.T. Digitalis strengthens heart action. It increases the force of the contractions, reduces the frequency of the pulsations, and over- comes Irregularity, h raises arterial tension partly by Increased muscular contraction of the heart but chiefly, according to Brun- ton, by contraction of the arterioles. It is used as a Heart Stimulant in all cases of weak, irritable or intermittent heart action. The direct diuretic action of digitalis is small, but in cardiac disease it has been found to. produce marked diuresis and therefore to prove of -value as a rule in cardiac dropsy. Dose: I tablet three or four times a day, reducing the dose if nausea, flushing of the face, or headache occur. SQUIBB'S MATERIA MEDICA 357 Tablets Digitalis and Buchu Compound, Squibb (Diuretic) Per 1000 Per 500 Per 100 CT. , , Chocolate-coated (C. C. T.) . , Digitalis 1 gr. 1 These tablets are employed in Extract Buchu I gr. . cardiac and renal dropsy. It Potassium Nitrate 1 gr. is maintained that digitalis Squill I gr, _ does not cause any stimula- tion of the epithelium of the kidney, but by its action on the heart in disease, it causes diuresis by increasing the blood supply to the kidneys. Squill has been found useful in passive forms of dropsy where , the heart is obstructed and the pulse weak; but its use is avoided when an irritable condition of the kidney exists. Buchu stimulates the mucous membrane, and with the nitrate of potassium increases the diuretic power of the combination. Dose: I tablet three times a day, between meals, with a large glass of Water. Tablets Digitalis and Cactus Compound, Squibb (Heart Tonic No. 2, Dr. Pultz) Per 1000 Per 500 Per 100 T.T. ChocoIate°coated (C. C. T.) Tr. Digit. U5.P.'90 Imin.' Tr. Cactus Grandifl. I min. Tr. Stroph. U.S.P.'90 1 min. Nitroglycerin %00 gr. J Although many consider the combination of a number of heart remedies unscientific, this formula enjoys consider- able use in cases of weak, irregular and irritable heart action. Dose : I tablet after meals or of tener if required by the exigencies of the case. Tablets Digitalis and Calomel Compound, Squibb (Diuretic No. 5) CT. Per 1000 Per 500 Per 100 Digitalis, calomel and squill .in combination are recom- mended by Ringer and other authorities in the treatment of renal and cardiac dropsy. Caffeine adds additional value to the formula by it» stimulation of the secreting structures of the kidneys and by increasing the flow of blood through the kidneys. Dose : 1 tablet every three or four hours with a glassful of water. Digitalis . V2 gr. Calomel ^/2 gr. Squill ^/a gr. Caffeine 1/4 gr. J The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low , a^ they can be made for that quality. Specify SQUIBB'S. 358 SQUIBB'S MATERIA MEDICA Tablets Digitalis and Iron Compound, Squibb (Heart Tonic, Dr. Gordinier) C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Fluidextract Digitalis 1 min. 1 Whilr combining several Iron Reduced ' gf- l>«af' drugs in one prescrip- Nitroglycerin V200 gf- f tion has been condemned by Tr; Stroph. UJ5.P.'90 3 min. 1 many practitioners, these tab- Strychnine Sulph. Veogr.j lets enjoy considerable use in functional disturbance as well as organic disease of the heart accompanied by anemia. They are prescribed as long as improvement continues; should, how- ever, flushing of ihe face or nausea or headache occur, they are discontinued for a while. Dose: 1 tablet after meals. Tablets Digitalis and Strophanthus Compound, Squibb (Heart Tonic and Stimulant, Dr. Da Costa) T.T. Per 1000 Per 500 Per 100 Cbocolate°coaied (C. C. T.) Tr. Digit. U.S.P.'90 2min.l Though objection has been Tr. Stroph. U.S.P.'90 2 mi?i. I Inade, on scientific principles, Tr. Bell. U.S.P.'90 1/2 min. [ to combining a number of Nitroglycerin VlOO gr. J heart remedies, these tablets are a favorite with many physicians. They are made from carefully prepared tinctures and may be relied upon for prompt therapeutic action. Dose : as a cardiac stimulant in collapse and angina, 1 or 2 tablets, repeated as necessary; for palpitation, smoker's heart and as a cardiac tonic, t tablet every three or four hours. Tablets Dinner. See Tablets Aloes and Mastic. Tablets Dipsomania. See Tablets Gold anj} Sodium Chlo- ride Compound. Tablets, Diuretic. See Tablets Digitalis and Buchu Compound. Tablets Diuretic No. 5. See Tablets Digitalis and Calomel Compound. f Tablets Dover's Powder 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 These tablets represent 5 grains of Squibb's Ipecac and Opium Powder. They combine coiivenience with accuracy of dose and certainty' of therapeutic effect. Dover's powder is known to relieve pain in inflammatory conditions with dry skin and fever, where no nausea exists, and has hence proved an excellent rem- edy in the early stage of a cold, taken at bedtime and its dia- phoretic action increased by a hot drink. Dose : 1 tablet every three hours, to quiet the nerves, and 2 tablets at bedtime, with a hot drink, in the early stage of cold. Used also in diarrhea, generally combined with small doses of calomel. SQUIBB'S MATERIA MEDICA 359 t* Tablets Dover's PoVder 2^^ gr., Squibb PerlOOO Per 500 Per 100 T.T. Chocolate-coated (C. C. T.) Opium Powdered I/4 gr. ) Each of these tablets is Ipecac 1/4 gr. J equivalent to 21/2 grains of Dover's powder, the milk sugar being omitted in order to make the tablets of convenient size. Dose: for children, 1 tablet; for adults, 1 tablet every hour in sudden cold, for four doses, or 4 tablets in one dose. t Tablets Dover's Powder 1 gr., Squibb Per 1000 Per 500 Per 100 C.T.. < Opium Powdered %o gr. | Dose: I tablet every hour in Ipecac n ; , . ho gr- 3 phthisis ; 1 tablet every half hour for three or four doses as a Diaphoretic and Nerve Sedative intfebrile diseases. t Tablets Dover's Powder 54 gr., Squibb Per 1 000 Per 500 Per 100 T.T. ; Dose : 1 tablet every houf for four doses, for children ; as a Sudorific in the early stage of a cold. ' t Tablets Dover's Powder and Aconite Comp., Squibb (Cold, Dr. Gage) Per 1000 Per 500 Per 100 C.T. Chocolate°coated (C. C. T.) Small doses of aconite and Dover's Powder 2 gr. Tr. Aconite US.P.'90 1 min. Quinine Sulphate 2 gr. Capsicuin ■'Atg'- Dover's powder reputedly act very well - together in the early stage of colds; inducing a free action of the skin, relieving muscular pain and soreness, allaying cough, quieting arterial excitement and favorably affecting the bronchial secre- tions. Quinine acts as an antipyretic. Capsicum stimulates the mucous membrane of ' the stomach and serves to cause a more rapid absorption. Dose: 1 tablet every three or four hours until the fever and oppression are relieved.. Two or three tablets at bedtime with a hot drink will frequently abort a cold. Squibb's Tablets are made from the Squibb quality of ingredients and by Improved processes that insure., accurate dosage and rapid and complete disintegration or solution in the system, hence prompt and full therapeutic effect. Specify SQUIBB'S. 360 SQUIBB'S MATERIA MEDICA t Tablets Dover's Powder and Belladonna Compound, Squibb (Bronchitis) T. T. Per 1000 Per 500. Per 100 Chocolate-coated (C. C. T.) Dover's Powder ^/lo gr. 1 Bronchial cough, with insuffi- Ext. Belladonna I/40 gr. I cieni secretion and painful Ipecac 1/20 gr- f and difficult expectoration. Quinine Sulphate Vi S'- J is mentioned' as the indication for the administration of these tablets. Dose: 1 tablet every hour for four or five doses, then 1 every two or three hours until relieved. Tablets Dyspepsia, Absorbent. See Tablets Pepsin and Charcoal Compound. Tablets Dyspeptic (Dr. E. Haworth). See Tablets Strych- nine and Ipecac Compound. Tablets Dyspeptic No. 2. See Tablets Bismuth and Cascara. Tablets Eisenzucker 3 gr., Squibb C.T. Per 1000 Per 500 Per 100 Eisenzucker is a palatable form for administering iron to chil- dren and delicate women. It contains about 3 percent, metallic iron in the form of saccharated oxide. It is readily absorbed and rarely causes any constitutional disturbance. Squibb's Eisenzucker Tablets are pleasant to the taste, and may be eaten as a confection. Dose: I to 3 tablets after meals. Tablets Eisenzucker 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: 1 to Z tablets after meals. Tablets Elaterin 1/10 gr., Squibb T. T. Per 1000 Per 500 Per 100 So many demands have,been made upon us for a reliable prep- aration of elaterium that we have decided to list the tablets of the active principle. These are employed as a Hydragogue Cathartic in ascites, as well as in the dropsy of kidney and heart disease. Their administration occasionally causes vomiting. Dose: 1 tablet every three hours for not more than three doses in succession. Tablets Elaterin % gr., Squibb T. T. Per 1000 Per 500 Per 100 Dose: 1 tablet with water, cautiously repeated in three hours if required. Tablets Emmenagogue. See TabletSvErgot and Manganese Compound. Tablets Endometritis. See Tablets Viburnum Compound No. 2. SQUIBB'S MATERIA MEDICA 361 Tablets Epileptic. See Tablets Triple Bromides .anc] Physo- stigma Compound. Tablets Ergot and Hydrastine, Squibb (Uterine Tonic) T. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Extract Ergot I/4 gr. \ Ergot causes a contraction of Hydrastine ^/lOO gf- 1 the non-striated muscular fibers, acting directly upon the muscular coat of the small arteries and arresting bleeding, hence used in menorrhagia and metrorrhagia, and in polypi and fibroid tumors. Hydrastine acts as an astringent and tonic to the mucous membranes, and also causes contraction of the mus- cular tissue of the vessels. Dose; 1 or 2 tablets three or four times a day. Tablets Ergot and Manganese Compound, Squibb (Emmenagogue) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Ejtt. Ergot V2 g'- Manganese Dioxide V2 gr. Ext. Cotton Root Bark I/2 gr. Ext. Black Hellebore %&■ Iron Sulphate Dried V2 S'- Aloes PurifiAl 1/2 gf- Oil Savine Vs '"''>• This combination of uterine remedies is reported to have proved useful in ammenorrhea and dysmenorrhea. Dose: 1 tablet three times a day a week before the expected period, gradually increasing to 1 tablet every two or three hours, and then reducing the frequency of the dose as the effect is produced. It is advised to supplement the treatment with hygienic measures and generous diet. * Tablets Euonymin Compound, Squibb (Hepatic, Dr. Kenyon) T. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) These tablets are employed in that condition known as "bil- iousness," with mental hebe- tude, coated toiigue, bad breath, dyspeptic -^ symptoms and constipation. Dose: I tablet after supper and 1 at bedtime I'dr' II or 2 at night, followed by 1 after meals every second day until the conges- tion is removed. This tiouse supplies only one quality of each product: that best suitedto the purposes intended. .The specification "Squibb's'l is not open to various interpretations;' it has a' plain, posi* five meaning. Therefore, when prescribing, specify SQUIBB'S. Euonymin Vsgr Podophyllin V20 gr. Ipecac Vsgr Calomel ^■Vsgr Aloin V12 gr 362 SQUIBB'S MATERIA MEDICA Tablets Expectorant, Anodyne. . See Tablets Ammonium Chloride and Sanguinarine Compound. Tablets Extract Cannabis. See Tablets Cannabis Extract. Tablets Extract Cascara. See Tablets Cascara Sagrada Extract. Tablets Extract Ergot Yn gr. Squibb T. T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Squibb's fluid and solid extracts of ergot have been the reliance of the medical profession for many; years. Tablets Extract ^rgot Squibb represent all the medicinal virtues. of tlie best Spanish Ergot in an active fqrm. If kept in wellrcorked bottles they retain their therapeutic properties indefinitely. Each tablet represents 1 1/4 grains of Ergot. Dose : 1 to 4 tablets every three or four hours, to control internal blepding and as a nervine. " Tablets' Extract Ergot 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C.t.) ' b •';>- -.ti r ,»" ^ Each tablet rejpresents 5 grains of the, best Spanish Ergot. Dose : 1 tablet every hour, to control internal hemorrhage ; I to A tablets after' parturition, to contract the' uterus and control bleeding. . ' - Tablets Extract Ergot 2 gr., Squibb C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Each tablet represents 10 grains of; the best Spanish Ergot. Dose : 1 tablet every t)vp or thnse hours, to cause uterine con- traction, to control hemorrhage, in the treatment of fibroids and as a nerve tonic Tablets Extract Nux Vomica. See Tablets Nux Vomica Extract. Tablets Fever No. 2 (Dr. Davis). See Tablets Aconite and Belladonna Compound. Tablets .Fluidextract Aconite. See Tablets Aconite Fluid- extract. Tablets Fluidextract Cascara. See Tablets Cascara Fluid- extract. Tablets Fluidextract Digitalis. See Tablets Digitalis Fluid- extract. ^Tablets Follicular Tonsillitis. See Tablets Aconite and Belladonna Compound No. 4. Ext. Gentian Igr. Ext. Nux Vomica i l/lO gr- Ext. Hydrastis V4gr. Capsicum VlO gr- Ext. Rhubarb Igr. Ipecac VlO gr. SQUIBB'S MATERIA MEDICA 363 Tablets Gargle Astringent. See Tablets Hydrastis and Alum Compound. Tablets Gastritis. See Tablets Silver Nitrate Compound. Tablets Gentian and Nux Compound, Squibb (Anorexia) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Loss of appetite depending upon an atonic state of the digestive organs is usually cor- rected- by these jtablets. They stimulate the salivary glands* and the gastric mucous mem- brane, increase their secretions, excite peristalsis, and thus aid in the process of digestion. Their action being also slightly laxative, congestion of the system is relieved and \ normal desire for food created. They have been found useful in habitual indigestion with loss of appetite, coated tongue and constipation. Dose : 1 or 2 tablets, shortly before meals, repeated in an hour or two if required. Tablets Glycerophosphates Calcium and Sodium^ Squibb C. T. Calcium Glycerophosph. I gr. 7 Clinical observation has dem- Sodium Glycerophosph. 1 gr. j onstrated that organic diseases- due to defective metabolism, as well as functional disturbances of the nervous system, are benefited by the use of the glycerophosphates, the administra- tion of which tends to cause improvement in nutrition of the nerves and in the organic functions, and to stimulate the processes. of repair by their effect upon oxidation and absorption. They are employed in all cases where phosphorus is indicated; in. neurasthenia, impaired vitality and depressed mental states, in. wasting diseases, phosphaturia, locomotor ataxia, functional impotence, etc. Dose: 1 to 3 tablets after meals and at bed- time. Tablets Glycerophosphates Compound, Squibb C. T. Per 1000 Per 500 Per lOO Sodium Glycerophosph. 1 gr. ] The addition of strychnine to Calcium Glycerophosph. 2 gr !■ the glycerophosphates of so- Strychnine Nitrate Ve4 gr- J dium and calcium is asserted to increase their efHciency in disorders of the nervous system with muscular weakness and functional disturbance. Dose : 1 or 2 tablets, after meals. The prices of the Squibb Products are in all instances as low/ as the quality and quantity of ingredients and the expense of nran- ufacture allow. They include containers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 364 SQUIBB'S MATERIA MEDICA Tablets Glycerophosphates Compound No, 2, Squibb (Dr. Wm. S. Gordon) C. X. Per 1000 Per 500 Per 100 Each tablet represents: Sodium Glycerophosph. 1 g' This combination has been used with asserted good re- sults in the weakened and depressed condition of the system following attacks of grip, in neurasthenia, melan- cholia, tuberculosis and loco- motor ataxia. Dose: I or 2 tablets. Calc. Glycerophosph. 2 gr. Tr. Nux Vomica, U.S.P.'90, 71/2 min. Elix. Gentian Comp. q. s. ad 2 drs. Tablets Gold and Sodium Chloride 1/10 gr., Squibb C. T. Per 1000 Per 500 Per 100 Gold salts are prescribed for their Nerve Tonic and Altera- tive effects in exhausted states of the system following sexual excess or abuse of alcohol or tobacco; in anemia, syphilis, in diseases of the kidney with malnutrition and albuminuria, etc. Dose: ) tablet after meals and at bedtime. Tablets Gold and Sodium Chloride Compound, Squibb ' (Dipsomania) Per 1000 Per 500 Per 100 Chocolate°coated (C. C. T.) Gold and Sod. Chlor. I/24 gr. 1 Gold and sodium chloride as Strychnine Nitrate l/eo gr- I '" combination with, the heart Nitroglycerin ^/400 gf- I '""J nerve tonics in this for- Atropine Sulphate V200 gr- [ mula, is reported to have given Tr. Digit. U.S.P. '90 3 min. , ^ood results in die treatment Oleoresin Capsicum Vsgr. J of the alcohol habit. Dose: 1 or 2 tablets every two houns, increased (cautiously) if necessary. Tablets Guaiacol tj-2 gr., Squibb Per 1000 Per 500 Per 100 Chocolaie'-coated (C. C. T.) Guaiacol was introduced into the materia medica by Professor Mueller as being superior to creosote. Wood creosote owes its therapeutic value largely to the. guaiacol it contains. However, the beneficial effects that might be derived from the use of guaia- col in tuberculosis are often not obtained on account of its '-'- ■ - ■*' Tablets Mercury Bichloride Compound. Wilson's . Squibb (Antiseptic, Wilson's) Bots. 'of 25, Per doz. Per 1000 . Per 500. , Per 100 C. T., White or Blue, or Coffin-shape , r< Mercury Bichloride ,72/10 gr. 1 These, i tablets i are intended Ammonium Chlor. 7 '^/jo gr. j for preparing antiseptic solu- tions. They are made with- out the addition of aijy foreign ihatter _and yield perfectly clear solutions with distilled water. 1 tablet dissolved in a pint of water makes a solution of about 1 : 1 000. When "Jiard" water (due to. presence, of lime salts) is used a precipitate is occasion- ally produced. Under these conditions Tablets Mercury Bi- chloride Compound Bernays' may be used to advantage. These tablets' are now furnished coffin-shaped, with skull and cross- bon^s and stamped "Poison." Tablets Mercury Iodide Red 1/100 gr., Squibb Per 1000 Per 500 Per 100 C.T. As an Alterative and Antiseptic red iodide of mercury has proved useful in diseases of the blood and of the absorbent and glandular systems. In syphilis and scrofula it is employed The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability- of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 376 SQUIBB'S MATERIA MEDICA Tablets Mercury Iodide Red 1/100 gr., Squibb (Cont.) to improve nutrition and overcome the anemic conditions; as a Cholagogue in disordered states of the liver ; and as an Anti- septic in some forms of diarrhea. In tonsillitis and quinsy it has been found to allay the inflammation and in the early stages frequently to abort an attack.- Dose: 1 tablet every two or three hours. Tablets Mercury Iodide Red 1/25 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: I tablet every three or four hours. Tablets Mercury Iodide Red 1/16 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: in hepatic torpor, 1 tablet every three hours; in con- stitutional treatment, 1 tablet three or four times a day. Tablets Mercury Iodide Red 1/12 gr., Squibb T.T. Per 1000 Per 500 Per 100 Dose : I tablet after meals and at bedtime, as an Antiluetic. Tablets Mercury Iodide Red 1/8 gr., Squibb Per 1000 Per 500 Per 100 T.T. Chocolate-coated (C .C. T.) Dose: 1 tablet three or four times a day, for constitutional treatment in syphilis. Tablets Mercury Iodide Red 1/6 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 tablet three or four times a day, after meals, in rather refractory cases of syphilis. Tablets Mercury Iodide Red 1/4 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 tablet tKree or four times daily, in obstinate cases of syphilis. Tablets Mercury Iodide Yellow 1/50 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Yellow iodide (protiodide) of mercury exhibits the same con- stitutional effect' as thered iodide, but ' its action is less severe. It is used to produce mercurialization with little systemic dis- turbance. Dose: I tablet every two hours as a Cholagogue and Intestinal Antiseptic; as an Antiluetic, I or 2 tablets three or four times daily, after meals. SQUIBB'S MATERIA MEDICA 377 ♦Tablets Mercury Iodide Yellow 1/25 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: I tablet every two or three hours as a Hepatic Stimu- lant and Intestinal Antiseptic. ♦Tablets Mercury Iodide Yellow 1/8 gr., Squibb Per 1000 Per 500 Per 100 T. T. Chocolate-coated (C. C. T.) Dose : 1 to 2 tablets every 2 or 3 hours as an Aniiluelic, dimin- ishing the dose as the symptoms ameliorate. ♦Tablets Mercury Iodide Yellow 1/6 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C- T.) Dose: I tablet every 2 or 3 hours, in the treatment of syphilis. ♦Tablets Mercury Iodide Yellow 1/S gr., Squibb Per 1000 Per 500 Per 100 T.T. Cbocolate-coated (C. C. T.) Dose : 1 tablet every, two or three hours, to produce mercuri- alization; reduce the dose as the effect is observed. ♦Tablets Mercury Iodide Yellow 1/4 gr., Squibb Per 1000 Per 500 Per 100 T.T. Chocolate-coated (C. C. T.) Dose: I tablet every two or three hours, to produce the con- stitutional effects of mercury. Tablets Mercury Iodide Yellow 1/3 gr., Squibb Per 1000 Per 500 Per 100 T.T. Chocolate-coated (C. C. T.) Dose : 1 tablet every three or four hours, to produce the con- stitutional effects of mercury, the dose being lessened as the symptoms improve. Tablets Mercury Iodide Yellow 1/2 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose : 1 tablet every three or four hours as an Antisyphilitic in severe cases, the dose being diminished as soon as the con- stitutional effects of mercury show themselves. Squibb's Tablets are made from the Squibb quality of ingredients, and by improved processes that insure accurate dosage and rapid and complete disintegration or solution in the system, hence prompt and full therapeutic effect. Specify SQUIBB'S. 378 SQUIBB'S MATERIA MEDICA Tablets Mercury Tannate 1/2 gr., Squibb Per 1000 Per 500 Per 100 Chocolate°coated (C. C. T.) Antisyphilitic ; not affected by the juices of the stomach, decom- posed in the intestinal tract. Dose: 1 tablet every two hours; less frequently when the desired effect is produced. Tablets Mercury Tannate 1 gr., Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: 1 tablet three or four times a day. Tablets Mercury and Iron, Squibb (Ferruginous Alterative) T.T. Per 1000 Per 500 Per 100 Merc. Iodide Yellow ^liS'-X The. administration of iron Reduced Iron I gr. ) with mercurous iodide has ' ' ' been found useful in anemic and cachectic conditions following syphilis. Dose: 1 or 2 tablets after meals, with water. Tablets Mercury and Potassium Iodide. See ' Tablets Potassium' Iodide and Mercury. ♦Tablets Mercury with Chalk 1/2 gr., Squibb Per 1000 Per 500 Per 100 T.T. This is a favorite method of administering mercury, especially in children's practice. It is used in congenital forms of syphilis, and as a, hepatic stimulant to correct disturbances of digestion with clay-colored stools and constipation. In tonsillitis in chil- dren and in mumps it is also employed with great benefit. Dose : in diarrhea, 1 tablet every two hours until relieved ; , in tonsillitis, 1 tablet every hour until symptoms improve; for constitutional treatment, 1 tablet three or four times a day. ♦Tablets Mercury with Chalk 1 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : I tablet every three or four hours for adults, as a Hepatic Stimulant and Alterative. Tablets Migraine. See Tablets Acetanilid Compound. Tablets Migraine No. 2. See Tablets Acetanilid Compound No. 2. Tablets Migraine No. 3. See Tablets Acetanilid Compound No. 3. Tablets Migraine No. 4. See Tablets Acetanilid Compound No. 4. SQUIBB'S MATERIA MEDICA 379 Tablets Migraine Improved. See Tablets Acetanilid Com- pound Improved. Tablets Milk, Squibb Per 250 Per 100 C.T. ; Milk Sugar 26 gr. Calcium Lactophosph. ^/e'gr. Calcium Carbonate 1 1/2 gr. Sodium Bicarbonate I/2 gr. Potassium Bicarb. I/12 gr. Sodium Chloride l/e gr. These tablets supply the necessary salts and the milk sugar wanting in cow's milk ; and experience has shown that cow's milk modified in this way makes an acceptable . . food for young children. In the majority of cases children thrive upon the milk so prepared Cleanliness is necessary in connection with the nursing bottles, nipples, etc. For use, 1 tablet is crushed and added to each eight ounces of milk, the number being increased as the con- ditions warrant. Tablets Milk of Bismuth. See Tablets Bismuth Oxide ' Hydrated. Tablets Milk of Magnesia, See Tablets Magnesia Aromatic. Tablets Mixed Treatment (Orthodox, Dr. Sherwell). See Tablets Potassium Iodide and Mercury Compound. fTablets Morphine, Camphor and Hyoscyamiis, Squibb (Anodyne) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Morphine Sulphate Veo gf- 1 These tablets exert a Sedative Camphor l/g gr. I and Hypnotic action and are Extract Hyoscyamus l/g gr. \ used for the relief of pain Oleoresin Capsicum ^60 gr- J and to induce sleep. They should not, however, be given for prolonged periods lest there be danger of .fastening the morphine Jiabit upon the patient. They are considered an ex- cellent anodyne, usually affording prompt relief in sleepless and restless, conditions accompanied' by pain. Dose: 1 tablet every half hour for three or four doses until relieved. fTablets Morphine Compound No. 3, Squibb T.T. ^ . _ Per 1000 Per 500 Per 100 Morphine Sulphate ^4 gr. 1 Anodyne, Antispasmodic and Atropine Sulphate Vl50 g'- J Hypnotib; contra-indicated in Brighl's disease. The addition of atropine lessens nausea and depressing effect. Dose: 1 tablet, cautiously repeated. This house supplies oniy one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations: it has.a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 380 SQUIBB'S MATERIA MEDICA f Tablets Morphine and Hyoscine Hydrobromides Compound, Squibb (Bromides Compound, Dr. Hubbard) Per 1000 Per 500 Per 100 T. T. . Morph. Hydrobrom. l/l6 gf- 1 This formula is an Anodyne Hyoscine Hydrobr. ^200 gr- f Hypnotic, and has been Camphor Monobrom. -^/2 gr. J found useful in nervous con- ditions, with pain and in- somnia, also in mild cases of mania. Dose : 1 tablet every three or four hours, cautiously administered, in excited states of the system with pain which prevents the patient from sleeping. ' fTablets Morphine Sulphate 1/16 gr., Squibb Perl cob Per 500 Per 100 T.T. Dose : 1 or 2 tablets, cautiously repeated every three or four hours for pain. Antidotes: evacuation of the stomach by means of an emetic or by the stomach pump or apomorphine hydrochloride hypodermically ; hot, strong coffee, stimulants; cold water dashed into the face; keeping the patient awake by moving him about; atropine hypodermically, and the galvanic current if required. t Tablets Morphine Sulphate % gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 or 2 tablets, cautiously repealed as occasion requires. t Tablets Morphine Sulphate 1/6 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose : 1 tablet, cautiously repeated as necessary. fTablets Morphine Sulphate 1/4 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose: 1 tablet, cautiously repeated as may be required, fTablets Morphine Sulphate 1/2 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose: 1 tablet, cautiously repeated as occasion requires. fTablets Morphine Sulphate 1 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose: 1 tablet only as needed, and cautiously administered. SQUIBB'S MATERIA MEDICA 381 Tablets Naphthol and i^istnuth Compound, Squibb C-T. , Per 1000 Per 500 Per 100 Betanaphfhol a/g g,. T " Th^se tablets are intended to Bismuth Subcarb. 22/b gr. arrest fermentation, both gas- Salol 1 gr. V trie and intestinal. They are Creosote | min. used in catarrhal conditions Oil Cloves q. 5. J with flatulence, pyrosis and _ idisordered secretions, and in the many reflex conditions arising from delayed or imperfect digestion ; also in typhoid and tuberculous diarrhea. Betanaph- thol in combination with bismuth subcarbonate acts as an ener- getic antiseptic and sedative; creosote and salol aid in over- coming the morbid conditions of the intestinal canal; and oil of cloves helps to disguise the taste of the creosote. Dose : in intestinal indigestion, I tablet before meals, repeated two hoirs afterwards if necessary; in tubercular diarrhea and typhoid, 1 or 2 tablets jevery two or three hours, depending upon the severity of the symptoms. Tablets Nausea. See Tablets Cerium Oxalate and Cocaine Compound. Tablets Nausea No. 2. See Tablets Bismuth and Cerium Oxalate Compound. Tablets Nerve Tonic No. 5. See Tablets Zinc Phosphide, Cannabis and Nux. Tablets Nervine. See Tablets Camphor and Hyoscyamus Compound. "■'-'' - Tablets Neuralgic (Dr. Kenyqn), See Tablets Zinc Phos- phide and Cannabis Compound. Tablets Neuralgic Brown^Sequard. See Tablets Cannabis^ and Aconite Compound.' . 'n. ; Tablets Neuralgic Brown=Sequard, Half Strength See Tablets Cannabis and Aconite Compound, Hajf Strength. Tablets Neur^gic Headache (Dr. Myers). See Tablets Acetanilid and Bromide Compound. ,- , Tablets Neuralgic Improved. See Tablets Acetanilid and Cannabis Compound, ' Tablets Neutralizing. See Tablets Rhubarb and Magnesia Compound. Tablets Night Sweat. See Tablets Agaricin Compound. The prices of the Squibb Products are in ali instances as low as the quality and quantity'of ingredients and the expense of man- ufacture allow. They include containers, pacl times a day, wherever digi- Strychnine Sulphate -^/sog'^J talis appears to be indicated in chronic valvular disease. Tablets Nux and Asafetida. Nux Vomica. See Tablets Asafetida and Tablets Nux and Ignatia Compound, Squibb Per 1000 Per 500 C.T. Chocolate-coated (C. C. T.) Tr. Nux Vom. U3.P. '90 1 min. Per 100 This formula has proved serviceable in the treatment of atonic dyspepsia. The tablets here offered are made from carefully pre- pared tinctures skilfully treated, and represent the formula in its original potency minus the alcohol. Dose: 1 tablet three times a day, before meals, with a swallow of water. Tr. Ignatia 1 min. Tr. Cinchona 5 min. Tr. Matricaria 1 min. Tr. Gentian Comp. 1 min. Tr. Calumba 1/2 min. Phosphorus VsOO gr. Aromatic Powder Igr. SQUIBB'S MATERIA MEDICA 383 Tablets Nux and Ipecac Compound, Squibb (Bitter Tonic, Dr. Frank E. West) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Tr. Mux Vom. UJS.P. '90 5 min. "I Nux vomica stimulates the Wine fpecac 1 min, _ functional activity of the Tr. Capsicum 2 min. peptic cells; in combina- Tr. Gentian Comp. 5 min. tioh. with ipecac, capsicum and gentian this effect is still further increased, and! many cases of digestive and intes- tinal torpor are corrected by their- administration. This formula has been found useful where the symptoms of coated tongue, loss of appetite, more or less gaslt;ic distress and. K^adache^ occur after eating. Dose: 1 tablet before meals, with water. , , ■• ,- '> '■' ^irir, ■ Tablets Nux and Pepsin, Squibb (Dr.* Skiff) Per lOPO Per 500 , Per 100 • .T,T. ,. , .,>..,,-., ,,;„., , ,: . Nux Vomica VlOOgf-l Nux vomica and pepsin rcon- i Pepsin I : ' ' VlO gr- J stitute a useful coinbination -I h— 1 ' ' ..' . . " in the' Irealnient of atonic I't dyspepsia. The ilose of each ingredient heing small, ,admit^ of ( its use in a large range of cases. We also offer this, combination in a more concentratedi form. (See below.) Dose: l.teiblet every two hours or, 2' tablets after meals, ^repeated as needed. Tablets Nux and Pepsin No. 3, Squibb T.T. Per 1000 Per 500 Per 100 Nux Vomica VlO 8'- 1 "^^'^ combination stimulates Pepsin 1 gr. J the gastric secretions iand hastens digestion. It has been lound useful in atonic dyspepsia. On account of the small quantity of nux vomica in the formula, the tablets may be given to either children or adults, in appropriate dosage. Dose: 1 or more tablets after meals, repeated in an hour if necessary. Tablets Nux and Phosphorus Compound, Squibb (Aphrodisiac, Dr. Landers) ^ Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Extract Nux Vomica l/s gf- 1 This formula is credited with Phosphorus ^llOO gr- l ''^^ power to correct lowered Extract Damiana I/4 gr. f vitality of the system as seen Gold and Sod. Chlor. I/20 gff J ■ '"f debility, neurasthenia and sexual exhaustion. Dose: I tablet after meals and at. bedtime. If difficulty is experienced In procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 384 SQUIBB'S MATERIA MEDICA Tablets Nux Vomica Extract 1/4 gr., Squibb Per 1000 Per 500 Per 100 T.T. Chocolate-coated (C. C. T.) Nux vomica is considered a valuable remedy in atonic dys- pepsia, stimulating the appetite, overcoming gastric atony and increasing intestinal peristalsis. It acts as a tonic upon the' heart and vasomotor centers. In functional paralysis, neuralgia, im' potence, incontinence of urine, and as a general nerve tonic it has also, been used with good results. The tablets offered here are made from an assayed extract; and the alkaloidal content being always the same, uniform and reliable therapeutic effects may confidently be expected. Dose: I tablet after meals. Tablets Occult Blood Test, Squibb per package containing 5 x 20 tablets and a dropping bottle of glacial acetic acid. It is essential that any test for occult blood be accurate; and important that it be simple in its technic. After considerable- experimenting. Dr. Dudley Roberts, of Brooklyn, N. Y., worked out an extremely satisfactory benzidin tablet, and in both private and hospital work he has come to use it to the exclusion of other tests. This tablet is composed of 1 part benzidin to 20 parts of sodium perborate triturated with great care and made up into a 3-grain tablet. The specimen to be tested, either a weak -emulsion of the stool or the stomach con- tents oi; urine, is placed either in a small saucer, pus basin or porcelain dish in sufficient quantity to wet the tablet thoroughly, but not to entirely immerse it. A drop or two of glacial acetic acid on ' the tablet if blood be present gives rise to a more or less immediate change in the tablet to a greenish blue. Experi- ence with its use gives a fairly accurate idea of the amount of occult blood present, depending on the extent and quickness of the color change. If the amount of blood is small, only the edge of the tablet may turn. Such is the simplicity of this tablet test for occult blood that a nurse or intelligent patient may watch the appearance or disappearance of occult, blood without laboratory apparatus of any kind, with merely a small dish and the handle of a spoon with which to make a thin emulsion. t Tablets Opium (Powdered) 1/4 gr., Squibb Per 1000 Per 500 Per 100 T. T. f-Iypnotic, Sedative and Anodyne. These tablets are made from Sqiiibb's powdered opium, and contain all of its properties in an unaltered form. Dose : 1 to 4 tablets repeated as required. t Tablets Opium (Powdered) 1/2 gr., Squibb T.T. Per 1000 Per 500 Per 100 Dose: I or 2 tablets, repeated as required. SQUIBB'S MATERIA MEDICA 385 fTablets Opium and Camphor, Squibb Per 1000 Per 500 Per 100 Cliocolate-coated (C. C. T.) ::} Camphor I/4 gr. j intestinal Astringent. Opium and camphor represent a favorite combination for' the relief of pains of a spasmodic character; also used in diarrhea accompanied by cramps. The tablets are supplied coaled only to prevent loss of camphor by volatilization.' Doise: ( or 2 tablets every 3 or 4 hours. fTablets Opium and Camphor Compound, Squibb *. (Sun Cholera) Per 1000 Per 500 Per 100 CIiocolate=coated (C. C. T.) It will be noted that this formula is equivalent to 15 minims of the mixture, Tincture Opium • Spirit Camphor Tiiicture Rhubarb ^ Tincture Capsicum Spirit Peppermint aa 3 niin. publicly exploited as the' Sun choler^ mixture. Sudden attacks of cramps and diar- rhea are usually relieved bj' these tablets. They represent the full therapeutical activity of the. formula, in a convergent and permanent form. In chronic diarrhea, Tablets Zinc Sulpho- carbolate Compoutid Squibb are considered more useful. Dose : .2 tablets, with water, followed by 1 tablet after each loose movement untif relieved. fTablets O^ium, Camphor and Lead, Squibb (Diarrhea, Dr.fSulIiyan) • Per 1000 Per 500 Per 100 C. T. Chocolate-coated (C. C. T.) Opium Powdered I/4 gr. ] Lead acetate acts _as , an intes- Camphor I/4 gr. tinal astringent, opium as an Lead Acetate Vb gf • antiperistaltic; in colliquative Ipecac Vs &• J diarrhea, camphor serves to check vomiting, to prevent cramps, and, by its stimulating effect upon the circulation, to restore warmth to the extremities; ipecac tends to quiet the stomach if nausea exists and to increase the activity oF the liver. Dose: 2 tablets, followed by I tablet every .lK>Hrj for Ave or six. doses; then 1 tablet after each .loos,e, movement. - The Squibb products are fecognized everywhere as the Quality Standard. They are of uniform parity and strength, hence thei-apeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 386 SQUIBB'S MATERIA MEDICA Tablets Orthodox. See Tablets Potassium Iodide and Mercury Compound. Tablets Oxgall Compound, Squibb (Dr. Wm. H. Porter) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Oxgall Purified Pancrealin Ext. Colocynth Comp. Quinine Hydrochlor. Ext. Nux Vomica Ext. Tareixacum Igr. Igr. V4gr. Hz gr. % gr. Igr.. OxgSll favors the assimila- tion of fats, tends' to prevent intestinal fermentation, in- creases the peristaltic action of the bovtrels and hence acts as a laxative; pancreatin assists in the digestion of fatty and starchy food and improves nutrition; quinine and nux vomica remove the atonic conditions; extract of colocynth com- pound and taraxacum stimulate the liver and overcome hepatic torpor. The combination is a favorite remedy in intestinal indigestion in women and persons of sedentary habits, acting remarkably well in neurasthenic patients. Dose : 1 or 2 tablets before meals, repeated in two hours if required. Tablets Papain and Charcoal Compound, Squibb (Absorbent Digestive) Per 1000 Per 500 Per 100 C.T. Papain Igr. Charcoal 2gr. Sodium Bicarbonate 2gr. Ext. Nux Vomica VlO gr. Ipecac ^/lO gr. Wintergreen Flavor -q.s. Antacid, Corrective, Digest- ive. Papain is a digestive ferment, and is active in alkaline as well as acid secre- tions. In combination with charcoal and sodium bicar- bonate -it has been found useful in delayed digestion, accompanied with fermentation, flatulence and pyrosis. Ipecac and nu:s vomica stimulate the peptic cells and hence overcome gastric atony. Tablets Papain and Charcoal Compound are used with generally good results in chronjc indigestion, in acute indigestion the result of over- eating or imperfect mastication of food, or where, from de- bilitated conditions, the secretion of gastric juice is deficient in amount or weak in digestive power. Dose: ordinarily I or 2 tablets are given immediately before meals or after each meal, with water, and repeated in an hour or two if required; some- times, however, 4 to 6 tablets are administered for one dose, with a glass of moderately hof water, for the relief of acute dyspepsia. It is maintained that the use of these tablets ma3r be continued for prolonged, periods without thereby weakening the digestive functions. T.T. Opium Powdered Camphor Acid Benzoic Oil Anise ^(25 gr V25 gr V25 gr V25 gr SQUIBB'S-MATERIA MEDICA 387 Tablets Papain Compound, Squibb Per 1000 Per 500 Per 100 C.T. Papain 3/^ gr. "j This is considered an excel- Charcoal 8/4 gr. I lent combination, agreeable to Sodium Bicarbonate 2 gr. f the taste and usually afford- Wintergreen Flavor q. s. J ing prompt relief in gastric indigestion, by virtue x>f its Antacid, Digestive and Corrective properties. It has been added to our list in response to repeated demands from physicians and to take the place of a popular proprietary remedy. Dose: 1 to 3 tablets after meals, repeated in an hour 6r two, if required. t * Tablets Paregoric 10 min., Squibb Per 1000 PerSOO Per lOO Each tablet is equivalent to 10 minims of Tinctura Opii Camphorata U. S. P. IXth Rev. Useful as a mild Ano- dyne in relieving pain and colic, and, in aljaying restless conditions in young children. The effect is more promptly produced if the tablets are given in hot water. Dose: I to 6 tablets according to the age. Tablets Pepsin 1 gr., Squibb Per 1000 PerSOO Per 100 T.T. The pepsin here used has a digestive strength of 1 to 3000. These tablets are indicated where gastric secretion is scanty or weak in digestive strength. Dose: 1 or 2 tablets after meals. Tablets Pepsin 3 gr., Squibb Per 1000 PerSOO Per 1 00 C.T. Dose: I tablet after eating, repeated in an hour if necessary. Tablets Pepsin 5 gr., Squibb Per 1000 PerSOO Per 100 C.T. Dose : 1 tablet after meals, repeated in an hour if necessary. Since we make only one quality of each product, that best suited to the purposes intended, the specification Squibb's" is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 388 SQUIBB'S MATERIA MEDICA Tablets Pepsin, Bismuth and Charcoal, Squibb C.T. Per 1000 Per 500 Per 100 Pepsin 2 gr. 1 These tablets possess Digestive, Bismuth Subnitrale 2 gr. > Sedative and Absorbent prop- Charcoal 2 gr. J eriies, and are employed chiefly in indigestion due to overeating, with acid eructations, pyrosis and flatulence. Dose : 1 or 2 tablets immediately after meals and repeated in an hour or two if required. Tablets Pepsin and Charcoal Compound, Squibb (Absorbent Dyspepsia) C.T. Per 1000 Per 500 Per 100 Pepsin 1 gr. 1 Absorbent, Digestive and Charcoal 2 gr. l- Antizymotic ; in flatulence. Sodium Bicarbonate 2^/2gr. J indigestion, acid eructations, pyrosis, fermentation, etc. Our process of manufacture prevents decomposition of the pep- sin, and our tablets will be found therapeutically active and free from the disagreeable odor common to most brands of this combination. Tablets Pepsin and Charcoal Compound are used in all types of simple indigestion due to overeating, improper mastication of food, or to weakened conditions of the digestive organs. Dose: Tor 2 tablets before or after meils, repeated in an hour or two if required. Tablets Pepsin and Nux. See Tablets Nux and Pepsin. Tablets Pepsin and Pancreatin Compound, Squibb C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Pepsin I gr. 1 Used in delayed or imperfect Pancreatin I gr. I digestion, supplying the gas- Celery Seed V4 gr. | trie and pancreatic ferments Calcium Laclophosph. I/4 gr. J necessary for the elaboration of food. The calcium laclo- phosphate is split in the stomach, producing lactic acid. Dose: I or 2 tablets after meals, repealed in an hour or two if required. Note. — Combinations of pepsin with pancreatin have been criticized in some quarters, it being maintained that in solution these ferments destroy one another, and that under physiologic conditions they are chemically impossible. This and the fol- lowing three formulas have been added to our list in response to many demands from physicians. In this connection we might stale that we do not' approve of all the formulas contained in this list, from a strict therapeutic standpoint, but our position as purveyors to the medical profession demands that we sup- ply those combinations of remedies which the e:(perience of many of our patrons seems to indorse; and the fact that we offer such combinations in response to an existing demand in no way implies any discourtesy to contrary opinions. SQUIBB'S MATERIA MEDICA 389 Tablets Pepsin Squibb C.T. Chocolate-coated (C. C. T.) Pepsin ; 3/4 gr. Pancreatin sy^ gr. Bismuth Subnitrate I gr. Ext. Nux Vomica l/lO gr- Sodium bicarbonate 2 gr. Ginger I/2 gr. quired. (See Note at end and Pancreatin Compound.) Tablets and Pancreatin Compoun4 No. 2, Per 1000 Per 500 Per 100 of Employed for relieving gastric and intestinal dyspepsia, and preventing acid eructations, flatulence and fermentation. Dose: 1 or 2 tablets after meals, repeated at hourly in- tervals for two doses, if re- discussion of Tablets Pepsin Squibb Pepsin and Pancreatin Compound No. 3, C.T. Pepsin Pancreatin Ipecac Ginger Bismuth Subnitrate Ext. Nux Vomica Wintergreen Flavor (Digestive) Per ioOO Per 500 Per 100 2gr.l 1 gr. VlO gr- */5 gr. 2gr. '■no gr- q.s.J A cSmbination of digestives and stomachic tonics is here ipreisented. Dose: 1 or 2 tablets with , water after meals, repeated in an hour or two if required. (See note at end, of discussion of Tab- lets Pepsin ' and Pancreatin Compound.) Tablets Pepsin, Pancreatin and Lactic Acid Coni=- pound, Squibb (Digestive 'Aromatic .5 gr.) , Per 1000 Per 500 Per 100 / C.T. Pepsin Saccharated 80 parts ] This combination is said to Pancreatin 10 parts exert a beneficial effect in cer- Acid Lactic I part tain forms of ' dyspepsia. Diastase 1 part | Dose: 1 or 2 tablets imme- Acid Hydrochloric 3 parts diately before or after meals. Aromatic Powder 6 parts J repeated in an hour or two as required. (See Note at end of discussion of Tablets Pepsin and Pancreatin Compound.) See Tablets Soda Mint Tablets Pepsin and Soda Mint. and Pepsin. , Tablets Phenacetin. See Tablets Acetphenelidin. Tablets Phenacetin and Salol. See Tablets Salol Acetphenelidin. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them ; and, in the words of William l\4iller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its founder." 390 SQUIBB'S MATERIA MEDICA Tablets Phenolphthalein 1 1/2 ^r., Squibb C.T. Per 1000 Per 500 Per 100 Pink'coated (P. C. T.) Phenolphthalein has been extensively used as a laxative and with generally good results. Its freedom from bitter taste, absence of unpleasant after-effects and small dose recommend its use for children and delicate women. Clinical reports have demonstrated its value as a safe and reliable remedy. Taken at bedtime it usually produces an evacuation the next morning, although in obstinate cases, two doses during the day are some- times required. Dose: for adults, I to 3 tablets at bedtime, repealed if necessary after breakfast the following morning; for children, ^/^ to t tablet, reducing the dose as the bowels resume their normal functions. Tablets Phenolphthalein 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Intended for more resistant cases of constipation. Doge: I or 2 tablets at bedtime; iim the beginning of the treatment and in obstinate cases, 1 or 2 tablets after supper, repeated at bedtime, reducing the dose as the bowels resume their normal functions. Tablets Phenolphthalein with Chocolate, Squibb C.T. Per 1000 Per 500 Per 100 Phenolphthalein 1 ^2 g'' 1 T''^ addition of chocolate to Chocolate <]■ s- ) phenolphthalein affords an agreeable method of admin- istering this remedy to children and delicate women. The tablets are entirely free from disagreeable taste and may be eaten as a confection. Their action has been found prompt and certain and no disagreeable after-effects have been noticed. These tablets are offered to offset the many secret preparations of this remedy. Dose: 1 to 3 tablets at bedtime; children, 1/4 to 1 tablet. Tablets Phosphorus and Nux Vomica. See Tablets Nux and Phosphorus. Tablets Physostigma and Triple Bromides. See Tablets Triple Bromides and Hyoscyamus Compound, Tablets Podophyllin 1/8 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Cathartic and Cholagogue, stimulating the liver, causing an increased flow of bile and producing free action of the bowels, appearing to act principally upon the small intestines, Podo- phyllin is used in jaundice and congested states of the system, with headache, sluggish liver and disordered bowels, with flatu- lence and colicky pains. In small doses it operates ^with little' disturbance; but larger doses often cause griping, which may be overcome by combination with other agents. (See Cascara combinations.) Dose : 1 tablet after meals ; or 1 or 2 tablets at bedtime. SQUIBB'S MATERIA MEDICA 391 Tablets Podophyllin 1/4 gr., Squibb T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Dose: 1 tablet after meals; or 1 tablet at bedtime. Tablets Potassium Bromide 5 gr., Squibb C.T. , Per 1000 Per 500 Per 100 Potassium bromide acts as a Cerebral and Spinal Sedative, in small -doses lessening nervous excitement, quieting the brain, the sexual system and the reflex centers of the spinal cord ; in large doses it paralyzes the cerebro-spinal centers. Hence it is used in excited stales of the nervous system, to allay reflex irritabil- ity; it is said to be contra-indicated in excitement due to nerve exhaustion. It is , given with good results in wakefulness caused By overwork or worry, in the convulsions of epilepsy, Bright's disease, and the convulsions of children, whether of centric 'origin, or depending upon other causes. In sexual excitement, threatened abortion, nervous headache, hysteria and delirium it is also deemed valuable. Doge: 1 to 3 tablets, dissolved in water, repeated every hour for two doses if necessary, to quiet the nerves and induce sleep; for convulsions, 3 to 6 tablets in water, repeated if necessary. Tablets Potassium Bromide 10 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: 1 to 3 tablets in water, as required. Tablets Potassium Chlorate 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Screw-cap pocket vials, per doz.. Potassium chlorate is used in affections of the mouth and throat, to allay inflammation; it is a popular" remedy in acute sore throat, with huskiness of the voice. In aphthee, ulcerative stomatitis and mercurial salivation it is used with good results; also in diphtheria and scarlatina. It is also employed to over- come the vocal fatigue of speakers and singers. Dose: 1 tablet, dissolved in the mouth, every two or three hours. Tablets Potassium Iodide 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 Used in syphilis, where the periosteum or fibrous portions of the softer organs are affected, and also where the more important organs have been attacked; in diseases of the glandular system, and to cause absorption of inflammatory effusions, as in pleurisy and pericarditis ; for the relief of syphilitic and rheumatic pains ; and in asthma and lead poisoning. Dose: for children, I tab- let every hour with water. Dispense in glass. The Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform' Purity and Efficacy, that is, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 392 SQUIBB'S MATERM MEDICA Tablets Potassium Iodide 2 gr., Squibb' C.T.' Per 1000 Per 500 ' Per 100 Dose : I tablet every hour or two with water, for syphilitic skin diseases, glandular' enlargements and chronic rheumatism. Tablets Potassium Iodide 5 gr., Squibb C.T. ' Per 1000 Per 500 Per 100 Dose : for asthma, 1 tablet every three or four hours with water. For secondary syphilitic disease and chronic rheumatism, 1 tablet with water, increasing to 4, after meals. fTablets Potassium Iodide and Belladonna Compound, Squibb (Antiasthmatic) C.T. Per 1000 Per 500 Per 100 Potassium Iodide 2V2gr.l Heroin (diacelylmoirphine) Heroin Hydrochlor. I/25 %'■ \ acts as a respiratory sedative Ext. Belladonna ^/lo gr. J and antidyspneic ; belladonna is an : antispasmodic and stimu- lant to the respiratory centers; potassium iodide afiects the secre- tions. Dose: I or 2 tablets, with water, every two or three hours. (Note. — The possibility -of habit formation from the prolonged use of this combination should not be overlooked.) Tablets Potassium Iodide and Lobelia Compound, Squibb (Antiasthmatic No. 2) C.T. Per 1000 Per 500 Per 100 Potassium Iodide 2 gr. Fluidextracl Lobelia 2 min. Potassium Bromide 2 gr. Fl.Ext.Euphorb.Pilul. 3 min. Nitroglycerin -1/200 gr. This formula, a slight modifi- cation of the prescription of Dr. Hare, has been used in the treatment of bronchial asthma and dyspnea with apparent success. It has been used for many years by a large class of physicians, and the repeated demands have seemed to us sufficient reason for adding it to our list. Tablets containing potassium iodide are liable to become damp and to discolor on exposure to air, hence they should be kept in well-corked containers and in a dry place, . and they should be dispensed in glass only. Dose: 1 or 2 tablets every three or four hours with water. Tablets Potassium Iodide and Mercury, Squibb (Syphilis) C.T. Per 1000 Per 500 Per 100 Potassium Iodide 2 ^Is gr. 1 Emplpyed in syphilitic diseases Corrosive Sublimate ^40 %'• 3 in the later stage, and in those cases where the iodide alone does not control the symptoms. Its use is usually per- sisted in and gradually increased to the point of tolerance, or until an improvement of the condition occurs. Dose: 1 tablet, with water, after meals. SQUIBB-3 MATERIA MEDICA 393 Tablets Potassium Iodide and Mercury Compound, Squibb (Mixed Treatment; Orthodox, Dr. S. Sherwell) CT. Per 1000 Per 500 Per 100 Potassium Iodide 2 gr. Syrup Iron Iodide 5 min. Mercury Bichloride ^let gr. Donovan's Solution 2 min. Tr. Nux Vomica 2 min. These tablets act as an Alter- ative Tonic. Their effect is a stimulation of metabolism, resulting in improved nutri- tion with an increased ex- cretion of the products of tissue waste. Upon ihe blood, the lymphatic" system and the skin, their action is said to be marked; in syphilitic and scrofu- lous diseases, chronic rheumatism, glandular enlargements and certain skin diseases they have been used with much benefit. They rarely interfere with digestion, and they may be admin- istered for long periods -it is claimed. Owing to the hygro- scopic nature of potassium iodide the tablets should be kept in well-corked bottles and in a dry atmosphere; |ind they should be dispensed in glass. Dose: I to 3 tablets immediately . ~ after meals, with a glass of water. Tablets Potassium Iodide and Phytolacca Compound Lntirheumatic) Per 1 000 Per 500 v Per 100 These tablets are employed in acut6 and chronic attacks of rheumatism. They should be preserved in well-corked bot- tles ' and dispensed in glass. Dose: 1 tablet with water every two .hours in acute attacks until the symptoms are re- lieved, then I every four hours for not more than three doses. In chronic cases, 1 tablet three or four times a day. Tablets Potassium Permanganate 1 gr., Squibb C.T. , Per 1000 ,^-Per,500 Per 100 Prepared from the Squibb special > quality of largfe crystals of permanganate, and loosely' compressed in order to dissolve quickly. Disinfectant and Deodorizer. Applied as a wash to sloughing ulcers'and as an injection in gonorrhea; given inter- nally in diphtheria, eruptive fever's, puerperal fever and ery- sipelas. Most frequently employed at present internally in amenorrhea. Dose: in zirmbtic diseases, I tablet with water every three hours; in amenorrhea, 1 tablet after meals; as an ■ injection, 2 to 4 tablets in a half-pint of water." Squibb (Ami . C. T. P Potassium Iodide Ext. Phytojacc Resin Guaiac Colchicine Digilalin, 2gr. ,.1,gr. 3gr. ^llOO gr- */lOO gr. ThW Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBffS.- 394 SQUIB B'S MATERIA MEDICA Tablets Potassium Permanganate 2 gr., Squibb Per 1000 Per 500 Per 100 C.T. Dose: as an Enunenagogue, 1 tablet three times a day after meals with water; as an injection, 2 to 4 tablets in a pint of water. Tablets Potassium Permanganate 3 gr., Squibb Per 1000 Per 500 Per 100 C.T. Dose: 1 tablet three times a day. For disinfectant solutions, I to 3 tablets in a pint of water. Tablets Potassium Permanganate 5 gr., Squibb Per 1000 Per 500 Per 100 C.T. For disinfectant solutions, 1 to 2 tablets in a quart of water. Tablets Powder, Dover's. See Tablets Dover's Powder. Tablets Powder Licorice Compound. See Tablets Com- pound Licorice Powder. Tablets Powder, Tully's. See Tablets Tully's. Tablets Quinine and Acetanilid Compound. See Tab- lets Acetanilid and Quinine Compound. Tablets Quinine and Acetphenetidin. See Tablets Acet- phenelidin and Quinine. fTablets Quinine and Camphor Compound, Squibb (Coryza No. 3, Dr. Henry J. Kenyon) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) A favorite remedy in the treat- ment of acute coryza with violent sneezing and itching of the nostrils. It is a modi- fication of the rhinitis for- mula, atropine being substi- tuted for belladonna, and a small quantity of morphine added. It is administered in repeated doses until the systemic effect of atropine upon the throat and the nasal discharge is observed, and then at less frequent intervals. Dose: I tablet every hour until the throat feels dry, then every 2 to 4 hours until symptoms improve, continuing the treatment in decreasing doses a day or two after the discharge has ceased. (NoTE.-^These tablets should be used cautiously, and the possible formation of the morphine habit guarded against. For those physicians, who on general principles, object to the administratioii of morphine or heroin. Tablets Quinine, Camphor and Belladonna are sug- gested.) Quinine Sulphate ^/a gr. Camphor I/2 gr. Morphine Sulphate l/e4 gr. Atropine Sulphate ^/aooo gr- Milk Sugar q. s. SQUIBB'S MATERIA MEDICA 395 ^Tablets Quinine and Camphor Compound No. 2, Squibb (Coryza No. 5. Dr. S. MacCuen Smith) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate l/io gr. Camphor I/4 gr. Morphine Sulphate l/ioo gr. Atropine Sulphate ^/eoo gf. Acid Arsenous ^hio gr. Strychnine Sulphate ^/240 gr. These tablets have been used with good effects in recurrent attacks of coryza. They are given until the systemic ef- fect of atropine is apparent, and then at longer intervals. For those physicians who ob- ject on general principles to- the administration of morphine, Tablets Quinine and Camphor Compound No. 5 are recommend- ed. Dose: I tablet every 2 or~3 hours until the symptoms im- prove, or 4 tablets at bedtime, with plenty of water. (See Note under Tablets Quinine and Camphor Compound, above.) tTablets Quinine and Camphor Compound No. 3, Squibb (Coryza) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate Camphor Opium Powdered Ammonium Chloride Ext. Belladonna Ext. Aconite VlO gr- 1/2 gr. -VlO gr. Very generally regarded as an excellent combination for averting attacks of acute coryza, the usual symptoms of muscular soreness, chilli- ness, hot, dry skin, sneezing and excessive nasal discharge being promptly arrested if the tablets are taken in the early stage. Dose: 2 tablets every hour or two until relieved. (See Note under Tablets Quinine and Camphor Compound, above; also Tablets Quinine, Camphor and Hyoscyamus Compound). tTablets Quinine and Camphor Compound No. 4, Squibb (Coryza No. 2) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate Camphc Opium Powdered Ammonium Chloride Ext. Belladonna Ext. Aconite V3 gr. //l5 Vs gr. ^/l5 gr. ^/l5 gr. Dose: for sudden colds, 2 tablets, then I every hour until the acute coryza dis- appears. (See Note under Tablets Quinine and Camphor Compound above.) Squibb's Tablets are made from the Squibb quality of ingredients and by improved processes that insure accurate dosage and Rapid and complete^ disintegration or solution in the system, hence prompt and full therapeutic effect. Specify SQUIBB'S. 396 SQUIBB'S MATERIA MEDICA p t Tablets Quinine and Camphor Compound, No. 5, Squibb (Coryza with Heroin) C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate l/io gr. Camphor I/4 gr. Heroin Hydrochlor ^/loo S'- Atropine Sulphate Veoo gr Acid Arsenous ^hio gf- Strychnine Sulphate ^240 gf- These tablets are commonly employed in recurrent attacks of coryza with severe parox- ysms of sneezing and itching of the nostrils. They are taken until the systemic eflects of atropine are observed, and then at longer intervals. Atropine, by its inhibitory action upon the nerves of the sensory glands of the nasal mucous membrane, arrests the discharge from the nose. Arsenic is highly recommended by Ringer for patients who suffer from frequent attacks of cold in the head. Camphor and quinine act as mild antipyretics. Hieroin serves to allay cough and inflammation. Dose : 1 tablet every hour, for colds in the head, until the throat feels dry, then every two or three hours, continuing for a day or two after the acute coryza disappears. (See Note under Tablets Quinine and Camphor Compound, above.) Tablets Quinine, Camphor and Belladonna, Full Strength, Squibb (Rhinitis, Full Strength) C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate I/2 gr. Camphor I/2 gr. Fluidext. Belladonna I/4 min. These tablets are just twice the strength of the half- strength tablets regularly supplied, and are intended for use particularly in robust patients. Dose: 1 tablet every half hour for 3 or 4 doses, or until the throat becomes dry, then in diminishing doses until the nasal discharge ceases, * Tablets Quinine, Camphor and Belladonna, Half Strength, Squibb (Rhinitis, Half Strength, Dr. Lincoln) T.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate I/4 gr. Camphor I/4 gr. Fluidext. Belladonna ^/g min. Acute attacks of rhinitis are as a rule markedly benefited by these tablets, it is claimed. Taken at the onset and per- sisted in until the throat becomes dry, these tablets have been found to check the sneezing and discharge from the nostrils and frequently to cut short the attack. Dose: 1 tablet every Jialf hour for four doses, then every hour or two until the constitu- tional effect of belladonna is observed, when the interval is lengthened to three hours and the tablets continued until the discharge from the nose disappears. Quinine Sulphate j)^ gr. Camphor h^ gr. Ext. Hyoscyamus i'/io gr. Ammonium Chloride J/^ gr. Ex(. Belladonna l/lO gf- Ext. Aconite l/io gr. SQUIBB'S MATERIA 'MEDICA 397 Tablets Quinine, Camphor and Hyoscyamus Com= pound, Squibb (Coryza Modified) Per 1000 Per 500 Per 100 Chocolaie°coated (C. C. T.) This is a modification of Tab- lets Quinine and Camphor Compound No, 3 (Coryza), the powdered opium, being re- placed by an equal quantity of extract hyoscyamus for the benefit of those physicians ob- jecting to the use of opium. Dose: 2 tablets with water, every hour or two until the coryza symptoms are relieved. Tablets Quinine and Capsicum, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Quinine Sulphate 2 gr. 7 The addition of capsicum to Capsicum I/4 gr. j quinine increases its physio- logical action, making a com- bination useful in malarial affections where the digestive action is weak and assimilation imperfect. Capsicum acts as a salivary and gastric stimulant, improves the appetite, hastens digestion, and increases the stomach's power of absorption^ Tablets Quinine and Capsicum Squibb- are used in the treatment of malaria, and also as a prophylactic in patients exposed to malarial influences. Dose: 1 to, 3 tablets, with water, every three or four hours. Tablets Quinine and Capsicum No. 2, Squibb (Dr. Wm. F. Kier) White or Pink°coated Per 1000 Per 500 Per 100 (W. C. T. or P. C. T.) Quinine 'Bisulphate 3 gr. \ These tablets contain more Capsicum I/4 gr- 1, quinine than Tablets Quinine and Capsicum and are hence more active as %n Antipejriodic. Dose : 1 to 3 tablets with water every 3 or 4 hours. Tablets Quinine and Iron Compound, Squibb (Aiken's Tonic) C.T. Per 1000 Per 500 -Per 100 Chocolate-coated (C. C. T.) This combination is consid- ered an excellent tonic in all weakened conditions of the system — overcoming anorexia, improving ' nutrition, stimu- lating metabolism and pro- ducing a general improvement in health. It is used in simple This house supplies only one quality of each product: that best suited to tlie" puriioses intended. Ttie specification Squibb's" is not open to various interpretations; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. Quinine Sulphate 1 gr. Iron Reduced % gj-. Acid Arsenous 1/go gr. Strychnine Sulphate Vsogr- E,xtract Gentian I/4 gr. 398 SQUIBB'S MATERIA MEDICA Tablets Quinine and Iron Compound, Squibb (Cont.) anemia, debility, and convalescence from acute disease. Special attention is given to the trituration of the ingredients so as to insure thorough subdivision and accurate dosage. Dose: 1 or 2 tablets three times a day, ten minutes before meals. Tablets Quinine and Iron Compound with Cascarin, Squibb (Aiken's Tonic Laxative) C.T. Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) •Quinine Sulphate I gr. Iron Reduced % gr. Cascarin I/2 gr. Acid Arsenous I/50 gr. Strychnine Sulphate ^/so gr. Extract Gentian I/4 gr. This is a modification of the time-honored Aiken's Tonic formula, and is adapted to those cases where the patient habitually suffers from con- stipation, or where the re- duced iron in the formula produces this effect. Dose: 1 or 2 tablets three times daily, before meals. Tablets Quinine and Salol, Squibb C.T. Per 1000 Per 500 Per 100 Quinine Sulphate 2!/^ gr, Salol (Phenyl Salicyl.) IVi gr. Quinine and salol have long been used in combination in the treatment of acute and chronic rheumatism, for. the re- lief of neuralgic pains, and as a safeguard against infection in malarial climates. As it is of the utmost importance that tablets of this nature break up readily in the system, special pains are taken to cause these tablets and others of similar -composi- tion to disintegrate at once in the presence of moisture. This can readily be demonstrated by dropping a tablet in a spoonful of water at body temperature; should the tablet not readily respond to this test it should be condemned as being unfit for use. Dose: as an Analgesic or Antipyretic, 1 tablet every half hour for three doses, then every two to four hours; as a prophylactic, 1 tablet after meals and at bedtime. Tablets Quinine, Strychnine and Iron. See Tablets Iron, Quinine and Strychnine. Tablets Quinine Bisulphate 1 gr., Squibb C.T.orCC.T. Per 1000 Per 500 Per 100 Quinine bisulphate is usually preferred to the sulphate where the acid secretion of the stomach is deficient, its more rapid absorption compensating for the lesser quantity of quinine alka- loid it contains. Employed as a tonic in debilitated conditions of the system, and for its aniiperiodic and antipyretic action in sufficient dosage in malarial affections. Dose: 1 tablet after meals for Tonic and Aniiperiodic effect; as an Antipyretic in children, I or 2 tablets every two hours. SQUIBB'S MATERIA MEDICA 399 Tablets Quinine Bisulphate 2 gr., Squibb Per 1000 Per 500 Per 100 e.T.orC.C.T. Dose: I tablet after meals, as a Tonic; in malarial affections and as an Antipyretic in fever, I to 5 tablets every th'ee or four hours. Tablets Quinine Bisulphate 3 gr., Squibb Per 1000 Per 500 Per 100 C. T. or C. C. T. Dose: 1 tablet every two or three hours, as an Antipyretic; as an Antiperiodic, 1 tablet after meals. Tablets Quinine Bisulphate 5 gr., Squibb Per 1000 Per 500 Per 100 C. T. or C. C. T. Dose: as an Antipyretic, 1 tablet every two or three hours; in ague, 1 tablet six, four and two hours before the expected paroxysm. Tablets Quinine Sulphate 1/10 gr., Squibb Per 1000 Per 500 Per lOO C. T. or C. C. T. Antiperiodic and Bitter Tonic, for children. Dose: 1 tablet three or four times a day, as a tonic; as an Antiperiodic, 1 / tablet every hour. Tablets Quinine Sulphate 1/2 gr., Squibb Per 1000 Per 500 Per 100 C. T. or C. C. T. Dose: 1 tablet every hour for malaria in children. Tablets Quinine Sulphate 1 gr., Squibb, Per 1000 Per 500 Per 100 C. T., C. C. T. or P. C. T. Dose: 1 or 2 tablets every two hours, in malarial fevers, de- creasing as symptoms improve or if ringing in the ears occurs. Tablets Quinine .Sulphate 2 gr., Squibb Per 1000 Per 500 Per 100 C. T., C. C. T., P. C. T. or W. C. T. Dose: as a general tonic, 1 tablet after meals and at bedtime; for malaria, 1 to 5 tablets, every three or four hours; for sudden colds, 1 to 5 tablets at bedtime with 10 grains Dover's powder. The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. Theyincludecontainers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 400 SQUIBB'S' MATERIA' MEDICA Tablets Quinine Sulphate 3 gr., Squibb ' ? ' C. T. or C. e. T. Per 1 000 Per 500 Per 1 00 Dose: as tonic, 1 tablet after meals and at bedtime; in malaria, 1 to 3 tablets every 3 or 4 hours; in colds, I to 3 tablets at bed- ' time, -with 10 grains Dover's powder. Tablets Quinine Sulphate 5 gr., Squibb C.T.orC.C.T. Per 1000 Per 500 Per 100 Dose: for malaria, 1 tablet six, four and two hours before the expected attack. Tablets Rheumatism. See Tablets Sodium Salicylate and Colchicine Compountd. Tablets Rhinitis, Full Strength. See Tablets Quinine, Camphor and Belladonna, Full Strength. Tablets Rhinitis, Half Strength. See Tablets Qui- nine, Camphor and Belladonna, Half Strength. Tablets Rhinitis, Infants'. See Tablets Aconite and Cam- phor Compound No. 2. Tablets Rhubarb Compound, Squibb C. T. Per 1 000 Per 500 Per 1 00 Chocolate°coated (C. C. T.) Rhubarb 2 gr. 1 For the treatment of habitual Myrrh 1 gr. 1 indigestion with constipation. Aloes Purified 1 ^/2 gf • f Rhubarb is a tonic laxative. Oil Peppermint ^/lo min. J It may be given for long pe- riods, it is said, without weak- ening the bowels. It acts pleasantly without griping an4 without tenesmus. Combined with aloes, which acts upon the lower bowel and the rectum, it stimulates all parts of the intestinal tract. Myrrh acts as a mild astringent and peppermint modifies the laxative action. Dose : 1 tablet af t^r meals. -. Tablets Rhubarb and Ipecac Compound, Squibb (Roosevelt Hospital) C.T. Per 1000 Per 500 Per 100 Rhubarb 1 gr. ] Special attention is given to Ipecac 1/g gr. 1 all our rhubarb combina- Sodium Bicarbonate 5 gr. [ tions, and they will be found Oil Peppermint I/20 miii. J superior products. Not alone is the rhubarb used of best quality, but in the manufacture decomposition of the ingredients is prevented and the tablets present a handsome appearance and are very acceptable to the taste. This combination is used in habitual indigestion with loss of appetite, coated tongue, bad breath and constipation, stimulating digestion, preventing fer- mentation, correcting acidity and relieving constipation. The cutaneous eruptions observed on the faces of patients with chronic dyspepsia are said to be greatly reduced, often cured, by treatment with these tablets. Dose: I tablet after meals. SQUiife'S MATERIA MEDTGA 40 1 Tablets Rhubarb arid Ipecac Compound No. 2, Squibb (Roosevelt Hospital) Perl 000 Per 500 Per 100 C.T. Rhubarb Ipecac Sodium Bicarbonate Oil Peppermint 2gr. Vs 5gr. V20 min. tion is more pronounced; Dose A modification of Tablets Rhubarb and Ipecac Com- ' pqund Squibb; the quantity of rhubarb being doubled. Preferred where the constipa- I I tablet after meals. Tablets Rhubarb and Ipecac Compound No. 3, Squibb (Rppsevelt Hospital) Per 1000 Per 500 Per 100 C.T. Rhubarb Ipecac Sodium Bicarbonate Tr. Nux Vom. U.S.P. '90 ' 5 min. Oil Peppermint 1/20 min. 2gr. 1/4 gr. 5ar. A modification of the Rhu- barb and Ipecac Compound formula, the change consist- ing in the increase of the quantity of rhubarb and ipecac and the addition of tincture of nux vomica, thus increasing its laxative effect, and rendering the combination of much more servicer in dyspepsia. Dose : 1 or 2 tablets with meals or immediately after. Tablets Rhubarb and Ipecac Compound No. 4, Squibb (Dr. M. L. Goodkind) Per 1000 Per 500. Per 100 Igr. C.T. Rhubarb Ipecac Sodium Bicarbonate 5 gr. Extract Nux Vomica I/4 gf • Oil Peppermint l/io min. Fluidext. Cascara 5 min. This formula is a modifica- tion of our. Rhubarb and Ipecac Compound, I/4 grain of extract .pf nux vomica and 5 minims of fluide:^tract of cascara being added. The tablets are thereby increased in laxative action and have proved an excellent remedy in constipation dependent upon an atonic condition of the ali- mentary canal. Cascara sagrada acts as a tonic laxative and its continued use is not known to debilitate the bowels. In constipation attended by flatulence, headache and indigestion these tablets Usually give satisfactory results, it is reported. Dose : 1 tablet just before meals, decreasing the frequency of the dose as the case requires. If difficulty is experienced in procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 402 SQUIBB'S MATERIA MEDICA Tablets Rhubarb and Ipecac Compound No. 4, Half Strength, Squibb (Dr. M. L. Goodkind) Per 1000 Per 500 Per 100 ChocoIaie°coated (C. C. T.) Rhubarb ^2 gr- Ipecac l/io gr. Sodium Bicarbonate 2 V2 g'- Extract Nux Vomica ^/g gr. Oil Peppermint I/20 niin. Fluidext. Cascara 2^/2 min. This formula is the same as the preceding one, with all the ingredients reduced one- half. Dose: 1 or 2 tablets immediately before meals with water. Tablets Rhubarb and Magnesia Compound, Squibb (Neutralizing) C.T. Rhubarb Magnesia Calcined Sodium Bicarbonate Cardamom Oil Peppermint Per 1000 Per 500 Per 100 1 gr. 1 This formula is a mild Ant- 1 gr. acid, Lsixative and Corrigent 3 gr. used in dyspepsia attended Vs gr- with constipation, fermenta- q. s. J tion and flatulence, in chil- ^ dren or in adults. In case the tablets cannot be swallowed, they may be crushed to a powder and given with a swallow of water. We call attention to the quality of the rhubarb contained 1 in these tablets ; it is the best Shensi rhubarb obtainable. Dose: 1 or 2 tablets after meals, repeated in an hour or two if required. Tablets Rhubarb and Soda, Squibb Per 1000 Per 500 Per 100 C.T. Chocolate-coated (C. C. T.) Rhubarb 1 1/2 gr- 1 An Alkaline Laxative and Sodium Bicarbonate 1 1/2 gr. \ Stomachic, employed in indi- Oil Peppermint q. s. J gestion with constipation, and the usual accompanying symptoms of loss of appetite, coated tongue, foul breath and headache. Also as laxative for children or adults; acting upon the bowels without griping. Their continued use does not debil- itate the intestinal functions, it is claimed. Dose: for children, depending on age, 1 to 2 tablets; for adults, 2. to 5 tablets at bedtime or in divided doses after meals. Tablets Rhubarb and Soda C.T. Rhubarb Sodium Bicarbonate Oil Peppermint No. 2, Squibb Per 1000 Per 500 Per 100 3gr. 3gr. q.s. These tablets are just twice the strength of the preceding; their action and uses are the same. Dose: 1 or 2 tablets after meals, or 2 tablets at bedtime, with water. SQUIBB'S MATERIA MEDICA 403 Tablets Rhubarb and Soda No. 3, Squibb C.T. Rhubarb 2^2 St. Sodium Bicarbonate 21/2gr, Oil Peppermint q Per 1000 Per 500 Per 100 These tablets contain the same ingredients as in Tab- lets Rhubarb and Soda, but , in larger quantities, and their uses are the same. Dose: I or 2 tablets after meals. Tablets Rhubarb and Sodiuiti Bicarbonate Compound. Squibb (Antidyspeptic) -_ Per 1000 PerSOO Per 100 Chocolate-coated (C. C. T.) Extract Rhubarb V4 gf- Sodium Bicarbonate 2 gr. Strychnine Sulphate 1/60 g' • Ipecac l/io gr. Capsicum I/4 gr. Extract Gentian I/2 gr. Anorexia, faulty digestion and hepatic torpor with con- stipation are the indications for these tablets. The union of gentian, a pure bitter tonic, capsicum, a salivary and di- gestive stimulant, and ipecac, a gastric and hepatic corrective, makes a tablet which improves the appetite and digestive action. Strychnine is known to act as a stimulant to the peptic cells, to overcome muscular atony and increase peristalsis. Rhubarb is both tonic and laxative. Sodium bicarbonate neutralizes hyperacidity. Tablets Rhu- barb and Sodium Bicarbonate Compound are used in atonic dyspepsia, in gastritis from abuse of alcohol, and in acute at- tacks of indigestion due to overeating or imperfect mastication. Dose : I tablet half an hour before meals, followed by 1 half an hour after meals if required. Tablets Saccharin (Soluble) ^^ gr„ Squibb Per 1000 Per 500 Per 100 C.T. Each tablet equals a lump of sugar in sweetening power. Con- venient for use in the army, on the battlefield and other places where sugar is difficult to obtain. Used medicinally in diabetes and obesity, and in dyspeptic condition where sugar is contra-indicated. Tablets Saccharin (Soluble) 1/2 gr., Squibb Per 1000 Per 500 Per 100 C.T. Screw-cap pocket vials per doz. The Squibb products are recognized everywhere as the Quality Standard. They are of uniform purity and strength, nence therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 404 SQUIBB'S MATERIA MEDICA Tablets Saccharin (Soluble) 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: I tablet for a cup of coffee or tea. Tablets Salol (Phenyl Salicylate) 1 gr., Squibb T.T. Per 1000 Per 500 Per 100 Salol is regarded as a safe and efficient Intestinal Antiseptic. It is not affected by the gastric juice, but is decomposed by the alkaline secretions of the small intestine into salicylic acid and .phenol, which products tend to correct morbid conditions of the intestinal tract. It is also used in the treatment of acute and chronic rheumatism, lumbago and sciatica. Owing to~the fact that salol is largely excreted by the kidneys as salicyluric acid, it is used in chronic inflammation of the bladder, gonorrhea and catheter fever. It rarely produces nausea or gastric dis- turbance it is stated; but where the renal functions are im- paired or constipation exists, toxic action may manifest itself. Tablets Salol Squibb disintegrate rapidly, and are the best method for administering this remedy. Dose : 1 to 4 tablets every two or three hours. [NoTE: Tablets containing salol should -not be exposed to direct sunlight or kept in a warm place, else they will not disintegrate quickly.] Tablets Salol (Phenyl Salicylate) 2% gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose : as an Intestinal Antiseptic, I or 2 tablets an hour before meals and two hours afterwards; for rheumatism, 1 or 2 tablets every hour until relieved; for catheter fever, gonorrhea and inflammation of the bladder, 1 tablet every two hours. Tablets Salol (Phenyl Salicylate) 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: as an Intestinal Antiseptic, 1 tablet every three or four hours; in acute rheumatism, 1 to 4 tablets every two or three hours. Tablets Salol and Acetanilid. See Tablets Acetanilid and Salol. Tablets Salol and Acetphenetidin, Squibb (Salol and Phenacetin) Per 1000 Per 500 Per 100 C.T. Salol (Phenyl Salicyl.) 21/2 gr. Acetphenetidin 2J/2 gr. This tablet is a favorite com- bination for reflex neuralgic and for rheumatic pains, as well as in the febrile stage of grip, in intercostal neuralgia, headache due to intestinal fermen- tation, and in acute attacks of tonsillitis, allaying pain, quieting restlessness and subduing fever. Dose: 1 tablet every half hour for two or three doses; then every two or three hours until relieved. These tablets should be kept in a cool place, as salol melts at about 106° F. SQUIBB'S MATERIA MEDICA 405 Tablets Salol and Copaiba Half=Strength, Squibb Per 1000 Per 500 Per 100 Chocolate^coated (C. C. T.) Salol (Phenyl Salicyl.) 1 gr. Copaiba 1 gr. Pepsin 1/4 gr. These tablets are used in catarrhal and infectious con- ditions of the urinary organs. They are skilfully prepared and represent the full thera- peutic activity of the formula, and the coating retains the volatile ingredients unaltered. They should be kept in a cool place. Dose : 2 or 3 tablets after meals, with plenty of water, three or four times a day. in combination with Oleoresin Cubeb, Oil Sandalwood and Qil Wintergreen. Tablets SaloJ and Phenacetin. See Tablets Salol and Acetphenetidin. Tablets Salol and Quinine. See Tablets Quinine and Salol. Tablets Salt 24 gr., Squibb Per 500 Per 100 C.T. These tablets are intended for preparing normal physiological salt solution. Dissolved in water in the proportion of 2 tablets in one pint, they yield a sohition containing about six-tenths (0.6) of one percent, of pure sodium chloride; 2 tablets dis- solved in 12 fi. ozs. of water make about 0.85 percent, solution. Distilled or sterile water should be used in preparing the solu- tion, which should be strained through absorbent cotton. Tablets Santonin 1/10 gr., Squibb Per 1000 Per 500 Per 100 C.T. Santonin is employed for the destruction of round and thread worms. It is considered one of the best remedies, but in poorly nourished children must be given with caution, as it occasionally causes vomiting, headache, etc. It is preferably given in the morning on an empty stomach, and followed in about four hours by a dose of castor oil or some other purgative. Dose: I to 5 tablets, depending on the age of child. Tablets Santonin 1/4 gr., Squibb Per 1000 Per 500 Per 100 T.T. Dose: I or 2 tablets, according to age, every two hours for not more than four doses, followed by a cathartic. Since we make' only one quality of eacli product, that best suited to tlie purposes intended, ttie specification Squibb s is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 406 SQUIBB'S MATERIA MEDICA Tablets Santonin 1/2 gr., Squibb T.T. Per 1000 Per 500 Per 100 Dose: For older children, 1 or 2 tablets, according to age, every two hours, for not more than four doses, followed by a purgative. Tablets Santonin and Calomel, Squibb T.T. Per 1000 Per 500 Per 100 Santonin I/2 gr. ) Calomel increases the an- Calomel I/2 gr. j thelmintic action of Santonin, and increases its efficacy as a purgative. These tablets are used against round and thread worms. Dose: I or 2 tablets every two hours for not more than four doses. If bowels do not move after the last dose, a dose of castor oil or a saline cathartic should be given. Tablets Santonin and Calomel No. 2, Squibb C.T. - Per 1000 Per 500 Per 100 Santonin 1 gr. 1 Dose : 1 tablet repeated after Calomel 1 gr. J two hours if necessary. Tablets Sciatica. See Tablets Aconite and Colchicum Com- pound, Tablets Sedative. See Tablets Triple Bromides and Cannabis Compound. Tablets Sedative No. 2. See Tablets Camphor, Hyoscyamus and Sumbul Compound. Tablets Sedative No. 3. See Tablets Asafelida and Valer- ian' Compound. Tablets Silver Nitrate 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 These tablets are made from pure silver nitrate by careful com- pression and without undue exposure; they dissolve readily in distilled water, yielding a clear solution. One tablet dissolved in an ounce of water yields about a I : 500 solution. They are used for the extemporaneous preparation of coUyria or injections, for which purpose they are admirably adapted. They darken by exposure to light, and are therefore furnished in black bottles. A slight blackening of the surface of the tablets, which is liable to occur in process of manufacture, should not condemn the tablet, as it usually occurs on the surface only and is diffi- cult to prevent. Directions: For solution, 1 tablet dissolved in 100 minims of water or 5 tablets to I fluidounce yields about a 1 percent, solution, and 1 tablet in 50 minims of water about a 2 percent, solution; these are used for instillation into the eyes of newborn infants to prevent gonorrheal ophthalmia. Only distilled water should be used imd the solution protected from light. SQUIBB'S MATERIA MEDICA 407 t Tablets Silver Nitrate Compound, Squibb (Gastritis) Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Silver, Nitrate " I/4 gr- 1 Nitrate of silver is a power- Ext. Opium l/g gr. ful Astringent to mucous Ext. Nux Vomica I/4 gr. ■ surfaces. It has been found Ext. Belladonna Vs gr- useful in inflamed conditions Potassium Nitrate I/2 gr. J of the stomach and intestines, as in gastritis, chronic ulcer and diarrhea. The pain often produted by its ingestion is bere guarded against by the opium and belladonna present. Pigmentation of the skin sometimes follows the continued use of these tablets, as it does with silver salts generally. Dose: t tablet with water an hour before eating; as an intestinal astringent, I tablet one or two hours after meals. Tablets Soda and Rhubarb. See Tablets Rhubarb and Soda. Tablets Soda-Mint, Squibb Per 1000 Per 500 Per 100 C.T. Screw-cap pocket vials per doz.. Sodium Bicarbonate 4^/4 gr.1 This is an agreeable Antacid Ammonium Carbonate ^/4 gr. > and gastric stimulant, employed Oil Peppermint q. s. J in nausea, hyperacidity, flat- ulence and indigestion. Squibb's highly purified sodium bicarbonate is used in these tablets, and they will be found more palatable than similar preparations. The presence of ammonium carbonate in the formula adds very much to their prompt therapeutic action, especially in cases where faintness is a symptom. Dose: 1 or 2 tablets repeated as required, allowed to dissolve in the mouth or taken with a swallow of water. Tablets Soda=Mint and Pepsin, Squibb Per 1000 Per 500 Per 100 C.T. Sodium Bicarbonate 4 1/2 gr. ] This combination at times Ammonium Carbonate I/4 gr. I gives relief in some forms of Pepsin I gr. f indigestion where there is an 'Oil Peppermint q. s, J excessive secretion of hydro- chloric acid. In these cases the tablets are administered directly after meals. Dose: 1 or 2 tablets, repeated as required. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high Ideals, but lived and labored for them; and, in the words of William Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, Integrity, zeal and devotion of its founder." 408 SQUIBB'S MATERIA MEDICA Tablets Sodium Benzoate 5 gr., Squibb Per 1000 Per 500 Per 100 C.T. Sodium benzoate is employed as an A^ltiseptic and Anti- rheumatic: in rheumatism, cystitis, gout, follicular tonsillitis, coryza, etc. Dose: 1 to 2 tablets three or four times a day, with a glass of water, between meals; in tonsillitis and thrush, I tablet allowed to dissolve slowly -in the mouth every two hours. Tablets Sodium Bicarbonate 5 gr., Squibb Per 1000 Per 500 Per 100 C.T. These tablets are made from Sqiiibb's high quality sodium bicar- bonate, which is perfectly free from carbonate and hence with- out the bitter taste common to the regular market article. They are used for correcting acidity' of the stomach, heartburn, and allied disturbances. Dose : 1 or . 2 tablets after meals, or as required, to be repeated if necessary in half an hotir. Tablets Sodium Bicarbonate and Bismuth. See Tablets Bismuth and Sodium Bicarbonate. Tablets Sodium Bicarbonate and Magnesia, Squibb Per 1000 Per 500 Per 100 C.T. Sodium Bicarbonate 10 gr.) A favorite Antacid and Magnesia Calcined Light 1 gr. ) Antizymotic, with mild laxative action when given in large doses. Dose: 1 or 2 tablets about two hours after meals, or every three or four hours if required. fTablets Sodium Bicarbonate Compound, Squibb (Colic No. 2, Infantile) Per 1000 Per 500 Per 100 T.T. Sodium Bicarbonate I gr Paregoric 2 min Oil Fennel q. s These tablets are ,used in fermentation, colic and rest- lessness in young children. As they are not unpleasant to the taste, children do not, as a rule, object to them. They dissolve readily in warm water, and the dose may be easily regulated to suit the age of the patient. Each tablet contains 2 minims of paregoric, equivalent to ^/i25 grain of powdered opium. Directions: Dissolve 10 tablets in 10 teaspoonfuls of warm water, and give 10 to 20 drops every ten or fifteen min- utes until relieved. SQUIBB'S MATERIA MEDICA 409 Tablets Sodium Bromide 5 gr., Squibb ...r •-' .••J.)'rj;i' C.T. Per 1000 Per 500 -'Per 100 Sodium bromide is the salt inosi frequently employed in nerve sedation, as it is less unpleasant to the taste and its continued use is said not -to cause such marked -depression as the potas' sium salt. ■ It is used in epilepsy, memia, and excited states of the nervous system with loss of sleep and reflex irritability. Dose : 1 or 2 tablets, with water, every hour or two until relieved. Tablets Sodium Bromide 10 gr., Squibb C.T. Per 1000 Per 500 Per 100 ' Dose : 1 tablet every hour for three doses, as a Hypnotic ; 2 or more tablets three times daily in epilepsy. Tablets Sodium Citrate 2 gr., Squibb C.T. Per 1000 Per 500 Per 100 These tablets are intended for use in the modification of cow's milk for infant feeding according to the method elaborated by Drs. A. C. Cotton, AUin and J. W. Vanderslice. The sodium citrate is said to inhibit dense coagulation of the milk and thus render it more digestible. Directions: A concentrated aqueous solution is knade with one or more tablets and added to the bottle of food at the time of feeding in quantities repre- senting 1 to 3 grains of the citrate to each fluidounce of pure milk in the feeding mixture;' the amount varies with the con- ditions, the object being to attain complete digestion of the milk as shown by the absence of curds in the stools. Tablets Sodium Citrate 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Used the same as the preceding tablets. Tablets Sodium Qlycocholate Compound, Squibb (Dr. A. C. Croft^) . Pink"Coated (P. C. T.) Per 1000 Per 500 Per 100 Sodium Glycochol,afe 1 gr. \ Glycocholate of sodium is Acid Salicylic Natural 1 gr. J indicated where the biliary secretion is deficient. It is regarded as an ideal, true Cholagogue, increasing the secre- tions from the liver where the secreting cells are intact. It has been observed to increase the flow of bile to a very large extent and to be of value in cholelithiasis. Rutherford estab- lished (he cholagogue effect of sodium salicylate, and the union of the two remedies is here offered for clinical trial, as has been suggested by Dr. A. C. Crof tan. Dose : 1 tablet before meals, with abundant water. ' The Squibb Ideals have taken concrete form in thie Squibb Products: these are universally recognized as standards of uniform Purity and Efficacy, that is, general ExcelJence and Reliability. Specify SQUIBB'S w/hen prescribing or ordering. 410 SQUIBB'S MATERIA MEDICA Tablets Sodium Phosphate 10 gr., Squibb C.T. PerlOOO Per 500 Per 100 Sodium phosphate acts as a Saline Cathartic. It is used mainly in the treatment of habitual constipation with hepatic torpor and mental hebetude. Dose: I to 3 tablets before breakfast, in a glass of hot water, to produce a natural movement of the bowels without debilitating effect. The sodium phosphate in these tablets is free from arsenic and their use may therefore be continued as long as necessary without danger. Tablets Sodium Phosphate Compound, Squibb (Laxative, Children's, Dr. E. Chapin) C.T. PerlOOO Per 500 Per 100 Sodium Phosph. Dried I gr. Rhubarb Powdered l/io gr. Sulphur 1/5 gr- Oil Peppermint q. s. This is an agreeable Laxative for young children. The ac- tion of the sodium phosphate is supplemented by rhubarb and sulphur. For use in very young children the tablets are crushed and mixed with a little water in a spoon. Dose: for infants, I to 3 tablets a day; for children one year or over, 3 tablets three times a day, in- creasing or reducing the dose as effect is produced. Tablets Sodium Salicylate 3 gr., Squibb O.T. PerlOOO Per 500 Per 100 Sodium salicylate is an Antiferment and Antirheumatic, It increases the excretion of urea and uric acid and corrects gastric and intestinal fermentation. In acute rheumatism it commonly allays pain and fever, reduces the swelling and inflammation and prevents cardiac complications. It is deemed useful also in chronic rheumatism and for the relief of neuralgic and sciatic pains. Its administration occasionally produces nausea, and it should not be given during the process of digestion. Strontium salicylate is usually substituted where the sodium salt disagrees with the patient. Dose: 1 tablet every two or three hours, with water. Tablets Sodium Salicylate 5 gr., Squibb C. T., Plain or Per 1 000 Per 500 Per 1 00 Wintergreen Flavor Dose: I to 3 tablets every three or four hours, with water. Tablets Sodium Salicylate from Natural Acid, 5 gr., Squibb Per 1000 Per 500 Per 100 C.T. By some practitioners sodium salicylate prepared from natural salicylic acid (so-called "true" salicylic acid) is claimed to be better borne by the stomach and to be therapeutically more active than that made from the synthetic acid. While this may be true when impure salicylic acid is used in the preparation of the sodium salicylate, it is extremely doubtful whether the natural product offers any advantages over a properly made SQUIBB'S MATERIA MEDICA 411 Tablets Sodium Salicylate from Natural Acid, 5 gr., Squibb (Cont.) and pure synthetic preparation. As there exists, however, a demand for (his article, we have added these tablets to our list. Dose: 1 to 3 tablets every three or four hours, with water. t Tablets Sodium Salicylate and Colchicine Compound, Squibb (Rheumatism, Dr. Liggett) C.T. Per 1000 Per 500 Per 100 Sodium Salicylate 5 gr. 1 Sodium salicylate is generally Colchicine Vl20 gr- f conceded to be an efficient Codeine Sulphate l/l6 gr- J remedy in articular rheuma- tism, relieving pain and in- flammation and reducing the fever. Colchicine favors elimi- nation of effete material, and frequently aborts an attack. Co- deine contributes a mild anodyne effect. These tablets have been found efficient in the treatment of acute and chronic at- tacks of rheumatism and gout. Dose: I tablet every three or four hours, with water, until the pain abates or the bowels move freely. t Tablets Sodium Salicylate and Colchicum Compound, No. 2, Squibb (Antirheumatic No. 3) C.T. Per 1000 - Per 500 Pfer 100 Sodium Salicylate 71/2g''-l These tablets have been found Wine Colchicum Seed I useful in acute and chronic U.S.P.'90 21/2 min. > rheumatism, arthritis, and Sodium Bicarbonate 2 gr. I rheumatic pharyngitis. They Wintergreen Flavor q. s. J contain a larger dose of sodium salicylate than other combinations listed, while the presence of sodium bicarbonate tends to lessen gastric irritation and correct hyperacidity. The addition of wintergreen renders them more palatable. Dose: 1 or 2 tablets every three or four hours. Tablets Sodium Salicylate Compound, Squibb (Antifermenlalive) C.T. Per 1000 Per 500 Per 100 ChocoIate°coated (C. C. T.) Sodium Salicylate 2 gr. ) These tablets are used for Ginger Powdered 2 gr. 1 their Carminative and Anti- Capscium Powdered ^/lo gr. ( zymotic action in attacks of Cardamom Powdered ^4 gf- J digestive disturbance attended by flatulence, pain and diarrhea. Dose: in flatulence or colic, I tablet, in water, one to two hours after meals, followed by 1 at bedtime, if necessary. In diarrhea, 1 or 2 tablets every two or three hours. The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: ttie SQUIBB quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 412 SQUIBB'S MATERIA MEDICA Tablets Sodium Succinate 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Sodium Succinate has latterly come into vogue as a Cholagogue and Alterative for use in the treatment of cholecystitis, choleli- ihiasis and catarrhal conditions of the gall bladder and bile duct. Clinical experience seems to prove that often under its prolonged use paroxysms of biliary colic become less frequent and less intense and sometimes cease entirely. By virtue of its cholagogue action, it tends to limit the formation of calculi and to aid in their elimination. Dose : 1 or 2 tablets three or four times a day. A saline cathartic should occasionally be given. t Tablets Sparteine Compound, Squibb (Qardiac, Dr. Waldslein) C.T, Per 1000 Per 500 Per 100 Sparteine Sulphate ^/lO gr. Codeine I/20 gf ■ Tr. Strophanthus U. S. p. '90 3 min. Caffeine Citraled I/2 gr. These tablets are used in rapid heart action with irreg- ular pulse, hurried respiration and derangement of the func- tions of the kidneys. Dose: I tablet every 3 or 4 hours. with water. Tablets Sparteine Sulphate 1/10 gr., Squibb C.T. Per 1000 Per 500 Per 100 Sparteine sulphate is considered by many physicians to be a useful Heart Tonic and Regulator in the incompetency of chronic valvular disease and in cardiac arhythmia; others em- ploy it mainly for its diuretic effects in cases of cardiac dropsy. It is believed to be free from cumulative action. Dose: I or 2 tablets three or four -times a day. (Note. — The dose of sparteine sulphate is variable. Some observers claim to ob- tain results from as little as 1/20 grain, while others recom- mend it to be given in 2-grain doses. It isi probably best to begin with a small dose, say I/IO grain, and rapidly increase it until effective.) Tablets Sparteine Sulphate 1/4 gr., Squibb T.T. Per 1000 Per 500 Per 100 Dose: I tablet every three or four hours, in irregular heart action and in dropsy. Tablets Strontium Salicylate 5 gr., Squibb C.T. Per 1000 Per 500 Per 100 Highly recommended by Dr. H. C. Wood as an Intestinal Antiseptic for gouty and rheumatic patients, and for its Anti- rheumatic effect in all cases where the salicylates are indicated. As an intestinal antiseptic, it is preferred by Dr. Wood to salol, naphthol, etc. Dose: ° I to 3 tablets with water every three or four hours; for fermentation and flatulence, 1 or 2 tablets before or immediately after meals. SQUIBB'S MATERIA MEDICA 413 Tablets Strontium Salicylate and Charcoal Compound, (Corrective) Per 1000 Per 500 Per 100 Strontium Salicylate acts as Squibb (C C.T. Strontium Salicylate 2gr Charcoal 2gr Gingerin //sgr Oleoresin Capsicum ^/lOO gr Oil Cloves q.s an Antizymottc similar to so- dium salicylate; in combina- tion with charcoal and car- Iminatives, as in jhis formula, its value is increased. These tablets have been found useful in gastric and intestinal indi- gestion with flatulence, fermentation, pain and diarrhea. Dose: I or 2 tablets before meals or immediately after, repeated in two hours if needed; for diarrhea, 1 tablet every two or three hours. '''Tablets Strophanthus Compound, Squibb T.T. ^ Per 1000 Per 500 Per 100 Tr. Sfrophan. U .S. P. '90 2 min. 1 The action of digitalis is Tr. Digitalis U. S. P. '90 3 min. ) here reinforced by that of strophanthus, this union, according to some authorities, producing a more regular action of the heart. Strophanthus is said to act on the heart in a manner similar to digitalis, but to be more rapid and less per- sistent. The careful selection of drug and the skill with which these tablets are prepared guarantee a prompt and uniform ther- apeutic action. Dose : t tablet every two hours, decreasing dose as the heart action becomes stronger emd more regular. ^Tablets Strophanthus Compound No. 2, Squibb T.T. Per 1000 Per 500 Per 100 Tr. Stroph. U.S.P.'90, 2 min. Tr. Digit. U.S.P.'90 2 min. Nitroglycerin VlOO gr- Although many consider the combination of a number of heart remedies unscientific, this formula enjoys consider- able use. The addition of nitroglycerin lessens arterial ten- sion and reduces the work of the heart. This tablet is em- ployed where the cardiac action is rapid, feeble or irregular, with pallid countenance and neuralgic pains. Dose: ) tablet three times a day. Tablets Strophanthus Compound No. 4, Squibb T.T. Per 1000 Per 500 Per 100 Tr. Stroph. U.S.P.'90 2 min. Tr. Digit. U.S.P.'90 2 min. Strychnine Sulphate ^/loo gr. Although objection h^s been made on scientific grounds to combining several heart drugs in one mixture, this formula is a favorite with many physicians. It is a modification of our Tablets Strophanthus Compound, the difference consisting in the addition of VlOO grain of strychnine sulphate. Dose: I tablet three or four tinies daily. Squibb's Tablets are made from the Squibb quality of ingredients and by improved processes that insure accurate dosage and rapid and complete disintegration on solution in the system, hence prompt and full therapeutic effect. Specify SQUIBB'S. 41.4 SQUIBB'S MATERIA MEDICA Tablets Strophanthus and Digitalis Compound. See Tab- lets Digitalis and Strophanthus Compound. Tablets Strychnine, Digitalis and Nitroglycerin. See Tablets Nitroglycerin, Digitalis and Strychnine. Tablets Strychnine and Ipecac Compound, Squibb (Anorexia No. 2; Dyspeptic, Dr. E. Haworth.) Chocolate-coated (C. C. T.) Per 1 000 Per 500 Per 1 00 Strychnine Sulphate I/40 gr. 1 This .combination has been Ipecac 1/g gr, I used in certain conditions of Rhubarb I/4 gr. f the system where the desire Capsicum l/s gr. J for food is below normal, and where digestion is faulty. It represents a combination of digestive stimulants and tonics, which, by increasing the secretion from the salivary and peptic glands, promote the elaboration and elimination of the contents of the stomach, with consequent returning appetite. Dose: 1 tablet before or immediately after meals, repeated in an hour if necessary. Tablets Strychnine, Iron and Arsenic. See Tablets Iron, Arsenic and Strychnine, ♦Tablets Strychnine Nitrate 1/60 gr., Squibb T.T. Per 1000 Per 500 Per 100 C. C. T. or P. C. T. Strychnine strengthens the action of the heart, excites the flow of the gastric juice, stimulates the peristaltic action of the in- testines and is deemed a good tonic in atonic conditions of the system. It stimulates the motor and vasomotor centers of the cord; according to Ringer, it lessens resistance of the cord and increases the diffusibility of impressions. It is used in muscular atrophy, neuritis, gastralgia, atonic dyspepsia, as a heart tonic, in neuralgic affections, in combating chronic alcoholism, and as a general tonic in anemia and debility. Dose; 1 tablet after meals in dyspepsia and as a general tonic, ♦Tablets Strychnine Nitrate 1/50 gr., Squibb Per 1000 Per 500 Per 100 T.T. C. C. T. or P. C. T. Dose: 1 tablet three times a day as a Stomachic Tonic in dys- pepsia; 1 tablet every three or four hours in the treatment of the alcohol habit, and as a general Tonic and Aphrodisiac. ♦Tablets Strychnine Nitrate 1/40 gr., Squibb Per 1000 Per 500 Per 100 T.T. C. C. T. or P. C. T. Dose: 1 tablet after eating, with a swallow of water. SQUIBB'S MATERIA MEDICA 415 ♦Tablets Strychnine Nitrate 1/30 gr., Squibb T.T. Per 1000 Per 500 Per 100 C. C. T. or P. C. T. Dose: I tablet every four hours, in atonic conditions of the bladder; 1 tablet after meals in 'dyspepsia with anorexia and gastralgia; in alcoholism, 1 tablet every four hours in combina- tion with othter tonics. (See also Tablets Gold and Sodium Chloride Compound, Squibb.) Tablets Strychnine, Quinine and Iron. See Tablets Iron, Quinine and Strychnine. ♦Tablets Strychnine Sulphate 1/100 gr., Squibb T.T. Per 1000 Per 500 Per 100 C. C. T. or P. C. T. Dose: As a general Tonic, I tablet three times a day, directly after meals. ♦Tablets Strychnine Sulphate 1/60 gr., Squibb T.T. Per 1000 Per 500 Per 100 C. C. T., R. C. T. or P. C. T. Dose: I tablet after each meal, as a Digestive and general Nerve Tonic. ♦Tablets Strychnine Sulphate 1/50 gr., Squibb T.T. Per 1000 Per 500 Per 100 C. C. T. or P. C. T. Dose : I tablet after meals and at bedtime as a Nerve and Gas- tric Stimulant. ♦Tablets Strychnine Sulphate 1/40 gr., Squibb T.T. , Per 1000 Per 500 Per 100 C. C. T., R. C; T. or P. C. T. Dose: 1 tablet after meals as a Cardiac and General Tonic and as z. Digestive Stimulant. ♦Tablets Strychnine Sulphate 1/30 gr., Squibb T.T. Per 1000 Per 500 Per 100 C. C. T., R. C. T. or P. C. T. Dose : 1 tablet af t^r meals and at bedtime as a Cardiac and General Tonic, Aphrodisiac, and Digestive Stimulant. ♦Tablets Strychnine Sulphate 1/20 gr., Squibb T.T. Per 1000 Per 500 Per 100 C.C.T. Dose: I tablet after meals as a Nerve ^onic. This house supplies only one quality of eacli product: thiat best suited to t)ie purposes intended. The specification Squibb's" is not open to various interpretations ; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 416 SQUIBB'S. MATERIA MEDICA Tablets Sulphocar.bolates Combined, Squibb C.T. Zinc Sulphocarb. 1 1/2 g*". Sodium Sulphocarb. 1 1/2 gr. Calcium Sulphocarb. 1^/2^ gr. Per 1000 Per 500 Per 100 These tablets are used as an Astringent and Antiseptic in intestinal fermentation, typhoid and tuberculous diarrhea, in- tesfinal catarrh, etc. Dose : I tablet, with water, before meals, repeated in two hours if necessary. 100 Tablets Sulphonethylmethane 5 gr., Squibb (Trional) Per 1000 Per 500 Pe C.T; For sleeplessness caused by mental excitement or worry, where pain is not a symptom, trional is considered a safe and reliable ■hypnotic, reported to be noncumulative and usually free from bad after-effects, except where constipation exists, which con- dition is overcome by the use of alkaline mineral waters. Dose: 1 tablet 'every hour 'for three doses Irefore retiring; or 3' at a dose, taken in ^soupi beef tea, hot milk or water. Tablets Sulphonethylmethane 5 gr., Squibb (Trional) Per 1000 Per 500 Per 100 C. T. Hypnotic. Dose : 1 tablet every hour for three doses before retiring, or 3 tablets at bne dose at bedtime, taken in hot tea, beef tea or hot milk. During its continued use, as with Tablets - SulphoBmethane, ili is' advised to give alkaline waters freely and to avoid constipation. Tablets Sulphonmethane 5 gr., Squibb (Sulphonal) C.T. 1000 Per 500 Per 100 Hypnotic, in simple insomnia and in sleeplessness present in mental diseases attended with excitement and delirium; also a Sedative in neuroses with a spasmodic element. Dose : I tablet every hour for three doses .'before retiring, or 3 or 4 tablets at one dose with a hot drink on retiring. ' Tablets Sulphur Compound, Squibb Per 1000 C.T. Chocolate-coated ,(C. C. T.) Per 500 Per 100 Sulphur Cream Tartar Ext. Ipecac EiXt. Capsicum , Acid Arsehous Calcium Sulpiride 5gr.] ,, '«'^- -^/lOO gr- ysoogi-- ^/lOOQ gr- ^k gr- . These tablets are used in the treatment . of boils, acne and piinples, with indigestion and constipation; also in pityriasis and chronic . eczema. Dose : I tablet three times a day, af- ter meals and at bedtime. SQUIBB'S MATERIA MEDICA 417 Tablets Sumbul, Camphor and'Ifyoscyamus Compound. See Tablets Camphor, Hyoscyamus and Su&bul Compound. Tablets Sumbul Compound, Squibb , (Dr. Coodell) Per 1000 Per 500 Per 100 Chocolatc'coated (C. C. T.) Extract Sumbul 1 gi". 1 These tablets possess Hema- Iron Sulphate Dried 1 gr. 1 tinic and Antispasmodic prop- Asaf etida ' 2 gr. f erties. They appear : to give Acid Arsenous I/40 gr. J best results in anemic patients, with nervous' or hysterical symptoms. The flatulence and distress after eating which us- ually cause so much disturbance in this class of patients are as ;a rule also corrected. The asafetida used in these tablets is of the highest quality, while its disagreeable odor and taste are completely masked by the very soluble coating. Dose: 1 or 2 tablets after meals and atbedtime. 1,,, .i fTablets Sumbul Compound No. 2, Squibb (Hysteria) Per 1000 -Per 500. Per 100 Chocolate°coated (C. C. T.) Extract Sumbul 1 gr. Iro^^ Sulphate Dried i 1 gr, Asafelida 2 gr. Acid'Arsenous ^/ibo gr. Apom^rphine Hydrochlor. VsQ^g'- ' The nervous manifestar tions grouped ui^der, the - title of hysteria are fre- quently relieved and their further development ar- rested by the use' of this , combination! of tonics and antispasmodics. Asaf etida and sum- bul have been -found useful' in spasmodic conditions, the forimer relieving the tympanites and colic. Riiiger mentions the useful- ness of apomorphine hydrochloride in hysteria; iron and arsenic, by improving the conditions of t}ie patient, tend to remove -the cause and often prevent recurrent elttacks. Dose: I tablet ' hourly for three or four doses, with a glass of water. . Tablets, Sun Cholera. See Tablets Qpiumi and Camphor Compound. Tablets, Syphilis. See Tablets Potassium Iodide and Mercury, Tablets Tannic Acid and Zinc Sulphate Compound. See Tablets Zinc Sulphate and Tannic Acid Compound. Tablets Terpin Hydrate 3 gr., Squibb Per 1000 Per 500 Per 100 C.T. Terpin hydrate is considered a valuable Antiseptjc Expectorant, free from disagreeable taste, not readily disturbing digestion, and in proper doses not causing constitutional disturbances. Thr^^ to five grains repeated every three or four hours produce in- leased secretion of bronchial mucus and facilitate expectoration. Terpin hydrate is insoluble in water, and unless tablets made from it disintegrate quickly in the stomach its efficiency is les- B 418 SQUIBB'S MATERIA MEDICA Tablets Terpin Hydrate 3 gr., Squibb (Cont.) sened or altogether destroyed; Tablets Terpin Hydrate Squibb break up at once in the system, as may be readily proved hy dropping a tablet into water, or holding one on the tongue for a few minutes. Dose : I tablet every three hours with water. Tablets Terpin Hydrate S gr., Squibb C.T. Per 1000 Per 500 Per 100 Dose: 1 tablet every three or four hours, with water. Tablets Terpin Hydrate and Creosote Compound, Squibb Per 1000 Per 500 Per 100 C.T. Chocolate-coated (C. C. T.) Terpin Hydrate 2 gr. 1 This formula has won favor Creosote 1 min. I in the treatment of tubercu- Strychnine Sulph. Veo €■*. | losis. It is said to arrest Eucalyptol 1/2 min. J morbid pathological changes in the alimentary canal and thus allow digestion to proceed in a natural way, with an im- provement in nutrition and increased resistance to the infection. Dose : 1 or 2 tablets after meals with water. t Tablets Terpin Hydrate and Creosote Compound No. 2, Squibb Per 1000 Per 500 Per 100 (C.T. Ciiocolate'coated (C. C.T.) This formula is a modifica- tion of the preceding one, to which an iron tonic and a ' cough sedative have been added. Dose: I or 2 tablets every three or four hours. Note. — ^These tablets should be used cautiously and the possible formation of the morphine habit guarded against. fTablets Terpin Hydrate and Heroin, Squibb C.T. Per 1000 Per 500 Per 100 Terpin Hydrate 2 grs. Creosote I min. Diacetylmorphine Hydro- chloride 1/48 gf. Strychnine Sulph. Veo gf • Eucalyptol V2 >»in- Iron Carbonate Sacch. 1 gr. Terpin Hydrate 2J/2 %"■ Diacetylmorphine' (Heroin) VsO g^ This formula is used to con- trol cough in acute and chronic bronchitis, pneumonia, grip and phthisis. Terpin hydrate is a stimulating expectorant, with antiseptic properties. In moderate doses it causes increased secretion of bronchial mucus,! facilitates expectoration, and may be continued without interfering with the appetite or digestion. Diacetylmorphine serves to allay cough, deepen respiration and quiet the pulse. Dose: 1 or 2 tablets every two or three hours until the cough is quieted, then at longer intervals, NoTE. — These tab- lets should be used cautiously and the possible formation of the niorphine habit guarded against. Mercury Iodide Red V30 gr Arsenic Iodide I/40 gr, Iron Iodide I/12 gr. SQUIBB'S MATERIA MEDICA 419 fTablets Terpin Hydrate and Heroin Compound, Squibb (Cough Sedative, Dr. F. W. Shaw) , C.T. Per 1000 fetSOO Per 100 Terpin Hydrate ^ 2^/g gr. This combination is Diacetylmorph. (Heroin) %ogr. . found useful in cough Pilocarpine Hydrochloride, 1/loqgf. , witji irritated throat PotassiuDi Dichromate I/200 gf- J and painful expectora- tion. Dose : I tablet every two or three hours until the cough abates, then at longer in- tervals. Note. — ^These tablets should be used cautiously and the possible foritiation of the morphine' habit guarded against. Tablets Three Iodides, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C.C.T.) Cutaneous diseases of a scaly nature, chronic rheumatism and tertiary syphilis are indi- cations for. the use of this formula. It represents three of the most powerful alteratives, which act upon the blood and absorbent system, . increase elim- ination of waste products, and by overcoming the impoverished state of the blood, tend to bring about a restoration of health. Dose: I tablet, with water, three or four times a day. Tablets Three Valerates, Squibb " ' (Three Valerianates) Per 1000 , Per 500 Per 100 Chocolatie-coaied (C. C. Ti) Iron VaWatel . I'gr. ] For the relief of the nervous Quinine Valerate 1 gr. \ symptoms usually seen in Zinc Valerate 1 gr. J hysterical subjects, these tab- lets are ■ often ' used with decided beneficial results. They act as an Antispasmodic, Ner- vine and Tonic. The disagreeable odor of the ingredients is well masked by the coating, and patients as a rule do not object to their administration. Dose : I or 2 tablets after meals, with water. Tablets, Throat (Dr. Quinlan). See Tablets Acid Benzoic and Belladonna Compound, Tablets Thyroid Gland 2 gr., Squibb C.T. Per 1000 Per 500 Per 100 These tablets are prepared from the thyroid glands of sheep, freed from fat, carefully cleaned' and dried at low temperature. Each tablet represents 10 grains of the /res/i gland in the stale of full therapeutic activity. Thyroid glands have been used as an Alterative,' Hemostatic and Antifat, in myxedema, obesity, struma, obstinate hemorrhage and cretinism. Dose : 1 tablet 3 times a da}r, gradually increased in accordance with the , tolerance of the patient. The prices of the Squibb Products are irt all instances as low as the quality and quantity of ingredients and the expense of n>an- ufactureallow. Jheyincludecontainers,pacl with reputed success in ob- Strychnine Arsenate ^60 &''• J stinale malarial affections, anemia and general debili- ta^ed conditions. They possess Tonic and Alterative properties, and by their action upon the blood and nutrition have been shown to overcome the depraved state of the system. By thorough trituration accurate dosage is assured; and as the tablets are prefared so that they rapidly disintegrate in the stomach, prompt and uniform therapeutic effects may con- fidently be expecledl Dose: 1 tablet with water after meals. SQUIBB'S MATERIA MEDICA 421 Tablets Triple Bromides, Squibb C-T. ., PeriOOO Per 500 Per 100 Sodiuni Bromide 2^/2 gr. Potassium Bromide 21/2 gr. Ammonium Bromide 2^/2 gr. The bromides are employed in nervous excitement due to nerve irritation, but not when caused by derangement of nerve function due to exhaustion. This tablet is employed in wakefulness and nervous conditions from overwork or worry, hysteria, chorea, epilepsy, tetanus, nausea, seasickness, and as a Nerve Sedative generally. Dose: 1 to 4 tablets, dissolved in . water, every three hours until efective. Tablets Triple Bromides No. 2, Squibb C.T, Per 1000 Per 500 Per 100 Sodiuin Bromide .5 gr. "j These tablets are just twice Potassium Bromide 5 gr. [■ the strength of the preceding. Ammonium Bromide 5 gr. J Dose : 1 or 2 tablets, dis- solved in water, three or four times daily, as a Nerve Sedative in epilepsy, etc. Tablets Triple Bromides Effervescent, Squibb C.T. Bottle of 25, ; bottle of 100, Ammonium Bromide 3 gr. 1 This formula represents a Sodium Bromide 6 gr. > pleasant, effervescent combina- Potassium Bromide 6gr.J tion of the three commonly prescribed bromides, twice the strength of the regular formula. Dose: 1 or 2 tablets with wateK taken while effervescing, three or four times a day. Keep the bottle well corked and in d dry place, and dispense the tablets only in bottles. Tablets T'riple Bromides and Cannabis Compound, Squibb (Sedative) C.T. PeriOOO Per 500 Per 100 Sodium Bromide 2^/2 g""* Potassium Bromide 2^/2 gr. Ammonium Bromide 2^2 gr. Tr. Cannabis U.S.P. "90 5 min Tincture Hyoscyamus . 5 min. Where the use of the bro- mides must be continued for any length of time this com- bination is said to exert a bet- ter sedative effect and cause less systemic disturbance than the individual doses of the separate salts. Tolerance is still further assisted by the modifying action of the hyoscyamus and the cannabis. These tablets are used in excited and irritable states of the nervous system, in wakefulness caused by over- work or worry, in hysteria, epilepsy, delirium, and to control seminal emissions and sexual exciteinent generally. Dispense in glass. Dose: 1 tablet every half hour or hour for three or four doses,, dissolved in water. If difficulty is experienced in procuring any Squibb product, in the original packages here listed, please notify us; we shall see that your wants are met promptly and satisfactorily. 422 SQUIBB'S MATERIA MEDICA Tablets Triple Bromides and Hyoscyamus Compound, Squibb (Triple Bromides and Physostigma Comp.; Epilep- tic, Dr. Batton) Per 1000 Per 500 Per 100 C. T. Used mainly in epilepsy with reputed success. Dose : 2 tab- lets three times a day, with water. Dispense in glass. Sodium Bromide 3 gr, Ammonium Bromide 3 gr. Potassium Bromide 3 gr. Extract Hyoscyamus Yi gr. , Tincture Physostigma 7^/i min. Tablets Triplex. See TabTets Aloes, Mercury and Podophyl- , lin. tTablets, Tully's, 2 1/2 gr., Squibb Per WOO Per 500 Per 100 T.T. Morphine Sulphate ^ogf-l These tablets represent the Camphor Powdered ^/s gr. ) active ingrcsdients of Tully's Powder (Powder Morphine Compound), part of the licorice, root and all of the chalk being ' omitted, however. They are used for their Diaphoretic and Soporific effects in the early stages of bronchial attacks, similarly tq Dover's Powder, the therapeutic action of the two prepara- tions being alike. Dose : 1 ^tablet every two or tl^ree hours until relieved; or 4 tablets at bedtime, with a hot drink. Tablets Urease, 0.1 Qm., Squibb Per 100 For the rapid estimation of urea in urine, blood, etc. (See Urease [Part 1]). Write for complete literature. Tablets, Uterine Tonic. See Tablet: Ergot and Mydrastine. ' Tablets, Vaginal Astringent. See Tablets Zinc Sulphate and Tannic Acid Compound. Tablets Valerates, Three. See Tablets Three Valerates. Tablets Viburnum Compound, Squibb ' Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) A combination of sev»a! drugs, t)elieved to act as a tonic to the uterine organs, al- lay inflammation and pain and relieve congestion. In pain- ful menstruation and where the flow is scanty or too pro- fuse they are said to be of benefit. Dose : 1 or 2 tablets every two or three hours with a swallow of hot tea, beginning, die treatment several days before the expected period. ' Ext. Viburnum Prunifol. I gr. Ext. Viburnum Opulus ' 1 gr. Ext. Aletris Farinosa I/2 gr. Ext. Helonias Dioica ^\2 gr. Ext. Mitchella Repens I/2 gr. Calophyllin I/4 gr. SQUIBB'S MATERIA MEDICA 423 Tablets Viburnum Compound No. 2, Squibb (Endometritis) Per 1000 Per 500 Per 100 Chocolatc-coated (C. C. T.) Ext. Viburnum Prunifol. 2 gr, Ext. Hainamelis 1 gr. Ext. Ergot 1/2 gr. Ext. Nux Vomica I/12 gr- Hydrastin l/ig gr. This formula is used in re- laxed and painful conditions of the uterine organs; in en- dometritis, alone or in con- junction with topical applica- tions; in dysmenorrhea and I metrorrhagia. The extracts in this formula are carefully pre- pared at our own laboratories, and are incorporated into tablets without heat, so that none of 'their therapeutic properties are destroyed. Oose: 1 tablet 3 or 4 times a day. Tablets Warburg's Tincture, Squibb (With Aloes) Per 1000 Per 500 Per 100 Chocolate-coated (C. C.T.) These tablets are prepared by careful evaporation of Warburg's Tincture at low temperature, and possess the full therapeutic activity of the preparation. Each tablet represents one tea- spoonfiil of the tincture. They have been used in malarial dis- orders with much benefit, but at times under their continued ad- , ministratipn the laxative effect may be too great. Do8e : 1 or 2 tablets 3 or 4 times a day, decreasing the dose or alternating with Tablets Warburg's Tincture \Ti>ithout aloes if the bowels move too freely. Tablets Warburg's Tincture without Aloes, Squibb Per 1000 Per 500 Ppr 100 Chocolate-coated (C. C. T.) Warburg's Tincture is often effective in chronic malarial con- ditions, where the usual remedies are of no avail. The tincture used in these tablets is carefully evaporated at low temperature, so that none of the volatile iiigredients are lost. The tablets represent the full potency of the formula in an active and sol- uble formJ Dose; I or 2 tablets three times a day, after meals, preceding the treatment by an active cathartic. Tablets Warburg's Tincture Improved, Squibb Per 1000 Per 500 Per 100 Chocolate-coated (C. C. T.) Warburg's Tindture (without aloes) I fl.di Acid Arsenous l/lOO gr- . The addition of arsenous acid to Warburg's Tincture serves to greatly improve its Antimalarial effects Dose : I or 2 tablets three times a day, after meak. Tablets Wash Astringent. See Tablets Lead and Zinc Compound. , The Sauibb products are recognized everywhere as the Quality Standard, they are of uniform purity and strerigth, Tience therapeutically dependable. When ordering or prescribing med- icinal products, you will do well always to specify SQUIBB'S. 424 SQUiBB'S MATERIA MEDICA Tablets WhoOping^Cough. See TaMsft Antipyrine and Heroin Compdund, Tablets Witch Hazel and Helonias Compound. See Tablets Helonias and Witch Hazel Compound. Tablets Zinc Phosphide and Cannabis Compound, Squibb (Neuralgic, Dr, Kenyon) T.T. Per 1000 Per 500 Per 100 Cfaocolate'-coated (C. C. T.) Zinc Phosphide Extract Cannabis Strychnine Sulphate Sodium Arsehile Aconitine Vie gr- I These tablets are employed in pains' caused by dei^angement ^/eo %"• • of nerve functions. In neu- ralgias, sciatica,' and spas- modic pains generally, they lessen nerve irritability and excitement, and, by improving the nutrition of the , nerves, tend to prevent a recurrence of the neuralgic attacks. Dose : 1 tablet every two hours for three doses, thei^ every thre^ or four hours. Tablets Zinc Phosphide, Cannabis and Nux, Squibb (Nerve Tonic No. 5) Per 1000 Per 500 Per 100 Chccolate'coated (C. C. T.) Zinc Phosphide Vsg'-l The action of these tablets is Extract Cannabis VgW- } 'hat of a Nerve Tonic' and Ext. Nux Vomica Vsgr-i Stimulant. They are' used mainly to control nervous irritability. Dose: I tablet with water after mpals. Tablets Zinc Sulphate 1 gr., Squibb C.T. Per 1000 Per 500 Per 100 These tablets contain only the Squibb quality of pure zinc sulphate, hence dissolve freely ,and yield a. dear solution in distilled water. They are intended for the convenient prepara- tion of astringent solutions. Directions: Dissolve 1 to 3 tablets in 1 fluidbunce distilled water, for use as a collynum, injection or local astringent application., Tablets Zinc Sulphate and Tannic Acid Compound, Squibb^ (Vaginal Astringent) C.T. Zinc Sulphate Acid Tannic Alum Acid Boric Fl. Cold. Seal, Colorl. 2gr. 2gr. 3gr. 6 gr. 1 min. Per 500 Per 100 For preparing vaginal douches that are used as an Astringent and Tonic to th^ vaginal mucous membrane, arrest liis- charge, and lessen inflamma- , tion. These tablets dissolve quickly in water and are very convenient. They are said to restore tonicity, remove foul odors, lessen discharge and to be useful also in septic conditions and relaxed states of the mucous membrane. Directions: 1 or more tablets, depending upon the symptoms, are dissolved in a quart of hot water and employed as a vaginal douche. SQtIIBB'S MATERIA MEDICA 42S Tablets Zinc Sulphocarbdiate 2 gt-., Squibb C.T. Per 1000 Per 500 Per 100 This formula is used for its Astringent and Antiseptic effect in intestinal catarrh attended with ifiatulente^) fermentation and inflammation. In typhoid fever, enteritis, tuberculous diarrhea and dysentery it is also said to act well. Dose: I tablet every two hours with water, 'Tablets, Zinc Sulphocarbolate and Calomel Coni° pound, Squibb (Cholera- Infantum) Dr. Fenwick) T.T. Per 1000. Per 500 Per. 100 Zinc Sulphocarb. I/20 gr. In the treatment of fermenta- Calomel •'•/bO g*- tive diarrhea in children, this Salol l/jQ gr. ■ formula has proved very Bismuth Subnitrate V2 gr. ,, effective, acting as an Anti- Pepsin 1/4 gr. J septic,,; Sedative and Astrin- gent. Dose: for infant's six months to one year old, 1 tablet 'every ; ten minutes for the first hour, then everj* half hour or hour utftil relisved. Tablets Zinc Sulphocarbolate Compound; Sqjuibb (Intestinal Antiseptic) , , , ' PerlOOO Per 500 Per 100 C.T. Zinc Sulphocarbol. Bismuth Subgallate Belanaphthol Copper Arsenite Oil Cinnamon 1 Vagr. Disordered digestion, coated 2 gr. tongue, flatulence and intes- V2 gr- ■ tinal catarrh are the indica- /20O gr- . tiOns J^or the use , of;, this q. s. J formula. Copper arsenite acts : .(') I. .as an alterative and antisep- tic and is ranked among the best remedies in intestinal indigestion and diarrhea, acting' *^ equally Well in acutt or chronic tases. Betanaphthol is considered; a reliable antiseptic. Zinc sulpho- carbolate and bismuth subgallate tend \p overcome atonic con- ditions of the mucous Wembrane and to allay the irritable and inflammatory state of the alimentary canal. Dose: I or 2 tab- lets with water every three' or four hours until relieved;' then I tablet after meals. ^ HYF>0PERMIC TABLETS Bottle ' of 100 fApomorphine Hydrochloride 1/20 gr., Squibb fApomorphine Hydrochloride 1/10 gr., Squibb.. Atropine and Morphine. See, Morphine and Atropine Tube of 25 Since we make only one quality; of each product, that best suited to the purposes intended,; the specification "Squibb's" is not open to various interpretations, but ,has a plain, positive meaning. When ordering Or prescribing, specify SQUIBB'S. 426 SQUIBB'S MATERIA MEDICA (JHypoiermic Tahlek, Cont) Bottle Tube of 100 of 25 Atropine Sulphate 1/200 gr., Squibb Atropine Sulphate 1/150 gr., Squibb Atropine Sulphate 1/100 gr., Squibb Atropine Sulphate 1/54 gr., Squibb Caffeine Citrated 1/4 gr., Squibb Caffeine Citrated 1/2 gr., Squibb Caffeine and Sodium Benzoate, 1/4 gr., Squibb Caffeine and Sodium Benzoate ,1/2 gr., Squibb Caffeine and Sodium Benzoate 1 gr., Squibb fCocaine Hydrochloride 1/10 gr., Squibb fCocaine Hydrochloride 1/4 sr., Squibb fCodeine Phosphate 1/8 gr., Squibb fCodeine Phosphate 1/4 gr., Squibb fCodeine Phosphate 1/2 gr., Squibb fCodeine Phosphate 1 gr., Squibb fCodeine Sulphate 1/16 gr., Squibb fCodeine Sulphate 1/8 gr., Squibb fCodeine Sulphate 1/4 gr., Squibb fCodeine Sulphate 1/2 gr., Squibb fCodeine Sulphate 1 gr., Squibb fDiacetylmorphine Hydrochloride 1/24 gr., Squibb f Diacetylmorphine Hydrochloride 1/12 gr., Squibb fDiacetylmorphine Hydrochloride 1/6 gr., Squibb Digitalin 1/100 gr., Squibb Digitalin 1/50 gr., Squibb Digitalin 1/25 gr., Squibb Digitalin and Strychnine, Squibb Digitalin VlOO g'- Strychnine Sulphate Veo gr. SQUIBB'S MATERIA MEDICA 427 {Hypodermic , Tahleis, Conl.) . ' Bottle Tube of 100 of 25 Digitalin and Strychnine Compound, Squibb P'g''?''" ,, VlOOgr. atrychnjne Nitrate l/go gr. Nitroglycerin 1/joo gr. Eserine Sallicylate 1/100 gr., Squibb Eserine Salicylate 1/60 gr., Squibb Eserine Salicylate 1/50 gr., Squibb tHeroin Hydrochloride 1/24 gr., Squibb tHer9in Hydrochloride 1/12 gr., Squibb fHeroin Hydrochloride 1/6 gr., Squibb fHubbard's Bromides No. 1, Squibb Morphine Hydrobromide I/4 gf ■ Hyoscine Hydrobromide VlOO gf- fHubbard's Bromides No. 2, Squibb Morphine Hydrobromide l/g gr. Hyoscine' Hydrobromide- VlOOgr- Hyoscine (Scopolamine) Hydrobromide 1/100 gr., Squibb Hyoscine Hydrobromide 1/50 gr., Squibb Mercury Succinimide 1/5 gr„ Squibb tMorphine Sulphate 1/16 gr., Squibb fMorphine Sulphate 1/10 gr., Squibb fMorphine Sulphate 1/8 gr., Squibb fMorphine Sulphate 1/6 gr.', Squibb fMorphine Sulphate 1/4 gr., Squibb fMorphine Sulphate 1/2 gr., Squibb fMorphine Sulphate 1 gr., Squibb Morphine' and Atropine No. 1, Squibb Morphine Sulphate ; , . I/2 gr. Atropine Sulphate V120 gf- f Morphin^ Wna Atropine No. 2, Squibb Morphine Sulphate ' ^4 gr. Atropin^,SuIphate VlSOIg''' The founder; of' the House' of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William Miller Baitl&tt, "th^ House of Squibb stands today as a living monument to the tionbi', integrity, zeal and devotion of its founder." 428 SQUIBB'S MATERIA MEDICA {Hypodermic Tablets, Con(.) Bottle Tube ■ of 100 of 25 fMorphine and Atropine No. 3, Squibb Morphine Sulphate l/s gr. Atropine Sulphate ^208 gf- fMorphine and Atropine No. 4, Squibb Morphine Sulphate l/s gf» Atropine Sulphate ■^/l50 gr- fMorphine and Atropine No. 5, Squibb Morphine Sulphate l/s g'- Atropine Sulphate •^/l50 gf- t Morphine and Atropine No. 6, Squibb Morphine Sulphate I/2 gr. Atropine Sulphate ^/lOO fMorphine and Atropine No.. 7, Squibb Morphine Sulphate I/4 gr. Atropine Sulphate VlOO gf" fMorphine, Atropine and Strychnine, Squibb Morphine Sulphate Vs g'- Atropine Sulphate ^/l50 gr- Strychnine Sulphate ^go g>'- Nitroglycerin 1/100 gr., Squibb Nitroglycerin and Strychnine, Squibb Nitroglycerin •^/lOO gf • Strychnine Nitrate I/50 gr. * Nitroglycerin and Strychnine Compound, Squibb Nitroglycerin VlOO gf- Strychnine Nitrate 1/eo gr- Atropine Sulphate VlOO gf' Physostigmine. See Eserine. Pilocarpine Hydrochloride 1/20 gr., Squibb Pilocarpine Hydrochloride 1/10 gr., Squibb Potassium Permanganate 1 gr., Squibb Scopolamine Hydrobromide 1/200 gr., Squibb Scopolamine Hydrobromide 1/150 gr., Squibb Scopolamine Hydrobromide 1/100 gr., Squibb f Scopolamine and Morphine No. 1, Squibb Scopolamine Hydrobromide Vj5p gf- \ Morphine Hydrobromide l/e gr. J SQUIBB'S/ MATERIA MEDICA 429 (Hypodermic Tablets, Cont.) Bottle Tjibe of 100 of 23 t Scopolamine and Morphine No. 2, Squibb Scopolamine Hydrobromide,.f/i5o gr. | Morphine Sulphate l/g gr. j t Scopolamine and Morphine No. 3, Squibb Scopolamine Hydrobromide VlOO gr- 1 • Morphine Sulphate I/4 gr. ) ' fScopolamine and Morphine No. 4, Squibb Scopolamine Hydrbb'romide Vl50 gr- 1 Morphine Sulphate I/4 gr. | Sparteine Sulphate 1/10 gr., Squibb Sparteine Sulphate 1/4 gr,, Squibb Sparteine Sulphate 1/2 gr., Squibb . Strychnine Nitrate 1/100 gr., Squibb Strychnine Nitrate 1/60 gr., Squibb Strychnine Nitrate 1/50 gr., Squibb Strychnine Nitrate 1/30 gi-., Squibb Strychnine Sulphate 1/400 gr., Squibb Strj^chnine Sulphate 1/200 gr., Squibb Strychnine Sulphate 1/100 gr., Squibb Strychnine Sulphate 1/60 gr., Squibb Strychnine Sulphate 1/50 gr., Squibb Strychnine Sulphate 1/40 gr., Squibb Strychnine Sulphate 1/30 gr., Squibb Strychnine Sulphate 1/25 gr., Squibb Strychnine Sulphate 1/20 gr., Squibb Strychnine and Digitalin. See Digitalin and Strychnine. Strychnine and Digitalin Compound. See DigitaJin and Strychnine Compound. Strychnine and Nitroglycerin. See Nitroglycerin and Strychnine. The Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that IB, general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 430 SQUIBB'S MATERIA MEDICA DISPENSING TABLETS For the convenient preparation of stock solutions. Bottle of 100 Acid Arsenous 1/4 gr., Squibb Acid Arsenous 1/2 gr., Squibb Acid Arsenous 1 gr., Squibb Atropine Sulphate i/2 gr., Squibb Atropine Sulphate 1 gr., Squibb Corrosive Sublimate 1/4 gr., Squibb Corrosive Sublimate 1/2 gr., Squibb Corrosive Sublimate 1 gr., Squibb Strychnine Sulphate 1/4 gr., Squibb Strychnine Sulphate 1/3 gr., Squibb Strychnine Sulphate 1/2 gr., Squibb Strychnine Sulphate 1 gr., Squibb OPHTHALMIC TABLETS While we do not offer a complete line of so-called "Ophthalmic Tablets," we do make a number of tablets that are eligible for use in ophthalmic practice, as coUyria. For convenience of reference we will repeat them here. Acid Boric 5 gr., Squibb Per 1000 Per 500 Per 100 Acid Boric and Zjnc Sulphate, Squibb Acid Boric 5 gr. Zinc Sulphate ^li gr. ■ fCocaine Hydrochloride 1 1/8 gr., Squibb Tube of 25, Copper Sulphate 1 gr., Squibb Per 1000 Per 500 Per 100 Eserine Salicylate 1/100 gr., Squibb Bottle of 100, Tube of 25, Eserine Salicylate 1/60 gr., Squibb Bottle of 100, . Tube of 25. Eserine Salicylate 1/50 gr., Squibb Bottle of 100. Tube of 25, Per 1000 Per 500 Per 100 Silver Nitrate 1 gr., Squibb Zinc Sulphate 1 gr., Squibb SQUIBB'S JVIATERIA MEDICA 431 SQUIBB'S TABLET CASES Squibb's Emergency Poc'ket Case No. 1 Of black sole leather, with hand-stitched corners and spring-button catch, and containing 24 filled vials. Squibb's Emergency Pocket Case No. 5 Of black sole leather and containing twenty 6-drachni screw-cap vials filled. Squibb's Emergency Pocket Case No. 8 Of genuine black grain leath^, with spring-button catch, and containing 24 filled vials. Squibb's Hypodermic Tablet Case No. 2 Flexible; made of black morocco leather, and con- taining 6 tube-vials, each holding 23 Hypodermic Tablets. Squibb's Hypodermic Tablet Case No. 3 Of grain leather, and containing 90 tubes of Hypo- dermic Tablets representing a comprehensive assort- ment for stock. LOZENGES Lozenges Acid Carbolic and° Menthol, Squibb ' (Antiseptic Mouth and Throat) , Per 1000 Per 500 Per 100 Acid Carbolic Menthol Oil Sassafras. ' S,ugar Acacia, of each tagion. intervals V40 gr. Vso gr- Useful in inflamed conditions of the mouth and throat, for correcting bad breath due to decayed teeth, in catarrh and disordered stomach, and as a prophylactic e^gainst con- Dose: 1 lozenge dissolved in the mouth at frequent until relieved. Lozenges Astringent Throat. See Lozenges Benzoic Acid and Catechu Compound. fLozenges Benzoic Acid and Catechu Compound, Squibb (Astringent Throat) Per 1000 Per 500 Per 100 Local Astringent and Seda- tive, in sore and inflamed throat with cough and hoarse- ness. Dose : I lozenge on the tongue every half ;hour or hour fpr four or five doses, then at longer intervals until relieved. Acid Benzoic V5gr. Catechu ■l/4Rr. Opium Powdered ^/so gr. Camphor */20 gr- Ext. Verba Santa '■1/4 Br. Sugar and Aromatic! q.S. The Sauibb Label on a package is a positive guaranty for the uniform' Purity and Reliability bf the product. We make only ONE quality: the SQUIBB quality; and our prices are as low . as they can be made for that quality. Specify SQUIBB'S. 432 SQUIBB'S MATERIA MEDICA Lozenges Bronchial. Compound. See Lozenges Cubeb and Hyoscyamua tLozenges Brown Mixture 7 gr., Squibb , Per 1000, , Per 500* Per 100 Opium Powdered Acid Benzoic Camphor Powdered Tartar Emetic ' ' ' Oil Anise ' ■ Licorice Sugar, of each ^/20 gf- V20 gr. V20. gr- ^Aog'r- Bronchial irritation and cough are allayed by these lozenges. They are of con- venient size for holding in ' the mouth and very palat- able, and the small dose of q. s.j- medicament admits of their frequent use. Useful in re- lieving inflammation of, the mucous membrane, hoarseness, ana oppression'^ of the chest, and in facilitating expectbralion. Dbse : I lozenge every half hour or hour allowed to dissolve upon the tongue. Stopped when secretion is well established or slight nausea occurs. tLozenges Brown Mixture with Ammonium Chloride 7 gr., Squibb Per 1000 Per 500 Per 100 The preceding, with 1 grain ammoniun^ chloride added. ' , , Lozenges Brown Mixture 20 gr., Squibb (75 min. Brown Mixture) bottle, lb., screw-cap vials containing 35, perdoz. Opium Powdered ' ^/'so gr. Acid Benzoic ^/go gr. Camphor Powdered ^^g^ gj. Tartar Emetic ®/l60 gr. Oil Anise, Licorice, Sugar of each q, s. Dose : 1 lozelhge every half hour or hour, allowed to dis- solve on the longue ; to be dis- continue^ when expectoration is' well established dr ' nausea occurs. Lozenges Brown Mixture with Ammonium Chloride, ,20 gr., Squibb bottle, lb The preceding, with 3: grains ammonium chloride added. Lozenges Cubeb and Hyoscyamus Compound, Squibb (Bronchial) Per 1000 Per 500 Per 100 1/3 gr. These lozenges act, as a stim- 1/4 gr. ulating Expectorant and mild '/s gr. Anodyne. They may be used 1 gr. • freely without disturbing the 1/6 gr. stomach, it is said, and have Vs gr- been found useful, in allaying l/so gr. J bronchial irritation and cough. Dose: I lozenge dissolved oa the tongue every half hour or hour until relieved. Oleoresin Cubeb Hyoscyamus Ammonium Chloride Ext. Licorice Balsam Tolu Senega Ipecac SQtJI^Ef'S' MATERIA MEDICA 433 fLozenges Menthol and Cocaine Compound, Squibb (Mehtholatea Throat) .■""■' PferlOOO ■' Per 500 Per 100 Meiithol '"-" 1/35 gr- Cocaine Hydrochl. I/28O gr- Oil Anise l/go min. Acid Benzoic : j Via gf- lEucalyptol , ,,,, ) VlSgr- Sugar , :,; q.|S. Used' in'vocaI_ fatigue of, pub- lic speakers or singers. They are' said to 'act as > a stimulant . to the vocal cords, overcome irritation and jstrengthen the voice, and; in sore, throat, to relieve the soreness and pain. Dose: 1 lozenge dissolved in the mouth' every fifteen minutes ' or half hour as necessary, i Lozenges Orthoform 1/4 gr., Squibb /Per 1000, ii, Per 500 .Per 100 Orthoform is a local anesthetic which has been recommended in lozenge form to relieve the pain, of swallowing in ulcerated t and tuberculous sore fhroat. It is claimed l;o b,e non^poisonous, and ^ to be without any ejlecl upon the mucous m^mb;i:£v>e save that ' of a powerful anesthetic whereyer nerve endings are exposed. In dysphagia, if taken about ten ininutes before meals, it usually relieves the pain of swallowing and enables th^ patient to take food without discomfort. gPose,: 1 or 2 lozenges allowed to dissolve in the mouth as occasion requires. , Lozenges,, Throat, iNlentholated. ^e^e Lozenges, Menthol and Cocaine Compound. ' , " ' ■ ' ■ « ' TROCHES 14 grainseach, 500 to the pound. Troches Acid Tannic, Squit^b , ,Per 1000 ,,; P«r,,500 , Per 100 ... .Trochisci: Aeidi 7'annici. . Each icoiilaining 1 grain (0.065 Cm.) tannic acid. Astringent, in mouth -and throat troubles. Troches Ammonium Chloride, Squibb j , Per 1000 Per 500 Per 100 Trochisci Ammonii Chloridi. 1 1/2" grains pure ammonium chloride, with extract licorice, tragacanth, sugar and syrup tolu. Expectorant, Antiseptic; in throat and bronchial ailments, Troches Catechu, Squibb, PerlOqO Per 500 .Per 100 Trochisci Camhir, N. F. Dropped from U. S. P. 1 grain in each. Used in mouth and throat inflammations, * Squibb's Tabjets are made from the Squibb quality of ingredients ,and,;by rmprovedi processes tliat insure accurate dosage . and rapid and complete disintegration or solutjon ii^.the system, hence propipt arid 'full therapeutic effect. Specify SQUIBB'S. 434 SQUIBB'S MATERIA MEDICA Troches Charcoal, Squibb Per 1000 Per 500 Per lOl) Trochisci Carhonis Ligni, N. F. Abcut 4.6 grains vsrood char- coal. Absorbent, in fermentative conditions of the gastro- intestinal tract. Troches Cubeb, Squibb Per 1000 Per 500 Per 100 Trochisci Cuheha. 0.3 grain (0.02 Gm.) oleoresin cubeb. Used in bronchial troubles and throat irritation. Troches Cubeb Square, Squibb Per 1000 Per 500 Per 100 One-half strength of preceding. fTroches Cubeb Compound, Squibb Per 1000 Per 500 Per 100 0.3 grain oleoresin cubeb, ^40 grain each of tartar emetic and morphine sulphate; thus having the medicinal constituents neces- sary to give a further expectorant and alterative together with sedative effect in cases requiring such. fTroches Cubeb Compound Square, Squibb Per 1000 Per 500 Per 100 One-half strength of preceding. Troches Elm, Squibb Per 1000 >, Per 500 Per 100 Trochisci Ulmi^ N, F. About 3 grains slippery elm bark, flavored with methyl salicylate. Demulcent, Troches Gambir. See Troches Catechu. fTroches Qlycyrrhiza and Opium, Squibb Per 1000 Per 500 Per 100 Opium Lozenglis; Wistar's Cough Lozenges. Formerly official. ^/l2 grain powdered opium, with extract glycyrrhiza, acacia, sugar and oil anise.' Troches Krameria, Squibb Per 1000 Per 500 Per lOO Formerly official. 1 grain extract krameria. Astringent; in mouth and thr^oat inflammations. Troches Magnesia, Squibb Per 1000 Per 500 Per 100 Containing magtiesia, nutmeg, sugar and tragacanth. Antacid, Carminative. Dose: 2 or more. Troches Peppermint, Squibb Per 1000 Per 500 Per 100 Trochisci Menlha Piperita!. I/5 minim oil pepoermint in each. Used as breath perfume and. carminative. SQUIBB'S MATERIA MEDICA 435 Troches Phenolphthalein, Squibb 'Per 1000 ', Per 500 Per 100 Trochisci Phenolphthaleini, N. F. * About I grain phenol- phthalein. Laxative Confection. Average Dose: 1 troche. Troches Potassium Chlorate, Squibb Per loop Per 500 Per 100 Trochisci Potassli Chlaratts. 21/2 grains potassium chlorate. Used mainly in aphthas. Troches Quinine Tannate, Squibb ; Per 1000 Per 500 Per 100 ; Trochisci Quinino: Tanrialh, N. F. About I grain quinine tannate. Nonbitter form of quinine medication, especially in- tended for use by children and others having a repugnance for the bitter taste of quinine sulphate. Average Dose; 1 troche. Troches Santonin, Squibb Per 1000 Per 500 Per 100 Trochisci Sanionini, N. F.; Worm Lozenges. ^2 grain san- tonin. Dose: I or 2, Troches Santonin Compound, Squibb , Pe,t-1000 Per 500 Per 1 00 Trochisci Sanionini Compositi, N. F. About I/2 grain each, santonin and calomel. Vermicide. Average Dose: I troche. (See also Tablets.) Troches Sodium Bicarbonate, Squibb Per 1000 Pe;r500 Per 100 Trochisci SodiiBicarbonaiis. 41/2 grains sodium bicarbonate. Antacid. Dose :^s needed. Troches Sulphur and Cream Tartar, Squibb Per lOOO Per 500 Per 100 Trochisci Sulphuris, el Polassii Bitartratis, N. F. About 4'/2 grains 'washed , sulphur and I grain cream of tartar. Alterative and Antipyic, used chiefly in chronic skin diseases. Average Dose: I troche. (See also Tablets Sulphur Compound.) PART III Biological Products THE Squibb Line of Antitoxins, Serums and Bac- terial Vaccines is a comprehensive one, yet it does not include any article of doubtful or unapproved efficiency. The products are made in our new Research and Biological Laboratories at New Brunswick, N. J. These are elaborately equipped and thoroughly up to date in their scientific appointments and apparatus, and are under the personal direction of Dr. John F. Ander- son, formerly Director of the Hygienic Laboratory of the U. S. Public Health Service. The Squibb Serums are small in bulk, high in potency, and low in total solids. They have been carefully tested by laboratory biological tests and the clinical effect of •each has been noted on the specific disease for which it is of value. They have been especially treated to elimi- nate serum sickness and anaphylaxis. The Squibb Vaccines are prepared according to the most improved methods. Many strains of each organism are used in preparing the stock vaccine. The Squibb Antitoxins, Vaccines, and Serums, except the Anti-Meningitic, are distributed in our special aseptic syringes, which may be depended upon to give excellent, service. The Vaccines are furnished also in aseptic am- puls accompanied by a syringe to each package. Squibb 's Anti-Meningitic Serum is distributed in our special Grav- ity Apparatus, which has the advantage of supplying the serum in sterile container ready for use by the gravity method, by which latter the danger of causing shock through the injection is much minimized. The directions, as furnished with each Squibb product, are comprehensive and indicate as accurately as possible the exact specific indications for use of the same, and point out the conditions under which it may be success- fully employed. Complete hterature on our Biological Products sent to physicians on request. 436 SQUIBB'S MATERIA MEDICA 437 ANTITOXINS © Diphtheria Antitoxin, Squibb / In a special aseptic Syringe, containing: 1000 Units, Immunizing Dose (Code Word: AhiJe) 3000 " Curative Dose 5000 10000 (Code Word: AcciJent) (Code Word; Address) (Code Word: Affluence) Serum Anildtphlhericum Pwificaium. Refined and concentrated; small in bulk, high in potency and low in total solids. Curative Dose : 5000 units in ordinary cases ; 1 0,000 units in croup and where treatment is begun late; 20,000 to 40,000 units in severe cases — repeated if required in 1 2 hours. Immunizing Dose : 1000 to 2000 units; protection lasts 2 to 4 weeks. Tetanus Antitoxin, Squibb In a special aseptic Syringe, containing: , 1500 Units. Immunizing Dose (Code Word: Admit) 3000 " Curative Dose (Code Word; Advance) 5000 •• >" " ■ (Code Word: Affair) Clear, very concentrated product. Curative Dose: initial, '10,000 units, intravenously, with 5000 to 10,000 units inlra- spin^lly; later injections at 12 to 24-hour intervals as necessary. Immunizing Dose: 1000 to 2000 units, repealed in very suspi- cious cases once or twice at 8-day intervals. Swab wound freely with tincture iodine. SERUMS Anti=Gonococcic Serum, Squibb In a special aseptic Syringe: 2X'0Cc. , (Code Word: .,4/temoon) Carefully standardized by opsonic complement fixation tests, and by protection tests, and proved of vfery high potency. Indi- cations ; Acute gonbcoccic aiHhritis and endocarditis and' gen- s eral sepsis complicating gonococcic' urethritis. Dose : 20 to 100 Cfc., hypodermically, every 24 hours as ileeded. This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations ; it has a plain, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 438 SQUIBB'S MATERIA MEDICA AntUMeningitic Serum, Squibb In a special Gravity Container complete with needle, rubber tubing, etc.: (Code Word: Agent) - 2X15 Cc. Indications: Epidemic cerebrospinal meningitis due to meningo- coccus infection. Dose: sutdurally, after withdrawal of cere- brospiiial fluid:" 1 to 5 years, 3 to 15 Cc; 5 to 10 years, 5 to 15 Cc; 10 to 15 years, 10 to 20 Cc; 15 to 20 years, 15 to 30 Cc; 20 years and over, 20 to 40 Cc Anti-Pneumococcic Serum, Squibb — ^T'ype I 50 Cc Vials (Code Word: Aggressive). Indications: Acute lobar pneumonia. Dose: Suhcutaneotisly, 2. to 4 hours before intravenous injection, 0.5 Cc; intravenously, 50 to 100 Cc, preferably mixed with equal Quantity flf sterile physiological salt splution, every 6 to 8 hours until crisis is past. Inject sloJvly and preferably, by gravity. Warm serum to -body temperature before use. Anti=Streptococcic Serum, Squibb In our special Syringe: 2X10 Cc (Pdde Word: /I ir) 20 Cc. Vials, without syringe, Jor local use, (Code Word: ^Hoy) Indications: Suhcutaneously and intravenously, postpartum sepsis, scarlet fever, spreading erysipelas, etc.; locally, sup- purating streptococcic wounds, puerperal sepsis, etc. Dose: 20 to ,200 Cc, repeated daily if needed. Anti-Streptococcic Serum., Rheumatic, Squibb 20 Cc Vials, without syringe (Code Word: Allure), .50 Cc. Vials, without syringe (Code Word: Alma), Indications: acute sepsis produced by 'streptococci and mani- fested by swelling of the joints, fe^r, angina and cardiac complications. Dose: intravenously (by preference), or intra- Thuscul(irly or subcutaneously, 20 Cc. to 50, Cc. repeated in 24 hours or oflener, according to the severity of the disease and the response. Normal Horse Serum, Squibb In our special Syringe: 2XlOCc .mhsii.- (CbJiC word: Alter) 20 Cc Vials, without syringe; for local use. .. ' ' V ^ ' (Code Word: Amalgam) > Indications : ^uicutanepusZl; smii intravenously, hemophilia, melaena neoni^torum, purpura hasmorrhagica, persistent epistaxis, typhoid'. , hemorrhage, gastric ' and duodenal hemorrhage, and general hemorrhages in leukemia and other blood diseases; also in septic diseases for which no immune serums have been made, , etc Locally, puerperal sepsis as a uterine pack, in chronic suppurating wounds or sinuses. Orally, pain and hemorrhage in gastric ulcer. Dose: Subaitaneously 20 to 30 Cc.;'Vepe^t'ed daily and increased if necessary ; Orally, 30 to 1 00 Cc. every 12 to 24 hours as needed. SQUIBB'S MATERIA MEDICA 439 BACTERIAL VACCINES All the Vaccines listed below are a]so prepared by us, upon request, in special doses that may be required. Such extra doses are supplied without extra charge. Acne Vaccine, Squibb In fully assembled aseptic Syringes, containing: 25. 50, 100, 200 million killed bacilli box of 4 Syringes (Code Word: Amaze) 50, 200 million killed bacilli, box of 2 Syringes (Code Word; Amber) In Ampuls: 10, 25. 50, 100, '200. 500 million killed bacilli, box of 6 Ampuls with Syringe (Code Word: Amiable) 50, 200 million killed bacilli, box of 2 Ampuls with Syringe (Code .Word: Amorous) Indications: Non-pustular acne vulgaris where comedones pre- dominate. Dose : 5 to 10 million bacilli, gradually increEising to larger doses, injected every three to five days. Squeezing out comedones, hot applications, massage and suitable dietetic meas- ures should not be neglected. (See Staphylo-Acne Vaccine.) Bacillus Coli Communis Vaccine, Squibb In fully assembled aseptic Syringes, contetining: 100, 200, 500, 1000 million killed bacilli, box of 4 Syringes (Code Word: Analysis) 100, 500 million killed bacilli, box of 2. Syringes (Code Word; Ancestor) In Ampuls: 2X100, 2X500. 2X1000 million killed bacilli, box of 6 Ampuls with Syringe (Code Word: A'JJucingy 100,. 500 million killed bacilli, box of 2 Ampuls with Syringe (Code Word: Afflict) Indications: Wounds' and abdominal or pelvic abscesses due to B. Coli Communis, . cystitis and pyelitis from same cause, etc. Dosq: 100 million bacilli, rapidly increased to 500 or 1000 million bacilli, subcutaneously every three to five days. The prices of the Squibb Products are in all Instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. Theyincludecontainers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 440 SQUIBB'S MATERIA MEDICA Bacillus Pertussis Vaccine, Squibb In fully assembled aseptic Syriiiges, containing: 25, 50, 100, 200 million killed bacilli box of 4 Syringes (Code Word: Anchor) 50, 200 million killed bacilli, box of 2 Syringes (Code Word: Andante) In Ampuls: 25, 50, 100, 200, 300. 500 million killed bacilli, box of 6 Ampuls with Syringe (Code Word: Andrew') 50. 200 million killed bacilli, box of 2 Ampuls with Syringe (Code Word: Anecdote) Indications: Prophylactic and curative of pertussis (whooping- cough). Dose: Prophylactic, 20, 50, and 1 00 million bacilli injected at five-day intervalsiLCUrad'vfe,' 25, 50, 100, 200, 300 and 500 million bacilli, every day if needed, according to the response and reaction. Qonococcus Vaccine, Squibb In fully assembled aseptic Syringes, containing: 100, 200, 350. 500 million killed gonococci, box of 4 Syringes (Code Word: Annual) 100, 500 million killed gonococci, bx>x of Z Syringes (Code Word: Anget) In Ampuls: , > 50, 100. 150. 350. 500, 1000 million killed gono- cocci, box of 6 Ampuls with Syringe (Code Word: Angliis) 100, 500 million killed gonococci, bok of 2 Ampuls with Syringe (Code Word: Anthem) Made from cultures of many different strains. Indications: Subacute and chronic* gonocotcus infection (urethritis, epididy- mitis, prostatitis, pyelitis, cystitis, arthritis, vulvovaginitis, salpin- gitis, iritis, endometritis, etc.). Dose: 100 million gonococoi, increased if necessary to 500 or even 1000 million, every three to five days. Meningococcus Vaccine Curative, Squibb In fully assembled aseptic Syringes, containing: 100. 200, 400, 500 million killed meningococci, box of 4 Syringes (Code Word: Appeal) 100, 500 million killed meningococci, box of 2 Syringes (Code Word: Appl^) In Ampuls: ' 2X100. 2X500. 2X1000 million killed meningol cocci, box of 6 Ampuls with Syringe (Code Word: Approve) 100. 500 million killed meningococci, box of 2 Ampuls with Syringe (Cbde Word: Apron) SQUIBB'S MATERIA MEDICA 44 1 Meningococcus Vaccine Curative^ Squibb (Cont.) Indications: Adjunct to anli-meningitic serum in j^ersisfent subacute or chronic epidemic meningitis. Dose: TOO million bacteria, increased until a decided response is had, every three to five days. Meningococcus Vaccine Imhiuniziiig, Squibb Assembled Syringes, containing: t 100, 500. lOqO million yiled meningococci,, box of 3 Syringes ; ' ■ "" (Code'Wo^d: A'nsTner) In Ampuls: IPP,^ 500, rOOO taillion killed meningococci, ' box of 3 Ampuls with Syringe CCbde Word: Arch) Indications: Prophylactic against epidemic meningitis; affords a high degree of immunity. Dose: 500, 1000 and 1000 million baeteria, hypbdermically, ; at intervals of a week to ten days. Pneumococcus Vaccine, Squibb In fully assembled aseptic Syringes, containing: TOO, 200, 400, 500 million; killed: pneum,ococci, box of 4 Syringes (Code Word: Arrest) 100, 500 million killed pneumococci, 's ;, i, . box of 2 Syringes (Code Word: ^rrivg) ,,.' In Ampuls: - > ' ' 'i 2X100, 2X500, 2X1000 million killed pneumococci, box of 6 Ampuls with Syringe" ■ • ■ (Code Wofd:;>lr5ena0 100, 500 million killed pneumococci, I box of 2 Ampuls with Syringe (Code Word: Artful) Indications ; , Lobar pneumonia, unresolving pneumococcic pneumonia, empyema, pyorrhea alveolaris, . chronic rhinitis, sinusitis, etc., caused by pneumococci. I)ose: In iicufe pneu- monia, 20 to 100 to 500 million bacteria, every three to five days; in chronic cases, larger doses are given (100 to 500 to 1000 million). © Smallpox (Variola) Vaccine, Squibb Glycerinated. Each dose in separate aseptic sealed glass tube. With bulb and needles. Boxof5, (Code Word: Brave) / , Boxof 10, (Code Word: Erpok) If difficulty is experienced in procuring any Squjl^t? .product, in the original packages here listed; please ncitify'us; we shall see that your wants are met promptly and satisfactorily. 442 SQUIBB'S MATERIA MEDICA Staphylo-Acne Vaccine, Squibb In fully assembled aseptic Syringes, coptalning: 100, 200, 400, 500 million killed staphylococci; and 25, 50,. 100, 200 million killed acne bacilli box or 4 Syringes (Code Word: Altaih) too, 500 million killed staphylococci; and 50, 200 million killed acne bacilli, box of 2 Syringes (Code Word: AUendance) In Ampuls: 2X100, 2X500, ,2X1000 million killed staphylo- cocci; and 2X20, 2X50, 2X100 million killed acne bacilli, box of 6 Ampuls with Syringe (Code Word: Altractive) 100, 500 million killed staphylococci ; and 50, 200 million killed acne bacilli, box of 2 Ampuls with Syringe (Code Word: AUribute) Indications : Acne, particularly pustular. As acne infection is almost always associated with the Staphylococcus albus, the joint use of staphylococci and acne bacilli usually gives prompter results than acne vaccine alone. Do8e: 100 to 1000 m^lioh staphylococci with 25 to 200 million acne bacilli, every three to five days. (See also Acne Vaccine.) Staphylococcus Vaccine, Squibb In fully assembled aseptic Syringe;, containing: '' 100, 200, 500, 1000 million killed staphylococci, box of 4 Syringes (Code Word: Author) too, 500 million killed staphylococci, box of 2 Syringes (Code Word: Automat) In Ampuls: 100, 250, 2X500, 1000, 2000 million killed staphy- ' lococci, box of 6 Ampuls with Syringe (Code Word: Automobile) too, 500 million killed staphylococci, box of 2 Ampuls with Syringe (Code Word: Autopsy) Containing the Staphylococcus albus, S. aureus, and S. citreus. Indications: Chronic furunculosis, carbuncle, chronic sinuses, sycosis, psoas abscess, persistent cutaneous abscess, impetigo, acne, chronic, suppurating glands, otitis media, osteomyelitis — any persistent infection due to staphylococci. Dose: 100 mil- lion, quickly increased to 500, 1000 or even more million bac- teria, according to the response, every three to five days. Streptococcus Vaccine, Squibb In fiilly asseihbled aseptic Syringes, containing: 100, 200, 500, 1000 million killed streptococci, box of 4 Syringes (Code Word: Avoid) iOb, 500 million streptococci, box of 2 Syringes (Code Word: Avomng) SQUIBB'S MATERIA MEDICA 443 Streptococcus Vaccine, Squibb (Cont.) In Ampurs: 2X100, 2X500, 2X1000 million killed streptococci, box of 6 Ampuls with Syringe (Code Wordr Avulsion) 100, 500 million killed streptococci, box of 2 Ampuls with Syringe (Code Word: A may) Indications: Indolent subacute and chronic suppurations of the skin, mucosae and joints, due to streptococci — :abscesses, cellu- litis, otitis media, chronic mastoid suppuration, oral suppuration, chronic puerperal sepsis, chronic streptococcic endocarditis, recurrent erysipelsis, scarlet fever, articular rheumatism, etc. Dose: Curative, 100 million streptococci, rapidly increased to 1000 million, subcutanebusly, every three to five days; prophy- lactic qf scarlatina, 250, 500 and 1000 million bacteria, at weekly intervals. ® Typhoid Vaccine, Squibb In fully assembled aseptic Syringes, containing: 100, 200, 500, 1000 million, killed bacilli, box of 4 Syringes (Code Word; Azure) 100, 500 million killed bacilli, 'box of 2 Syringes (Code Word: flatfc/e) 500, 2X1000 million killed bacilli, box of 3 Syringes (Code Word: Availing) In Ampuls: 2X160, 2X500, 2X1000 million killed bacilli, box of 6 Ampuls with Syringe (Code ' Word : Bear) 1 00, 500 miliion killed bacilli, box of 2 Ampuls with Syringe (Code Word: Bedding) 500, 2X1000 million killed , typhoid bacilli, ' ! , box of 3 Ampuls with Syringe (Code Word: Blacken) Dose: Curative, 500 million bacilli as initial, repeated at four- day intervals as long as required, each dose increasing by 500 million over preceding dose unless too great local or general febrile reaction ensue ; usually two to four injections are re- quired. Immunizing, men of 1 50 JO ,200 lbs., 500 million, 1000 million and 1000 million bacilli,; at intervals of seven to ten days ; women and children less in proportion to their weight. Note.— 'All the above Vaccines are also supplied, upon re- quest, in vials containing 20 Cc, without syringes, at per vial. Write for Complete Literature. The Squibb products are recognized everywhere as the Quality Standard. They are of . urhiform purity and strength, , hence therapeutrcally dependabfe. vyhen ordering or prescribing med- icinal 'products, you vvili do well: 'always to specify SQUIBB'S. 444 SQUIBB'S MATERIA MEDICA Autogenous Vaccine, Squibb Prepared from samples of pus or cultures submitted. Twelve doses if necessary, in aseptic Ampuls Pasteur Anti=Rabic Vaccine, Squibb 21 treatments, each in an aseptic sealed Ampul, with Syringe, ready for use, packed in Caloris container (Code Word: Abandon) The Pasteur Treatment for prevention of rabies is an established success. Almost complete protection may be expected if the full course of treatments be instituted promptly after the bite . of the rabid animal. The Squibb Treatments are so prepared that they may be administered by the physician at his office or at the house of the patient. The doses of Anti-Rabic Vaccine will be sent daily by special delivery mail and numbered in the order in which they are to be administered, commencing with dose No. I and continuing in regular sequence to the end of the treatment, usually 21 doses. The doses should be kept in a cool place until used. Doses Nos. 1 and 2 are given the first day, doses 3 elnd 4 the second day, and then one dose daily to the end of the treatment. Leucocyte Extract, Squibb 10 Cc. in our special aseptic Syringe (Code Word: Boating) Prepared from healthy leucocytes of the horse, according to the method of Hiss. Indications: acute infectious diseases where accurate bacteriological diagnosis cannot be made — erysipelas, meningitis, pneumonia, septicemia, pyemia, acne, carbuncle, furunculosis, etc. Also used in conjunction with specific serums and vaccines where positive diagnosis cannot be made. Solution Hypophysis (Solution Pituitary Body.) See Part I of this book. Thromboplastin, Squibb. 20 Cc. vial, , Made according to the method devised ty Dr. Alfred F. Hess of the Research Laboratory of the New York City Department of Health. A true physiological Hemostatic, acting by supplying normal properties to the blood' stream, and not chemically. Of uniform activity; safe, efficient, non-irritating and easily applied. It represents the thromboplastic substances contained in ox brain, carefully tested physiologically and standardized, and kept aseptic by addition of 0.3 percent. triki;esol. Has been used v/ith uniform success in controlling hemorrhage after removal of adenoids and other nose and throat surgery; rectal bleeding, hemorrhage after removal of hemorrhoids, and after circumcision; in melsena neona- torum,, dental bleeding, old ulcers, efc; by mouth in gastric or intestinal hemorrhage. Considered Indicated in all types of ^ hemor- rhage from small veins and capillaries. Applied direct to: the SQUIBB'S MATERIA MEDIGA 445 Thromboplastin, Squibb (Cent.) bleeding surface by means of cotton, gauze or tampon, kept in place a few minutes. Dose : by mouth in gastfic or intestinal hemorrhage, 20 mils (Cc), with a. glassful of water, several limes daily, if necessary. Keep in ice box. NoTE: For suhculaneous and inlra- muscular infection, to increase the coagulability of- the blood. Throm- boplastin Hypodermic should be used, in doses of 10 to 20 Cc. every 24 to 72 hours, according to indicaiions. Urease. See Part I of this work. THERAPEUTIC INDEX Squibb's Biological Products Abscesses: Bacillus Coli Communis Vaccine, Staphylococcus Vaccine, Streptococcus Vaccine. Acne: Acne Vaccine, Staphylo-Acne Vaccine, Staphylococcus Vaccine, Leucocyte Ektract. Adenitis: Staphylococcus Vaccine, Streptococcus Vaccine. Anthrax: Staphylococcus Vaccine, Leucocyte Extract. Arthritis: Anti-Gonococcic Serum, Anti-Sfreplococcic Serum Rheumaticus, Gonococcus Vaccine, Streptococcus Vaccine. Bleeding: Normal Horse Serum, Thromboplastin. Boils: Staphylococcus Vaccine, Leucocyte Extract. Carbuncle: Staphylococcus Vaccine, Leucocyte Extract. Cellulitis: Streptococcus Vaccine, Cer^bro=spinaI Meningitis: Anti-Meningitic Serum, Menin- gococcus Vaccine. Conjunctivitis, Gonorrheal: Anti-Gonococcic Serum, Men- ingococcus Vaccine. Cystitis: Bacillus Cpli Communis Vwcine, Gonococcus Vac- cine. Dental Bleeding: Thromboplastin. Diphtheria: Diphtheria Antitoxin. Duodenal Hemorrhage: Nprmal Horse Serum, Thrombo- plastin. Eczema: Staphylococcus Vacpine. . Empyema: Pneumococcus Vaccine, Leucocyte Extract. Endocarditis: Anli-Gonocpccic Serum, Gonococcus Vaccine, Streptococcus Vaccine. . ,-! , Since vie make only one quality of each product, that best luited to the purposes intended,. the sRecificatron Squibfa'sV is not open to various interpretations, but has a plain, positive meaning. When ordering or prescribing, specify SQUIBB'S. 446 SQUIBB'S MATERIA MEDICA Endometritis Qonorriieal: Gonococcus Vaccine. Epididymitis: Anti-Gonococcic Semm, Gonococcus Vaccine. Epistaxis, Persistent: l Normal Horse Serum, Thromboplastin. Erysipelas: Anti-Slreptbcoccic Serum, Streptococcus Vaccine, Leucocyte Extract. Felon: Streptococcus Vaccine. Fistulous Sinuses: Anti-Streptococcus Serum, Normal Horse Serum, Pneumococcus Vaccine, Staphylococcus Vaccine, Strep- tococcus Vaccine. Furunculosis: Staphylococcus Vaccine, Leucocyte Extract. Gastric Hemorrhage r' Normal Horse 3e«nm, Thromboplastin. Gonorrhea: Anti-Gonococcic Serum, Gonococcus Vaccine. Gonorrheal Rheumatism: Anti-Gonococcic Serum, Gonococ- cus Vaccine. Hematemesis; Hemophilia; and Hemorrhage: Normal Horse Serumi Thromboplastin. Hydrophobia: Pasteur Anti-Rabic Vaccine. Impetigo: Staphylococcus Vaccine. Infected Wounds: Anti-Streplococcic Serum, Bacillus Coli Communis Vaccine, Staphylococcus Vaccine, Leucocyte Ex- tract. Iritis, Gonorrheal: Gonococcus Vaccine. Ischio-rectal Abscess: Bacillus Cpli Communis Vaccine, Staphylococcus Vaccine, Streptococcus Vaqcine, Leukemia: Normal Horse Serum, Thromhoplastin. Lymphadenitis : Staphylococcus Vaccine, Streptococcus Vaccine. Mastoiditis: Staphylococcus Vaccine, Streptococcus Vaccine. Melaena Neonatorum: Normal Horse Serum, Thromboplastin. Meningitis, Epidemic: Anti-Meningitic Serum, Meningo- coccus Vaccine, Leucocyte Extract. ■ "'* Meningitis, Subacute or Chronic: Meningococcus Vaccine, Leucocyte Elxtract. Metrorrhagia: Normal Horse Serum, Thromboplastiff.' - Middle Ear Disease: Staphylococcus Vaccine, Streptococcus Vaccine. Orchitis: Anti-Gonoeoccic Serum, Gonococcus Vaccine. Osteomyelitis: Staphylococcus Vaccine. Otitis Media: Staphylococcus Vaccine, Streptococcus Vac- SQUIBB'S MATERIA MEDICA 447 Peritonitis: Bacillus Coli Communis Vaccine. Pertussis: Bacillus Pertussis Vaccine. Phlegmon: Streptococcus Vaccine. ' , Pneumonia: Pneumococcus Vaccine, Leucocyte Extract, P0St=0perative Bleeding: Normal Horse Serum. Thrombo- plastin. Prostatitis: Gonococcus Vaccine. Psoas Abscess: Bacillus Coli Communis Vaccine, Staphy- lococcus Vaccine, Streptococcus Vaccine. Puerperal Sepsis: Anti-Streptococcic Serum, Normal Horse Serum, Streptococcus Vaccine. Purpura Hemorrhagica: Normal Horse Serum, Thrombo- plastin, Pustular Acne: Staphylo-Acne Vaccine. Pustular Rosacea: Staphylo-Acne Vaccine. Pyelitis: Bacillus Coli Communis Vaccine, Gonococcus Vaccine. Pyelo=nephritis : Bacillus Coli Communis Vaccine, Gonococcus Vaccine. Pyemia: Leucocyte Extract. Pyorrhoea Alveolaris: Pneumococcus Vaccine. Rabies: Pasteur Anti-Rabic Vaccine. Rectal Abscess : Bacillus Coli Communis Vaccine, Staphylococ- cus Vaccine, Streptococcus Vaccine. Rheumatism: Streptococcus Vaccine, Anti-Streptococcic Ser- um Rheumatic. Rhinitis, Chronic: Pneumococcic Vaccine. Salpingitis: Bacillus Coli Communis Vaccine, Gonococcus Vaccine. ' Sapremia: Leucocyte Extract. , Scarlet Fever: Anti-Streptococcic Serum, Streptococcus Vaccine. Sepsis, Qonococcic: Anti-Gonococcic Serum, Gonococcus Vaccine. Sepsis, Post=partum: Anti-Streptococcic Serum, Leucocyte Ej[ tract. Septicemia: Anti-Streptococcic Serum, Normal Horse Serum, Leucocyte Extract. The founder of the House of Squibb, Dr. Edward R. Squibb, not only had high ideals, but lived and labored for them; and, in the words of William Miller Bartlett, "the House of Squibb stands today as a living monument to the honor, integrity, zeal and devotion of its.founder." 448 SQUIBB'S MATERIA MEDICA Sinuses,' Suppurating: Anti-Slreptococcic Serum, Normal Horse Serum, Pneumococcic Vaccine, Staphylococcus Vaccine, Streptococcus Vaccine. , Smallpox (Variola) : Smallpox Vaccine. Sore Throat, Septic: Streptococcus Vaccine. Suppurating; Wounds or Sinuses: Anti-Streptococcic Serum, Normal Horse Serum, Streptococcus Vaccine. Sycosis: Staphylococcus Vaccine. Tetanus: Tetanus Antitoxin. Tonsillitis: Staphylococcus Vaccine. ,> Typhoid Fever: Typhoid Vaccine. Ulcers, Old. Thromboplastin. . ; '. 'j' Urethritis: Anti-Gonococcic Serum, Gonococcus Vaccine. Vaginitis, Gonorrheal: Gonococciis Vatcine. Variola: Smallpox Vaccine. Vesiculitis: Gonococcus 'Vaccine;' Vulvo=viginitis,' Qonofrheal: Gonodoccus Vaccine. Whooping Cough: Bacillus Pertussis Vaccine. Wounds, Infected: Anti-Streptococcip Serum, Bacillus CoU. Communis Vaccine, Staphylococcus Vaccine, Leucocyte Ex- tract. PART IV Squibb's Analyzed Reagents, Reagent Chemicals, Test Solutions, Volumetric Solutions, and Indicators FOR many years the Squibb standard of quality has stood for the best that can be produced in the line of drugs and chemicals. To these lines we have added a list of Reagents, prepared from our regular stock of high-grade chemicals by repeated purification. Each lot of chemical is first sampled in order to determine its suitability for reagent purposes. If accepted, all possible impurities present are carefully determined by check analyses. Since the impurities of reagent chemicals are present in very small amounts, -we employ quantities suffi- ciently large to insure accurate quantitative results. The usual procedure consists in applying tests on a quantity of from 10 to 20 Gm. of the reagent chemical, and if no appreciable reaction is obtained "none" present is reported. If, however, there is the slightest indication of a reaction, then a suitably large quantity of the material is taken in order to obtain a satisfactory weighable result. With such reagents as are employed in relatively small quantities, we usually take 10 Gm. of the sample; while with others, such as sodium carbonate or ammonium ox- alate, which are Used in larger amounts in analyses, we take from 25 to 1 00 Gm. for each determination. The average percentage of impurity, found is expressed on the label in the nearest higher round number. For foreign metals, such as react with hydrogen sulphide or ammon- ium sulphide, samples ranging from 5 to 1 Gm. are .tested, and if an appreciable reaction is noted a suffi- ciently large quantity is taken and the impurities de- termined and stated on the label. 449 450 SQUIBB'S MATERIA MEDICA At the foot of this page we show an illustration of our Reagent labels ; and after that we present a list of the Reagents now available, together with the Test Solutions, Volumetric Solutions, Indicators, and Test Papers offered under the Squibb label. We shall be glad to prepare any additional ones for which there may be a demand. Prices are omitted. Owing to the disturbed condition of the chemical market, prices are changing constantly. We shall be glad to receive your want lists, showing the quantities and subdivisions desired, and to submit our quotations. NOTE. — In addition to the list of Reagent Chemi- cals, we offer a full line of chemicals of a degree of purity usually exceeding the standards of the U. S. Pharmacopoeia and adapted for all lines of chemical work where the highest purity Reagent is not required. Write for quotations. SQUIBB'S REAGENT Ammonium Carbonate Approx. NH4HCO3NH4NH2CO2 contains: percent.: Non-volatile Matter (20 Gm.) none Chloride (20 Gra.) none Sulphate (20 Gm.) none Thiocyanate (20 Gm.) none Calcium. . . . , (20 Gm.) none Iron (1 Gm., colorimetric) none Tar Bases. . ..:... (5 Gm.) none The figures in parentheses express the quantities taken for each determination. LOT 14741 E-R:SQsnBB &.SONS. NewYork MANCIACrDiaNG CHEMISTS TO THE MEDICAL PROFESSION SINCE 1858 SQUIBB'S MATERIA MEDICA 451 SQUIBB'S ANALYZED REAGENTS Acid Acetic! Glacial, Squibb's Reagent g. s. bottle": 5 lbs 1 lb I/4 lb I oz Tested for: Non-volatile substances-HCl-SOs-SOa-HCOOH- Ca-Fe^Empyreumatics-Heavy Mefals. Acid Acetic Anhydride, Squibb's Reagent g. s. bottle: 5 lbs...<...l lb...;...l/4 lb 1 oz Tested for: Non-volatile substances-HCl-Heavy Metals. Acid Arsenous. See Arsenic Trioxide. Acid Boric (Crystals), Squibb's Reagent g. s. bottle: 5 lbs I lb I/4 lb 1 oz Tested for: Cl-^03-Ca-Alkalies-Si02-Fe-Pb. Acid Chromic. , See Chromium Trioxide* Acid Citric, Squibb's Reagent bottle: 1 lb :Vi lb 1 oz Tested for: Non-volatile substances-SOg-Ca-Fe-Pb. Acid Gallic, Squibb's Reagent bottle: 1/i lb ' oz Tested for: Non-volatile substances-Cl-SOa-Fe-Ca^Mg- Tannin, Acid Hydrobromic (34%), Squibb's Reagent g. 3. bottle: 1 lb I/4 lb I oz ... Tested for: Non-vqlatile substances — HCl-SOg-Ca-Fe- Heavy Metals-HPH2d2- Acid Hydrochloric Cone. (36%), Squibb's Reagent g. s. bottle: 5 lbs 1 lb.... .-..1/4 lb.......1 oz Tested for: Non-volatile substances-JChlolrine-SOs-SOa-As- Fe-Heavy Metals. Acid Hydrochloric (25%), Squibb's Reagent Same as above. Acid Hydrofluoric (42%), Squibb's Reagent ceresin bottle : 1 lb I/4 lb I oz Tested for: Non-volatile substances— HCl-S03-S02—H2SiF6— Ca-Mg-Al-Fe. Acid Molybdic (85%), Squibb's Reagent bottle: 1/4 lb I oz Tested for: Mo03-Cl-S03-P205-N03-As-Fe-NH3-InsoI. in NH3. Acid Nitric Cone. (69%), Squibb's Reagent g. s. bottle: 5 lbs 1 lb 1/4 lb I'oz Tested for: Non-volatile substances-HCl-SOg-As-HIOs-Fe- Heavy Metals. The Squibb Ideals have taken concrete form in the Squibb Products; these are universally recognized as standards of uniform Purity and Efficacy, that is, .general Excellence and Reliability. Specify SQUIBB'S when prescribing or ordering. 452 SQUIBB'S MATERIA MEDICA Acid Nitric (25%), Squibb's Reagent Same as above. Acid Oxalic, Squibb's Reagent bottle: 5 lbs 1 lb 1/4 lb I oz Tested for: Non-volatile substances-Cl-SOs-NO^-NHa-Ca- Fe-Pb. Acid Phosphoric (88%), Squibb's Reagent g. ». bottle: 5 lb I lb 1/4 lb 1 oz Tested for: Halogen Acids-SOs-NOa-As-Ca-Mg-Fe- "Ous" Acids-Heavy Metals. Acid Phospho=Tungstic, Squibb's Reagent 1-oz. bottle: Tested for: P-NH3-WO3. Acid Sulphuric (98%), Squibb's Reagent g. =. bottle: 5 lbs 1 lb 1/4 lb Tested for": Non-volatile substances-HCl-NOa-NHs-As-Fe- Fb-Heavy Metals. Acid Sulphurous, Squibb's Reagent g. s. bottle: 1 lb !4 lb 1 oz Tested for: Non-volatile substances-As-Fe-Heavy Metals- Assay. Acid Tannic, Squibb's Reagent bottle: I lb..... ..1/4 lb 1 oz Tested for: Non-volatile substances-Metals-Moisture. Acid Tartaric (Pb Free), Squibb's Reagent bottle: 1 lb., 1/4 lb 1 oz Tested for; Non-volatile substances-Cl-SOa-Ca-Fe-Pb. Alcohol, Anhydrous (99.97% by vol.), Squibb's Re- agent bottle: 1 lb 1/4 lb.. Tested for: Gravity— Residue-Fusel Oil— Aldehyde— Furfural- Oxidizable impurities. Alcohol, Methyl (99.5% by wt.), Squibb's Reagent bottle: 1 lb ..1/4 lb Tested for: Residue— Acetone— Empyreumatics—Oxidizable im- purities. Aluminum-Ammonium Sulphate, Squibb's Reagent bottle: 5 lbs I lb 1/4 lb 1 oz Tested for: Cl-Ca-Mg-As-Fe-Heavy Metals. Aluminum Nitrate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested- for: Cl-SOs-Ca-Mg-Fe-Heavy Metals. Aluminum=Potassium Sulphate, Squibb's Reagent bottle: 5 lbs I lb 1/4 lb 1 oz Tested for: Cl-Ca-Mg-As-Fe-Heavy Metals. Ammonia Water Cone. (28%), Squibb's Reagent g. s. bottle: 5 lbs 1 lb I/4 lb Tested for Non-volalile substances-Cl-SOs-Tar Bases-Fe- Heavy Metals. SQUIBB'S MATERIA MEDICA 453 Ammonium Carbonate (Cubes), Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Non-volatile substances-Cl-SOg-CNS-Ca-Fe-Tar ■Bases-Heavy Metals. Ammonium Chlori^le, Squibb's Reagent bottle: 5 lbs 1 lb I/4 lb 1 oz. Tested for: Non-volatile substances-SOa-CNS-Ca-Fe-Tar Bases-Heavy Metals. Ammonium Chromate, Squibb's Reagent bottle: 1/4 lb 1 oz Tested for: Cl-SOs-Ca-Mg-Al-Fe-Alkalies. Ammonium Molybdate, Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for: MoOs-Cl-SOg-NOa-PgOg-Foreign Metals. Ammonium Nitrate, Squibb's Reagent bottle: lib 1/4 lb 1 oz Tested for: Non- volatile substances-Cl-SOa-Ca-Fe-As- Heavy Metals. Ammonium Oxalate, Squibb's Reagent bottle: I lb 1/4 lb . 1 oz ' Tested for: Non-volatile substances-CI-SOs-Ca-Fe-Heavy Metals. Ammonium Persulphate, Squibb's Reagent bottle: 1 lb.. "..... 1/4 lb....... I oz Tested for: Non-volatile substances-Cl-Ca-Mg-Al203-Fe- - Si02-Heavy Metals-Free Acid-Assay. Ammonium Phosphate (Dibasic), Squibb's Reagent Tested for: Cl-S03-N03-C02-Ca-As-Fe-Salts of Alkalies. Ammonium Sulphate, Squibb's Reagent bottle: 5 lbs 1 lb 1/4 lb 1 oz Tested for: Non-volatile substances-Cl—CNS-Ca—Fe— Heavy Metals. Ammonium Sulphocyanate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Non- volatile substances-Cl—SOg-Fe— Heavy Metals-Insoluble in Alcohol. Antimony^Potassium Tartrate, Squibb's Reagent bottle: I lb 1/4 lb I oz Tested for: Cl-SOs-^a-Fe-Pb. Arsenic Trioxide, Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: Non-volatile substances-Cl-S— Ca— Mg— Fe. Asbestos Wool Purified, Squibb^s Reagent Selected, long-fibre, for Gooch Crucible Work, The Squibb Label on a package is a positive guaranty for the uniform Purity and Reliability of the product. We make only ONE quality: the SQUiB6 quality; and our prices are as low as they can be made for that quality. Specify SQUIBB'S. 454 SQUIBB'S MATERIA MEDICA Barium Acetate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Foreign matter not ppt. by H2SO4-CI-NO3-SO3- Sr-Ca-Fe-Heavy Metals'. Barium Carbonate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Alkalies-Cl-SOg-Ca-Sr-Fe-Heavy Metals. Barium Chloride, Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: Foreign matter not ppt. by H2SO4-CIO3-NO3- Ca-Sr-Fe-Heavy Metals. Barium Hydroxide, Squibb's Reagent bottle: I lb 1/4 lb Tested for: Alkalies-Cl-S-C02-Ca-Sr-Fe-Heavy Metals. Barium Nitrate, Squibb's Redgent bottle: 1 lb 1/4 lb 1 oz Tested for: Foreign matter not ppt. by H2SO4— Cl-Sr— Ca— Fe- Heavy Metals. Benzol (Benzene), Squibb's Reagent bottle: 1 lb 1/4 lb....... Tested for: Gravity— Boiling-point-Non-volatile substances- Thiophen-CS2. Bismuth Nitrate (Crystals), Squibb's Reagent g. s. bottle: 1 lb J/4 lb 1 oz Tested for: Cl-SOg-As-Fe-Pb-Cu-Ag. Bismuth Subnitrate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for:. Cl-S03-C02-Ca-Mg-Alkalies-As-Fe-Pb-Cu. Cadmium Iodide, Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: SOs-Zn— Fe. Cadmiuni'Potassium Iodide, Squibb's Reagent 1-oz. bottle: Tested for: SOg-NOs-IOg-Fe. Cadmium Sulphate, Squibb's Reagent 1 -oz. bottle : Tested for: Cl-Zn-Fe. Calcium Carbonate (Precipitated), Squibb's Reagent bottle: 1 lb 1/4 lb Tested for: SOs-Mg-Sr-Ba-Al-Fe^Heavy Metals. soluble salts. Calcium Chloride (Crystals), Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: SOs-Mg-Sr-Ba-Al-Fe-Heavy Metals. Calcium Oxide (From Reagent CaCOa), Squibb's. Re= ■ agent 1-lb bottle: Tested for: Cl-S03-N03-C02-P20g-Mg-Al-Si02-Fe- Alkalies. SQUIBB'S MATERIA MEDICA 455 Carbon Disulphide, Squibb's Reagent bottle: 1 lb 1/4 lb Tested for: Non-volatile substances-SOa-SOg-Foreign Sul- phides. Carbon Tetrachloride, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Non-volatile substances-Cl-HCl-Organic impuri- ties-Aldehydes-CS2. Chromium Trioxide (Chromic Acid), Squibb's Reagent g. s. bottle: 1 lb 1/* lb 1 oz ' Tested for: S03-Hr>^03-Ca-^Mg-Alkalies. Cobalt Chloride, Squibb's Reagent g. s. bottle: 1/4 lb 1 oz. 1 Tested for: SOs-NOa-Alkalies-Ca-Ni-Cu-Pb-Zn-Fe. Cobalt Nitrate, Squibb's Reagent g. s. bottle: I/4 lb./ 1 oz. Tested for: CI-SOg-Altalies-Ca-Cu-Ni-Zn-Fe. Copper Sulphate, Squibb's Reagent bottle: 1 lb 1/4 lb ...1 oz Tested for: Cl-Alkalies and Alkaline Earths-Si02-Fe-For- eign Metals. Ether, Anhydrous, Squibb's Reagent soldered tin: 1 lb 1/4 'b Tested fx>r: Sp. Gr.— Residue— Aldehydes- Vinyl Alcohol— Thio- compounds Ferric-Ammonium Sulphate, Squibb's I^agent bottle: 1 lb 1/4 lb 1 oz Tested for: Cl-NOa-rAlkalies-Cu-Fe. Ferric Chloride, Squibb's Reagent bottle: 1 lb 1/4 lb .1 oz...i... Tested for: HCl-Basic Salt-Fe-SOs-NOs-PaOs-As-Ca- Pb-Cu-AIkaliis. Ferrous Sulphate, Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for: Cl-Alkalies-Cu-Pb-Free Acid. Iodine, Resublimed, Squibb's Reagent g. s. bottle : I lb ''■ji \h 1 oz. Tested for: Non-volatile substances-Cl-CN. Lead Acetate, Squibb's Reagent bottle: 5 lbs I lb 1/4 lb I oz Tested for: Cl-NOa-Al-Fe-Foreign Melals-Ca-Mg-Alka- lies-Basic Salt. Lead Nitrate, Squibb's Reagent bottle: 1 lb..... '..1/4 lb 1 oz Tested for: CI-SOs-Al-Fe-Foreigfl Metals-Ca-Mg-AIkalies. This house supplies only one quality of each product: that best suited to the purposes intended. The specification "Squibb's" is not open to various interpretations; it has a pISin, posi- tive meaning. Therefore, when prescribing, specify SQUIBB'S. 456 SQUIBB'S MATERIA MEDICA Lead Oxide Red, Squibb's Reagent bottle: I lb 1/* lb 1 oz Tested for: Cl-SOs-NOg-Ca-Alkalies-^iOa-Fe-Pb metal. Lead Oxide Yellow, Squibb's Reagent Tested for: Cl-C02-N03-^i02-Ca-Mg-Al-Fe-Cu-InsoIu- ble in Acetic Acid. Lead Peroxide (Manganese=free), Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Cl-SOs-NOs-Mn-SiOa-Water-soluble salts- Assay. Litmus Paper, Squibb In vials of 100 strips and in tubes of 2 sheets. We prepare Litmus Paper of three different degrees of sen- sitiveness. Our regular red or blue quickly responds to N/250 alkali or acid V. S. Our neutral responds to either N/1000 alkali or acid V. S. Our dark-red or dark-blue, for technical purposes, responds quickly to N/100 alkali or acid V. S. We supply regular **red" or "blue" paper on unspecified orders. Magnesium Chloride, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: S03-P205-As-Ca-Ba-Al-Fe-Heavy Metals. Magnesium Sulphate, Squibb's Reagent bottle: 5 lbs....,..l lb 1/4 lb 1 oz Tested for: Cl-P206-Ca-Sr-Alkalies-As-Fe-Heavy Metals. Manganese Dioxide (Precipitated), Squibb's Reagent bottle: 1 lb... ...1/4 lb I oz Tested for: CI-N03-S03-Si02-Ca-Mg-Fe-AlkaIies-Assay. Manganese Sulphate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Cl-NOa-Ca-Mg-Fe-Alkalies. Mercuric Bromide, Squibb's Reagenty 1-oz. bottle: Tested for: Non-volatile substances-Fe-As-Foreign Metals. Mercuric Chloride, Squibb's Reagent bottle: 5 lbs 1 lb 1/4 lb I oz Tested for: Non-volatile substances-SOs— As-Fe-Calomel and Basic Salt— Foreign Metals. Mercuric Oxide, Red, Squibb's Reagent Tested for: Non-volatile substances-Cl-SOs-NOs-Fe-Pb-Cu. Mercury, Squibb's Reagent stone bottle: 5 lbs I lb I/4 lb I oz Non-volatile substances-Fe— Foreign Metals. Nickel=Ammonium Sulphate, Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for; Cl-NOs-Pb-Cu-Fe-Co. Nickel Nitrate, Squibb's Reagent bottle:,! lb .1/4 lb ..1 oz Tested for: Cl-SOa-Fe-Cu-Co-AIkalies, SQUIBB'S MATERIA MEDICA 457 Nickel Sulphate, Squibb's Reaeent bottle: 1 lb 1/4 lb I oz Tested for: Cl-NOs-Co-Fe-Pb-Cu-Alkalies. Potassium Acetate, Squibb's Reagent totlle: 1 lb 1/4 lb I oz... Tested for: Cl-^Og-Ca-Fe-Heavy Metals. Potassium Bicarbonate, Squibb's Reagent bottle: 5 lbs 1 lb I/4 lb 1 oz Tested for: Cl-^Os-NOg-Ca-Al-^iOs-Fe-Heavy Metals- Kesidue on ignition. Potassium Bisulphate (Crystals), Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for: Cl-NOs-As-Ca-Mg-Al-^iOa-Heavy Metals- Assay. Potassium Bitartrate, Squibb's Reagent bottle: I lb 1/4 IbV. I oz Tested for: Cl-SOa-Ca-NHs-Al-Fe-Pb. Potassium Bromate, Squibb's Reagent 1-oz. bottle: Tested for: Cl-Bromide-SOs-Heavy Metals. Potassium Carbonate (Anhydrous), Squibb's Reagent bottle: -5 lbs 1 lb : .% lb 1 oz . Tested for: Cl-S03-N03-CarMg-Al-Si02-Fe-Heavy Metals Potassium Chlorate, Squibb's Reagent bottle* 5 lbs.. ..... 1 lb 1/4 lb •. . 1 oz.. . . Tested, for: Cl-SOs-NOg-Ca-lV^-As-Fe-Heavy Metals. Potassium Chloride, Squibb's Reagent bottle: I lb. .1/4 lb 1 oz Tested for: SOa-NOg-Ca-Mg-I-Fe-Heavy Metals, Potassium Chromate, Squibb's Reagent bottle: 5 lbs I lb...;...l/4 lb I oz Tested for: Cl-SOs-Ca-Mg-Al-Fe. Potassium Dichromate, Squibb's Reagent bottle: rib 1/4 lb 1 oz Tested for: Cl-SOs-Al-Alkaline Earths-Heavy Metals. Potassium Ferricyanide, Squibb's Reagent bottle: 5 lbs.. ) lb 1/4 lb.. I oz Tested for: CI-SO3-CO2. Potassium Perrccyanide, Squibb's Reagent bottle: 5 lbs I lb 1/4 lb I oz Tested for: CI-SO3-CO2. Potassium Hydroxide (by Alcohol), Squibb's Reagent lottle: I lb 1/4 lb I oz Tested for:. Cl-SOg^NOg-COa-SiOa-Ca-Al-Fe^N-Heavy Metals. The prices of the Squibb Products are in all instances as low as the quality and quantity of ingredients and the expense of man- ufacture allow. They incfude containers, packing and boxing. When ordering or prescribing medicinal products, specify SQUIBB'S. 458 SQUIBB'S MATERIA MEDICA Potassium Iodide, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz.. ..... Tested for: Cl-CN-S03-N03-C02-K:OH'-I03-F^Heavy Metals. Potassium Nitrate, Squibb's Reagent bottle: 1 lb 1/4 lb....... I oz Tested for: Cl-S03-N02-C10s-Ga-Fe-Heavy Metals. Potassium Permanganate, Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: Cl-SOs-NOs-ClOs-Ca-Fe. Potassium Persulphate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Cl-SiOz-Fe-Pb-Mn-NHg. Potassium-Sodium Tartrate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Halogens-SOs-NHs-Ca-Fe-Pb. Potassium Sulphate, Squibb's Reagent bottle: 5 lbs 1 lb 1/4 lb 1 oz Tested for: Cl-NOs-As-NHs-Ca-Mg-Fe-Heavy Metals. Potassium Sulphocyanate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Cl-^Os-NHs-Fe. Silver' Nitrate (Crystals), Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: Cl-Cu-Bi-Pb-Fe-SiOa-Ca-Alkalies. . Sodium Acetate (Crystals), Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for: Cl-SOs-Ca-Fe-Heavy Melals. Sodium Acetate Anhydrous, Squibb's Reagent bottle: 5 lbs 1 lb 1/4 lb 1 oz Tested for: C1^03-Ca-Fe-Heavy Metals. Sodium^Ammonium Phosphate, Squibb's Reagent bottle: 5 lbs 1 lb 1/4 lb I oz Tested for: CI-S03-N03-C02-As-Ca-Fe-Heavy Metals. Sodium Bicarbonate, Squibb's Reagent bottle: 1 lb 1/4 lb.. 1 oz , Tested for: Cl-S03-Mono-carbonal6-NH3-Ca-Na2S203- CNS-P205-Al-Si02-Fe-Heavy Metals. Sodium Bisulphate, Squibb's Reagent bottle: 1 lb 1/4 lb 1 oz Tested for: ~ Cl-As-Si02-Ca-Mg-Al-Fe-Heavy Metals- Assay. Sodium Bisulphite, Squibb's Reagent bottle: 1 lb....;.. 1/4 lb 1 oz Tested for: Cl-Ca-Mg-As-Fe-Pb-Insoluble matter-Heavy Metals — ^Assay. Sodium Bitartrate, Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: Cl-S03-Ca-Fe-Pb. SQUIBB'S MATERIA MEDICA 459 Sodium Borate, Squibb's Reagent bottle: 5 lbs 1 lb .1/4 lb 1 oz Tested for: Cl-^S03-C02-Ca-Fe-Heavy Metals. Sodium Carbonate (Crystals), Squibb's Reagent bottle: 5 lbs 1 lb.. .... .1/4 lb. I oz Tested for: Cl-SOa-NOg-PgOg-NHg-Ca-Mg-Al-SiOz- Fe-NaOH-Heavy Metals-Loss at 120° C. Sodium Carbonate Anhydrous, Squibb's Reagent bottle: I lb ..1/4 lb.......l oz Tested for: C1^03-P2Q5^i02-Ca-NH3-Mg-Al-Fe-H20- Heavy Metals. Sodium Chlorate, Squibb's Reagent bottle: 1 lb 1/4 lb I oz Tested for: Cl^Os-NOg-Ca-Mg-Fe-As-Heavy Metals. Sodium Chloride, Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for: SOs-NHs-Ca-Ba-Mg-I-^Fe-Heavy Metals. Sodium Citrate, Squibb's Reagent bottle: 1 lb 1/4 lb.. I oz.. . . . . . tested for: Cl-SOs-As-Ca-Fe-Metals. Sodium Cyanide, Squibb's Reagent bottle: I lb.. 1/4 lb....... I oz Tested for: Cl-SQs-COj-Fe-CNS-Ferrocyanide-HCN. Sodium Hydroxide (by Alcohol), Squibb's Reagent bottle: 1 lb 1/4 lb ..1 oz Tested for: Cl-S03-C02-Ca-AI-Si02-Fe-N-Assay, Sodium Nitrate, Squibb's Reagent bottle: I lb 1/4 lb.......l oz Tested fort Cl-SOs-JCa-Mg-Fe-NOs-IOs-ClOg-Heavy Metals. Sodium Nitrite, Squibb's Reagent bottle: I lb 1/4 lb 1 oz Tested for: Cl-SOg—Fe— Assay. Sodium Nitroprusside, Squibb's Reagent 1-oz. bottle: Tested for SO3. Sodium Oxalate (Soerensen's Salt), Squibb's Reagent bottle: 1 lb 1/4 lb I oz....:.. Tested for: Cl-SOs-K-Fe-Organic Foreign compounds- Hygroscopic Moisture-Neutrality (Bureau of Standards). Sodium Peroxide, Squibb's Reagent bottle: I lb 1/4 lb Tested for: Cl-S03-P205-Si02-Al-Fe-Heavy Metals- Assay. If difficulty is experienced in procuring any Squibb product, in ttie original paclplied in a case containing a certified hydrometer, a thermometer, a glAss jar and a tube of litmus paper. The amount of total solids can be roughly estimated by Haser's method. This consists in multipl)ring the last two figures of the specific gravity by 2.33. For example, if the specific gravity is 1 .020, multiply 20 by 2.33, which gives 46.6 Gra., the amount of total solids in each 1 ,000 mils (Cc), of the urine. If a person voids 1,500 mils (Cc.) of urine daily the total amount of solids eliminated therewith is 46.6 x 1 .5, or 69.9 Gm. The quantity of urea eliminated can be quickly and accurately estimated by the use of Urease Squibb. Com- plete information on this product will be found among the scientific notes at the end of this book. Squibb's Urea Apparatus will also be found convenient for the purpose. Complete directions accompany the out- fit. The abnormal constituents found in various patholog- ical urines are albumin, sugar, acetone, bile, indican, blood, casts, pus, spermatozoa, and epithelial cells. SQUIBB'S MATERIA MEDICA 483 In testing urine clean test tubes and fresh reagents are essential. A separate pipette should be used for each solution employed. (See list df Test Solutions, Part IV of this book.) Albumin Tests If the urine is cloudy, it should be filtered through filter paper — not talcum, fuller's earth, magnesium carbonate or charcoal; before testing it for albumin freshly voided urine should be- allowed to coo], and no specimen of urine to which the heat test has been applied should be used for the nitric acid contact test. The first two tests are approved by the Association of Life Insurance Med- ical Directors and employed by the medical examiners. HEAT TEST If the urine is acid, take one-half test-tube of the filtered urine, add one-sixth of its volume of saturated salt solu- tion (five ounces to the pint), hold the tube by the lower portion and boil the ui!)per one-third. If a cloud forms it consists of either albumin or earthly phosphates. Add two or three drops of diluted nitric acid, boil again, and add three drops more of the acid; if the cloud remains albumin is present, but if the cloud entirely disappears the precipitate is phosphatic and albumin is absent. If the urine is alkaline or neutral, take one-half test- tube of the filtered urine, add We-sixth of its volume of saturated salt solution and then a sufficient number of drops of diluted nitric acid, or of 33 per cent, acetic acid, to render faintly acid. This must be done in all cases where the urine is alkaline or neutral, for albumin will not be precipitated from such urine by heat. When this has been done apply heal as directed in the preceding paragraph. NITRIC ACID CONTACT TEST (hELLER's TEST) Take a perfectly clean and dry test-tube having caliber of about one inch (a conical wineglass is preferable) , and place into it about one inch of urine; allow concentrated flitric acid to flow^slowly from a pipette down the side of the inclined test-tube underlying the urine. Wait five min- utes. By use of dark background look very closely for 484 SQUIBB'S- MATERIA MEDICA white band or cloud of albumin just above junction of acid and urine. ■<■- ; ' ,' Ort place into a test-tube of large diameter about one inch of concentrated nitric acid, then incline the tube and from a pipette allow an equal volume of urine to flow slowly down the side, of .jhe tube, carefully overlaying the acid. If albumin is present, by the use of a dark back- ground a zone will be seen just above the point of contact of the urine and the acid, the intensity of the cloud de- pending on the amount of albumin present. If no cloud is seen, the tube should be set aside,- and re-examined in one-half hour, because the reaction for albumin is some- times slow. • "■ ■ - (Note: — ^Urates and, copaiba and some other resins may give a white ring. The former are dissolved on heat- ing; the latter, by the eidditionbf alcohol. Albumin is not affected, by either treatment.) : i . '. ESBACH's PICRIC AtlD TEST Drop the urine into, a clear- if tbe urine has been foujid to. con- tain more than a faint trace of albumin the latter should first be removed by boiling and filtering. ' ; ■- . ■ ■ ■- I /'J,-. remains clear, it SQUigB'S MATERIA MEDICA 485 shows that the . Eehling's solution is, in good .condition.. Now add a few d^ops. jof the urine; warm the; mixture but dtt not boil, and- add ;a few more drops of the urine j-Wiarm again, and, so on until the amount of urine added equals one-JiJdf the- volume of test solution used. If the specific ■. gravity of the urine to be tested is belowi 1 .020 the urine may be added' in equal v.cjume to the test- solution., i If. sugaris present, a jrellow or red precipitate of 'suboxide of copper appearsii n-iFhis occurs quickly if much sugar is present. (If the amount of sugar is less thani one jiercent., the reduction will not appear until after several, minutes — ' five to thirty. If a reduction does not take place in thirty minutes sugar is absent; if, on the other hand, the result of the test is still doubtful, the test tube should be set aside from twelve to eighteen hours and then the sediment ex- amined to see if there has been any' deposit of the suboxide of copper. . .1 , . /.-, ; ; -' \-'' (^b^E.-^— We also furnish Fehlirig's Test Solution Elements complete, for executing the t^st, and for the ap- proxiniate. <7uantifdiive determination of sugar.) HAINES'S TEST Put 1 fluidrachnji of Haines's T^st Solution Squibb into a. test tuib(e and boil gently; ^^ 8 to- 10 drops of the suspected, prine and agaiii l^gil, gently,^. If sugar is present,., a copious , yellow or ';yellowisl^-;red precipitate qf copper suboxide separates;, ifthe, amount pf sugar in the urine is small the reduction may require from five to thirty minutes, but iT no change has taken place in thirty minutes sugar is absent. If the result of the test is still doubtful, the test tube should be "set aside and allowed to stand from twelve to eighteen hours and then the deposit examined for the presence of a suboxide of copper. (Notes. — ^A grayish or greenish precipitate of phos- phates which ..almost always forms through the action of the alkali in Fehling's or Haines's solution, should not be mistaken for a deposit of. suboxide of oc^per, which is al- ways .yellow, or red.. • Simple, decolorization of either Feh- ling's or Haines's ^oliitionjby the urine should not; be con- sidered a positive reaction for sugar, for sometimes a conr 486 SQUIBB'S MATERIA MEDICA centrated and strongly acid urine wliich is sugar-free. will decolorize the copper ; on the other hand, a decolorization may indicate a beginning reduction of the copper, particu- larly when only a trace of sugar is present. Under such circumstances it is advisable to let the test tube stand for twelve to eighteen hours, before arriving at a definite conclusion. In testing for traces of sugar, when the tube is set aside it is well to dilute the contents with about 2 volumes of water. TTiis reduces the density of the solu- tion, and enables any cuprous oxide to subside that might otherwise remain in suspension. Tests for Acetone lange's test Mix 15 mils (Cc.) of the urine with 0.5 to I mil of acetic acid, and add a few drops of freshly prepared con- centrated solution of sodium nitroprusside. Overlay with ammonia water. At the point of contact a violet ring forms. lieben's test Distill a portion of the urine after adding a few drops of phosphoric acid. To the distillate in a test tube add a few drops of compound solution of iodine (Lugol's solu- tion) and then sufficient solution of potassium hydroxide to render , the mixture decidedly alkaline. A yellow pre- cipitate consisting of iodoform will at once form if acetone is present. Tests for Bile Pigments gmelin's test Add fuming nitric acid to the urine contained in a test tube, by inclining the same and pouring down the side slowly; the acid will form a layer under the urine. If bile pigment is present colored rings form near the jimction of the two liquids ; a green ring above, and under this a blue, violet-red, and reddish yellow. If the green and violet red rings are wanting, it indicates the probable presence of lutein. SQUIBB'S MATERIA MEDICA 487 (Note. — Fuming nitric acid may be prepared by add- ing a few drops of formaldehyde solution to regular nitric acid and carefully warming until it assumes a red color.) rossbach's test Filter the urine through filter paper. After it has all passed through, apply a drop of nitric acid to the filter. A pale-red spot will be formed, surrounded by red, violet, blue, and green circles. heller's test • Pour about 5 mils (Cc.) of concentrated hydrochloric acid into a test tube and add enough urine to impart a color to it. Then carefully pour nitric acid down the side of the tube so as to form a layer on the bottom. A play of colors at the junction of the two layers indicates bile pigments. Tests for Indican mcmunn's test Boil about 5 mils (Cc.) of the urine with an equal volume of hydrochloric acid and a few drops of nitric acid. Allow to cool, then shake with 2 at 3 mils of chloroform. The latter becomes colored violet. jaffe's test Mix 10 mils (Cc.) of the urine with an equal amount of concentrated hydrochloric acid and 2 or 3 mils of chloroform; add solution of chlorinated soda drop by drop, shaking after each addition. The chloroform will gradually become colored blue. Slight excess of the soda solution will cause no harm, but a large excess may inter- fere with the test. Blood Tests Roberts's occult blood test Blood may he conveniently detected by means of Dr. Dudley Roberts's Occult Blood Test Tablets, described in the Tablet section of this book. The microscopic and spectroscopic tests are also very satisfactory. 488 SQUIBB'S MATERIA MEDICA GUAIAC TEST Mix equal volumes of fresh tincture guaiac and "ozon- ized"' oil of turpentine (that is, old turpentine oil that has been exposed to the air and sunlight for some time) , and cautiously overlay the mixture^ on the urine contained in a test tube. At the junction of . the two layers a grayish precipitate forms and immediately above it a blue ring if blood is present. On agitation the entire* mixture turns blue. Pus may give the same reaction, bat the blue ring disappears on boiling ; not so "with blood. Detection of Pus The best means of detecting pus is the microscope. However, the following test is often employed: Let the urine settle in a conical graduate. Pour off the superna- tant liquid from the sediment. Add to the latter a few drops of concentrated solution of potassium or sodium hydroxide, and stir. , Pus becomes colored greenish, and gelatinizes to, a tough mass. (Mucus is partly dissolved by this treatment, Vfiih the fontiation of a flocculent pre- cipitate.) , '"' Uric Acid and Urate Tests Strongly acidulate the urine wth hydrochloric acid and set aside for 24 hours. Yellowish-red crystals of uric acid will deposit on the bottoiit and sides of the test tube. By comparing this tube with one containing a similar t|uaritity of normal urine treated in the same manner, an approximate idea may be obtained of the amount of uric acid in the abnormal specimen, sufficiently accurate for ordinary practical purposes. The murexide or WeiJM's test is conducted by evap- orating to dryness a few, drops of the urine in a watch glass or porcelain capsule, adding a drop or two of nitric acid, again "evaporating carefully and then adding one or two drops of ammonia water. Murexide (ammoniuin purpurate)"V/ill' be formed, and be shown by a purple coloration. ' ' SQUIBB'S MATERIA MEDICA 489 CO OS !>. t> t^ CO CD r-t 00 Th '^^T-HCOCCiCDroi>l>iO»000'^OiOCflOS'-' •a 'V •s CO. 1 i o u so a* « 5J u o .^ 03 O c5 fl a 5l -S - O o © oj »-< ^-* ^^ ffi: M ^ § b b b ■* 1> IN CO CO •o>oNt~(M(Neom-*_r-Hoo iOcD(NtOTtf0500lM(NtDM5t>l>02lOi-lOS>OCO a5^lO-'.iod'*CO o i 3 CD nS" £SP CD 3- S J a'i .3 ■'-' .2 5 o pS ,y o .ri- ft O .2 -S .^ w w o •§ o o g. ■g "S "S "S "^ '^ '3%'^ CJ O- -O c3 ^ ^ ^ ^ , , ._ , .g .^ .^ .^ ^ _ ^ _ ^1 o ft -8, -a WW T3 Xi o t o ft o -^ ft += S^ o ffl h-l -d T) o p >?Cu B O ^ja CO ii=^i:ili-i|Si ■9 oji ■& !^ » 5 "43C^ a "^ i^-|Nll°||l|riE g|3 .a ■g o P-SQ §ls .Soils' AH |-s1|ll fttS .. P.-S t4 fa >» L2flp.3Q,>&o a 9 S o ■EgSS-& ■^ S o > o a g 5 S = 3:S 5 bp 5& pc4«a 5 H e3 Q.sJ?5 v-^ ^ s § >i t3 a> i .■? i s-ils J s £3 >'^ issp'sl a -3 S g >:, <" O o w ml s. !§■§ ■a >>-s s ■S-t*-^ 3 O cS o a o llllll I o'&a'a L-3 SQUIBB'S MATERIA MEDICA 491 'B"S'S s.aJS's'asls'Sh-. jSjjj o « « S-^M . OSS «_ S^. g-f. ..g,-^ •Sl-al si "-§'«§ JN mi «3 9 5 ?l»'^l S ^TsM pa's o*S H iS'-*?^ djS ^IJ *- >>£ ■fl I (3 p O g^ .S 13 M ? A lip ji a M * la's, aS g-J gia o > a g> 3 a .a . « " "I -a 3 ■ illtfiili iiiljjj III s III Eh o-&«aT3 Mil , d d ( <§lJlilO- CO Oi 00 O d !>.gi Within twenty- four hours 1 IK -a Usually onSth day but maybe on 3rd or not unta 7th day Within twelve to twehty- hours h . isil iSsll II issi Il OS S-a as skid's SI ^1 ill ill I SS'.S-S 492 SQUIBB'S.' MATERIA MEDICA Obstetric Calendars ^TiUARf^ ATaf To use this obstetric calendar~ of Dr. William L. ' Canton, New York, City, take the date of the beginning of the last menstruation, add to it the number in the circle which accompanies the name of the month in which it oc- cuwed, and to the sum prefix the narne oi.the month next occurring in the same circle, going around the circle in the direction taken by the hands of a watch;^— This date is the day oh which labor should occur. For example: May 20+4=24+Feb.=Feb. 24 Sept. 4+7=1 l-|-June=June 11 ^ If the sum of the nunfbers carries the d^t^ °v^'' int** the succeeding month, use such succeeding month to de- termine the month of labor. -- - _. Mar. 30+5=April 4+Jan.==)|n. 4 SQUIBB'S/ MATERIA MEDICA 493 SCHULTZE's^ modification^ of NAGdfi.E?S, METHOD < Subtract three month's from the date of the beginning of the last menstruation, then add to this date the niimber occurring in the segment of the circle bearing the name of the latter month. . If }he year is, a leap year add; the number in parentheses^,, The res.ulting date is that on which labor is due. ;-. May 20 V- 3 mo. = Feb. 20 + 4 = Feb. 24 September 4 — 3 mo. = June 4 + 7 == June 1 I Mar. 30 -^ 3; mo. = Dec. 30 + 5 = Jan. 4 494 SQUIBB'S MATERIA MEDICA Drugs that AfFect the Color of Urine Carbolic Acid (Phenol) may cause it to be brown. Diuretics and copious quantities of water and other' bever- ages cause urine to become lighter in color. Methylene Blue turns it green if acid. Renal Irritants render if darker. Santonin makes it more yellow if acid, purple if alkaline. Senna may render it red if acid, yellow if alkaline. Sulphonmethane (Sulphonal) may turn it very dark. Drugs That Color the Stools Bismuth salts color them black or very dark gray. Colchicum and its preparations tint them greenish. Iron and its salts color them black. Mercury and its compounds make them green. Purgatives cause them to be darker. Drugs Excreted With the Milk Arsenic and its compounds. Opium and its preparations. Bromides. Quinine and its salts. Hexamethylenamine. Sulphur. Iodine and Iodides. Vegetable Cathartics. Lead salts. Volatile Oils. Mercurials. Drugs That Often Cause Cutaneous Eruptions or Itching Antitoxins and Sera. Copaiba. Arsenic and its compounds. Iodine and Iodides. Belladonna and its prepa- Opium and Opiates. rations. Quinine Salts. Bromides. Salicylic Acid and its Chloral Hydrate. salts. Volatile Oils. SQUIBB'S MATERIA MEDICA 495 SO' ■ss si e S O 3 s e 5 so H CO g^ H gl W II ft. ■§! 0$.. .S ft eagS sal's o 5 O pt 1-i cr, * ^ 00 to ffi 00 ■* CD 00 IN CD ; (N 1^ CO (N CO t^ OS o C^ OS CO 00 t^ •* IN ( « r-i l-H IN CO lO t> c '^ -^ c4 ■* d ^00 IN d -* - d O IC o »o l-H l-H (N s 1:^ l-H CO ■* OS IN 00 (N l-H T-t (N s? l> ■!)H 00 IN CO TH !N 00 ■* ( in tH •■* ta 1-H IN s T-H CO •* OS 00 o C OS ■'S< OS 00 00 ^ iH l-H (N CO Is ""-, ^ o 6? OS ' OJ 00 l> CD ^ c l-H lO IN 1 iH T-H IN CO 1-H C<1 CO •* , CO 00 IN CO ^ I> ■* 00 o 00 l-H (N CO l-H i-H 1?? to CO m OS !?i 00 ■* CD 00 o ^ ■* oi 00 I> i> ta ■* 1-H 00 cc IN 1— I IN CO la t> l-H l-H 1-H «! ^ CO to IN 00 ■* CO 00 IN CO H (N Th d CO 00 t> d ■2 CO •^ !-l l-H l-H IN CO la t^ ■* a> 00 - l^ CD lO IN 'It es l-H (N lO 00 l-H t^ CO in CD :s »H_ c4 ■* d d co l-H 00 l-H ^ ^ t^ CO ■Sg lO 1— t CO ■* m 00 9^ ' CO B •* 02 , 00 t- CD ■* CO OS CO 1-H "3 d 6 1-4 (N CO ui l> d l-H g .So CO IN l-H I^ IN •* W3 t; o N ^ OS CO 00 i> ,CD ■* CO -^2 6 d d 1-i 1-5 ^ .eg Tt^ 00 to ■* N HH 1-H CI S 00 l-H I> S2 ■* lO 1-H IN ■ CO ^-H ^ C3 d d d d tH l-H ci CO P5 O, .sS- g s o g o l-H N sa £2 O l-H CO ^ CO OS Cfl 00 ■^ C3 d d d d d rH 1-H (N r>. ■^ 00 IN ""co~ •*. « & S 5 r-l ■* 00 iH fc; sa o l-H N CO ^ CO OS CO 00 6 d d d d d d iH tH :D i-t C% Viscous Mineral Oil, Crystal-clear, Odor- less, Tasteless, and Non-irritating. An Efficient, . Harmless Intestinal Evacuant and Lubricant TYPES DF MINERAL OIL For the successful treatment of intestinal stasis' and constipation, the employment of a mineral oil of correct constitution and of highest purity is imperative. In pursuance of our long-established and well-knoWn policy to supply of every product only the best quality for the purpose intended, we have made a thorough and exhaustive study of all American and Russian mineral oils obtainable. After more than five yeairs of such careful investigatior^ and research we are able "to statg,: First. — There are two distinct types of mineral ojl for intern&l use oifered in the market, differing greatly in physi- cal and in chemical properties, namely": (a) The light oils Tvith no ' characteristic viscosity. They belong to the methane^ or paraffin series of hydro- carbons jind include" not only all the low gravity oils of the methane series which are imported from Russia but also all American mineral oils: except - the Squibb Mineral Oil. (b) The heavy oils of considerable viscosity. They consist principally of polymethyl'enes, i.e.,^ hydrocarbons of the naphthene series. These are -derived solely from crudes found only in certain parts of Russia and, also in California.' which-latter crude has a naphthene con- tent far greater than "any other known crude Jh the world. 496 SQUiBB'S MATERIA MEDICA 497 In short, numerous comparative, tests made by us show the Californian heavy oil to , differ in esseijitial respects from, all other American oils and also to be superior to the Russian oils. . |We, therefore, have selectedjhjs, C^Ji/ornian /leavi; oil of high viscosit\} as the pe^t mineral oil obtainable for the internal treatment of intestinal stasis and con- stipation, and supply it alone on all orders,. It is refined under our control and exclusively for us only by the Sl^Tidard, Oil Company of California, which has no connection with any; other_ Standard Oil Company? s This Liquid . Petrolatum Squibb; . Heavy (Cali- fornian), meets the quality specifications as follows: . Jt is pure; free from, paraffins, inorganic me^tter, organic PITRITY sulphur compounds and all inju- rious hydrocarbons such as anthra- — — ■_ 1 cene, phenanthrene, chrysene and all oxidized acid and basic bodies. u ' It is coZor/ess, o^or/ess' and 'fai/eZess. ;.-- ji:: ; cDcr-iri/- It has the V.erv High Specific SPpCJFIC Graviiyi GRAVITY 0.886 to 0:895 at 1 5? C. (59° F.) — ■ ^ 0.861 to 0.890 at 25° C. (77° F.) '-'/( has the Exceptionally High Natural Viscosit;^ 571 to 586 Saybolt at 25'=^ C. (77°-F,) ~- 265 to 278 Saybolt.at 37,7°'C.(iqO°.F.) or, according to U.S. P. standard, VISCOSITY 7.0 to' 7:6 at 25° C.;(77° F.) '•"' - - - ^ I which is "bver four points higher than thfe requirements of thrU. S.P. (IX Revision)/ , This'high viscosity J|s, of supreme importance because tiie ciinical' value of liquid petrolai^uni is in lubrication, and true viscosity is the index of lubricating power. - In selecting a mineral pil for infernal use, it should be borne in 'mind that viscosity and specific gravity '^ear no necessary relation to each other. .v-Again it should ^. re^nembered tfiat thin oil to which 'paraffin has been ^ddefl m^y^a^pefr viscous,- bi^t upon tjEiSting I will, show .itself tq be ^rp^lly a thiij-oil. A Aijl oil never li^jicates,,as,weiras oiie that is highly viscous, Aiid,an oil oif low viscosity may pass 'through the intestine 498 SQUIBB'S MATERIA MEDICA without producing any serviceable lubrication ; also a thin oil b apt to cause leakage or dribbling. Further, viscosity diminishes verp rapidls as the tem- perature rises. This is particularly true of all thin oils. It is essential for the physician to know that the liquid petrolatum that he uses has the necessary viscosity at the, temperature of the inside of the intestine. Therefore, special attention is called to the particularly high and efficient viscosity of Liquid Petrolatum Squibb, Heavy (Californian) at 37.7° C. (100° F.). Also, this viscosity is natural; the Squibb oil is not sophisticated in any way and therefore maintains its high viscosity at body temperature. Action and Remedial Uses Liquid Petrolatum Squibb, Heavy ( Calif ornian) , is not an aperient, a laxative, a cathartic or a purgative, but a mechanical lubricant. It is not absorbed by the stomach or intestine, does not act on and is not acted upon by the fluids of the gastro-intestinal tract, and passes out of the body un- EVACUANT changed and in the same quantity f^*^R that it entered. During its passage GENERAL USE it lubricates the lumen of the gut, softens faeces, prevents injury of the mucous membrane by scybala, allows repair of an already abraded mucosa, relieves ir- ritated or fatigued myenteric ganglia, and thus, by per- mitting a rapid passage of the intestinal contents, prevents the proliferation of bacteria and the production of toxins and a consequent toxaemia. In short, its use establishes and maintains a proper body drainage, i.e., a normal bowel activity, allowing better digestion and absorption of food, without the formation of a habit. Liquid Petrolatum Squibb, Heavy (Californian) , is used to correct the constipation of pregnancy, to avoid the hemorrhoidal condition which so often attends it, to prevent or re- DURING PREG- lieve postpartum intestinal stasis, NANCY AND and for all other conditions for LACTATION which it is indicated. Liquid Petrolatum Squibb may be used IN SURGERY SQUIBB'S MATERIA MEDICA 499 by the mother in any necessary amount, without fear of any influence on her child, since the oil does not enter the maternal circulation, but exercises its influence in a mechanical way in the gastro-intestinal tract alone. It is used surgically as an aid in differentiating a surgi- cal intestinal case from one non-surgical; also as a pro- phylactic to prevent the ascent of intestinal bacteria, thereby pre- venting secondary infection of bili- ary and other ducts; also to regulate the bowels before and after operation. ' It is useful as a dressing for burns, also for nasal packings and spray. Liquid Petrolatum Squibb, Heavy" (Californian) , sprays better than does a light IN NOSE oil, and lubricates the nasal AND THROAT mucosa more thoroughly ^ind the 1 lubrication is more lasting. As pure liquid petrolatum has no physiological action, it may be given in any quan- tities without harm. As it is not chemically active and resists chemical change, it is compatible with any medica- cation indicated. However, certain facts about dosage are worthy of note. The length and calibre of the gastro- intestinal tract differ not only with age, but in. different individuals of the same age, therefore the quantity -of oil necessary for lubrication may vary. Also the conditions for which h,eavy liquid petrolatum is indicated are various, so the size and number of doses will vary. Then, too, there must be considered the nature, amount and consis- tency of the contents of the bowel ; the pathological relax- ation or hypertonicity of the intestinal walls ; the degree of entero- or viscero-ptosis ; the number, kind and place of adhesions, bands or kinks; also whether the life of the patient is active or sedentary. Larger and more frequent doses are necessary at the beginning of treatment than after a normal intesrtinal condition has been established. In every case a mini- ADMINISTRATION OF SQUIBB'S MINERAL OIL 5.0iO SQUIB B'S. MATERIA MEDIQA mum regulating . do^e, should be : determined and ' main- tamed, not became more oihivould do harm, but becattse it Tvould 'he wasted.' ■ t.:: ■ >;r, -i Intestinal' lubrication can be produced best when the gastro-intestinal tract is comparatively empty. -■ The best time for administration, then, is between jinpals, and at bedtime. Howeyer, individual prefereppes. for other times may be gratified, For an adult,, to begin rvith one tablespwonful- twice .a j^ayr between meals -and on-go- DOSAGE .jjig jQ [jgj^ jgj-gy increasing or de- creasing the same according' to effect desiredv Children and infants in proportion. As Liquid Petrolatum Squibb, Heav\) {Calif omian), is odorless and tasteless, flavpring or a menstruum is not necessary, although such may be added if desired.. The following facts concerning Squibb's Mineral Oil are worthy of emphasis?^ /. Liquid: Petrolatum Squibb, Heavv {CaUfprnian) is a piire naphthene oil. This is an impbrtani fact be- cause a naphthene oil is not 'likely to be contaminated Tviih hydrocarbons Tvhich can be absorbed from the in- testine by the humari- system, while all other American oils, as i»ell as Russian oils, are quite likely to be so contaminated. Explanation-^-ParaSin trudes, i.e., petroleum as it comes from the earth; contain many hydrocarbons be- sides those which belong to the methane series. Such are olefins and acetylenes, and other unsaturated hy- drocarbons. These unsaturated' hydrocarbons are readily absorbed by the human system and cause bodily harm when so absorbed. In refilling, it is more or less difficult to free a paraffin oil from all olefins, etc., if such are abundant in the crude, and an oil is undesir- able for internal use if it contain any olefins or other unsaturated hydrocarbons. Again, olefins, acetylenes, and similar hydrocarbons may, under Certain conditions, be formed from pure paraffin oil, in spite of the greatest care to avoid the- SQUIBB'S MATERIA -MEDICA 501 ronnation oi' them. -Thus, '=\when !fcrudei petroleum is refined in an endeavor to get a paraffin oil as pure as possibly, what is, ,)tnpwn as ",p;racking" may occur. 'Crjacking" is a tacj^nical jterm whiclv denotes a change of some hydrocarbons into hydrocarbons of lower density and of other , different cliaracteritics. This is due , to the heat,, pressure, etc. ' , / ' - Sometimes "cracking" is done purposely to obtain these different. hydrocarbons; but when paraffin is refined the heat- and time necessary for refining may cause differ- ent hydroca-riyons to form, although they may not be d#sii:ed. It is -therefore difficult to obte^in a pure paraffin oil. -•■ — - /": ) !' Naphthenesi however, are much more stable than paraffins and resist chemical action much more strongly. Again, in highly concenti'ated' naphthene crudes, sUch as those 'from Galifornia, undesirable hydrocarbons or' other compounds do not exist inany q^Uantity, andithe stability of the naphthene molecule allows a refining process which can easily free the oil from any and all undesiretble com- pounds- that may , be present, and this withoiit the forma- tion of olefins or other unsaturaited hydrocarbons. ■^ Therefore, while a paraffin oil may not be a safe or otherwise desirable oil for internal use,' a naphthene oil (refined from Calif ornian crude' composed almost en- tirely of naphthenes) is faultless. Further, and whatValso is important, a naphthene oil is capable of: a much . higher viscosity than is a paraffin oiL Such a |>ure, safe, aiid highly -viscous naphthene oil is Liquid Petrolattim'Sq^liblD, HeftVy (Californian). //. Liquid Pettolalum Squibb, Heav^ {Calif ornian), is superior ,notrOnln,, to , all olh&r-j American mineral qils, but also to the. Russian oils. ^ - ,l j^^, Explanaiion.^-F or two reasons a .naphthene ::Pil is - superior-f or internal use to airy, paraffin pil, , . -i - ■I, Because 'a; naphthene oil is not contaminatedf with ''unsaturated" hydrocarhons. " Unsaturated^ hydrocar- bons are olefeis; acetylenes, etc., which because some carbon atodis- in the, molecule: are , not; /saturated, with hydrogen, f.Ci* have more than-onie bond'.of union, may 502 SQUIBB'S MATERIA MEDICA be absorbed from the Intestinal tract and do harm when in the human system. 2. Also, a naphthene oil can be mad^ to have a much higher viscosity, and the chief value of a mineral oil for internal use depends upon its high viscosity. All American mineral oils except Liquid Petrolatum Squibb, Heavy (Califomian) are composed chiefly of paraffins. Liquid Petrolatum Squibb, Heavy (Cali- fomian), is composed wholly of naphthenes. Further, a Russian mineral oil is not necessarily a naphthene oil. It is true that the Russian Baku oil has been found to contain about 80% of naphthenes. However, other Russian oils (Uke the Pennsylvania oils) are composed principally of paraffins. Thus a mineral oil, although it may be a genuine Russian oil, may be no better than an ordinary American oil, while even if it is a genuine Baku oil, the best that Russia has to offer, it is not as good as the Califomian oil, which is the best the world has, be- cause even in the crude it is composed' almost entirely of naphthenes. So then, if the best Russian mineral oil were under consideration, the Heavy Califomian Oil is superior to it, because Heavy Califomian Oil is composed entirely of naphthenes. This is both an important distinction and an important difference. ///. A highly viscous oil V>ill lubricate the Jvalls of the intestine and otherwise act in the bowels better than will a thin oil. A naphthene oil has a much higher true viscosifj; than has a paraffin oil. Therefore a pure naphthene oil is the best mineral oil for internal use. Explanation. — Lubricating the intestine, softening the feeces, and inhibiting bacterial growth and the speedy removal of faeces from the colon are the four valu- able factors in the successful working of mineral oil for internal use, and any mineral oil offered for internal use should fulfil all these requirements, which it cannot do unless it has a sufficiently high true viscosity. The more viscous the oil the more slowly it is dis- tributed over the inside walls of the intestine; the more SQUIBB'S MATERIA MEDICA 503 tenaciously it holds to the bowel wall, and the longer its lubrication remains effective. (Thin oils quickly run off from the walls, collect in the rectum, and leak out). The more viscous the oil the more intimately it will mix with the faeces. Also a thin oil, even after mixing, may run out again. The more viscous the oil the longer it will remain mixed. Indeed, a highly viscous oil when once mixed with the' faeces will not separate from them before the faeces are expelled. The permanent mixing effectually softens the faeces, keeps them soft, and favors speedy and easy expulsion, without injury to the bowel •wall. Again, the more thoroughly a mineral oil is mixed with the faeces the less water (moisture) the faeces can contain. Moisture is necessary for the growth and increase in numbers of bacteria. This keeping water out of the faeces is one way in which a ■\;J5Cous mineral oil inhibits bacterial .growth. Another way in which the growth and numerical in- crease of bacteria is prevented by a highly viscous oil such as Squibb's Mineral Oil is by coating with oil the material used, as food by the bacteria, and also by coat- ing the bacteria themselves. All micro-organisms require food if they are to grow and multiply, and if this food is so enclosed in a coating of oil that the bacteria can not get at it, or make use oT it if they do come in contact with it, or if the micro- organisms themselves are so covered that they cannot receive nourishment, they cannot grow and multiply. A thin oil will not effectively coat either food of use to bacteria or the bacteria theinselves, while a highly viscous oil will coal both. Thus Liquid Petrolatum Squibb, because it is highly viscous at the temperature of the inside of the intestine, effectually deprives intestinal bac- teria of the nourishment necessary for their growth and^ proliferation. Again, a highly viscous oil effectively coats the inside of the intestine and permits the healing of any abrasions. It is quite common for food residues to wound the intes- tine. These little wounds may let bacteria and toxins 504 SQUIBB'S MATERIA MEDICA enter the blood stream. Thin oils neither coat the intestine thoroughly enough, nor for a sufficiently long time to permit healing. A highly viscous oil, such as Squibb's Mineral Oil, will effectively coat the abrawled surface and give ample opportunity for healing. IV. — A normal passage of the botvel contents is to be sought and maintained because an abnormal 'delay in the passing on and out of the contents of the intestine causes mani; conditions which produce ultimate discomfort or disease. Explanation. — If there is- stasis, i.e., a slowing of the • normal movement of the bowel, then irritation of the lining membrane of the intestine and even inflammation of it may result. Delay allows the proliferation of bacteria. Now bacteria, by their action on proteids, may produce substances that may act as poisons (toxins) if they are abSBrbed into the system from the bowel. Therefore if bacteria increase abnormally there may be produced toxins which a diseased intestinal membrane may absorb, and these toxins when in the system may cause trouble in parts of the body "remote from where they entered. A thin mineral oil cannot keep up a normal movement of the bowel, or indeed any series of continual movements, unless it is taken so frequently and in such quantities as to cause distress, indigestion and leakage. As Liquid Petrolatum Squibb, Heavy (Californian) , is pure and highly viscous, it will produce and continue desirable bowel movements and finally restore normal bowel activity, and will do this without forming a habit of taking oil. Further, as the necessary dosage of Squibb's Mineral Oil is small, it is an economical oil; also in any such dosage there will be no leakage or other disagreeable symptoms attending its use. V. — If desirable results from the use of a good "Min- eral oil are to be had, attention must be given to the natural Tvajj the oil Works as rvell as to the hatural way SQUIBB'S MATERIA MEDICA 505 the bodily organs are affected by oil, i.e., the size of the dose and the time ■ of talphg must be taken into account. This is as true of mineral oil as of any other remedy. Explanation. — 1. Mineral oil in the stomach may coat over large masses of food. Now, as it is neces- sary for the digestive fluids to have free access to food if a normal digestion is to take place, and as the digestive fluids cannot easily get at masses of food coated with mineral oil, it, is evident that i mineral oil should , not be taken at a time when such coating of food coiild take place, namely within an hour before or after eating. ^,„;.^,^^ ^ , ,.._,,;-, Although the>' chances of noticeable disturbance from this cause may be. remote in many cases, inasmuch as it is never necessary to take mineral oil, near the time of eating, it is best to avoid taking mineral oil wtihin one hour of eating, either before or after. -2. Another physiological action of mineral oil, , one with which you need not biirden your mind but which, in order to meet ■ some doctor's difficulty, you may find it necessary at times- to recall, is this:. As long as oil of any kind is in the stomach, the pylorus, does not open as often or, as fully as it, does if no oil is, present, and thus ^ food is kept in the stomach longer than it should be jgtained. Such a -delay may cause symptoms of indi- gestion. This condit^ia can be prevented by avoiding the taking, ^i .pij near the time of eating. ; 3. If much more oil. than is necessary to completely lubricate the walls of the intestine and to fflUy soften the faeces is taken, the • excess may leak out, so it is well not to take excessive doses of the; oil. yi. — Liquid Petrolatum may dissolve intestinal tox' ins, hold them in solution and quickly eliminate them from the body. Explanation. — Under abnormal conditions in the bowel, various products may he formed which not only may cause distress in; the intestine,, but also, if they are absorbed', in the system, may act as poisons (toxins). These when held in solution by liquid petrolatum are 506 SQUIBB'S MATERIA MEDICA not as likely to be absorbed in the system as when they are free and they will be eliminated quickly with the stools. Sometimes these substances have color emd the liquid petrolatum holding them in solution may be seen colored. However, all color of liquid petrolatum as it appears in the stools is not due to toxins. Many non- toxic substances may color it. This speedy and non-irritating elimination of the con- tents of the bowel tp liquid petrolatum is the factor of greatest value in preventing the formation, the retention and absorption of toxic material. VII. — As Mineral Oil is not a medicine but an aid to physiological bodily functioning, it may be necessary to continue the taking of it for some time if the desired results are to be had. Explanation. — The action of mineral oil when taken internally is that of a mechanical lubricant of the bowels, softener of the faeces, and remover of toxins. It prp- tects the membrane and prevents injury to it, while it softens faeces and prevents the accumulation of moisture in them and hence inhibits the growth and the increase of bacteria. Thus it relieves irritation, allows healing of the intestinal membrane, and permits normal processes of nourishing the body to be restored. In other words, it puts a stop to abnormal processes and allows nature to re-establish normal activities. Nature cannot do this all at once. How long it will take will depend on how extensively and to what degree the normal processes have been deranged. The oil must be taken for a time long enough to permit complete restoration of the normal bowel activity. It is of interest that, however long the oil may be taken, no habit of taking oil will be formed. So the-taking of mineral oil should be persisted in until the desired results are had. VIII. — Note: For the reasons given above, and also for other causes Tvhieh it is not possible to set forth within the Umits of such brief summaries of facts as have been here made, it is important, rvhen ordering mineral oil for internal use, to specify SQUIBB'S. Squibb's Chlorinated Antiseptics and Disinfectants CMoramine-T, Chloramine-T Paste; Dichloramine-T; Chlorcosane; Halazone Tablets. Chloramine-T Squibb is water-soluble, while DicMor- amine-T Squibb is oil-soluble, for which Chlorcosane Squibb is the one satisfactory GENERAL solvent. Chloramine-T Sur- DESCRIPTION gical Paste is ready for imme- diate application. These are available and easily used antiseptics and are of the high- est value and greatest convenience in every-day civil practice. Halazone Squibb is an effective disinfectant for small quantities of water for drinking. It should be borne in mind that while the result of the researches of Dr.. H. D. Dakin, the chloramines are not "Dakin's Solution." What is technically known as "Da- kin's Solution" is a neutral solu- tion of sodium hypochlorite. It is an efficacious antiseptic but requires for its successful use special apparatus and a twenty-four hours' service of a nurse, inasmuch as a continuous application is necessary, as well as frequent bacterial examination of the wound. Then, too, the solution itself is difficult to make and quite unstable. The chloramines are very different from this. They are the outcome of Dakin's efforts to overcome the diffi- culties presented by the neutral solution of sodium hypo- chlorite. So while the Dakin solution is efficacious and of value in military hospitals and other institutions where specialists in chemistry and bacteriology are in constant attendance and the nursing force is adequate, the chlor- 507 CHLORAMINES ARE NOT "DAKIN'S SOLUTION" 508 SQUIBB'S MATERIA MEDICA amiiiel are of 'Valtte^n'-srtialiiio^italr and ill every-ilay civil surgerjrjias.i theyi-d'o not resjuire^any, spfecial appa- ratus, specialist's, or' extra pbrsdnnel. They* sire easily made ready j fo^ u|a;. by "simfily dissQlving ^the Chlor- 8unine-T in water or the DicTiloramirie^T in C!lilorcosane. They are applied by means of gauze, tampK)n, packing, or by'spfay; Renewal - of tener than once in twenty-four hours is seldom necessary. ,";-( -j., ..jjv..i CHLORAMINE-T SQUIBB (Water-Soluble) Chloraraine-T, a name shortened for convenience in use , from toluene-parasodiumsulphonchloramine, desig- CHLORAMINE-Tt I nates a wlute. crystalline solid, . , I without odor, and contammg 12.6 percent, of chlorine. Readily soluble in water, its solutions have a bitter taste and are comparatively stable, no appreciable decompo- sitipn taking place upkjn exposure to ordinary room light and temperature. Compared with an equimolecular solu- tion of neutral sodium hypochlorite, ChloraBnine-T gives up its chlorine less rapidly, has an antiseptic value about four times greater than that of the hypochlorites, is more efficient in the presence of blood' than is neutral sodiiiiii hypochlorite, has a relatively shght solvent action on necrotic tissue, has a prolonged antiseptic activity, and is less irritating than the hypochlorites. "In severe septic conditions much of the Chloramine-T is promptly decomposed by the secretions. This is true of all anti-i septics of the chlorine group and is even more marked in the case of hjfpochlorifes than with Chloramine-T."^ Dakin writes, "In place of the hypochlorite, the more stable Chloramine-T has been used to a considerable ' extent and with particular suc- COMPARED WITH SODIUM HYPpCHLORITES cess in fresh industrial acci- dents. It is usually used in 0.5-2 percent, solution and its action is similar to that of hypo- chlorite save that necrotic tissue is less rapidly removed."^ Again, "Chloramine-T can be used in stronger solution (up to two percent.) than can the hypiochlorites. It is more stable and exerts, more pro- ^A Handbook of Antiseptics, by Henry Drysdale Dakin and Edward Kellogg Dunham. ^Ibid. RELATIVE ACTION OF SQUIBB'S MATERIA MEDICA 5D9 longed antiseptic action. . '^ . .^ It is not toxic -'and is l«ss irritating than the hypbchlorites."^ While in no case inferior, under certain conditions, it is considerably more efficient than are they. - Chloramine-T may be used' in solution or dry (rubbed into gauze) or in a paste. Dakin says that Chloramine-T can be used in stronger solu- tions than can the hypochlo- rites. A two percent, solution is considerably more potent than the usual solution of sodium hypochlorite. ''It is not toxic and is lessL irritating thain the hypochlorites" and has but . little solvent action on necrosed tissue. : It is well suited for use on wouads previously cleansed" with- hypo- chlorites or DichloraminerT, and in suitably dilute solu- tions may be used in the eye and on other sensitive parts." •,!-■>,!■>.•. -. ■; "In equimolecular solutions its germicidal activity is about fourjtimes that of sodium hypochlorite," il- e., Dakin's Solution.? . .■ . "Itsi germicidal auition is rapidly exerted'-and in most re- spects it resembles theihypq- -i chlorites 'closely-, though -de- ■ cidedly- less irritating than the latter."^ Itimiy be applied (for wound treatment) in solution, in the -dry state as an impregnation of gauze, or in a cream-like i>aste. ' . .• . "Although there were no cases reported to show that four percent, solutions of 03' Chloi*amine-T were unduly ir- STHENGTH OF rfta'ting, subsequent experience SOLUTION has -shown that there i^no'bc- "i"^ ~- ~- ■ casion for exceeding a concen- tration of 2 percent. For, las Chloramine-T has, weight for-. weight, as great a germicidal power as sodium' hypd- chlorite, a 2 percent, solution is considerably more potent ■than the neutral solution of. sodium hypbchlorite (Dakin's Solution-), usually empbyed (0.5 percent.). Jlie 2 per- cent, solution may be used for the treatment pr septic -wounds, using the same methods as employed foi- the hypochlorites."* ^Dakin and Dunham, Handbook of Antiseptic^- ,aibid. -■ SIbid. ,--■'! :■' . •Ibid.- '..-■,■■ ■' ■'■ GERMICIDAL VALUE OF 510 SQUIBB'S MATERIA MEDICA Chloramine-T* has been used with success to irrigate the pleural cavity in empyae- USES OF I ma, the urinary bladder, the gall bladder, sinuses, the ure- thra, etc. Also as a douche for the vagina, the ear and the nose. It has also been found to exert a satisfactory germi- cidal action in the eye when used in a 1:1 000 solution. To disinfect meningococcus carriers Chloramine-T used by steam spray and applied locally in water solu-j tions has been employed with FOR CARRIERS J success. Dakin further writes, ~ • "In spite of limitations, chiefly imposed by anatomical conditions, valuable results have been obtained . . . with the use of antiseptics in the treatment of meningococcus carriers among soldiers '■'■ in the following ways: 1 . By use of steam spray and solution of Chlor- amine-T. 2. Local aippHcation of Chloramine-T in water and especially Dichloramine-T dissolved in oil. Gordon and Flack used 0.5 percent, solution of Chloramine-T or 1 .2 percent, solution of zinc sulphate. "The Chloramine-T gave the better results especially with persistent carriers," although to a slight degree it was not as well tolerated as the solution of zinc sulphate. For full description of methods employed and the character of results the original articles* should be consulted. Since Chloramine-T is non4oxic and is stable, "the choice of strength must be left to the judgment of the surgeon. In practice, it is advisable to keep a 2 percent, solution in stock and dilute this, if necessary, either with water, or in case of considerable dilu- tion, with normal saline solution. A 2 percent, solution is sUghtly hypotonic and when an approximately isotonic medium is desired, normal saline solution should be used as a diluent. Chloramine-T, like hypochlorites, has a corro- sive action on most metals and should not be used ~-for the 'Dakin and Dunham, Handbook of Antiseptics, *For authorities^ exSbt references to quotations, details of uses, etc., see "Squibb's Chlorinated Antiseptics, Disinfectants and Solvents," Revised Edition, 1918. October, Brochure No. 9. STOCK SOLUTION OF CORRODES METALS SQUIBB'S MATERIA MEDICA 511 sterilization of instruments."^ For sprays, atomizing tubes of glass are preferable. Again: "ChloraminerT is well adapted for use in im- pregnated gauze, for which very few substances of high r.RViMrAii7i7 I antiseptic value have proved DBY IN GAUZE | guecessful. It is possible, for example, to incorporate in the gauze Chlo*ramine-T to an amount equal to 25 percent, of the weight of the gauze ... an amount, how- ever, larger than is advisable, 5 percent, being adequate. ,. . . The gauze should not be moistened before use. ... It can be used dry for lightly packing and subsequently moistened, if necessary, when in posi- tion."^ Impregnated gauze is of most value in recent wounds to check progress of infection, therefore particu- larly usef'ul for industrial accidents "where treatment can be promptly instituted." Further: ''Chlorainine-T and Dichloramine-T give materially better results than the hypochlorites w'hen act-, ing on organisms in a blood medium."^ Chloramine-T Surgical Paste Squibb is composed of one percent, of toluene-parasodiumsulphonchloramine in the neutral base sodium stearate. , This paste is sufficiently firm not to flovi away when applied to a wound and yet fluid enough to be moulded to the anfractu- osities of a granulating surface or of a fractured bone. "Chloramine-T Paste is designed to maintain in an aseptic condition wounds which already have been dis- infected or to sterilize wounds RATIONALE OF CHLORAMINE-T SURGICAL PASTE FOR WHAT CHLORAMINE-T PASTE IS USEFUL which are only slightly infected. It should be applied only to wounds which yield small quan- tities of secretion; which Have little or no necrotic tissue, or 'which have only little or no infection."* "Chloramine-T Paste cannot sterilize severely infected wounds."® Carrel and Hartmann, 'Dakin and Dunham, Handbook of Antiseptics. "Ibid. sibjd. ' Vour. Exp. Med., N. Y., XXVI, p. 97. »Ibid., p. 118. 512 SQUIBB'S MATERIA MEDICA after prolonged investigation, state as their conclusions that " ( I ) under the conditions of our experiments chlor- amine paste maintains the asepsis of a wound already sterile, and sterilizes an infected wound. (2) Under the same conditions chloramine paste causes no apparent modification of the cicatrization curve of an aseptic wound. "^ Dakin and Dunham write: "When the frequent re- newal of the antiseptic is impracticable or not desired, recourse may be had to pastes or oils . . . which embody a store of antiseptics that may be gradually utilized. The mild antiseptic action ... of Chlor- amine-T Paste is often useful to maintain sterility and prevent reinfection of wounds which have previously received more vigorous treatment."^ . . . "The paste is not oleagenous. It has a creamy consistency and can be spread readily. As the antiseptic is dissolved in the water constituting- the chief bulk of the paste, it has ready access to the parts treated."' For full directions for the use of Chloramine-T Sur- gical Paste, see Journal of Experimental Medicine, Vol. XXVI, pp. 91 and 97. DICHLORAMINE-T SQUIBB (Oii^Soluble) (A) Nature of Dichloramine-T .Dichloramine-T, shortened for convenience in use from toluene parasulphondichloramine, is the name of a crys- talline solid, slightly yellowish in color, of somewhat sweetish taste, and having a pungent odor resembling chlorine. It differs from Chloramine-T in having the sodium atom replaced by an atom of chlorine. Dichloramine-T is comparatively stable under ordinary conditions tut solutions of it are somewhat unstable. It is only very slightly soluble in water but rather freely DICHLORAMINE-T DEFINED Voiir. Exp. Med., N. Y., XXVI, p. 118. ^Dakin and Dunham, Handbook of Antiseptics. »Ibid. SURGICAL. VALUE OF SQUIBB-S MATERIA MEDICA 513 cr>i itoTi ,^, ^^ I soluble in chlorinated- eucalyp- SOLUBILITY OF tol. and. particularly, in chlor- cosane (see below). It is a very active germicide. Like certain other compounds contaming chbrme. it should be protected from light and be kept in black bottles. "Solutions are not permanent.^ especially in the pres- ence of liquid petrolatum, but a 10 per cent, solution of Dichloramine-T in chlorinated eucalyptol may be kept in a colored bottle for at least one month wfth but 25 per cent, (^composition." This solution may Jjc mixed extempore with chlorinated paraffin oil.^ « Dakin and Dunham" say that "when prolonged (anti- septic) action is required and frequent application is im- possible, recourse must be had to more stable mixtures which yield up their store of antisep- tic slowly," such as the oily solution of Dichloramine-T. Again: "Dichloramine-T in oil solution has a great advantage over the other chlorine antiseptics in that it may be used in high concentration, and its action is of much longer duration." ' (B) Advantages of Dichloramine-T Lee, Sweet, Hendrix and Le Conte' write. "We offer as a solution of the serious obstacle of skin irritation of the usual chlorine preparations a J>ractically stable, non- irritating, synthetic double chlor- amine conrpound, toluene-par- asulphondichloramine or Di- chloramine-T. this chemical to be used in strengths varying from 5 to 10 per cent, (from twenty to forty times the mass of germicide ever present in the usable concentrations of hsTJOchlorites) dissolved in a chlorinated oil in order that the germicide will be liber- ated over a period of from eighteen to twenty-four hours instead of from thirty minutes to one hour, as with the hypochlorite solutions." fDakin, Lee, Sweet, Hendrix, Le Conte, Jour, Am. Med. Assn., LXIXj Np. 1, 1917, July 7, p. 29, col. 1. 'Dakin aiid Dunham, Handbook of Antiseptics. 'J. A. M. A., 1917,. July 7, p. 29, col. 1. NO IRRITATION OF SKIN FROM 514 SQUIBB'S MATERIA MEDICA (C) Hpnr to Use DkhloTamine-T Dakin and Dunham^ say, "Dichloraiiiine-T dissolved in dily -media may be sprayed USES OF uf)on wound-surfaces or poured - — ■- into accessible parts of deep wounds. ... It is suitable for cases requiring prolonged antiseptic treatment, and for first dressings of recent wounds which do not require irrigation. It is used also for nasal^ antisepsis. It has great advantage over other chlorine antiseptics in that ADVANTAGES OF I it may be- used in high concen- tration and its action is. of much longer duration. Its application is extremely simple and it ordinarily need not be renewed more than once in twenty-four hours." Dakin and Dunham recommend "for surgical purposes a 6.5 to 10 per cent, solution in treated .eucalyptol and paraffin oil, . . . applied by a glass atomizer, poured into Wound cavities or introduced into sinuses by a cotton swab. The amount of the solution needed for each treatment is- extremely small, 1 to 2 Cc. being sufficient for most moderate sized wounds." "The technic of the application of Dichloramime-T is 1 simplicity itself in contradislinc- HOW TO USE [ tion to that of Dakin, Carrel. Dehelly and Depage. After a careful surgical preparation of the wound at the primary dressing, and excision of all foci of infection and of devitalized tissues, the solution is applied on surface wounds with an atomizer in the form of a spray. In deep wounds the cavities are filled with the liquid. When depen- dent drainage exists because of the location of the wounds, or when it has been made purposely, the lower evening is temporarily closed with gauze and then the cavity is filled with the oil, thus covering all the wound surfaces. The ^Dakin and Dunham, Handbook of Antiseptics. "'Dakin, Lee, Sweet. Hejidrix and Le Conte., /. A. M. A., LXIX, No. 1, 1917, July 7, p. 29, col. 2. STRENGTH OF OILY SOLUTION SURFACE AND DEEP WOUNDS SQUIBB'S MATERIA MEDICA 515 DEPENDENT DRAINAGE dependent drainage is then re-established by removing the temporary gauze obstruc- tion. This privilege of depen- dent drainage cannot be prac- ticed with the use of aqueous solutions and the Dakin-Carrel-Dehelly-Depage technic in which the wound must act permanently as a basin to hold the weak solution. We believe that too much stress capnot be laid on tiiis advantage. We have found that it is necessary to apply the oil but once in twenty- four hours, and the wounds should be covered with only a few layers of gauze to avoid the absorption of the oil by the dressings." NATURE OF "CHLORCOSANE CHLORCOSANE SQUIBB (The One Solvent for Dichloramine-T) Chlorcosane-'^ is prepared from paraffin wax by replac- ing part of the hydrogen with chlorine. It is a bland, almost tasteless oil, of high viscosity and in itself inert. Chlorcosane, when at ordinary room temperature, dis- solves Dichloramine-T only very slowly. "To prepare a solution . . . warm about one-quarter of the amount of Chlorcosane required to about 80° Centigrade, add the Dichloramine-T, stir or other- wise agitate the mixture until a solution is had, then add the remaining three-quarters of the Chlorcosane, which should be at room temperature, and if necessary filter the whole solution through dry fluted filter paper. Chlor- cosane will hold from 8 to 1 per cent, of Dichloramine when the solution is at ordinary room temperature." "Solutions of Dichloramine-T in Chlorcosane are re- markably stable considering the high reactivity of Dichloramine. Light is the HOW TO DISSOLVE DICHLORAMINE-T IN CHLORCOSANE STABILITY OF SOLUTION greatest cause of deterioration. Solutions should be kept in amber (or, preferably, black) iThe substance of what is here said concerning Chlorcosane is taken from Major E. K. Dunham's Herter Lectures, New York, 1918, January* 516 SQUIBB'S MATERIA MEDICA bottles and protected from iieat and moisture." As a rule a solution properly made will keep under favorable conditions for several weeks. Decomposition should be distinguished from the formation of precipitate on account of chilling the solution. If a solution of Dichloramine-T in Chlorcosane is chilled to a certain degree, Dichlora- mine-T will be thrown out of solution. By gently warm- ing the solution this precipitate will be dissolved. For application to wounds a solution stronger than 5 per cent, of Dichloramine-T should not be used. "The solution may be applied directly to the surface of the wound by any convenient way, spraying being considered the best." Since 5 i>er cent, and stronger solutions are too viscous for use HOW TO USE ;„ ^ hand atomizer, a power SOLUTIONS OF apparatus is necessary with a pressure of from 1 5 to 20 pounds. It is better not to thin the solution by a diluent. If a suitable atomizer is not available, "a grooved director, cotton swab, medicine dropper or a glass syringe may be employed. ... In ordinary wounds the application may be once in 24 hours and the dressings very light. For gangrenous or for foul wounds a more frequent application should be made, as the active chlo- rine is consuined more rapidly" (by such wounds). For spraying the nasO-pharynx a 1 per cent, or a 2 per cent, solution is best. HALAZONE SQUIBB (For the Disinfection of Small Quantities OF Water) Dakin calls attention to the unsuitableness of chlorine gas, bleaching powder or sodium hypochlorite for the dis- infection of small quantities of water. Also to the fact that while the acid sulphates of the alkali metals are "undoubtedly useful," the taste imparted by these salts is quite disagreeable to some persons, the solutions of them attack metallic water bottles, and chiefly they do not possess the potency or security afforded by a disinfectant of the chlorine group. Therefore the difficult problem of readily sterilizing small individual quantities of water was SQUIBB'S MATERIA MEDICA . 517 I carefully studied by Dakin because of its importance. As a result he found "the most suitable substance that we have as yet is parasulphondichloraminobenzoic acid." Halazone is a short term for parasulphondichloramino- benzoic acid, CI2N.SO2.C6H4.GOOH. It is a white powder, "sparingly Soluble in water and in chloroform and insoluble in petroleunl." It is best kept and used in tablet form. Dakin's experirnents^ show that "a concentration of 1:300000 will sterilize an ordinarily heavily contami- nated water (e. g. containing cqli, typhoid or cholera organisms) in about thirty minutes." It has little or no action jon ordinary metals, — a "slight action . of no practical moment on aluminum — and imparts 'a just perceptible' but not disagreeable taste to water. Tea brewed with or without the addition of Halazone to the water cannot be distinguished. Even in larger doses Halazone is not toxi&." For use Halazone should be combined with dry sodium carbonate or with dry borax as such increases its solu- bility in water. Dakin consid- ers the best form iii which to use Halazone is tablets. "The practical success of the disinfectant depends very largely on the stability of the tablet." If properly made "tablets are quite stable enough for practical use."^ Dakin and Dunham* write, "The problem of steriliz- ing small individual quantities of water . . . is much more difficult (than ol large qiiantities) , and up to the present it has not been perfectly solved. The use of hypochlorites for such purposes is difficult, owing to the instability of small tablets containing the minute quan- tity of active disinfectant. In their place acid sulphates of the alkali metals have been extensively used in tablet form, but the superior potency, of many chlorine com- pounds would indicate that a stable potable chlorine dis- infectant suitable for the sterilization of small quantities HALAZONE TABLETS ^Handbook of Antiseptics, Dakin and Dunham. ^British Medical Jdurnal, 1917, May 26, I, p, 682. See also British Medical Journal, 1916, Jan. 29, Prbc. Roy. See. ,B. 89, 1916, p. 23'2. 518 .SQUIBB'S MATERIA MEDICA of water is desirable. With this end in view, we have made a number of experiments with various types of substances, one of whieh we believe to be worth practical application. . . . The substance which is the most suitable that we have yet found is parasulphondichl9ra- minobenzoic acid . . . and appears to be effective and reasonably stable. The presence of the COOH group confers a slight but definite degree of solubility in water, which is increased by dispensing it with alkaline salts such as sodium carbonate or bicarbonate, borax or sodium phosphate. . . . Since the synthetic name of the disinfectant is inconveniently long for ordinary use, we propose to apply the name 'Halazone' to the tablets containing it. . . . From the .results (of fexperi- ments) it appears that a concentration of 1 : 300000 is sufficient to sterilize an ordinarily heavily contaminated water in about thirty minutes. Such a concentration could be relied upon to remove colon, typhoid, or cholera organisms. Special experiments showed that the sub- stance in tablet fornl was efficacious when acting on water contained in aluminum- bottles, although a very trifling action on the metal may be observed if tablets are allowed to remain undisturbed in long contact with the metal. We believe such action to be of no practical moment. The concentration of disinfectant given above is just perceptible to the taste, especially in warm water con- taining little organic matter, but the water is perfectly palatable.. One point of advantage possessed by the present disinfectant over most h3^ochlorite preparations is the fact that the active chlorine is less rapidly used up, so that the process of disinfection continues for a con- siderably longer period." The various Squibb chlorinated products are obtain- able in convenient packages, as follows: Chloramine-T Squibb Powder — Amber vial, 582 gr. Amber bottle, 6^ oz. Surgical Paste, 2 oz. tube, J4 lt>-. 1 lb. bottles. Tablets, 4.6 gr., in bottles of 1 00. 500 and 1 .000. Chlorcosane Squibb, J4 Pt-. ' pt- bottles. Dichloramine-T Squibb, 1 oz., ^ lb.. I lb. bottles. SUPERIORITY OF squibb:s TABLETS SQUIBB'S MATERIA MEDICA 519 Squibb's Tablets The great European war has again demonstrated the value of tablet medication. Tablets haVe the approval of the Medical Department of the U. S. Army and Navy, and have been used in the service almost to the exclusion- of pills or capsules. Squibb's Tablets differ from all others; they contain the Squibb quality of ingredients, the formulas are more scien- tifically studied, they are ac- curate in dosage, and because of rapid disintegration, produce prompt and definite therapeutic effects. The rapidity with which the tablet responds, in the presence of watery fluid, such as the saliva or gastric :secretion may be demonstrated by dropping a calbmel or bismuth tablet in water and noticing the result. Ad- vantage may be taken of this fact in treating children or adults who cannot swallow a tablet. If the tablet" is put Into a spoon and a little water added the tablet breaks down to a powdery condition at once. The coating used on the Squibb Tablets is freely soluble, and applied only- in sufficient quantity to mask the taste during the process of swal- lowing; it does not harden by age, and only momentarily hin- ders the disintegration of the tablet, at the. same time it masks all disagreeable odor and taste, prevents decompo- sition, and retards loss of volatile ingredients. . Examinations in our Control Laboratory , of some chocolate-coated Strychnine Sulphate Tablets Squibb over twelve years old, demonstrated the coating to be freely soluble, the disintegration very rapid and the med- ical content as active as when the .tablets were made. Squibb Tablets containing such insoluble medicaments as Acetanilid; Aspirin, Calomel, Bismuth 'salts, Salol, etc., dis- integrate at once in the presence COATED TABLETS NOT AFFECTED BY ACE TABLETS OF INSOLUBLE MEDICAMENJS of water, in the sdliva, or in the digestive secretions. ONLY FIRST QUALITY DRUGS ACCEPTED CAREFULLY EXAMINED FOR FOREIGN MATTER 520 SQUIBB'S MATERIA MEDICA Squibb's Superior Botanicals AH the botanical and other crude drugs used in tiie Squibb Laboratories are obtained from the best known sources and only those of first quality are employed. Ship- ments are accepted: by us only after they have been examined and passed by our e3q)ert pharmacognosists, and by our Control -- Laboratories where they are, .tested chemically; and in many instances they are subjected to additional tests in our Physiological Laboratories. Each drug is first examined macroscoplcally and microscopically, to establish its identity. Then it is thor- oughly garbled to remove any foreign' drugs or parts of the plant which may have been included in the harvesting and which are not included by the official definition. For example: If the bark of the root is the part which the Pharmacopoeia directs to be used, we exclude all bark of the stem and all undue quantities of woody material. Likewise, when leaves are officially specified, stems, etc., must not be present. Also inspection must show plainly that the drug, after collecting, was promptly arid carefully dried and kept in a clean place; and there must be no evidence of fer- mentation or of dirt accumulated during the drying. Fer- mentation caused by packing drugs before they are per- fectly dry is one of the chief causes of change in the active principles. Drugs for which the Pharmacopoeia prescribes a definite alkaloidal strength, are assayed carefully to make ASSAYFD ^^^^ '^^•^ ^^^ ^' \ea^ of that CHEMICALLY AND strength; and in those instances PHYSIOLOGICALLY where biological assay is offi- I cially suggested, the drugs are subjected to the proper tests at our Physiological Laboratories. Furthermore, we also physiologically test andi standardize our ergot prepara- tions, as well as a number of other potent drugs for-which there is no chemical assay established. SPICES ARE OF DIETETIC IMPORTANCE A LINE OF PURE SPICES SQUIBB'S MATERIA MEDICA 521 Squibb's Pure Spices The purity of spices is a matter of as great importance as is the quality of the food to which they are added. In the popular mind the' sole value of spices lies in their prop- erty of imparting an agreeable flavor to food. Aside, however, from this well-knovra virtue, spices are of great dietetic importance, and their selec- tion with the view of obtaining them of full strength and of a high standard of quality is deserving of careful consideration. However, eveii to-day spices are adulterated, or low grades and exhausted residues are reinforced by good ones, to be offered as desirable condiments. Appreciating this condition, the House of E. R. Squibb & Son's supplies a line of spices which are absolutely pure and of highest quality. These can unhesitatingly be recom.- mended to all who desire condiments of distinctive qual- ity and such as are free from sophistication of any kind. The whole spices are selected with the greatest ,care, assayed to make sure they come up to the high standards set by the Squibb Laboratories, and then immediately ground, great care being~taken to avoid volatilization of the essential oils. Inasmuch as these Squibb Spices are pure and con- sequiently of exceptionaF strength, they require to be used in quantities much smaller than ordinary. Therefore, they are economical. A trial is convincing of their excellence. The list comprises: Allspice, Cinnamon, Cloves^ Gin- TU17 criniRR I IST ger. Mace, MJstard (English), 5f pS^e'IpICES^ Nutmeg, Paprika, and Pepper (black, red and white). I hese -r-^. — -spices are put up in air-tight, sifter-top cans holding J4 lb., 2 ozs., and 1 oz, respec- tively, convenient :for table use. They are sold only through druggists; they are not obtainable from grocers. SPANISH RYE ERGOT BEST 522 SQUIBB'S MATERIA MEDIGA Squibb's Ergot Products The House of E. 'R. Squibb & Sons has for a long time been recognized as the first producer of ergot .prep- arations of exceptional quality and absolute reliability. What Dr. Stearns was to the introductory therapy of ergot, Dr. Squibb has been in its pharmacy; he studied it, experimented with it unceasingly, and established the name "Squibb's Ergot" firmly in medicine. Medicinal ergot is a poisonous, parasitic fungus grow- ing on rye. Its value depends very largely upon cautious se- lection, thorough cleansing, careful preservation, correct manipulation ^ until all its essential principles are ex- tracted, and proper packing of the" finished product. Spanish rye ergot is far superior to all other kinds, as the peculiar atmospheric conditions of the Spanish penin- sula favor a more mature and otherwise better growth of the fungus. Squibb's Ergot preparations are made from this Spanish rye ergot 'exclusively. Each year a fresh lot is secured, and upon receipt of. an importation it is subjected to a very thorough process of cleansing by which all extraneous and inert matter is removed. Then as soon as practicable this clean ergot is ground and im- mediately extracted by the Squibb repercolation process, and made up into those preparations which are recog-, nized as safe and efficient for administration. Finally, Squibb's Ergot preparations are carefully tested physiologically according to the method recommended by Drs. Eidmunds and Hale {Hygienid Lab. Bull. No. 76), and admirably conform to their standards. Particular mention may be made of Squibb's Sterile Ergot, an alcohol-free preparation for hypoder- mic or intramuscular injection, physiologically standard- ized so that each mil (Cc.) represents 2 Gm. of Ergot. Consequently, the use of Squibb's Ergot in any of its forms is in no sense a matter of clinical experiment, so often attended with serious risk, but the application of a proven remedial agent carefully prepared, tested and standardized. ' ;., SQUIBB'S ERGOT PRODUCTS TESTED PHYSIOLOGICALLY WELL-SEASONED BARK ONLY VALUABLE SQUIBB'S MATERIA MEDICA 523 Squibb's Cascara Products ' Cascara Sagrada (Rhamnus Purshiana) was discov- ered in Montana, on the banks of a tributary of the T->To/-'/-.\/t7Dv r^T? Columbia River, about 1805, CASCARA SAGRADA °y '"^ members of the farst North American transconti- '- nental exploring expedition under the command of .iUewis and Clark. The plant, along vvrith a number of other unknown drugs collected on the journey, was sent to Frederick Pursh, a German bot- anist of Philadelphia, for botanical study; hence the name "Rhamnus Purshiana." Fresh Cascara Sagrada is believed to contain a fer- ment which is said to be responsible for unpleasant results produced when the drug is administered; while it is maintained that the seasoned bark, such as has been kept a year or more before elaborating it, owes its valuable properties as a laxative, ^ree from griping, to the fact that the ferment has been exhausted by standing. The Squibb Laboratories do not use any cascara bark unless it has been seasoned for more than a Sear; and of such only the choicest bark is employed. 'This care insures a maximum of efficacy and a free- dom from undesirable by-effects to the various prepa- rations of cascara which are marketed under the Squibb label. These include: Extract, Fluidextract, Aromatic Fluid- extract, and Fluid Cascara Aromatic Non-Alcoholic. This non-alcoholic product is identical with Aromatic Fluid- extract Cascara U. S. P. in strength and flavor, but the alcohol has been omitted without sacrificing the keep- ing qualities of the preparation. It has the therapeutic advemtage of eliminating any alcohol effect, a result especially desirable in the case of children. It can unhesitatingly be recommended in preference to the official preparations, and it is offered at a lower price because of the absence of alcohol. For descriptions of these various preparations, see the respective titles in Part I of this book. SQUIBB CASCARA PREPARATIONS 524 SQUIBB-S MATERIA MEDICA Squibb's Compound Alum Powder formerly known as Surgical Powder, consists of ex- siccated alum, camphor and carbolic acid. It was intro- duced by Dr. E. R. Squibb in 1868, and has steadily grown in favor among the medical profession as an emergency dressing and wash. As a styptic, it coagulates blood and at the same time contracts ends of capillary vessels, -thus stopping hem- orrhage unless it be from a large artery. As an antiseptic, it is useful as a first dressing for wounds, to which it may be applied either dry or in solution. As a stimulant, it hastens formation of healthy granu- lation tissue, thereby causing rapid healing of wounds. I As an escharotic, it serves to destroy exuberant growth of granulations and promote normal healing. .As an absorbent, it keeps the wound dry, rendering foul discharges and infection from outside impossible. As an astrirfgent, it prevents hypersecretion and tends to restore the mucous glands to normal activity. As an Emergency Dressing, Squibb's Compound Alum Powder will control hemorrhage and prevent sepsis, giving time to prepare necessary material or transport the patient where all is in -readiness. As a Routine Dressing, Squibb's Compound Alum Powder serves for protecting approximated edges of clean wounds; for protecting and hastening repair. in all •wounds v«th loss of tissue, also of granulating abdominal wounds after laparotomy; for cleaning up ulcers of any size and nature, etc. ; it is also useful in, solution for the nose and throat, as a vaginal douche, etc., and as solu- tion or powder in post-partum hemorrhage. Squibb's Compound Alum Powder should not be sprinkled on sparingly, but applied abundantly. Although in some cases its application may cause slight pain, all discomfort soon passes away and the wound remains painless. Squibb's Compound Alum Powder is offered only in sifter-top cans, which should be kept well closed and in a dry place when not in use. ACTION OF SQUIBB'S MATERIA MEDICA 525 Solution Hypophysis Squibb (Solution of Pituitary Body) Solution Hypophysis Squibb is a sterile aqueous solu- tion of the water-so Juble principles of the posterior lobe of the "pituitary body (hypophysis cerebri). It is stand- ardized, a 1 :20,Q00 dilution of it having the same activ- ity on the isolated uterus of the virgin guinea pig as a 1:20,000,000 solution of histamine. Solution Hypophysis Squibb is a vaso-constrictor. It PHYSIOLOGICAL '' ^''.° ^ Pf^^^^^f stimulant for unstriped muscles, especially ■ those of; the uterus. It acts also, on the intestines and blad- der, particularly when there is lack of normal tone. It exercises apparently a specific action on renal activity.. It has been employed with good results to stimulate USES OF 1 *^^ contractions of the uterus in the second stage of Icibor, in ~- - ■ uterine atony and post-partum hemorrhage, as w,ell as in certain other forms of uterine hemorrhage. It has also found use in certain forms of pulmonary hemorrhage. In post-operative .shock and other conditions of low blood pressure its use has been followed by favorable and persistent results. Its stim- ulating action on the intestines and ^bladder have made it useful in the retention of urine and the jntestinal paresis and distention that may follow abdominal operations. In diabetes insipidus its administration has effectively con- trblled the thirst and polyuria. The dose ranges from 0.3 to 1 .0 Cc. (5 to 1 6 minims) hy- podermically or intramuscular- ly, repeated in 30 to 60 minutes if necessary. The smaller doses are used when it is' desired to stimulate the contractions of the uterus in labor; the larger to control uterine hemorrhage or relieve shock or visceral atony. The skin at the pjoint of injection sjioirid be sterilized, preferably by painting with tincture of iodine. Solution of Hypophysis Squibb is put up in 1 Cc. (1 mil=I6 min.) and 0.5 Cc. (0.5 mil=8 min.) ampuls, and offered in boxes of 6 ampuls. DOSAGE MODE OF ACTION 526 SQUIBB'S MATERIA MEDICA Thromboplastin Squibb Thromboplastin Squibb is a tissue juice from ox brain. It contains all the cerebral thromboplastic substances, including a full complement of kephalin. It is tested physiologically, standardized, and then kept aseptic by the addition of 0.3 per cent, of tricresol. Thromboplastin Squibb is a ruKruac-a trustworthy hemostatic ready ' for instant use. It is efficacious in all kinds of capillary hemorrhage. It will not, however, take the place of a ligature when the hemorrhage is from large veins or arteries or from arteries of moderate size. It should not be relied upon when the vessels, however small, can be closed by clamp ligature or torsion. Thromboplastin Squibb controls hemorrhage by fur- nishing to the blood principles necessary to ensure normal clotting. It does not act me- chanically by forming a local clot nor by constricting the ves- sels but by a true physiological action. Thromboplastin Squibb is supplied in two forms, i. e., either for use locally or for use hypodermically. As a rule local application, which should always be free, is effective. If it does not prove so, then Thromboplastin Hypodermic'Sqmhb should be injected. Thromboplastin Squibb has been used successfully in Mr/un-KT TMr.T,-ATiri-> 1 hemophilia; hemorrhage from WHEN INDICATED ^i i-v i t £ li- the umbilical cord; rrom tiie frenum of the tongue; from' the jaw after extraction of teeth; for bleeding after tonsi- lectomy removal of adenoids, etc. By oral administration it has controlled hemorrhage from the stomach also in some cases from the intestine. The farther from the pylorus the site of, hemorrhage is the less is to be expmcted from the administration' of Thromboplastin Squibb by mouth as it is likely to lose some of its activity on account of digestion during it^ passage through the stomach, duo- denum and jejunum. It has proved efficacious in nasal hemorrhage from diphtheritic and other toxic conjditions, in hemorrhage attending acute leukemia, in blefeding from the kidneys, urinary bladder, prostate, • spinal' cord, etc. SQUIBB'S MAtERIA MEDICA 527 Leucocyte Extract Squibb Leucocyte Extract Squibb is of use in combating in- PURPOSE I fections, and is a product the value of which has been veri- fied by biological investigations and established by clinical experience. It is prepared under the strictest aseptic conditions, PREPARATION I ^?°^^«^S _ to the method of Hiss. By injectmg a sterile veg- ' etable^ protein into the pleural cavities of rabbits or other animals* a purulent exudate is incited, which, when collected, centrifuged, purified, extracted, and proved bacteria free, constitutes Leucocyte Extract Squibb. • It should not replace specific vaccines, specific serums or specific antitoxins. It is of use in connection with the indi- cated vaccine or seirum in acute constitutional infections, such as pyemia, septicemia, and sapremia. Distinct improvement has also been shown to follow its use in labor and post-influenza pneumonia. Equally good results are obtained in erysipelas. It may be used alone while an autogenous vaccine is in prepara- tion or may be Used by itself when it is impossible to obtatin a satisfactory diagnosis, i. e., impossible to deter- mine what microorganism causes the infection. In such cases, as a rule. Leucocyte Extract Squibb is niore desirable than a stock vac- cine, and its use is always more rational than that of a mixed INDICATIONS FOR COMPARATIVE VALUE vaccme. Leucocyte Extract Squibb is put up in syringes of 10 mils (Cc.) each, which is the average dose to be given ADMINISTRATION I one to three times daily. After thorough steriuzation at ^ the ' point of injection the extract is injected subcutaneously. The most desirable sites ior injection are the abdominal wall and the loose tissues of the back. Complete literature will be sent physicians on request. 528 SQUIBB'S MATERIA MEDICA Squibb's Assayed Tinctures The physician when prescribing an alkaloidal tincture, should know, and has a right to demand, that a product be dispensed from which he may obtain prompt action and definite resuhs. The Squibb Assayed Tinctures are made from the best selected drugs, in strict accordance with the official formulas and processes, and are carefully assayed and accurately standardized. In the case of the potent tinctures for whichthe Pharmacopoeia demands or merely recommends physiological assays, those prep- arations are tested by the methods therein outlined and proved to be of standard activity. Uniformity of strength may therefore be depended upon. The following list comprises the tinctures to which assay processes are applied according to the latest revision of the U. S. P. A comprehensive description of each, giving its prop- erties, uses and "doses, is given under the respective^ titles of these tinctures in Part I of this book. We here append a list of them: Tincture Aconite Root Squibb {Tinctura Acpniti). Tincture Belladonna Leaves Squibb ( Tinctura Bel- ladonna Folium). Tincture Cannabis Squibb {Tinctura Cannabis). Tincture Cinchona Squibb (.Tinctura Cinchonce). Tincture Cinchona Compound Squibb {Tinctura Cin- chona Composita). Tincture Colchicum Seed Squibb {Tinctura Colchici Seminis). Tincture Digitalis Squibb {Tinctura Digitalis). Tincture Digitalis Fat-free Squibb. Tincture Hydrastis Squibb {Tinctura Hydrasti?i). Tincture Hyoscyamus Squibb ( Tinctura H^oscyami) . Tincture Nwi Vomica Squibb {Tinctura Nucis Vomica) . Tincture Opium Squibb {Tinctura Opii). Tincture Opium Deodorized Squibb ( Tinctura Opii Deodorati). Tincture Physostignaa Squibb {Tinctura Ph}}sostig- matis). Tincture Stranionium Leaves Squibb {Tinctura Stramonii) . Tincture Strophanthus Squibb {Tinctura Strpphanthi) . SQUIBB'S MATERIA MEDICA 529 Physiological Standardization , Physiological ^ standardization is the application of quantitative physiological methods to medicinal products in order ^at they may be uniform in potency. The idea of such standardization is not new, nor are the methods employed new, but are such as have been in constant use for some of the finer work of physiology and pharmacol- ogy. One great value of physiological standardization is the determination of the potency of certain drugs of therapeu- tic importance which do not, however, lend themselves to assay by chemical or by physical methods. This may be because the active principle is unknown or because the chemical reactions or the physical properties revealed are not sufficiently distinctive to be of value. Further, the active principle, although known, may be present in such a very minute amount that assay by chemical or physical methods can not be accurate. Also, in drugs in which there are several active principles, chemical and physical analyses may for many reasons be impractical. If, therefore, such drugs can be standardized physiolog- ically, that is to say," be made in such a way that a cer- tain bulk of them will always produce a certain physiolog- ieial effect, a condition most valuable for clinical medi- cine has been established. The United States Pharmacopoeia, IXth Revision, has provided physiological assay for certain drugs. All these drugs are assayed by the Squibb Laboratories ac- cording to the U. S. P. method, the details of which can be learned from the Pharmacopoeia. Furthermore, this standardization has been extended to other drugs by the Squibb Laboratories and additions to the _ list will be niade as rapidly as processes can be devised for such standardization. Thus the Squibb Laborato.ries constitute one of the elective means by which knowledge of drugs, the science of pharmacology, is advancing and by its contributions to general knowledge assume a share in the establishment of medicine as an exact science. Brochures on the sub- ject of physiological staiidardization pay be had by physicians upon application, , 53a SQUiBB^S' MATERIA MEDICA Sodium Phdsphiite ' Squibh Sodium phosphate is now prescribed extensively by the medical profession and is also used by the laity as a laxative and mild purgative. It is also said to regulate the secretion of bile and is, therefore, a very important article. , . ' - . Much of the sodium phosphate of the market contains arsenic. , This poisonous impurity is due to the s.ulphuric acid used in the process of manufacture. • Medical literature describes numerous instances of serious arsen- ical poisoning which it attributes to the' use of sodium phosphate containing this impurity. In many cases, although the quantity of arsenic was comparatively' small, the accumulation of arsertic in the system from repeated doses of the sodium phosphate produced dis- tressing and in several cases disastrous results. Believing, therefore, that the physician should have at hand and that there should be available for the public a sodium phosphate that is free from arsenic, the Squibb Laboratories furnish a product that fully meets such a demand. All of Squibb's sodium phosphate is tested for arsenic by a method that is far more delicate than that suggested by the U. S. P., IXth Revision, and in all analyses large quantities of the sodium phosphate are used in order to be sure that Sodium Phosphate Squibb can be considered arsenic-free even when used in very large or in often repeated doses. Furthermore, because of the process of recrystallization which it has undergone, Squibb's Sodium Phosphate is free from all other objec- tionable impurities. It is colorless, odorless, and has a cooling, saline taste. The finished product is granulated to permit of more convenient dispensing and dosing than is obtainable ■with the ordinary crystalline variety. It enjoys appreciative use among those who realize that quality in medicine is the first consideration. ^ Because sodium phosphate is normally a very efflorescent chemical the Squibb product Is placed on the market only in I lb. and Y4 lb. sealed tin containers and not in the cheap paste-board cartons in which so great a part of the sodium phosphate of commerce is found. SQUIBB'S MATERIA MfLDICA 531 Squibb's New Silver Preparations: Solargentum and Protargentum Sdlargentum Squibb (sol=colloid, argentum^sil- ver) is a true colloid of jmetallic silver ; and Protar- gentum Squibb (prot=protein, argentum=silver)^ is a xTA-T-iior rM7 I ti'ue colloid of a salt of silver. NATURE OF r- i ■ r n .l tach possesses in ruU the prop- erties of its respective class. "See "Silver Preparations, Colloidal" and "Silver Protein Compounds" in A^eiv and Nonofficial Remedies, 1919. These Squibb silver preparations are of use wh,erieyer colloidal silver or silver protein is indicated: for instance, -INDICATIONS FOR I ^"^ prophylaxis or for the treat- ment or gonorrhea and other m- fections of the urethra ; for con- junctivitis and other infections of the eye, including , ophthalmia neonatorum; and for infections of the ear, nose, throat, etc. Both Solargentum Squibb and Protargentum Squibb are freely soluble in either cool or warm water. For SOLUTIONS OF 1 making "soluUpns,:'distilbd water should be used. 1 he temperature of the water pref- erably should be low, and even for use cool "solutions" are more efficacious than warm. They should never exceed 37" C (98.6° F). When made properly, "solu- tions" of Solargentum Squibb are stablfe. "Solutions" of Protargentum Squibb, however, are not stable and there- fore they should be made only as wanted. A prescrip- tion for Protargeiitum Squibb should call for a "fresh solution" and fof only enough to last the patient three days or less. ■ In making aqueous "solutions" of Solargentum Squibb, the entire quantity of the flakes may be put into the re- quired amount of water arid the whole stirred or shaken. F(3r a "solution" of Solargentum Squibb in glycerin, first moisten the required quantity of flakes with a few drops of cool water (only enough to moisten them and maker them into a .very thick paste), then add the glycerin (colder in which the pasty Solargentum Squibb will dissolve quickly. Colloidal silver is insoluble in 532 SQUIBB'S MATERIA MEDICA glycerin alone. Caution. It has been recommended to heat the glycerin in a mortar and grind up . ^lie colloidal flakes while heating. Such a procedure almost invariably will destroy the colloid and render -the "solution" irri- tating and less active as an antiseptic. As this heating process is often used by pharmacists, care should be taken that only the "cold water-glycerin" process be used. To make a "solution" of Protargentum Sqiubb it is best to sprinkle the required amount of the powder upon the surface of the water and allow the Protargentum Squibb to dissolve itself gradually, which it does in a very short time. If simple stirring is attempted, the wet^ powder will mass itself on the stirring rod and time and patience will be lost. If preferred the Protargentum Squibb may be triturated with water in a mortar. Solargentum Squibb contains from 19 per cent, to 22 per cent, pure silver, and is an antiseptic and an effective germicide. When mixed with water it will not ionize, no/->Drn-rii7e i-M? therefore it will not precipitate or coagulate protem. Conse- quently in any strength "solu- tions" it is non-caustic, non- astringent, non-irritating. The usual strengths of "solu- tions" of Solargentum Squibb for clinical use are from I per cent, to 25 per cent., or even 50 per cent. Protargentum Squibb contains about 8 per cent, of pure silver. Up«n mixing with water the disperse phase ionizes while in colloidal suspension. Its "solutions," therefore, are not permanent, ' are slightly irritating and somewhat astringent. The usual strength of "solutions" of Protargentum Squibb for clinical uses are from j/^ per cent, to 5 per cent, an average strength of 2 per cent, being ordinarily preferred. It should be borne in mind that a colloid of metallic silver always can be used in a "solution" of much greater IMPORTANT ^[^"Sth than can a silver pro- jyjQ-j-£ tern, notwithstandmg that the actual silver content of the col- ~"' ^ loid is much greater than that of the protein. Further, for equal antiseptic and germ- icidal action, greater strength of the metallic colloid is SOLUTIONS' ■ SQUIBB'S MATERIA MEDICA 533 necessary. For instance, although Solafgentum Squibb contains about 20 per cent, of silver, two-and-a-half limes as much as Protargentum Squibb contains, the strength of clinical "solutions" of Solargentum Squibb are from 1 per cent, to 50 per cent, as against an average strength of 2 per cent, for Protargentum Squibb. USE BY U. S. N. '^^ United States Navy AND U. S. A.' ' ^as been and is purchasing Solargentum Squibb in very . large quantities for general distribution to their medical stations, both on land and sea, at home and abroad. Also the Medical Department of the United States Army has been and is using Solargentum Squibb in rapidly increasing quantities. Further, it has adopted Protargentum Squibb for the prophylactic treatment of venereal diseases, the strength of "solution" authorized being 2 per cent. Squibb's Fluidextracts These are manufactured from the most active drugs obtainable on the market or possible to procure by direct importation. . Thorough exhausting of the assayed and otherwise tested drug assures the production of fluid- extracts of a standard strength. These all contain the maximum amount of active principle and accurately repre- sent the drug. The process of extraction employed is the well-known repercolation process, which originated in the Squibb Laboratories. The menstrua are those which most effectively extract the medicinal ingredients of the drugs, and thus are theoretically true solvents of them; and the strength of the alcohol employed is fully that prescribed by the U. S. P. In all instances in yhich the U. S. Pharmacofxeia prescribes a definite alka- loidal strength for the assayed fluidextracts, the Squibb products are accurately adjusted to that standard; and where the Pharmacopoeia requires or merely recom- mends a phvsiological assay process the Squibb fluid- extracts are carefully tested and standardized- thereby. RAPID DEVELOPMENT THE SQUIBB BIOLOGICAL LABORATORIES 534 SQUIBB'S MATERIA MEDICA Squibb 's Biological Products The production of antitoxic serums, bacterial vaccines and similar biological products, for the immunization and specific treatment of certain highly infectious diseases, has made rapid development dur- ing the past two decades. Ac- tive immunization with bacteria, or their products, has come into general use, not only as a preventive measure, but- as a cure of infectious diseases. To-day the rationale of vaccine and serum therapy has become so firmly established that a large number of biological products find a place in the armamentarium of the pro- gressive physician. The Squibb Biological prod- ucts are scientifically prepared in the new Squibb Research and Biological Laboratories at New Brunswick, N. J. These are elaborately equipped with the most upt-to-date ap- paratus, and the scientific appointments, under the direct supervision of Dr. JoHN H. Anderson, formerly Director of the Hygienic Laboratory, U. S. Public Health Service, are second to none in the country. The Squibb Vaccines are prepared under the most im- proved scientific methods. The stock vaccine is a prod- uct of many strains of each organism. Vaccines are of the greatest value in locahzed infections. Their action ex- tends to cells remote from the seat of infection, stimu- lating them, too, to generate antibodies, which the blood current brings to the area of infection. The Squibb Serums are of high concentration, small in bulk, and high in potency and efficiency and low in solids. They are all tested with the most meticulous care by biologic kbpratory experts. The clinical effect of each physiologically tried out on the specific disease for which it is prepared as a curative agent. The Squibb Vaccines are marketed in aseptic ampuls, accompanied by a syringe for each package. The antitoxins and serums, with the exception of the THE SQUIBB SERUMS AND VACCINES SQUIBB'S MATERIA MEDICA 533 anti-meningitic serum, are distributed; in special aseptic syringes. AKtT-T «/iT-x,.»,r-,.-i.,^ The Anti-Meningitic Seriim ANTI-MENINGITIC j^ ^^^^^^^ f„, administration in a special gravit'^ apparatus, which has the advantage of supplying the serum in a sterile container always ready for use by the gravity method which lessens the danger to shock. Specify "SQUIBBS" when ordering biological prod- ucts, and thus insure results. SERUM SQUIBB IN GRAVITY APPARATUS Food Allergens Squibb Allergy is hypersensitiveness of the system to some TM7i7iMi'T-T/-\Ki 1 matciial introduced into it. Al- DEFINITION 1 . £ 1 r 1 lergy to roods, or rood poison- ~ ing, or food idiosyncrasy, as it is sometimes called, is a hypersensitiveness to the proteins which enters into the' ordinary diet of the individual. It is due, probably, to a previous sensitization of the individual by certain proteins, and thus is a form of anaphylaxis. MANIFESTATION l" . ^°°^ allergy may manifest -. - itselr m a great many ways, • e.g., by the appearance of eczema, asthma, urticaria,- complicated vaspro'ofbr' dis^' turbances of the larger air passages, cardio-vascular con- ditions involving the kidneys, and in many otlie'r ways. It has been known for some. time that egg white, shell- fish, pork, cow's milk, woman's milk, strawberries, barley, oatmeal, and a large number of other food substances cause, in some persons, a disturbEince sufficiently marked to demand remedial attention. In the treatment of food allergy the first important step .„ . is to determine w;hat food or foods cause the systemic dis- — -^ turbance. This can be done by inoculating the patient with several possible food allergens and the specific food protein will manifest itself by a- reaction at the site of inoculation as described below. Of course, the, food protein used for diagnosis must be pure. ■ i . INOCULATE 536 SQUIB B'S MATERIA MEDIGA To make the inoculation it is necessary only to wash HOW TO ^^^ inner surface of the fore- arm with sterile water or physi- ological salt solution, avoiding the use of alcohol, ether, or any other antiseptic solution. A slight scarification should be made, which should penetrate only the outer layers of the skin, great care being taken not to draw any blood. If now upon the scarified spot a small amount of the offending food protein be placed, together with a drop of sterile water, a reaction will take place at the site of the inoculation, which will manifest, itself by the appear- ance of a distinct urticarial wheal within five minutes to half an hour. It is always best to make a control scarifi- cation on which merely the physiological salt solution or the sterile water should be placed. No untoward results follow such inoculation if it is made properly. To remove the hypersensitiveness to a protein, either the specific protein may be elimr TREATMENT inated froni the diet, or immuni- zation may be brought about by feeding the patient with small amounts of the anaphylac- togenic substance until he becomes fully desensitized. The Squibb Laboratories now produce potent food allergens in large variety, the " ftfllowing being a partial list. A complete list may be had upon application. Milk — Cow's milk (all proteins), cow's milk casein, cow's milk albumin, cow's milk globulin, human milk. Egg — Egg (all proteins). Egg white (all proteins), egg albumin, egg yolk (all proteins), egg yolk globulin. Cereals — Barley, rice, wheat, corn, rye, oat. Beverages — Coffee, tea, cocoa. Vegetables — Navy bean, lima bean, pea, asparagus, spinach, while potato, sweet potato, carrot, turnip, tomato, squash. Frail — Orange, strawberry, blackberry, raspberry, cherry, peach, plum, prune, banana, watermelon, canteloupe. Meat — Beef, Iamb, mutton, veal, pork, chicken, horse. ,Sea Foods — Cod- fish, salmon, lobster, crab, oyster, clam. Nuts — PeanUt, chestnut, English walnut, black walnut, hickory nut, pecan, almond, butternut, Brazil nut. SQUIBB FOOD ALLERGENS SQUIBB'S MATERIA MEDICA 537 Squibb's Anaesthetics The Squibb line of anaesthetics include Ether, Chloro- form, Ethyl Chloride, and Ethyl Bromide. Each is made in one quality only, the best pxjssible for anaesthesia, so when "Squibb's" is had, there is no danger from an inferior product. Ether Squibb is made only in the Squibb Labora- tories by a- process devised by Dr. E. R. Squibb and long since brought to practical perfection. Its physical and chemical characteristics were determined by exhaus- tive cHnical experimentation. Thus the Squibb Ether has always proved itself the best for anaesthesia and been recognized as the standard. Chloroform Squibb is made in the Squibb Labora- tories by the Squibb process and purified by a special process devised by Dr. E. R. Squibb. The outcome of these processes is a chloroform in vital respects superior to the chloroform of the U. S. P. No better chloroform for anaesthesia can be made than Chloroform Squibb. Ethyl Chloride Squibb is pure. This is necessary if it is for anaesthesia by inhalation. In order that no mistake.be piossible. Ethyl Chloride Squibb, like . all other products of the Squibb Laboratories, is made in one quality only. This is put up in, glass tubes to prevent decomposition, >vhich invariably takes place in a metal container. • These tubes are of two kinds : one delivering a quantity of. ethyl chloride sufficient for producing gen- eral anaesthesia, but too large a quantity for freezing; the other delivering a quantity the most economical and other- wise the most satisfactory for freezing as a local anaes- , thetic, but too small an amount for general anaesthesia. In ordering, the purpose for which the product is intended should be mentioned, although the quality of ethyl chlor- ide is the same in both cases. , , Ethyl Bromide Squibb is made with the same care as are the other Squibb anaesthetics, and requires no more extended description than is found on page 78 of this Materia Medica. The Medical Department of E. R. Squibb & Sons has prepared several monographs on inhalation anesthesia, copies of which may be had by physicians upon [their request. >■. 538 SQOIBB'S MATERIA MEDICA Squibb's Milk Sugar Specially prepared and purified for the home modifica- tion of milk for infant feeding.- It is obvious that for so ir/->r. ixtrAKiT ■ important a purpose as infant FOR INFANT , j. ..l • i ^ lU FEEDING reedmg, nothmg but Ihe very highest quality of Milk Sugar should be used; and such is Squibb's. It is added not merely to sv^eeten the food and render it more palatable, but to furnish the proper proportion of solubie carbohydrates necessary for the infant's nutrition and growth. Cow's milk contains between 2j/2 and 4 per cent, of proteins, and about 4 J/2 Per cent, of milk sugar; woman's milk contains only 1 J/^ per cent, of proteins and 7 per cent, of milk sugar. Hence in cow's milk there is an excess of proteins and a deficiency of milk sugar. It is therefore necessary to dilute the cow's milk, in order to diminish the protein content (for it is the proteins that cause much of the trouble to the infant's digestion) ; but this dilution also lowers the percentage of milk sugar, thus further increasing the original deficiency of this constituent. Hence the necessity for the addition of milk sugar. Squibb's milk sugar is perfectly free from butter^fat, starch and cane sugar, which are very liable to produce • gastric fermentation ; and it is also free from acids- and other foreign substances" that might prove in- jurious to the infant. Squibb's Milk Sugar is in the form of an impalpable powder, having been bolted through a No. 120 silk bolting cloth; and it exceeds the most exacting recognized tests for purity. Inasmuch as milk sugar readily absorbs odors and moisture, and in consequence hereof becomes contaminated and unfit for use, the Squibb product is offered only in sealed tins, in 1-lb. and '/4-lb. sizes, and not in paste- board boxes. Directions for pr^aring inodified milk are printed on the cans. Specify Squibb's when ordering milk sugar, and thereby insure obtaining a product of the greatest merit and reliability. FREE FROM BUTTER-FAT, STARCH AND CANE SUGAR SQUIBB*^S MATERIA MEDICA 539 Squibb's Digitalis Products The Squibb Laboratories make use of only the choicest and most carefully cured EHgitalis leaves. This is evi- denced by.ithe beautiful green color of the Squibb fluid- extract and tinctures. Each shipment of leaves is care- fully examined by our expert pharmacognosists, and its freedom from admixture with foreign leaves and other adulterants is assured. After the leavies have passed this examination, a liberal sample of it is .made into the official tincture and is then tested physiologically according to the method outlined in the U. S. P. ,, If the finished drug does not admirably come up to the official , standard in every respect, the entire lot of leaves is rejected. As a rule, the leaver accepted by the Squibb Laboratories are much more active than the Pharmacopoeia demands and the preparations made from them are carefully adjusted to a potency of 25 per cent, above the official standard. In this v\^ay full activity and uniformity of strength are assured for such an important product as Digitalis. t Tincture Digitalisr.Squibb is assayed not only by the U. S. P. method, as^ mentioned above, but its activity is aJso determined by the "cat method" thus giving a double check on its physiological activity. Fluid Extract Digitalis Squibb is biologically assayed by the same double checking system as the tincture just mentioned. A Fat-free Tincture Digitalis is supposed to be borne better by the stomach than is the. ordinary tincture, there- fore the Squibb Laboratories make a fat-free tincture, which should be specified if desired. It is prepared from leaves from which the fat has been removed by a method which does not extract or otherwise interfere with any of the proximate principles. It is of the same strength as the U. S. P. tincture, and is physiologically tested by the Hatcher "cat method" and adjusted so that each mil . (Cc.) represents one cat unit (Hatcher's standard)., Whole, Ground, or Powdered Digitalis }ea.ves, and a Soft and a Powdered Extract Digitalis, are also offered under the Squibb label. For complete descriptions see Digitaliis, Extract Digi- talis, Fluidextract Digitalis and Tincture Digitalis titles in Part I of this MATERIA Medica. 540 SQUIBB'S MATERIA MEDICA Squibb 's Household Products There are many articles of a medicinal and semi- medicinal nature for which employment is found in every household. For the toilet there are numerous articles whose quality should be of the best; while for general household purposes — cooking, milk modification, disin- fection, etc.' — the purest and best articles are lieeded. The following products are well known for their purity, uniformity and efficiency: Squibb's Baking PoTvder. Absolutely pure, very ac- tive, hence econon)ical to use. Squibb's Cold Cream. A superior product, safe to use wherever Cold Cream is required. Squibb's Milk Sugar. Exceptionally pure; fine pow- der. Especially designed for milk modification. Squibb's Olive Oil. Best Virgin; free from adulter- ants; brilliant, and of most agreeable taste. Squibb's Pure Spices. Of absolute purity, hence of unusual strength. Squibb's Castor Oil. Scarcely any unpleasant taste because of its purity ; well borne, effective. Squibb's Cod Liver Oil. Cold pressed "shore" oil; almost free from disagreeable odor and taste. Squibb's Benzoinated Cream. A healing salve for chafed surfaces, sunburn, cracked lips, etc. Squibb's Flexible Collodion. Liquid Court-Plaster. Impervious coating for cuts; does not crack. Squibb's Magnesium Sulphate. Repurified; a distinc- tive quahty with hardly any bitterness. Squibb's Sodium Bicarbonate. Highest purity, hence bitterless and efficient. Squibb's Sodium Phosphate. Arsenic-free, therefore may be taken freely arid often, without harm. Squibb's Solution Hydrogen Peroxide. Of excep- tional strength and keeping qualities. Squibb's Talcum Poivder. Of correct composition; free from starch, chalk, and other foreign substances; impalpable, neutral, non-irritating. Squibb's Zinc Stearate. Antiseptic, water-shedding dusting powder for infants as well as adults. Scarcely visible when applied. ABSOLUTELY PURE VIRGIN OIL SQUIBB'S MATERIA MEDICA 541 Squibb's Olive Oil It is not generally known that much of whaf is sold as "Olive Oil" or Salad Oil is nothing but cotton-seed oil without even a trace of olive oil in it; and mixtures of olive oil with cotton-seed or peanut oil are brazenly offered as pure olive oil. Squibb's Olive Oil is guar- anteed absolutely free from adulteration and meets the most rigid known tests for perfect purity as yrell as regards physical characteristics. It is the very best quality of what is known as Virgin Olive Oil; that is, the first oil that exudes on subjecting the olives to gentle pressure, this portion representing the best, the most pajatable and the most nutritious oil. Only the full grown, perfectly soimd olives of the proper blackish- violet color are used, all bruised, decayed or otherwise unsound fruits being rejected. Squibb's Olive Oil is therefore a brilliant oil of greenish-yellow color, and most pleasant, nutty taste. Recently olive oil has come into prominence as an efficient means of quickly restoring the opsonic index after surgical anaethesias. For this important purpose only a perfectly pure quality such as\Squibb's answers; an article laden with stearins and other" heavy impurities is but slowly -absorbed an3 therefore means loss of precious time. Why take any risks? I Squibb's Olive Oil is put up in special bottles of 1 pint, Yz pint ^^^ /4 P'nt — full measure, and can be obtained in these original packages at all first class drug stores. It should be kept in a cool place as all pure olive oil solidifies at 0°C.; gentle heat will restore its fluidity. ' _ An interesting monograph en- AN INTEREST- titled "Surgical Anaesthesia in ING TREATISE its Relation to Immunity," giv- '■ ^ ing a statement of recent find- ings concerning olive oil as a speedy restorer of the patient's power to resist infection, will be mailed to physicians on application. PROMPT RESTORER OF THE OPSONIC INDEX 542 SQUIB B'S MATERIA MEDICA Barium Sulphate Squibb For X-Ray Work Formerly Barium Sulphate was used only in the arts, and not in or on the human body. However, latterly it has been brought forward for use in taking X-Ray pic- tures of the stomach and of the intestines. Of course, for this purpose only a specially prepared quality is eligible, one of which is absolutely free from soluble barium salts so as to be wholly without toxic action. Such a product is Barium Sulphate Squibb for X-Ray work. This is pre- pared from highly pure materials and most carefully tested chemically and spectroscopically for perfect free- dom from soluble barium salts and other pKJSsibly harmful iiripurities. Barium Sulphate Squibb for X-Ray Work occurs as an extremely fine, white, odorless, tasteless and relatively light powder, which is insoluble in water and the organic solvents as well as in acids and in dilute alkalies. It therefore passes through the system wholly unchanged and unabsorbed, and as it is absolutely free from soluble salts there is no possibility of untoward action. Barium Sulphate Squibb is used in 10 to 50 per cent, mixtures for X-Ray esophogeal and gastro-intestinal ex- aminations. A suitable test meal for examination of the stomach and intestines consists of a mixture of Barium Sulphate Squibb 5 oz., sugar Yl oz., cocoa 54 oz-, cornmeal Yi oz. and water 7 fl. oz. The sulphate may - be considerably increased if necessary. It is also employed in opaque enemas where shadow pictures of the colon and intestines are desired. Such an enema should be non-irritating to the bowel ; sufficiently large to fill the entire bowel ; fluid enough to flow freely and fill recesses, yet sufficiently thick to hold the barium in good suspension. In view of the fact' that many grades of Barium Sul- phate on the market contain soluble barium salts and are hence dangerous to use, care should be taken to clearly specify and accept only Barium Sulphate Squibb for X-Ray work. SQUIBB'S MATERIA MEDICA 543 Squlbb's Magnesia Magma (Milk of Magnesia Squibb) Squibb's Magnesia Magma is an official product con- taining only the pure magnesium hydroxide, in the per- centage specified in the U. S. P. suspended in water and conforming in all respects to the chemical and phy- sical tests laid down by that authority, but is superior to the U. S. P. and most magnesia magmas as shown below. The Squibb Magnesia Magma is made, from the highly purified Magnesium Sulphate Squibb while the U. S. P. product is made from U. S. P. grade Mag- nesium Carbonate. Both ^ocesses produce the hydrated magnesium oxide but the Squibb product jinishes velvety smooth while others are distinctly gritty. Again, the Squibb product has, but a slight alkaline taste while the U. S. P. article and most other market varieties have a pronounced alkaline taste. Two promi- nent factors contribute to these distinct advantages of the Squibb Magnesia Magma over others. In its manufac-r ture only chemicals of Squibb purity are used and, again, the process is carried out under the most exacting condi- tions and with complete control from first to last. The elegance of the product shows the result. It is much used by adults for fermentative dyspepsia, quickly correcting conditions arising from excessive acid- ity, and' for the colic of infants it is almost a specific. It w^ll maintain a continuous alkaline condition in the mouth and hence is much in favor as a dentrifice overcoming any acidity present in the mouth and dental interspaces, and thus protecting the teeth against untimely decay. There- fore in rational therapeutics it is indicated in erosion, for gingival caries, in tooth caries of pregnancy, and all oral pathological conditions due to hyperacidity of the mouth secretions, whether of local or systemic origin. Squibb's Magnesia Magnla-is offered in Yl pint -and in [pint bottles,, its continued use will demonstrate that it is a highly superior product. 544 SQUIBB'S MATERIA MEDICA SQUIBB'S IM- PROVED AP- PARATUS STAND SQUIBB'S SPE- CIFIC GRAVITY APPARATUS Squibb's Testiilg Apparatus It does not seem to be generally known that E. R. Squibb & Sons make several convenient and inexpensive pieces of apparatus for use of physicians and pharmacists. They are briefly described below. This apparatus stand has been in use in the Squibb Labo- ratories for years and has proved very satisfactory. It consists of a nickel-plated up- right rod, secured in an iron cylinder base. Its advan- tages are its stability, neat appearance and compactness. The usual attachments are supported by the rod. Price $2.30. Supplied in a neatly packed case and consists of a thermom- eter, hydrometer (urinometer) , urine jar or tube, and litmus paper. The urinometer is ad- justed to read accurately without corrections at the con- venient temperature of 25° C. Temperature corrections can easily be made however as shownSn the accompany- ing directions. The complete outfit is supplied for $2.25. This consists of the necessary solutions, tubes and pipette for performing Fehling's sugar test — usually used on urine sam- ples. It comprises 50 mils (Cc.) each of cc^per sulphate solution and alkaline tar- trate solution, together with, two test tubes and a I mil pipette; all packed in a pasteboard case. Full directions are enclosed. The set supplies sufficient fluid for several tests and extra solutions can be obtained of E. R. Squibb & Sons' as found necessary. Price $1.00, ; This apparatus consists of the necessary pieces and solu^ lions for the quantitative estima- tion, of urea by the hypobromite method (or hypochlorite method if preferred). The parts are complete and compact and sufficient solution is supplied for several tests. Extra solutions may be ob- tained of E. R. Squibb & Sons if desired. Price $2.45. SQUIBB'S SUGAR TEST- ING OUTFIT SQUIBB'S UREA APPARATUS Please Remember That the SQUIBB products cost no more than other makes, except In very few instances, where a slight advance over ordinary market prices is charged for the reason that it is impossible to furnish the Squibb Quality at a price lower than that we make at time of delivery. That the SQUIBB products are readily obtainable under the original Squibb label in all parts of the United States at the prices and in the subdivisions named in the foregoing pages. That the SQUIBB products are carried in stock by wholesale houses every- where, and can be supplied by the jobbers as promptly as any other brand. Therefore, if you prefer SQUIBB'S to other makes, do not hesitate to demand it, wherever you may' be located; and see to it that your specification is obeyed. Your active coopera- tion will be greatly appreciated by E. R. SQUIBB & SONS CONTENTS Part I — Drugs and Chemicals Official Products, and Non-Official Chemicals, Phar- maceuticals and Newer Remedies. Arranged in Alphabetical Order .' 1-297 Part II — Medicinal Tablets Mouth Tablets, Hypodermic Tablets, Dispensing Tablets, Ophthalmic Tablets, Tablet Cases, Lozenges and Troches 298^35 Part III — Biological Products Antitoxins, Serums, Vaccines, Leucocyte Extract and Thromboplastin; also Biological Therapeutic Index. . 436-448 Part IV— Reagents, Test Solutions, Etc. Analyzed Reagents, Test Solutions, Volumetric Solutions and Indicators 449-464 Part V — Veterinary Products Hypodermic Tablets, Solution Tablets, Tablet Case, Anti-Hog Cholera Serum, Mallein, Distemper Vaccine, Distemper Serum, Tetanus Antitoxin and Tuberculin 465—470 Part VI — Miscellaneous Glossary of Therapeutic Terms 471 The Metric System, with Table of Equivalents 478 Thermomelric Equivalents 481 Practical Urinalysis, with Tests Commonly Employed. . 482 Volume at 25° C. of 1 lb. Av.'of Some Liquids. ..... 489 Chart of Eruptive Fevers 490 Obstetrical Calendars 492 Drugs That Affect the Color of Urine 494 Percentage Solution Table 495 Part VII— Scientific Notes Detailed Information Concerning a Number of Important Squibb Products 496-544